Dr. Wang began her exploration of the distal nephron mechanisms in dopamine-mediated sodium transport when she joined the laboratory of Dr. Pedro Jose as an Instructor in the Department of Pediatrics at Georgetown University School of Medicine. This was after completing her research fellowship with Dr. Mark Knepper, Laboratory of Kidney and Electrolyte Metabolism, NHLBI, NIH in 2003. Dr. Wang discovered that a greater amount of the distal nephron is involved in salt-sensitive hypertension and blunted pressure natriuresis associated with disruption or dysfunction of dopamine receptors in mice than was previously thought. The involvement of the distal nephron may be independent of renin, angiotensin II, and/or aldosterone. She has also studied the direct effect of dopamine receptors on sodium transport in mouse polarized distal convoluted cells and micro-dissected nephron segments. Dr. Wang is well trained in renal molecular physiology and has published more than 20 manuscripts in the field, 8 of which as first author or co-first author. More recently, she discovered that the dopamine receptor D5 regulation of sodium transporters/channels in the distal nephron (thick ascending limb and collecting tubule) plays an important role in salt-sensitive hypertension in mice, independent of the renin-angiotensin II-aldosterone system. She continues to study the mechanisms involved in dopamine-mediated natriuresis.
Education and Training
- Yanzhou University, Medical School, China: BS - 1981 - Medicine
- Nanjing Medical University, China: MS - 1987 - Medicine, nephrology
- Nanjing Medical University, China: PhD - 1994 - Medicine, nephrology
- Duke University Medical Center: 1998-1999 - Research Associate
- LKEM, NHLBI, NIH: 1999-2003 - Research Fellow
Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks H, Nielsen S, Knepper MA. The Renal Thiazide-Sensitive Na-Cl Cotransporter as Mediator of the Aldosterone-Escape Phenomenon. J of Clin. Invest,108:215-222, 2001.
Masilamani S, Wang XY, Nielson J, Kwon TH, Brooks H, Beutler K, Hager H, Nielson S, Knepper MA. Time course of changes in renal NHE3, NKCC2, NCC, Na-K-ATPase and ENaC expression with dietary NaCl restriction. Am J Physiol Renal Physiol. 283: F648-F657, 2002.
Turban S, Wang XY (co-first author), and Knepper MA. Regulation of NHE3, NKCC2 and NCC Abundance in Kidney during Aldosterone-Escape Phenomenon: Role of NO. Am J Physiol Renal Physiol.285:F843-51, 2003.
Bek MJ, Wang X (co-first and corresponding author), Asico LD, Jones JE, Zheng S, Li X, Eisner GM, Grandy DK, Carey RM, Soares-da-Silva P, Jose PA. Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice. Hypertension. 47:288-95, 2006.
Armando I, Wang X, Villlar MVA, Jones EJ, Asico DL, Escano C, Jose PA. Reactive Oxygen Species-Dependent Hypertension in Dopamine D2 Receptor-Deficient Mice. Hypertension. 49:672-8, 2007.
Wang X, Villar VA, Armando I, Eisner GM, Felder RA, Jose PA. Dopamine, Kidney and Hypertension: Studies in Dopamine Receptor Knockout Mice. Pediat Nephrol, 23:2131-2146, 2008.
Wang X, Armando I, Upadhyay K, Pascua A, Jose PA.The regulation of proximal tubular salt transport in hypertension: an update. Curr Opin Nephrol Hypertens. 18:412-420, 2009.
Esteva-Font C, Wang X, Ars E, Guillén-Gómez E, Sans L, González Saavedra I, Torres F, Torra R, Masilamani S, Ballarín JA, Fernández-Llama P. Are Sodium Transporters in Urinary Exosomes Reliable Markers of Tubular Sodium Reabsorption in Hypertensive Patients? Nephron Physiol. 114:25-34, 2010.
Wang X (corresponding author), Luo Y, Escano CS, Yang Z, Asico L, Li H, Jones JE, Armando I, Sibley DR, Jose PA. Upregulation of renal sodium transporters in D5 dopamine receptor deficient mice. Hypertension. 55:1431-1437, 2010.
Wang X, Li F, Jose PA, Ecelbarger CM. Reduction of renal dopamine receptor expression in obese Zucker rats: role of sex and angiotensin II. Am J Physiol Renal Physiol. 299:F1164-1170, 2010.
Note: Wang XY and Wang X refer to the same person.