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Pedro A. Jose

Pedro A. Jose M.D., Ph.D.

Academic Title: Adjunct Professor
Primary Appointment: Medicine
Location: UMMC N3W143

Personal History:

Pedro A. Jose, MD, PhD, is Professor of Medicine and Physiology, University of Maryland School of Medicine, Adjunct Professor of Biochemistry and Molecular & Cellular Biology, Georgetown University School of Medicine, and Visiting Professor, 3rd Military Medical University of China, Chongqing, China. Dr. Jose received his MD degree, magna cum laude, meritissimus, from the University of Santo Tomas, Philippines, placed first in the Philippine National Board Examinations, and received his PhD degree in Physiology (dissertation defended with distinction) from Georgetown University. Dr. Jose is certified by the American Board of Pediatrics, American Board of Pediatric Nephrology, and American Society of Hypertension Specialist in Clinical Hypertension. He holds a US patent on G protein-related kinase mutants in essential hypertension (US #6,660,474) and a provisional patent on Compositions and Methods for Identifying and Diagnosing Salt Sensitivity of Blood Pressure (US Provisional Patent Application #61,636,576).

Research Interests:

Dr. Jose has published on hypertension-related research since 1987 and on salt-sensitive hypertension since 1993. He has studied the pathogenesis of hypertension, including the role of genetics in humans, rats, and mice, in vitro and in vivo. Dr. Jose is a recognized expert on the role of dopamine receptors in the regulation of renal function, epithelial sodium transport, vascular function, and blood pressure.  He has also contributed novel and important information on signal transduction and cellular trafficking of dopamine receptors, including the D1-like (D1R and D5R) dopamine receptors.  He is a co-author of the seminal article that described for the first time the deletion of Drd1, the mouse D1R gene (249 citations). Dr. Jose is also a co-author of the article that described for the first time the deletion of the Drd5, the mouse D5R gene (77 citations). His publications (340) have been cited more than 6,000 times, with 31 cited more than 50 times, 16 of which were cited more than 100 times.  Dr. Jose has mentored 41 post graduate fellows, 10 PhD students, 2 MS students, 10 college students, and 6 high school students. Dr. Jose has held several executive positions in academe and industry and chaired several NIH Study Sections. His research has been recognized by several awards, including the 2007 Ernest H. Starling Lecturer, Water and Electrolyte Homeostasis Section, American Physiological Society, 2003 Lewis K. Dahl Memorial Lecturer (Council for High Blood Pressure Research American Heart Association), and an NIH MERIT Award, as well as a US patent (G protein-related kinase mutants in essential hypertension, US Patent Number 6,660,474) and a US Provisional Patent Application (Serial No. 61,636,576, Compositions and Methods for Identifying and Diagnosing Salt Sensitivity of Blood Pressure). Four of his publications were on the cover of scientific journals and five were the subject of editorial commentary. Dr. Jose’s research is currently funded by R37HL023081-32, R01DK039308-25, R01HL092196-05, P01HL074940-08, P01HL068686-10, and BIAL NA35786.  Deciphering the role of variations of GRK4 in the causation of human essential hypertension was the second advance and discovery cited by the Director of the National Heart, Lung, and Blood Institute for its FY 2004 Budget Justification to the US Congress.


Selected Publications (from 340):

  1. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H. Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA. 91:12564-8, 1994. PMC45479
  2. Yu P-Y, Asico LD, Eisner GM, Jose PA. Selective regulation of renal phospholipase C isoforms by dopamine1 agonists: correlation with in vivo studies. J Clin Invest. 95:304-8, 1995. PMC295432
  3. Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal HJ, Jose PA. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest. 97:2283-8, 1996. PMC507308
  4. Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico L, Jose PA, Taylor SI, Westphal H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet. 12: 106-9, 1996.
  5. Asico LD, Ladines C, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, Felder RA, Eisner GM, Jose PA. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest. 102:493-8, 1998. PMC508909
  6. Zeng C, Yang Z, Wang Z, Jones JE, Wang X, Altea J, Mangrum AJ, Hopfer U, Sibley DR, Eisner GM, Felder RA, Jose PA. Interaction of AT1 and D5 dopamine receptors in renal proximal tubule cells. Hypertension. 45:804-10, 2005 (cover picture). Free article
  7. Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, Sibley DR, Eisner G, Felder RA, Jose PA. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via ubiquitin-proteasome pathway in mice and human cells. J Clin Invest. 118:2180-9, 2008. PMC2373421
  8. Zeng C, Asico LD, Yu C, Villar VM, Shi W, Luo Y, Wang Z, He D, Liu Y, Huang L, Yang C, Wang X, Zhou L, Hopfer U, Eisner GM, Jose PA. Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int. 74:750-9, 2008 (cover picture, subject of an editorial commentary). Free article
  9. Escano CS, Armando I, Wang X, Asico LD, Pascua A, Yang Y, Wang Z, Lau YS, Jose PA. Renal dopaminergic defect in C57Bl/6J mice. Am J Physiol Regul Integr Comp Physiol. 297:R1660-9, 2009. PMC2803619
  10. Rex E, Rankin ML, Yang Y, Lu Q, Gerfen CR, Jose PA, Sibley DR. Identification of RanBP 9/10 as interacting partners for protein kinase Cγ/δ and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. Mol Pharmacol. 78:1-12, 2010 (cover picture). PMC: PMC2912060
  11. Asico L, Zhang X, Jiang J, Cabrera D, Escano CS, Sibley DR, Wang X, Yang Y, Mannon R, Jones JE, Armando I, Jose PA. Lack of Renal Dopamine D5 Receptors Promotes Hypertension. J Am Soc Nephrol. 22:82-9, 2011. PMC3014037
  12. Zhang Y, Fu C, Asico LD, Villar VA, Ren H, He D, Wang Z, Yang J, Jose PA, Zeng C. Role of Gα12- and Gα13-protein subunit linkage of D3 dopamine receptors in the natriuretic effect of D3 dopamine receptor in kidney. Hypertens Res. 34;50:1011-15, 2011. (subject of editorial commentary)
  13. Cuevas S, Zhang Y, Yang Y, Escano C, Asico L, Jones JE, Armando I, Jose PA. Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production. Hypertension. 59:446-52, 2012. PMC3395064
  14. Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA, Felder RA. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 60:396-403, 2012. PMC3406928
  15. Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, Park MJ, Sobota RS, Underwood PC, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins PN, Adler GK, Williams SM, Jose PA, Felder RA. Salt Sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension. 60:1359-66, 2012 "PMC in process"