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Nuria Gonzalez-Montalban Ph.D.

Academic Title: Academic Fellow
Primary Appointment: Institute of Marine and Environmental Technology
NGonzalez-Montalban@som.umaryland.edu
Location: IMET, N3061
Phone: 410-234-8827

Publications:

  1. Gonzalez-Montalban N, Lee YJ, Makarava N, Savtchenko R, Baskakov IV. Changes in prion replication environment cause prion strain mutation. FASEB J 2013. Epub 2013 May 31.
  2. Gonzalez-Montalban N, Baskakov IV. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during Protein Misfolding Cyclic Amplification. PLoS One 2012 7 (7): e41210.
  3. Sans C, Garcia-Fruitos E, Ferraz RM, Gonzalez-Montalban N, Rinas U, Lopez-Santin J, Villaverde A, Alvaro G. Inclusion bodies of fuculose-1-phosphate aldolase as stable and reusable biocatalysts. Biotechnol Prog. 2012 Mar-Apr 28 (2): 421-7.
  4. Gonzalez-Montalban N, Makarava N, Savtchenko R, Baskakov IV. Relationship between conformational stability and amplification efficiency of prions. Biochemistry 2011 Sep 20; 50(37): 7933-40.
  5. Domingo-Espin J, Vazquez E, Ganz J, Conchillo O, Garcia-Fruitos E, Cedano J, Unzueta U, Petegnief V, Gonzalez-Montalban N, Planas AM, Daura X, Peluffo H, Ferrer-Miralles N, Villaverde A. Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions. Nanomedicine (Lond). 2011 Aug; 6(6): 1047-61
  6. Garcia-Fruitos E, Vazquez E, Gonzalez-Montalban N, Ferrer-Miralles N, Villaverde A. Analytical Approaches for Assessing Aggregation of Protein Biopharmaceuticals. Curr Pharm Biotechnol. 2011 May 5; 12: 1530-1536.
  7. Gonzalez-Montalban N*, Makarava N*, Ostapchenko VG, Savtchenko R, Alexeeva I, Rohwer RG, Baskakov IV. Highly Efficient Protein Misfolding Cyclic Amplification. PLOS Pathog. 2011 Feb 10; 7 (2). *Both authors contributed equally to this work.
  8. Saccardo P, Villaverde A , Gonzalez-Montalban N. Peptide-mediated DNA condensation for non viral gene therapy. Biotechnol Adv. 2009 Jul-Aug;  27(4):432-8.
  9. Martinez-Alonso M, Gonzalez-Montalban N, Garcia-Fruitos E, Villaverde A. Learning about protein solubility from bacterial inclusion bodies. Microb Cell Fact. 2009 Jan 8; 8(1): 4.
  10. Martinez-Alonso M, Gonzalez-Montalban N, Garcia-Fruitos E, Villaverde A. The functional quality of soluble recombinant polypeptides produced in Escherichia coli is defined by a wide conformational spectrum. Appl Environ Microbiol. 2008 Dec; 74(23): 7431-3.
  11. Gonzalez-Montalban N, Natalello A, Garcia-Fruitos E, Villaverde A, Doglia SM. In situ refolding and activation in bacterial inclusion bodies. Biotechnol Bioeng. 2008 Jul 1; 100(4): 797-802
  12. Garcia-Fruitos E, Martinez-Alonso M, Gonzalez-Montalban N, Valli M, Mattanovich D, Villaverde A. Divergent Genetic Control of Protein Solubility and Conformational Quality in Escherichia coli. J Mol Biol. 2007 Nov 16;374(1):195-205.
  13. Gonzalez-Montalban N, Garcia-Fruitos E, Villaverde A. Recombinant protein solubility - does more mean better? Nat Biotechnol. 2007 Jul;25(7):718-20.
  14. Gonzalez-Montalban N, Villaverde A, Aris A.  Amyloid-linked cellular toxicity triggered by bacterial inclusion bodies.  Biochem Biophys Res Communq. 2007 April 13; 355(3):637-642.
  15. Vera A, Gonzalez-Montalban N, Aris A, Villaverde A.  The conformational quality of insoluble recombinant proteins is enhanced at low growth temperatures.   Biotechnol Bioeng. 2006 April 15;96(6):1101-6. 
  16. Gonzalez-Montalban N, Garcia-Fruitos E, Ventura S, Aris A, Villaverde A. The chaperone DnaK controls the fractioning of functional protein between soluble and insoluble cell fractions in inclusion body-forming cells. Microb Cell Fact. 2006 Aug  7; 5:26.
  17. Garcia-Fruitos E, Gonzalez-Montalban N, Morell M, Vera A, Ferraz RM, Aris A, Ventura S, Villaverde A. Aggregation as bacterial inclusion bodies does not imply inactivation of enzymes and fluorescent proteins.  Microb Cell Fact. 2005 Sept 12; 4:27.
  18. Gonzalez-Montalban N, Carrió MM, Cuatrecasas S, Aris A, Villaverde A. Bacterial inclusion bodies are cytotoxic in vivo in absence of functional chaperones DnaK or GroEL. J Biotechnol. 2005 Sep 10; 118(4):406-12.
  19. Vera A, Aris A, Carrio MM, Gonzalez-Montalban N, Villaverde A. Lon and ClpP proteases participate in the physiological disintegration of protein aggregates. J Biotechnol. 2005 Sep 23; 119(2):163-71.
  20. Carrio MM, Gonzalez-Montalban N, Vera A., Villaverde A, Ventura S. Amyloid-like properties of bacterial inclusion bodies. J Mol Biol. 2005 Apr 15; 347(5):1025-37.