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Jack M. Guralnik M.D., Ph.D., M.P.H.

Academic Title: Professor
Primary Appointment: Epidemiology & Public Health
Location: Howard Hall, 200
Phone: (410) 706-2406

Personal History:

Dr. Jack Guralnik spent 25 years doing epidemiologic research at the National Institute on Aging, NIH and was Chief of the intramural Laboratory of Epidemiology, Demography and Biometry. He received his M.D. degree from Jefferson Medical College in Philadelphia and M.P.H. and Ph.D. degrees from the University of California, Berkeley. He is Board Certified in Public Health and General Preventive Medicine.

Dr. Guralnik was in the intramural epidemiology research program at the National Institute on Aging from 1985-2010. He has received multiple professional awards during his career. In 2005 he was awarded an Honorary Doctorate from the University of Tampere, Finland and in 2009 received the NIH Director's Mentoring Award.

His primary areas of interest in the epidemiology of aging include the study of physical functioning and disability, the benefits of physical activity, the prevalence and impact of multiple co-existing chronic conditions, factors associated with healthy aging, methods of assessment of health and functional status, and trends in demographic and health status characteristics of the older population. He has published over 550 journal articles and book chapters in these areas of aging research and has taught and lectured extensively in the U.S. and abroad.


LaCroix AZ, Guralnik JM, Curb JD, Wallace RB, Ostfeld AM, Hennekens CH. Chest pain and coronary heart disease mortality among men and women in three communities. Circulation 1990;81:437-446.

Schneider EL, Guralnik JM.  The aging of America: Impact on health care costs.  JAMA 1990;263:2335-2340.

Guralnik JM, LaCroix AZ, Abbott RD, Berkman LF, Satterfield S, Evans DA, Wallace RB. Maintaining mobility in late life. I. Demographic characteristics and chronic conditions.  Am J Epidemiol 1993;137:845-857.

LaCroix AZ, Guralnik JM, Berkman LF, Wallace RB, Satterfield S. Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity, and body mass index.  Am J Epidemiol 1993;137:858-869.

Guralnik JM, Land KC, Blazer D, Fillenbaum GG, Branch LG.  Educational status and active life expectancy in older blacks and whites. N Engl J Med 1993;329:110-116.

Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB.  A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission.  J Gerontol Med Sci 1994;49:M85-M94.

Pahor M, Guralnik JM, Salive ME, Chrischilles EA, Brown SL, Wallace RB.  Physical activity and risk of severe gastrointestinal hemorrhage in older persons.  JAMA 1994;272:595-599.

Corti M, Guralnik JM, Salive ME, Sorkin JD.  Serum albumin and physical disability as predictors of mortality in older persons.  JAMA 1994;272:1036-1042.

Guralnik JM.  Understanding the relationship between disease and disability (Editorial). J Am Geriatr Soc 1994;42:1128-1129.

Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB.  Lower extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-561.

Corti MC, Guralnik JM, Salive ME, Harris T, Field TS, Wallace RB, Berkman LF, Seeman TE, Glynn RJ, Hennekens CH, Havlik RJ.  HDL cholesterol predicts coronary heart disease mortality in older persons. JAMA 1995;274:539-544.

Guralnik JM, Fried LP, Salive ME.  Disability as a public health outcome in the aging population. Ann Rev Public Health 1996;17:25-46.

Ferrucci L, Guralnik JM, Simonsick E, Salive ME,  Corti MC, Langlois J.  Progressive versus catastrophic disability: A longitudinal view of the disablement process.  J Gerontol Med Sci 1996;51:M123-M130.

Guralnik JM.  Assessing the impact of comorbidity in the older population.  Ann Epidemiol 1996;6:376-380.

Ferrucci L, Guralnik JM, Pahor M, Corti M-C, Havlik RJ.  Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled.  JAMA 1997;277:728-734.

Guralnik JM, Leveille SG. Race, ethnicity, and health outcomes - unraveling the mediating role of socioeconomic status (Editorial).  Am J Public Health 1997; 87:728-730.

Guralnik JM,  Leveille SG,  Hirsch R,  Ferrucci L, Fried LP. The impact of disability in older women. J Amer Med Women's Assoc 1997;52:113-129.

Penninx BWJH, Guralnik JM, Ferrucci L, Simonsick EM, Deeg DJH, Wallace RB.  Depressive symptoms and physical decline in community-dwelling older persons. JAMA 1998;279:1720-1726.

Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, White L.  Mid-life grip strength as a predictor of old age disability. JAMA 1999;281:558-560.

Guralnik JM, Ferrucci F, Pieper CF, Leveille SG, Markides KS, Ostir GV, Studenski S, Berkman LF, Wallace RB.  Lower extremity function and subsequent disability: Consistency across studies, predictive models, and value of gait speed alone compared to the short physical performance battery.  J Gerontol Med Sci 2000;55:M221-231.

Guralnik JM, Ferrucci L, Balfour JL, Volpato S, Di Iorio A.  Progressive versus catastrophic loss of the ability to walk: Implications for the prevention of mobility loss.  J Am Geriatr Soc 2001;49:1463-1470.

Guralnik JM, Alecxih L, Branch LG, Wiener JM. Medical and long-term care costs when older persons become more dependent. Am J Public Health 2002;92:1244-1245.

Lunney JR, Lynn J, Foley DJ, Lipson S, Guralnik JM.  Patterns of functional decline at the end of life. JAMA 2003; 289:2387-2392.

Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia.  Blood 2004;104:2263-2268.

Fredman L, Magaziner J, Hawkes W, Hebel JR, Fried LP, Kasper J, Guralnik J. Female hip fracture patients had poorer performance-based functioning than community-dwelling peers over 2-year follow-up period. J Clin Epidemiol 2005;58:1289-98.

Melzer D, Gardener E, Guralnik JM. Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing. Age Ageing 2005;34:594-602.

Shumway-Cook A, Patla A, Stewart AL, Ferrucci L, Ciol MA, Guralnik JM. Assessing environmentally determined mobility disability: self-report versus observed community mobility. J Am Geriatr Soc 2005;53:700-704.

Marsh AP, Rejeski WJ, Hutton SL, Brown CL, Ip E, Guralnik JM.  Development of a lateral mobility task to identify individuals at risk for mobility disability and functional decline. J Aging Phys Act 2005;13:363-81.

Volpato S, Leveille SG, Blaum C, Fried LP, Guralnik JM.  Risk factors for falls in older disabled women with diabetes: the Women's Health and Aging Study. J Gerontol Med Sci 2005;60:1539-45.

Penninx BW, Pahor M, Woodman RC, Guralnik JM.  Anemia in old age is associated with increased mortality and hospitalization. J Gerontol Med Sci 2006;61:474-9.

Jylha M, Volpato S, Guralnik JM,  Self-rated health shows a graded association with frequently used biomarkers in a large population sample. J Clin Epid 2006;59:465-471.

Guralnik JM, Butterworth S, Wadsworth ME, Kuh D.  Childhood socioeconomic status predicts physical functioning a half century later. J Gerontol Med Sci 2006;61:694-701.

Coppin AK, Ferrucci L, Lauretani F, Phillips C, Chang M, Bandinelli S, Guralnik JM. Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairments. J Gerontol Med Sci 2006;61:86-91.

Minkler M, Fuller-Thomson E, Guralnik JM.  Gradient of disability across the socioeconomic spectrum in the United States. N Engl J Med 2006;355:695-703.

Patel KV, Harris TB, Faulhaber M, Angleman SB, Connelly S, Bauer DC, Kuller LH, Newman AB, Guralnik JM. Racial variation in the relationship of anemia with mortality and mobility disability among older adults. Blood 2007;109:4663-70.

Corti MC, Baggio G, Sartori L, Barbato G, Manzato E, Musacchio E, Ferrucci L, Cardinali G, Donato D, Launer LJ,  Zambon S, Crepaldi G, Guralnik JM.  White matter lesions and the risk of incident hip fracture in older persons:   Results from the PRO.V.A. (PROgetto Veneto Anziani) Study. Arch Int Med. 2007;167:1745-1751. 

King AC, Guralnik JM. Maximizing the potential of an aging population through shaping an active and vital old age.  (Commentary). JAMA 2010;304:1944-5.

Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J. Gait speed and survival in older adults.  JAMA. 2011;305:50-58.