B.S., 1996, Biological Sciences, Carnegie Mellon University
Ph.D., 2004, Microbiology, Columbia University (Dr. Aaron Mitchell)
Postdoctoral fellow, 2005-2007, Yale University (Dr. Jorge Galan)
Postdoctoral fellow, 2008-2010, Yale University (Dr. Michael Snyder)
Assistant Professor, 2010-present, Institute for Genome Sciences at the University of Maryland School of Medicine
Candida albicans is the major invasive fungal pathogen of humans and the fourth most common cause of nosocomial infections, accounting for approximately 10%. It is the etiological agent of mucosal infections in healthy individuals as well as life-threating infections in immunocompromised patients. The ability of C. albicans to cause disease largely depends upon its ability to rapidly alter its gene expression in response to environmental signals to ensure survival in different host niches.
My research focuses on utilizing genomics, transcriptomics, genetics and molecular biology to identify and characterize genes and pathways that are important for C. albicans, and fungal pathogens in general, to cause disease.
Bruno V.M., Wang Z., Marjani S.L., Euskirchen G.M., Martin J., Sherlock G., Snyder M. “Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq” Genome Research (2010) Sep 1. [Epub ahead of print]
Martin J, Bruno V.M., Fang Z., Meng X., Blow M., Zhang T., Sherlock G., Snyder M., Wang Z. “Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads.” BMC Genomics (2010) Nov 24;11(1):663
Bishop, A.C., Sun, T., Johnson, M.E., Bruno, V.M., Patton-Vogt, J. “Robust utilization of phospholipase-generated metabolites, glycerophosphodiesters, by Candida albicans: Role of the CaGit1 permease” Eukaryotic Cell. (2011) Dec; 10(12):1618-27
Camarena, L., Bruno, V.M., Euskirchen G., Poggio, S., and Snyder, M. “Molecular Mechanisms of Ethanol-Induced Pathogenesis Revealed by RNA-Sequencing” PLoS Pathogens. (2010) Apr 1;6(4):e1000834.
Bruno, V.M., Hannemann, S., Lara-Tejero, M., Flavell, R.A., Kleinstein, S.H., and Galán, J.E. (2009). “Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in intestinal epithelial cells.” PLoS Pathogens 5(8):e1000538. Epub 2009 Aug 7.
Chamilos, G., Nobile, C.J., Bruno V.M., Lewis R.E., Mitchell A.P., Kontoyiannis, D.P. (2009). “C. albicans cell wall integrity regulator Cas5 promotes virulence in murine and Toll-mutant fly models” J Infect. Dis. 200(1):152-7
Chiang, L.Y., Sheppard, D.C., Bruno, V.M., Edwards, J.E., Mitchell, A.P., and Filler, S.G. (2007). “Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis” Cellular Microbiology 9(1):233-45.
Bruno, V.M., Kalachikov, S., Subaran, R., Nobile, C.J., Kyratsous, C., and Mitchell, A.P. (2006). “Control of the C. albicans Cell Wall Damage Response by Transcriptional Regulator Cas5.” PLoS Pathogens 2(3): 204-210
Bruno, V.M. and Mitchell, A.P. (2005). “Regulation of azole drug susceptibility by Candida albicans protein kinase CK2.” Molecular Microbiology 56(2): 559-573.
Richard, M.L., Nobile, C.J., Bruno, V.M., and Mitchell, A.P. (2005). “Characterization of Candida albicans biofilm-defective mutants.” Eukaryotic Cell 4(8): 1493-1502.
Bruno, V.M. and Mitchell, A.P. (2004). “Large-scale gene function analysis in Candida albicans.” Trends in Microbiology 12(4): 157-161.
Li, M., Martin, S.J., Bruno, V.M., Mitchell, A.P., and Davis, D.A. (2004). “Candida albicans Rim13p, a protease required for Rim101p processing at acidic and alkaline pHs.” Eukaryotic Cell 3(3): 741-751.
Nobile, C.J., Bruno, V.M., Richard, M.L., Davis, D.A., and Mitchell, A.P. (2003). "Genetic control of chlamydospore formation in Candida albicans." Microbiology 149(Pt 12): 3629-37.
Davis, D.A.*, Bruno, V.M.*, Loza, L., Filler, S.G., and Mitchell, A.P. (2002). "Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis." Genetics 162(4): 1573-81. (* contributed equally)