Personal History:I am a practicing vascular surgeon with an interest in clinically relevant vascular biology. I graduated from the University of Massachusetts Medical School in 2001. While pursuing my medical degree, I performed research in cardiovascular physiology. Upon completion of my degree, I trained in general surgery at the Beth Israel Deaconess Medical Center in Boston, Massachusetts. I was able to interrupt for two years for a post-doctoral fellowship. It was during this time that I began some of the work on which my lab now focuses. After completion of general surgery residency I matriculated to the University of California, San Francisco for a vascular surgery fellowship. During this fellowship I was able to hone my research questions and begin the framework for future grant applications. I came to the University of Maryland in 2010. I am presently funded by grants through the Veterans Administration and the Vascular Cures Foundation. I have close collaborations with several members of the Center for Vascular and Inflammatory Diseases faculty. Being both a practicing surgeon and a scientist allows me to ask clinically relevant research questions and use technically difficult animal models. The University of Maryland fosters an environment that nurtures the “bench-to-bedside-(to-bench)” concept and supports translational research.
Research Interests:I am interested in all aspects of vascular biology. Presently, my research focuses primarily on the formation of intimal hyperplasia. A normal blood vessel is a three-layer structure consisting of the intima, media, and adventitia. The intima is populated with endothelial cells. In the setting of trauma – including surgical bypass, angioplasty, or stenting – the normally quiescent, contractile medial smooth muscle cells dedifferentiate. These cells revert to a more primitive migratory, proliferative, and secretory phenotype. These cells migrate to the intimal and cause the lesion observed in intimal hyperplasia. Intimal hyperplasia reduces vessel diameter and ultimately limits the patency of all cardiovascular reconstructions. We are presently focusing on methods of specifically inhibiting vascular smooth muscle cell migration and proliferation. Present treatments for the prevention of intimal hyperplasia inhibit both smooth muscle and endothelial cell migration and proliferation. We have identified a protein, MARCKS, that when knocked down inhibits smooth muscle cell migration and proliferation with no effect on endothelial cells. We are elucidating the mechanism of the differential effect of MARCKS signaling in these two cell types. This protein is potentially a powerful target for the prevention of intimal hyperplasia. We are presently working on open surgical models and catheter-based endovascular models of drug delivery. Other areas of interest are the use of nanoparticles to target specific cell types for drug delivery. Our group is well suited for this type of clinically relevant translational science. Both the Center for Vascular and Inflammatory Diseases and the University of Maryland foster collaborations that support translational research.
Monahan TS, Belek K, and Sarkar R. Results of Radiofrequency Ablation of the Lesser Saphenous Vein in the Supine Position. Journal of Vascular and Endovascular Surgery 2011;46(1):40-4.
Monahan TS. Nonrecurrent inferior laryngeal nerve. Vascular and Endovascular Surgery 2010; 45(1):90-1.
Andersen ND, Chopra A, Monahan TS, Malek JY, Jain M, Pradhan L, Ferran C, and LoGerfo FW. Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo. Journal of Vascular Surgery 2010; 52(6):1608-15.
Monahan TS, Chuter TAM, Reilly LM, Rapp JH, and Hiramoto JS. Long-Term Follow-Up of Neck Expansion after Endovascular Aortic Aneurysm Repair. Journal of Vascular Surgery. 2010;52(2):303-7.
Shrikhande GV, Scali ST, Da Silva CG, Damrauer SM, Csizmadia E, Putheti P, Matthey M, Arjoon R, Patel R, Siracuse JJ, Maccariello ER, Andersen ND, Monahan TS, Kocher O, Usheva A, Veves A, Kaczmarek A, and Christiane Ferran. O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-null Mice. PloS One 2010; 5(12):e14240.
Monahan TS, and Owens CD. Risk factors for vein graft failure. Seminars in Vascular Surgery. 2009;22(4):216-26.
Monahan TS, and Schneider DB. Fenestrated and branched stent grafts for repair of complex aortic aneurysms. Seminars in Vascular Surgery 22(3):132-9, 2009.
Monahan TS, Andersen ND, Martin MC, Malek JY, Shrikhande GV, Pradhan L, Ferran C, and LoGerfo FW. MARCKS silencing differentially affects human vascular smooth muscle and endothelial cell phenotypes to inhibit neointimal hyperplasia in saphenous vein. FASEB Journal. 2009 Feb;23(2):557-64.
McIntyre TP, Monahan TS, Villegas L, Doyle J, and Jones D. Telemedicine enhances effective communication and enriches medical education. Surgical Laparoscopy Endoscopy and Percutaneous Techniques. 2008 Feb;18(1):45-48.
Shrikhande GV, Hamdan AD, Monahan TS, Pomposelli FB, Scovell SS, Logerfo FW, and Schermerhorn ML. Low ejection fraction predicts shortened survival in patients undergoing infrainguinal arterial reconstruction. World Journal of Surgery. 2007 Dec;31(12):2422-6.
Monahan TS, Andersen ND, Panossian H, Kalish JA, Contreras MA, Phaneuf MD, Shrikhande GV, Ferran CJ, and LoGerfo FW. A novel function for cadherin 11/OB-cadherin in vascular smooth muscle cells: modulation of cell migration and proliferation. Journal of Vascular Surgery 2007 March;45(3):581-9.
Andersen ND, Monahan TS, Jain M, Daniel S, Caron LD, Pradhan L, Ferran C, and LoGerfo FW. Gene silencing in human vascular cells using small interfering RNAs. Journal of the American College of Surgeons 2007 March;204(3):399-408.
Monahan TS, Phaneuf MD, Contreras MA, Andersen ND, Popescu-Vladimir A, Bide MJ, Dempsey DJ, Mitchell RN, LoGerfo FW, and Hamdan AD. In vivo testing of an infection-resistant annuloplasty ring. Journal of Surgical Research. 2006 Jan;130(1):140-5.
Phaneuf MD, Bide M, Hannel S, Platek M, Monahan TS, Contreras MA, Phaneuf T, LoGerfo FW. Development of an infection-resistant, bioactive wound dressing surface. Journal of Biomedical Materials Research 2005 Jul 18;74A(4):666-676.
Monahan TS, Shrikhande GV, Pomposelli FB, Skillman JJ, Campbell DR, Scovell SD, LoGerfo FW, and Hamdan AD. Preoperative cardiac evaluation does not improve or predict perioperative or late survival in asymptomatic diabetic patients undergoing elective lower extremity arterial reconstruction. Journal of Vascular Surgery 2004;41:38-45.
Lancey R, and Monahan TS. Correlation of clinical characteristics and outcomes with an injury grading system in blunt cardiac trauma. Journal of Trauma-Injury Infection & Critical Care. 54(3):509-15, 2003.
Monahan TS, Sawmiller DR, Fenton RA, Dobson JG. Adenosine A2a receptor activation increases contractility in isolated perfused hearts. American Journal of Physiology, 279: H1472-H1481, 2000.
Text Book Chapters::
Monahan TS. Acute atraumatic lower extremity ischemia. In Vascular emergencies – expert management for the emergency physician. Robert Rogers editor. Cambridge University Press. 2013.
Monahan TS. Microvascular changes in diabetes. Diabetes and peripheral vascular disease: diagnosis and management. Gautam Shrikhande editor. Springer Science. 2013.
Shrikhande GV, Monahan TS, and Pomposelli FB. Vascular Surgery. Pocket Surgery. 2011, Goldfarb M editor. Lippincott Williams & Wilkins, 2001 Market Street, Philadelphia, PA 19103.
Monahan TS, LoGerfo FW. Endothelialization of Prosthetic Vascular Grafts. Endothelial Biomedicine. 2007, William Aird editor. Cambridge University Press, 32 Avenue of the Americas, New York, NY 10013-2473.
Monahan TS, LoGerfo FW. The Healing of Ulceration, Infection, and Minor Amputation Following Revascularization in Patients with Diabetes. Trends in Vascular Surgery 2004, William H Pearce and James ST Yao, eds. Precept Press, 875 N. Michigan Ave. # 1416, Chicago, Illinois 60611.
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