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Wei  Lu
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Wei Lu Ph.D.

Academic Title: Associate Professor
Primary Appointment: Radiation Oncology
wlu@umm.edu
Location: UMMC/Gudelsky
Phone: 410-706-6511
Fax: 410-328-2618

Personal History:

Dr. Wei Lu received his Ph.D. in Biological Engineering at the University of Missouri in Columbia, Missouri. Dr. Lu is currently an Assistant Professor in the Department of Radiation Oncology at the University of Maryland School of Medicine. From 2006 to 2009, Dr. Lu was an Instructor, and in 2010 became an Assistant Professor at Washington University in St. Louis, Missouri.

Certifications:

  • 2010 - American Board of Radiology, Therapeutic Radiologic Physics

Research Interests:

Dr. Lu’s research interests include PET/CT for tumor definition and response evaluation, image guided radiation therapy, 4D-CT for tumor motion, and biomedical image analysis.

Clinical Speciality:

Therapeutic Medical Physics


Grants & Contracts:

NIH/NCI R01CA172638
PI: W. Lu
Quantitative PET/CT Analysis to Improve Evaluation of Tumor Response”

NIH/NCI R01CA124766-05
PI: W. D’Souza
Feedback Control of Respiration Induced Tumor Motion with a Treatment Couch”

NIH/NCI R01CA130814-03
PI: W. D’Souza
High-Throughput Computing for a Distributed Multi-Plan Radiotherapy Computing Framework”

NIH/NIAID 272201000046C-0-0-1
PI: T. MacVittie
“Medical Countermeasures Against Radiological Threats (MCART)”

DHHS/BARDA HHS00100201100007C
PI: T. MacVittie
Advanced Development of AEOL 10150 as a Medical Countermeasure for Pulmonary Injury Associated with ARS and DEARE”

Philips Medical Systems
PI: W. Lu
4D-CT Simulation Using Dynamic Contrast Enhancement

Flo-Dickey Funk Research Fellowship
W. Lu
“Imaging System for Pupillary Light Reflex”

NIH 1 R01 CA096679
PI: D. Low
“Lung Trajectory Mapping”

NIH 1R01 CA134541-01
PI: P. Parikh
Incorporating Real-time Localization in Radiation Therapy Planning and Delivery”

NIH 1R01CA116712-01A2
PI: D. Low
Positron Emission Tomography for Radiation Therapy”

NIH 1R21 CA131979-01A1
PI: W. Lu
“PET-Guided Tumor Volume Delineation for Radiation Therapy”

NIH 2 R01 CA0966792009
PI: D. Low
“Lung Trajectory Mapping for Radiation Oncology”


Honors & Awards:

  • 1992 - Outstanding performance in National Entrance Exam, Tsinghua University 1998 Alpha Epsilon, Honor Society of Biological Engineering
  • 2001 - Outstanding Service Award for Friendship Association of Chinese Students and Scholars, University of Missouri – Columbia
  • 2001 - Outstanding Graduate Student in Biological Engineering, University of Missouri – Columbia
  • 2003 - Flo-Dickey Funk research fellowship for vision and neurological research, University of Missouri – Columbia
  • 2003 - Outstanding Graduate Student in Biological Engineering, University of Missouri – Columbia
  • 2003 - Tau Beta Pi, the Engineering Honor Society
  • 2003 - First Honorable Mention in Poster Competition based on scientific merit at Missouri Life Science Week
  • 2012 - First Place Poster – Oncology: Clinical Diagnosis Track, Society of Nuclear Medicine Annual Meeting 2012
  • 2012 - Science Council Research Symposium ORAL PRESENTATION and the BEST IN PHYSICS POSTER DISCUSSION, 2012 American Association of Physicists in Medicine Annual Meeting

Publications:

Books and Chapters

W. Lu, L. Santanam, C. Noel, P. J. Parikh, and D. A. Low, “Four-Dimensional Treatment,” in Quality and safety in radiotherapy, edited by T. Pawlicki, P. B. Dunscombe, A. J. Mundt et al. CRC Press/Taylor & Francis, Boca Raton, FL, (2011).

D. A. Low, W. Lu, J. A. Purdy, C. A. Perez, S. H. Levitt, “Chapter 10. Intensity Modulated Radiation Therapy” in Technological Basis of Radiation Therapy, [edited by] S.H. Levitt, J.A. Purdy, C.A. Perez. 4th ed. Springer. New York, NY, (2006).

Journal Articles

S. Kupongsak, J. Tan, I. Hatem, W. Lu, B. Guthrie, and M. Tanoff, "Set point determination from sensory evaluations for food process control," Journal of Food Process Engineering. 27, 87-102 (2004).

W. Lu and J. Tan, "Analysis of image-based measurements and USDA characteristics as predictors of beef lean yield," Meat Science. 66, 483-491 (2004).

W. Lu and J. Tan, "Grain pattern characterization and classification of walnut by image processing," Wood and Fiber Science. 36, 311-318 (2004).

D. A. Low, P. J. Parikh, W. Lu, J. F. Dempsey, S. H. Wahab, J. P. Hubenschmidt, M. M. Nystrom, M. Handoko, and J. D. Bradley, "Novel breathing motion model for radiotherapy," Int J Radiat Oncol Biol Phys. 63, 921-929 (2005).

W. Lu, D. A. Low, P. J. Parikh, M. M. Nystrom, I. M. El Naqa, S. H. Wahab, M. Handoko, D. Fooshee, and J. D. Bradley, "Comparison of spirometry and abdominal height as four-dimensional computed tomography metrics in lung," Med Phys. 32, 2351-2357 (2005).

W. Lu, P. J. Parikh, I. M. El Naqa, M. M. Nystrom, J. P. Hubenschmidt, S. H. Wahab, S. Mutic, A. K. Singh, G. E. Christensen, J. D. Bradley, and D. A. Low, "Quantitation of the reconstruction quality of a four-dimensional computed tomography process for lung cancer patients," Med Phys. 32, 890-901 (2005).

W. Lu, P. J. Parikh, J. P. Hubenschmidt, D. G. Politte, B. R. Whiting, J. D. Bradley, S. Mutic, and D. A. Low, "Reduction of motion blurring artifacts using respiratory gated CT in sinogram space: a quantitative evaluation," Med Phys. 32, 3295-3304 (2005).

W. Lu, J. Tan, and R. Floyd, "Automated fetal head detection and measurement in ultrasound images by iterative randomized Hough transform," Ultrasound Med Biol. 31, 929-936 (2005).

J. D. Bradley, A. N. Nofal, I. M. El Naqa, W. Lu, J. Liu, J. Hubenschmidt, D. A. Low, R. E. Drzymala, and D. Khullar, "Comparison of helical, maximum intensity projection (MIP), and averaged intensity (AI) 4D CT imaging for stereotactic body radiation therapy (SBRT) planning in lung cancer," Radiother Oncol. 81, 264-268 (2006).

H. Handels, R. Werner, T. Frenzel, D. Saring, W. Lu, D. Low, and J. Ehrhardt, "Generation of 4D CT image data and analysis of lung tumour mobility during the breathing cycle," Stud Health Technol Inform. 124, 977-982 (2006).

W. Lu, M. M. Nystrom, P. J. Parikh, D. R. Fooshee, J. P. Hubenschmidt, J. D. Bradley, and D. A. Low, "A semi-automatic method for peak and valley detection in free-breathing respiratory waveforms," Med Phys. 33, 3634-3636 (2006).

W. Lu, P. J. Parikh, J. P. Hubenschmidt, J. D. Bradley, and D. A. Low, "A comparison between amplitude sorting and phase-angle sorting using external respiratory measurement for 4D CT," Med Phys. 33, 2964-2974 (2006).

G. E. Christensen, J. H. Song, W. Lu, I. El Naqa, and D. A. Low, "Tracking lung tissue motion and expansion/compression with inverse consistent image registration and spirometry," Med Phys. 34, 2155-2163 (2007).

E. D. Donnelly, P. J. Parikh, W. Lu, T. Zhao, K. Lechleiter, M. Nystrom, J. P. Hubenschmidt, D. A. Low, and J. D. Bradley, "Assessment of intrafraction mediastinal and hilar lymph node movement and comparison to lung tumor motion using four-dimensional CT," Int J Radiat Oncol Biol Phys. 69, 580-588 (2007). 2149909

J. Ehrhardt, R. Werner, D. Saring, T. Frenzel, W. Lu, D. Low, and H. Handels, "An optical flow based method for improved reconstruction of 4D CT data sets acquired during free breathing," Med Phys. 34, 711-721 (2007).

H. Handels, R. Werner, R. Schmidt, T. Frenzel, W. Lu, D. Low, and J. Ehrhardt, "4D medical image computing and visualization of lung tumor mobility in spatio-temporal CT image data," Int J Med Inform. (2007).

R. Werner, H. Handels, J. Ehrhardt, D. Saring, T. Frenzel, W. Lu, and D. Low, "Motion artifact reducing reconstruction of 4D CT image data for the analysis of respiratory dynamics," Methods Inf Med. 46, 254-260 (2007).

H. Li, W. L. Thorstad, K. J. Biehl, R. Laforest, Y. Su, K. I. Shoghi, E. D. Donnelly, D. A. Low, and W. Lu, "A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours," Med Phys. 35, 3711-3721 (2008).

W. Lu and J. Tan, "Detection of incomplete ellipse in images with strong noise by iterative randomized Hough transform (IRHT)," Pattern Recognition. 41, 1268-1279 (2008).

W. Lu, J. Tan, K. Zhang, and B. Lei, "Computerized mouse pupil size measurement for pupillary light reflex analysis," Comput Methods Programs Biomed. 90, 202-209 (2008).

J. R. Olsen, W. Lu, J. P. Hubenschmidt, M. M. Nystrom, P. Klahr, J. D. Bradley, D. A. Low, and P. J. Parikh, "Effect of novel amplitude/phase binning algorithm on commercial four-dimensional computed tomography quality," Int J Radiat Oncol Biol Phys. 70, 243-252 (2008). 2702992

D. Yang, W. Lu, D. A. Low, J. O. Deasy, A. J. Hope, and I. El Naqa, "4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling," Med Phys. 35, 4577-4590 (2008). 2673589

S. R. Chaudhari, S. M. Goddu, D. Rangaraj, O. L. Pechenaya, W. Lu, E. Kintzel, K. Malinowski, P. J. Parikh, J. D. Bradley, and D. A. Low, "Dosimetric variances anticipated from breathing- induced tumor motion during tomotherapy treatment delivery," Phys Med Biol. 54, 2541-2555 (2009).

G. Li, N. C. Arora, H. Xie, H. Ning, W. Lu, D. Low, D. Citrin, A. Kaushal, L. Zach, K. Camphausen, and R. W. Miller, "Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate," Physics in Medicine and Biology. 54, 1963-1978 (2009).

G. Li, H. Xie, H. Ning, W. Lu, D. Low, D. Citrin, A. Kaushal, L. Zach, K. Camphausen, and R. W. Miller, "A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change," Phys Med Biol. 54, 4113-4130 (2009).

T. Zhao, W. Lu, D. Yang, S. Mutic, C. E. Noel, P. J. Parikh, J. D. Bradley, and D. A. Low, "Characterization of free breathing patterns with 5D lung motion model," Med Phys. 36, 5183-5189 (2009). 2774350

D. A. Low, T. Zhao, B. White, D. Yang, S. Mutic, C. E. Noel, J. D. Bradley, P. J. Parikh, and W. Lu, "Application of the continuity equation to a breathing motion model," Med Phys. 37, 1360-1364 (2010). 2847940

R. Werner, B. White, H. Handels, W. Lu, and D. A. Low, "Technical note: development of a tidal volume surrogate that replaces spirometry for physiological breathing monitoring in 4D CT," Med Phys. 37, 615-619 (2010). 2816987

D. Yang, S. M. Goddu, W. Lu, O. L. Pechenaya, Y. Wu, J. O. Deasy, I. El Naqa, and D. A. Low, "Technical note: deformable image registration on partially matched images for radiotherapy applications," Med Phys. 37, 141-145 (2010).

B. M. White, D. A. Low, T. Zhao, S. Wuenschel, W. Lu, J. M. Lamb, S. Mutic, J. D. Bradley, and I. El Naqa, "Investigation of a breathing surrogate prediction algorithm for prospective pulmonary gating," Med Phys. 38, 1587-1595 (2011). 3060936

T. Zhao, B. White, K. L. Moore, J. Lamb, D. Yang, W. Lu, S. Mutic, and D. A. Low, "Biomechanical interpretation of a free-breathing lung motion model," Phys Med Biol. 56, 7523-7540 (2011).

T. J. Macvittie, A. Bennett, C. Booth, M. Garofalo, G. Tudor, A. Ward, T. Shea-Donohue, D. Gelfond, E. McFarland, W. Jackson, W. Lu, and A. M. Farese, "The Prolonged Gastrointestinal Syndrome in Rhesus Macaques: The Relationship Between Gastrointestinal, Hematopoietic, and Delayed Multi-organ Sequelae Following Acute, Potentially Lethal, Partial-body Irradiation," Health Phys. 103, 427-453 (2012).

S. Richardson, J. Garcia-Ramirez, W. Lu, R. J. Myerson, and P. Parikh, "Design and dosimetric characteristics of a new endocavitary contact radiotherapy system using an electronic brachytherapy source," Med Phys. 39, 6838-6846 (2012).

S. Tan, S. Kligerman, W. Chen, M. Lu, G. Kim, S. Feigenberg, W. D. D'Souza, M. Suntharalingam, and W. Lu, "Spatial-temporal [(1)(8)F]FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy," Int J Radiat Oncol Biol Phys. 85, 1375-1382 (2013). 3606641

S. Tan, H. Zhang, Y. Zhang, W. Chen, W. D. D'Souza, and W. Lu, "Predicting pathologic tumor response to chemoradiotherapy with histogram distances characterizing longitudinal changes in (18)F-FDG uptake patterns," Med Phys. 40, 101707 (2013). 3785537

M. Xue, H. Zhang, S. Kligerman, P. Klahr, W. D'Souza, and W. Lu, "Individually optimized uniform contrast enhancement in CT angiography for the diagnosis of pulmonary thromboembolic disease-A simulation study," Med Phys. 40, 121906 (2013).

A. M. Kazi, T. J. Macvittie, G. Lasio, W. Lu, and K. L. Prado, "The MCART Radiation Physics Core: The Quest for Radiation Dosimetry Standardization," Health Phys. 106, 97-105 (2014).

W. Lu, G. A. Neuner, R. George, Z. Wang, S. Sasor, X. Huang, W. F. Regine, S. J. Feigenberg, and W. D. D'Souza, "Audio-Visual Biofeedback Does Not Improve the Reliability of Target Delineation Using Maximum Intensity Projection in 4-Dimensional Computed Tomography Radiation Therapy Planning," Int J Radiat Oncol Biol Phys. 88, 229-235 (2014).

H. Zhang, S. Tan, W. Chen, S. Kligerman, G. Kim, W. D. D'Souza, M. Suntharalingam, and W. Lu, "Modeling Pathologic Response of Esophageal Cancer to Chemoradiation Therapy Using Spatial-Temporal (18)F-FDG PET Features, Clinical Parameters, and Demographics," Int J Radiat Oncol Biol Phys. 88, 195-203 (2014).

A. Reese, W. Lu, and W.F. Regine. “Utilization of IMRT and IGRT in pancreatic cancer: Is It necessary?”. Sem. Radiat Oncol. (In Press).