Current research involves the management of ESRD patients. Epotein and renal ostrodystophy have been my most recent areas of investigation. Both peritoneal and hemodialysis populations have been utilized in investigative and sponsored research activities.
Renal issues in CHF patients are an area of ongoing investigation, and a study of the effectiveness of isolated ultrafiltration in improving cardiac symptoms and renal function as assessed by gfr measurement is currently ongoing.
Currently management of ESRD patients is the major clinical emphasis. A significant effort is being invested in the P&T-2 course involving stewardship of the course and organization of content and delivery.
Light PD, Hall-Craggs M: Amyloid deposition in a renal allograft in a case of Amyloidosis secondary to Rheumatoid Arthritis. Am. J. Med. 66:532-536,1979.
Reed WP, Light PD, McLaughlin J: High patency rate of internal arteriovenous fistulas in non-uremic patients with normal veins. J. Cardiovascular Surg. 23:501-504, 1982.
Carpenter WT Jr., Sadler JH, Light PD, Hanlon TE, Kurland AA: Schizophrenia and Dialysis, Artif. Organs, Vol. 7, No. 3:357-364, 1983.
Carpenter WT, Sadler JH, Light PD, et al: The therapeutic efficacy of hemodialysis in schizophrenia. N. Engl. J. Med. 308:669-675, 1983.
Reed WP, Light PD, Sadler JH: Access for hemodialysis by means of long-term atrial venous catheters. Kid. Inter. 25:838-840, 1984.
Reed WP, Light PD, Sadler JH: Single-Needle Hemodialysis by Means of Implantable Central Venous Catheters. First International Symposium on Single Needle Dialysis, Ed. S. Ringoir, R. Vanholder, P. Ivanovick, ISAO Press, Cleveland, 1984.
Hall-Craggs M, Light PD, Peters RW: Development of immune complex nephritis during treatment with the calcium channel-blocking agent nifedipine. Human Path. 15:691-694, 1984.
Reed WP, Light PD, Sadler JH: Right atrial catheters as access for hemodialysis. Artif. Organs 8(1):456-460, 1984.
Reed WP, Moody MR, Light PD, Newman KA, Costerton JW: Bacterial Colonization of Hemasite Access Devices. Surgery 99:308-317, 1986.
Cameron EW, Resnik CS, Light PD, Chen-Chin S: Hemodialysis-related amyloidosis of the sternoclavicular joint. Skeletal Radiol 26:428-430, 1997.
Roghmann MC, Fink JC, Polish L, Maker T, Brewrink J, Morris JG, Light PD. Colonization with Vancomycin-resistant enterococci in chronic hemodialysis patients. Am J Kidney Dis, 1998; 32:254-257.
Fink JC, Armistead N, Turner M, Gardner J, Light PD: Hemodialysis adequacy in Network 5: Disparity between states and the role of center effects. AM J Kidney Dis. 33(1):97-103, 1999.
Fink JC, Burdick RA, Kurth S, Armistead N, Turner M, Shickle L, Light PD. The significance of serum creatinine values in incident end stage renal disease patients. Am J Kidney Dis 1999; 34: 694-701.
Fink JC, Gardner JF, Armistead NC, Turner M, Shickle L, Light PD. Within center correlation in dialysis adequacy. J Clin Epidemiology 53:79-85, 2000.
Dowling TC, Briglia AE, Hanes DS, Light PD, Hise MK, Watkins PB, Henrich WL. Cytochrome P4503A (CYP3A)-mediated drug metabolism is reduced in ESRD patients. J Am Soc Nephrol 2000;11:(9):59.
Jerome I. Tokars, MD, MPH, Paul Light, MD. , John Anderson, MD, Elaine R. Miller RN, Joan Parrish, RN, Nancy Armistead, MPA, William R. Jarvis, MD, Todd Gehr, MD. A prospective study of vascular access infections at seven outpatient hemodialysis centers. American Journal of Kidney Diseases, Vol 37;6(June),2001:1232-1240.
Tokars JI, Gehr T, Jarvis WR, Anderson J, Armistead N, Miller, ER, Parrish J, Qaiyuumi S, Arduino M, Holt SC, Hill BC, Light PD. Vancomycin-resistant enterococci colonization in patients at seven hemodialysis centers. Kidney International 2001;60:1511-1516.
Fink JC, Blahut SA, Briglia AE, Gardner JF, Light PD. The effect of center versus patient-specific factors on variations in dialysis adequacy. J Am Soc Nephrol 12: 164-169, 2001.
Fink JC, Rochussen J, Blahut SA, Reddy M, Light PD. The use of erythropoietin prior to the initiation of dialysis and its impact on mortality in new end stage renal disease patients. Am J Kidney Dis 2001; 37: 348-355.
Dowling TC, Fink JC, Briglia AE, Hanes DS, Light PD, Stackiewicz L, Karyekar CS, Eddington ND, Weir MR, Henrich WL. Characterization of hepatic cytochrome P4503A activity in patients with end-stage renal disease. Clinical Pharmacology & Therapeutics 2003;73(5):427-434.
Light PD, Spar B, and Moran M: Renal Assessment and Management. Medical Perioperative Management. '89/90' Norwalk: Appleton, Lange, 1989 - 150-175.
Light PD. Reuse of Hemodialysis Membranes in Chronic Dialysis Therapy. In: Principles and Practice of Dialysis, 3rd Edition, Chapter 2, Pages 16-27. eds. Henrich WL, Lippincott Williams & Wilkins. Philadelphia, PA, 2003.