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Personal History
Education
- 1984-1990 Medical Doctor, M.D., University of Medicine and Pharmacy "Carol Davila", Faculty of Medicine, Bucharest, Romania
- 1980-1984 Baccalaureate Diploma (High School Diploma), Mathematics Physics High School No. 3, Bucharest, Romania
Clinical Training
- 1990-1992: Medical Intern, Fundeni Clinical Hospital, Bucharest, Romania
Fellowships
- 1992-97: Fogarty International Center, Bethesda, MD
Principal Positions Held
- November 1, 2009- Present: Assistant Professor
Department of Anesthesiology
University of Maryland School of Medicine
Baltimore, MD - July 1, 2003- October 31, 2009: Assistant Professor
Department of Neuroscience
Georgetown University School of Medicine
Washington, D.C. - February 1, 2000-June 30, 2003: Research Instructor
Department of Neuroscience
Georgetown University School of Medicine
Washington, D.C. - Aug.1997-January 30, 2000: Research Instructor
Department of Biochemistry and Molecular Biology
Georgetown University School of Medicine
Washington, D.C. - Sept. 1992-July 1997: Visiting Fellow (Post-doctoral fellowship)
Laboratory of Immunobiology
Center of Biologics Evaluation and Research (CBER), Food and Drug Administration
Bethesda, MD 20892 - Nov. 1990-May 1992: Medical Intern
Department of Internal Medicine, Fundeni Clinical Hospital
Bucharest, Romania
Research Interests
Dr. Stoica's research focuses on mechanisms and modulation of neuronal cell death after central nervous system injury, including in vitro studies using primary neuronal cultures and in vivo studies using rodent models of experimental traumatic brain and spinal cord injury. The program is highly interdisciplinary, utilizing molecular and cellular biology, biochemistry, pharmacology, behavior, confocal microscopy and quantitative histological analysis.
There are 2 main lines of investigation:
- examining mechanisms of caspase-dependent versus caspase-independent neuronal cell death after CNS traumatic injury;
- elucidating the role of cell cycle activation in neuronal cell death after CNS traumatic injury.
Publications
Piao CS, Stoica BA, Wu J, Sabirzhanov B, Zhao Z, Cabatbat R, Loane DJ, Faden AI. Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury. Neurobiol Dis. 2013 Jan 8. doi:pii: S0969-9961(13)00008-9. 10.1016/j.nbd.2012.12.017. [Epub ahead of print] PMID: 23313314
Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging. 2012 Dec 27. doi:pii: S0197-4580(12)00590-8. 10.1016/j.neurobiolaging.2012.11.013. [Epub ahead of print] PMID: 23273602
Loane DJ, Stoica BA, Byrnes K, Jeong W, Faden AI. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Neurotrauma. 2012 Nov 30. [Epub ahead of print] PMID: 23199080
Zhao Z, Loane DJ, Murray MG 2nd, Stoica BA, Faden AI. Comparing the Predictive Value of Multiple Cognitive, Affective, and Motor Tasks after Rodent Traumatic Brain Injury. J Neurotrauma. 2012 Aug 27. PMID: 22924665
Sabirzhanov B*, Stoica BA*, Hanscom M, Piao CS, Faden AI. Overexpression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem. 2012 Aug 21. doi: 10.1111/j.1471-4159.2012.07927.x. PMID: 22909049 (* first authors)
Wu J, Kharebava G, Piao C, Stoica BA, Dinizo M, Sabirzhanov B, Hanscom M, Guanciale K, Faden AI. Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo., PLoS One. 2012;7(7):e42129. Epub 2012 Jul 25. PMID: 22848730
Wu J, Pajoohesh-Ganji A, Stoica BA, Dinizo M, Guanciale K, Faden AI. Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion., J Neuroinflammation. 2012 Jul 11; 9(1):169. PMID: 22784881
Loane DJ, Stoica BA, Faden AI. Metabotropic glutamate receptor-mediated signaling in neuroglia. Wiley Interdiscip Rev Membr Transp Signal. 2012 Mar; 1(2):136-150. Epub 2012 Jan 11. PMID: 22662309
Wu J, Stoica BA, Dinizo M, Pajoohesh-Ganji A, Piao C, Faden AI. Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury. Cell Cycle. 2012 May 1;11(9):1782-95. Epub 2012 May 1.PMID: 22510563
Piao CS, Loane DJ, Stoica BA, Li S, Hanscom M, Cabatbat R, Blomgren K, Faden AI. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis. 2012 Jun; 46(3):745-58. Epub 2012 Mar 9, PMID: 22426396
Byrnes KR, Loane DJ, Stoica BA, Zhang J, Faden AI. Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation. 2012 Feb 28;9:43. PMID: 22373400
Shruti V. Kabadi*, Bogdan A. Stoica*, Marie Hanscom, David J. Loane, Giorgi Kharebava, Michael G. Murray II, Rainier M. Cabatbat, Alan I. Faden. CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury. Neurotherapeutics. 2012 Apr;9(2):405-21. PMID: 22167461 (* first authors)
Kabadi SV, Stoica BA, Loane DJ, Byrnes KR, Hanscom M, Cabatbat RM, Tan MT, Faden AI. Cyclin D1 Gene Ablation Confers Neuroprotection in Traumatic Brain Injury. J Neurotrauma. 2012 Mar 20;29(5):813-27. Epub 2012 Jan 13. PMID: 21895533
Kabadi SV, Stoica BA, Byrnes KR, Hanscom M, Loane DJ, Faden AI. Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma. J Cereb Blood Flow Metab. 2012 Jan;32(1):137-49. doi: 10.1038/jcbfm.2011.117. PMID: 21829212
Wu J, Stoica BA, Faden AI. Cell cycle activation and spinal cord injury. Neurotherapeutics. 2011 Apr;8(2):221-8. Review.
Cernak I, Chang T, Ahmed FA, Cruz MI, Vink R, Stoica B, Faden AI. Pathophysiological response to experimental diffuse brain trauma differs as a function of developmental age. Dev Neurosci. 2010;32(5-6):442-53
Kabadi SV, Hilton GD, Stoica BA, Zapple DN, Faden AI. Fluid-percussion-induced traumatic brain injury model in rats. Nat Protoc. 2010 Sep;5(9):1552-63.
Stoica BA, Faden AI, Programmed Neuronal Cell Death Mechanisms in CNS Injury, book chapter 12 in â?oAcute Neuronal Injury-The Role of Excitotoxic Programmed Cell Death Mechanismsâ? Denson J. Fujikawa editor, Springer 2010
Stoica BA, Faden AI. Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics. 2010 Jan;7(1):3-12.
Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI. Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 2009 Jul;66(1):63-74.
Stoica BA, Byrnes KR, Faden AI. Cell Cycle Activation and CNS Injury. Neurotox Res. 2009 Oct.
Loane DJ, Stoica BA, Pajoohesh-Ganji A, Byrnes KR, Faden AI. Activation of metabotropic glutamate receptor 5 (mGLUR5) modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem. 2009 Jun.
Byrnes KR, Stoica B, Loane DJ, Riccio A, Davis MI, Faden AI. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia. 2009 Apr 1;57(5):550-60.
Stoica B, Byrnes K, Faden AI. Multifunctional drug treatment in neurotrauma. Neurotherapeutics. 2009 Jan;6(1):14-27. Review.
Hilton GD*, Stoica BA*, Byrnes KR, Faden AI. Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. J Cereb Blood Flow Metab. 2008 Nov;28(11):1845-59. Epub 2008 Jul 9. (* first authors)
Byrnes KR, Stoica BA, Fricke S, Di Giovanni S, Faden AI. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain. 2007 Nov;130(Pt 11):2977-92. Epub 2007 Aug 9.
Faden AI, Stoica B. Neuroprotection: challenges and opportunities. Arch Neurol. 2007 Jun;64(6):794-800.
Carney RS, Alfonso TB, Cohen D, Dai H, Nery S, Stoica B, Slotkin J, Bregman BS, Fishell G, Corbin JG. Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. J Neurosci. 2006 Nov 8;26(45):11562-74.
Loftus LT, Li HF, Gray AJ, Hirata-Fukae C, Stoica BA, Futami J, Yamada H, Aisen PS, Matsuoka Y. In vivo protein transduction to the CNS. Neuroscience. 2006;139(3):1061-7. Epub 2006 Mar 9.
Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle. 2005 Sep;4(9):1286-93. Epub 2005 Sep 15.
Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8333-8. Epub 2005 May 27.
Stoica BA, Movsesyan VA, Knoblach SM, Faden AI. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci. 2005 Jul;29(3):355-71.
Knoblach SM, Alroy DA, Nikolaeva M, Cernak I, Stoica BA, Faden AI. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32.
Movsesyan VA, Stoica BA, Yakovlev AG, Knoblach SM, Lea PM 4th, Cernak I, Vink R, Faden AI. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death Differ. 2004 Oct;11(10):1121-32.
Movsesyan VA, Stoica BA, Faden AI. mGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem. 2004 Jun;89(6):1528-36.
Cernak I, Vink R, Natale J, Stoica B, Lea PM 4th, Movsesyan V, Ahmed F, Knoblach SM, Fricke ST, Faden AI. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. J Cereb Blood Flow Metab. 2004 May;24(5):564-78.
Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004 Jul 2;279(27):28367-74. Epub 2004 Apr 21.
Lea PM 4th, Custer SJ, Stoica BA, Faden AI. Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia. J Neurotrauma. 2003 Nov;20(11):1233-49.
Natale JE, Ahmed F, Cernak I, Stoica B, Faden AI. Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. J Neurotrauma. 2003 Oct;20(10):907-27.
Stoica BA, Movsesyan VA, Lea IV PM, Faden AI. Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci 2003 Mar;22(3):365-382.
Movsesyan VA, Yakovlev AG, Dabaghyan EA, Stoica BA, Faden AI. Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. Biochem Biophys Res Commun 2002 Nov 29;299(2):201-207.
A.Hamid Boulares, Anna J. Zoltoski, Bogdan A. Stoica, Olivier Cuvillier, Mark E. Smulson. Acetaminophen Induces a Caspase-Dependent and Bcl-xl Sensitive Apoptosis in Human Hepatoma Cells and Lymphocytes. Pharmacology & Toxicology 2002, 90, 38-50.
Stoica BA, Boulares AH, Rosenthal DS, Iyer S, Hamilton ID, Smulson ME Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. Toxicol Appl Pharmacol 2001 Mar 1;171(2):94-106.
Rosenthal DS, Simbulan-Rosenthal CM, Liu WF, Stoica BA, Smulson ME Mechanisms of JP-8 jet fuel cell toxicity. II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of Bcl-2 family members.. Toxicol Appl Pharmacol. 2001 Mar 1;171(2):107-116.
Martin MB, Franke TF, Stoica GE, Chambon P, Katzenellenbogen BS, Stoica BA, McLemore MS, Olivo SE, Stoica A. A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin growth factor I. Endocrinology. 2000 Dec;141 (12):4503-4511.
Smulson, M.E., Simbulan-Rosenthal, C., Boulares, A. H., Yakovlev, A., Stoica, B., Iyer, S., Luo, R., Haddad, B., Wang, Z. Q., Pang, T., Jung, M., Dritschilo, A., and Rosenthal, D. S. Roles of poly(ADP)ribosylation and PARP in apoptosis, DNA repair, genomic stability, and functions of p53 and E2F-1. Adv Enzyme Regul. 2000;40:183-215. Review.
Yakovlev AG, Wang G, Stoica BA, Boulares HA, Spoonde AY, Yoshihara K, Smulson ME A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by Poly(ADP-ribose) polymerase. J Biol Chem 2000 Jul 14;275(28):21302-21308.
Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iver S, Smulson M. Role of poly(ADP-ribose)polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 1999 Aug 13;274(33):22932-22940.
Yakovlev AG, Wang G, Stoica BA, Simbulan-Rosenthal CM, Yoshihara K, Smulson ME. Role of DNAS1L3 in Ca2+ and Mg2+ dependent cleavage of DNA into oligonucleosomal and high molecular mass fragments. Nucleic Acid Res 1999 May 1; 27(9): 1999-2005.
Bonvini E, DeBell KE, Veri MC, Graham L, Stoica B, Laborda J, Aman MJ, DiBaldassarre A, Miscia S, Rellahan BL. On the mechanism coupling phospholipase Cgamma1 to the B- and T-cell antigen receptors. Adv Enzyme Regul. 2003;43:245-69.
Graham LJ, DeBell KE, Veri M, Stoica B, Mostowski H, Bonvini E, Rellahan B. Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity. FEBS Lett 2000 Mar 31;470(3):273-280.
KE Debell*, BA Stoica* , M-C Veri, A Di Baldassare, S Miscia, LJ Graham, BL Rellahan, M Ishiai, T Kurosaki, E Bonvini Functional independence and interdependence of the Src-homology domains of phospholipase C gamma-1 in B cell receptor signal transduction. Mol Cell Biol, Nov 1999, p. 7388-7398. (* first authors)
Graham LJ*, Stoica BA*, Shapiro M, DeBell KE, Rellahan B, Laborda J, Bonvini E. Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl. Biochem Biophys Res Commun 1998 Aug 19;249(2):537-541. (* first authors)
Stoica B, DeBell KE, Graham L, Rellahan BL, Alava MA, Laborda J, Bonvini E. The amino-terminal Src homology 2 domain of phospholipase C gamma-1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1. J Immunol 1998 Feb 1;160(3):1059-1066.
Rellahan BL, Graham LJ, Stoica B, DeBell KE, Bonvini E. Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway. J Biol Chem 1997 Dec 5;272(49):30806-30811.