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Bogdan A Stoica
 

Bogdan A Stoica M.D.

Academic Title: Assistant Professor
Primary Appointment: Anesthesiology
bstoica@anes.umm.edu
Location: BRB, 6-015
Phone: 410-706-5186
Fax: 410-706-1639

Personal History:

Bogdan Stoica, MD, is an Assistant Professor of Anesthesiology and Faculty Member at the Center for Shock, Trauma and Anesthesiology Research (STAR) at the University of Maryland School of Medicine, Baltimore, Maryland. Dr. Stoica has attended the University of Medicine and Pharmacy "Carol Davila", Faculty of Medicine, Bucharest, Romania and obtained his MD degree in 1990. In 1992, Dr. Stoica received a Visiting Fellowship from the Fogarty International Center and started his postdoctoral training at the Laboratory of Immunobiology, Center of Biologics Evaluation and Research (CBER), Food and Drug Administration where he studied T cell signal transduction. In 1997 Dr. Stoica became a Research Instructor in Department of Biochemistry and Molecular Biology, Georgetown University Medical Center where he studied the modulation of cell death/apoptosis by Poly(ADP-ribose) polymerase. In 2000, Dr. Stoica was recruited to the Department of Neuroscience, Georgetown University Medical Center, where he worked on mechanisms of neuronal cell death in experimental models of traumatic brain injury (TBI). He became an Assistant Professor in 2003. Dr. Stoica joined the faculty of the University of Maryland School of Medicine in November 2009 and is currently Assistant Professor of Anesthesiology. His research continues to focus on the mechanisms of secondary injury following experimental TBI including neuronal cell death and neuroinflammation and the identification of effective therapeutic interventions.

Research Interests:

Dr. Stoica's research focuses on mechanisms and modulation of neuronal cell death after central nervous system traumatic injury, including in vitro studies using primary neuronal cultures and in vivo studies using rodent models of experimental traumatic brain injury (TBI) and spinal cord injury (SCI). The program is highly interdisciplinary, utilizing molecular and cellular biology, biochemistry, pharmacology, behavior, confocal microscopy and quantitative histological analysis. The goal of Dr. Stoica's research is to identify the key mechanisms involved in neuronal cell death in response to TBI, and to develop novel therapeutic strategies to modulate these processes in the acute and chronic periods of recovery after TBI aiming to attenuate post-traumatic neuronal loss and neurological deficits.

There are 4 main lines of investigation:

  1. examining mechanisms of caspase-dependent versus caspase-independent neuronal cell death after TBI
  2. elucidating the role of cell cycle activation in neuronal cell death after TBI
  3. investigating the role of microRNA in post-traumatic secondary injury
  4. analysis of the neuroprotective effects of exercise following TBI

Publications:

  1. PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury. Stoica BA, Loane DJ, Zhao Z, Kabadi SV, Hanscom M, Byrnes KR, Faden AI. J Neurotrauma. 2014 Jan 29. [Epub ahead of print] PMID: 24476502 [PubMed - as supplied by publisher]
  2. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. Kabadi SV, Stoica BA, Loane DJ, Luo T, Faden AI. J Cereb Blood Flow Metab. 2014 Jan 8. doi: 10.1038/jcbfm.2013.228. [Epub ahead of print] PMID: 24398934 [PubMed - as supplied by publisher]
  3. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. Loane DJ, Kumar A, Stoica BA, Cabatbat R, Faden AI. J Neuropathol Exp Neurol. 2014 Jan;73(1):14-29. doi: 10.1097/NEN.0000000000000021. PMID: 24335533 [PubMed - in process]
  4. Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation. Xue F, Stoica BA, Hanscom M, Kabadi SV, Faden AI. CNS Neurol Disord Drug Targets. 2013 Oct 28. [Epub ahead of print] PMID: 24168364 [PubMed - as supplied by publisher]
  5. Zhao Z, Faden AI, Loane DJ, Lipinski MM, Sabirzhanov B, Stoica BA. Neuroprotective effects of geranylgeranylacetone in experimental traumatic brain injury. J Cereb Blood Flow Metab. 2013 Aug 14. doi: 10.1038/jcbfm.2013.144. PMID: 23942364
  6. Piao CS, Stoica BA, Wu J, Sabirzhanov B, Zhao Z, Cabatbat R, Loane DJ, Faden AI. Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury. Neurobiol Dis. 2013 Jan 8. doi:pii: S0969-9961(13)00008-9. 10.1016/j.nbd.2012.12.017. [Epub ahead of print] PMID: 23313314
  7. Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging. 2012 Dec 27. doi:pii: S0197-4580(12)00590-8. 10.1016/j.neurobiolaging.2012.11.013. [Epub ahead of print] PMID: 23273602
  8. Loane DJ, Stoica BA, Byrnes K, Jeong W, Faden AI. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Neurotrauma. 2012 Nov 30. [Epub ahead of print] PMID: 23199080
  9. Zhao Z, Loane DJ, Murray MG 2nd, Stoica BA, Faden AI. Comparing the Predictive Value of Multiple Cognitive, Affective, and Motor Tasks after Rodent Traumatic Brain Injury. J Neurotrauma. 2012 Aug 27. PMID: 22924665
  10. Sabirzhanov B*, Stoica BA*, Hanscom M, Piao CS, Faden AI. Overexpression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem. 2012 Aug 21. doi: 10.1111/j.1471-4159.2012.07927.x. PMID: 22909049 (* first authors)
  11. Wu J, Kharebava G, Piao C, Stoica BA, Dinizo M, Sabirzhanov B, Hanscom M, Guanciale K, Faden AI. Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo., PLoS One. 2012;7(7):e42129. Epub 2012 Jul 25. PMID: 22848730
  12. Wu J, Pajoohesh-Ganji A, Stoica BA, Dinizo M, Guanciale K, Faden AI. Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion., J Neuroinflammation. 2012 Jul 11; 9(1):169. PMID: 22784881
  13. Loane DJ, Stoica BA, Faden AI. Metabotropic glutamate receptor-mediated signaling in neuroglia. Wiley Interdiscip Rev Membr Transp Signal. 2012 Mar; 1(2):136-150. Epub 2012 Jan 11. PMID: 22662309
  14. Wu J, Stoica BA, Dinizo M, Pajoohesh-Ganji A, Piao C, Faden AI. Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury. Cell Cycle. 2012 May 1;11(9):1782-95. Epub 2012 May 1.PMID: 22510563
  15. Piao CS, Loane DJ, Stoica BA, Li S, Hanscom M, Cabatbat R, Blomgren K, Faden AI. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis. 2012 Jun; 46(3):745-58. Epub 2012 Mar 9, PMID: 22426396
  16. Byrnes KR, Loane DJ, Stoica BA, Zhang J, Faden AI. Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation. 2012 Feb 28;9:43. PMID: 22373400
  17. Shruti V. Kabadi*, Bogdan A. Stoica*, Marie Hanscom, David J. Loane, Giorgi Kharebava, Michael G. Murray II, Rainier M. Cabatbat, Alan I. Faden. CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury. Neurotherapeutics. 2012 Apr;9(2):405-21. PMID: 22167461 (* first authors)
  18. Kabadi SV, Stoica BA, Loane DJ, Byrnes KR, Hanscom M, Cabatbat RM, Tan MT, Faden AI. Cyclin D1 Gene Ablation Confers Neuroprotection in Traumatic Brain Injury. J Neurotrauma. 2012 Mar 20;29(5):813-27. Epub 2012 Jan 13. PMID: 21895533
  19. Kabadi SV, Stoica BA, Byrnes KR, Hanscom M, Loane DJ, Faden AI. Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma. J Cereb Blood Flow Metab. 2012 Jan;32(1):137-49. doi: 10.1038/jcbfm.2011.117. PMID: 21829212
  20. Wu J, Stoica BA, Faden AI. Cell cycle activation and spinal cord injury. Neurotherapeutics. 2011 Apr;8(2):221-8. Review.
  21. Cernak I, Chang T, Ahmed FA, Cruz MI, Vink R, Stoica B, Faden AI. Pathophysiological response to experimental diffuse brain trauma differs as a function of developmental age. Dev Neurosci. 2010;32(5-6):442-53
  22. Kabadi SV, Hilton GD, Stoica BA, Zapple DN, Faden AI. Fluid-percussion-induced traumatic brain injury model in rats. Nat Protoc. 2010 Sep;5(9):1552-63.
  23. Stoica BA, Faden AI, Programmed Neuronal Cell Death Mechanisms in CNS Injury, book chapter 12 in â?oAcute Neuronal Injury-The Role of Excitotoxic Programmed Cell Death Mechanismsâ? Denson J. Fujikawa editor, Springer 2010
  24. Stoica BA, Faden AI. Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics. 2010 Jan;7(1):3-12.
  25. Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI. Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 2009 Jul;66(1):63-74.
  26. Stoica BA, Byrnes KR, Faden AI. Cell Cycle Activation and CNS Injury. Neurotox Res. 2009 Oct.
  27. Loane DJ, Stoica BA, Pajoohesh-Ganji A, Byrnes KR, Faden AI. Activation of metabotropic glutamate receptor 5 (mGLUR5) modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem. 2009 Jun.
  28. Byrnes KR, Stoica B, Loane DJ, Riccio A, Davis MI, Faden AI. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia. 2009 Apr 1;57(5):550-60.
  29. Stoica B, Byrnes K, Faden AI. Multifunctional drug treatment in neurotrauma. Neurotherapeutics. 2009 Jan;6(1):14-27. Review.
  30. Hilton GD*, Stoica BA*, Byrnes KR, Faden AI. Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. J Cereb Blood Flow Metab. 2008 Nov;28(11):1845-59. Epub 2008 Jul 9. (* first authors)
  31. Byrnes KR, Stoica BA, Fricke S, Di Giovanni S, Faden AI. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain. 2007 Nov;130(Pt 11):2977-92. Epub 2007 Aug 9.
  32. Faden AI, Stoica B. Neuroprotection: challenges and opportunities. Arch Neurol. 2007 Jun;64(6):794-800.
  33. Carney RS, Alfonso TB, Cohen D, Dai H, Nery S, Stoica B, Slotkin J, Bregman BS, Fishell G, Corbin JG. Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. J Neurosci. 2006 Nov 8;26(45):11562-74.
  34. Loftus LT, Li HF, Gray AJ, Hirata-Fukae C, Stoica BA, Futami J, Yamada H, Aisen PS, Matsuoka Y. In vivo protein transduction to the CNS. Neuroscience. 2006;139(3):1061-7. Epub 2006 Mar 9.
  35. Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle. 2005 Sep;4(9):1286-93. Epub 2005 Sep 15.
  36. Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8333-8. Epub 2005 May 27.
  37. Stoica BA, Movsesyan VA, Knoblach SM, Faden AI. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci. 2005 Jul;29(3):355-71.
  38. Knoblach SM, Alroy DA, Nikolaeva M, Cernak I, Stoica BA, Faden AI. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32.
  39. Movsesyan VA, Stoica BA, Yakovlev AG, Knoblach SM, Lea PM 4th, Cernak I, Vink R, Faden AI. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death Differ. 2004 Oct;11(10):1121-32.
  40. Movsesyan VA, Stoica BA, Faden AI. mGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem. 2004 Jun;89(6):1528-36.
  41. Cernak I, Vink R, Natale J, Stoica B, Lea PM 4th, Movsesyan V, Ahmed F, Knoblach SM, Fricke ST, Faden AI. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. J Cereb Blood Flow Metab. 2004 May;24(5):564-78.
  42. Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004 Jul 2;279(27):28367-74. Epub 2004 Apr 21.
  43. Lea PM 4th, Custer SJ, Stoica BA, Faden AI. Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia. J Neurotrauma. 2003 Nov;20(11):1233-49.
  44. Natale JE, Ahmed F, Cernak I, Stoica B, Faden AI. Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. J Neurotrauma. 2003 Oct;20(10):907-27.
  45. Stoica BA, Movsesyan VA, Lea IV PM, Faden AI.  Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway.  Mol Cell Neurosci 2003 Mar;22(3):365-382.
  46. Movsesyan VA, Yakovlev AG, Dabaghyan EA, Stoica BA, Faden AI.  Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. Biochem Biophys Res Commun 2002 Nov 29;299(2):201-207.
  47. A.Hamid Boulares, Anna J. Zoltoski, Bogdan A. Stoica, Olivier Cuvillier, Mark E. Smulson. Acetaminophen Induces a Caspase-Dependent and Bcl-xl Sensitive Apoptosis in Human Hepatoma Cells and Lymphocytes.  Pharmacology & Toxicology 2002, 90, 38-50.
  48. Stoica BA, Boulares AH, Rosenthal DS, Iyer S, Hamilton ID, Smulson ME Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. Toxicol Appl Pharmacol 2001 Mar 1;171(2):94-106.
  49. Rosenthal DS, Simbulan-Rosenthal CM, Liu WF, Stoica BA, Smulson ME Mechanisms of JP-8 jet fuel cell toxicity. II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of Bcl-2 family members.. Toxicol Appl Pharmacol. 2001 Mar 1;171(2):107-116.
  50. Martin MB, Franke TF, Stoica GE, Chambon P, Katzenellenbogen  BS, Stoica BA, McLemore MS, Olivo SE, Stoica A.  A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin growth factor I.   Endocrinology. 2000 Dec;141 (12):4503-4511.
  51. Smulson, M.E., Simbulan-Rosenthal, C., Boulares, A. H., Yakovlev, A., Stoica, B., Iyer, S., Luo, R.,  Haddad, B., Wang, Z. Q., Pang, T., Jung, M., Dritschilo, A., and Rosenthal, D. S. Roles of poly(ADP)ribosylation and PARP in apoptosis, DNA repair, genomic stability, and functions of p53 and E2F-1.  Adv Enzyme Regul. 2000;40:183-215. Review.
  52. Yakovlev AG, Wang G, Stoica BA, Boulares HA, Spoonde AY, Yoshihara K, Smulson ME A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by Poly(ADP-ribose) polymerase. J Biol Chem 2000 Jul 14;275(28):21302-21308.
  53. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iver S, Smulson M.  Role of poly(ADP-ribose)polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.  J Biol Chem 1999 Aug 13;274(33):22932-22940.
  54. Yakovlev AG, Wang G, Stoica BA, Simbulan-Rosenthal CM, Yoshihara K, Smulson ME.  Role of DNAS1L3 in Ca2+ and Mg2+ dependent cleavage of DNA into oligonucleosomal and high molecular mass fragments. Nucleic Acid Res 1999 May 1; 27(9): 1999-2005.
  55. Bonvini E, DeBell KE, Veri MC, Graham L, Stoica B, Laborda J,  Aman MJ, DiBaldassarre A, Miscia S, Rellahan BL. On the mechanism coupling phospholipase Cgamma1 to the B- and T-cell antigen receptors. Adv Enzyme Regul. 2003;43:245-69.
  56. Graham LJ, DeBell KE, Veri M, Stoica B, Mostowski H, Bonvini E, Rellahan B.  Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity. FEBS Lett 2000 Mar 31;470(3):273-280.
  57. KE Debell*, BA Stoica* , M-C Veri, A Di Baldassare, S Miscia, LJ Graham, BL Rellahan, M Ishiai, T Kurosaki, E Bonvini Functional independence and interdependence of the Src-homology domains of phospholipase C gamma-1 in B cell receptor signal transduction.  Mol Cell Biol, Nov 1999, p. 7388-7398. (* first authors)
  58. Graham LJ*, Stoica BA*, Shapiro M, DeBell KE, Rellahan B, Laborda J, Bonvini E. Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1        increase the domain's association with Cbl.  Biochem Biophys Res Commun 1998 Aug 19;249(2):537-541. (* first authors)
  59. Stoica B, DeBell KE, Graham L, Rellahan BL, Alava MA, Laborda J, Bonvini E.  The amino-terminal Src homology 2 domain of phospholipase C gamma-1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1.  J Immunol 1998 Feb 1;160(3):1059-1066.
  60. Rellahan BL, Graham LJ, Stoica B, DeBell KE, Bonvini E.  Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway. J Biol Chem 1997 Dec 5;272(49):30806-30811.