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Personal History
Dr. Qun Zhou received his M.D. training in China and a PhD in Pharmacology and Toxicology from West Virginia University. After completing postdoctoral training in Dr. Nancy Davidson' laboratory at Johns Hopkins University, he started as assistant professor at the University of Maryland School of Medicine.
Research Interests
Currently, his laboratory is focusing on the impact of microRNAs (miRNAs) on breast cancer development. In addition, his laboratory is seeking to define impact of epigenetic regulators on miRNA expression in vitro and in vivo models. These studies will seek to provide scientific rationales for future therapeutic strategies to treat/prevent breast cancer.
Publications
SELECTED PAPERS Zhou,Q., Zaroui, M., Lucktong, A., Moniwa, M, Davie, J.R and Strobl, J.S. (2000) Rapid Induction of Histone Hyperacetylation and Cellular Differentiation in Human Breast Tumor Cells Lines Following Degradation of Histone Deacetylase. Journal of Biological Chemistry 275: 35256-35263. PMID: 10938272
Zhou,Q., Yao,Y., and Ericson, S.G. (2004). The Protein Tyrosine Phosphatase CD45 is Required for IL-6 Signaling in U266 Myeloma Cells. International Journal of Hematology 79:63-73. PMID: 14979481
Keen,J.C., Zhou, Q., Park, B.H., Pettit,C., Mack,K.M., Blair,B., Brenner,K. and Davidson, N.E. (2005) Protein phosphatase 2A (PP2A) Regulates Estrogen Receptor alpha (ER) Expression through Modulation of ER mRNA Stability. Journal of Biological Chemistry 280:29519-24. PMCID: 15965230
Zhou, Q. and Davidson, N.E. (2006) Silencing Estrogen Receptor α in Breast Cancer Cells. Cancer Biology and Therapy 5:848-849. PMID: 16921265
Zhou,Q., Atadja, P. and Davidson, N.E. (2007) Histone Deacetylase Inhibitor LBH589 Reactivates Silenced Estrogen Receptor Alpha (ER) Gene Expression without Loss of DNA Hypermethylation. Cancer Biology and Therapy 6: 64-9. PMID: 17172825
Vered,S., Zhou,Q. and Davidson, N.E. (2007) Epigenetic regulation as a new target for breast cancer therapy. Cancer Invest. 25:659-65. PMID: 18058459
Zhou,Q., Agoston,A.T., Atadja,P., Nelson,W.G., and Davidson, N.E. (2008) Inhibition of Histone Deacetylases Promotes Ubiquitin-dependent Proteasomal Degradation of DNMT1 in Human Breast Cancer Cells. Molecular Cancer Research 6: 873-83. PMID: 18505931
Zhou,Q., Shaw, P.G. and Davidson, N.E., (2009). Inhibition of Histone Deacetylase Suppresses EGF Signaling Pathways by Destabilizing EGFR mRNA in ER-negative Human Breast Cancer Cells. Breast Cancer Research and Treatment 117:443-51 PMID: 18683042
Zhou,Q., Shaw, P.G. and Davidson, N.E. (2009) Epigenetics meets estrogen receptorâ?"regulation of estrogen receptor by direct lysine methylation. Endocrine-Related Cancer 16:319-23 PMID: 19208734
Yao, Y and Zhou, Q (2010) A Novel Antiestrogen Agent Shikonin Inhibits Estrogen Dependent Gene Transcription in Human Breast Cancer Cells. Breast Cancer Research and Treatment 121:233-40 PMID: 19760501
Yao Y, Li H, Gu Y, Davidson NE, Zhou Q (2010) Inhibition of Class III HDAC Activity Suppresses Estrogen-dependent Gene Transcription Carcinogenesis 31:382-7 PMID: 19995796
Zhou Q, Chaerkady R, Shaw PG, Kensler TW, Pandey A, Davidson NE (2010) Screening for Therapeutic Targets of Vorinostat by SILAC-based Proteomic Analysis in Human Breast Cancer Cells Proteomics 10:1029-39 PMID: 20049865
Yao Y, Brodie AM, Davidson NE, Kensler TW, Zhou Q (2010) Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Res Treat. 124:585-91 PMID: 20623181
Yang M, Yao Y, Eades G, Zhang Y, Zhou Q (2011) MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res Treat. [Epub ahead of print] PMID:21638050
Eades G, Yao Y, Yang M, Zhang Y, Chumsri S, Zhou Q (2011) MiR-200a regulates SIRT1 and EMT-like transformation in mammary epithelial cells. J Biol Chem. [Epub ahead of print] PMID:21596753
BOOK CHAPTERS
Vered Stearns, Qun Zhou and Nancy E. Davidson. Chapter 26: Epigenetic Regulation as a New Target for Breast Cancer Therapy. In: Gary H. Lyman, Harold J. Burstein, editors. Breast Cancer Translational Therapeutic Strategies. New York: JOHN WILEY& SONS; 2007. p.285-295.
Faculty members:
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