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James M. Donahue

James M. Donahue M.D.

Academic Title: Assistant Professor
Primary Appointment: Surgery
Location: 29 South Greene Street, Suite 504
Phone: 410-328-6366

Personal History:

Dr. James Donahue is an assistant professor of surgery in the division of Thoracic Surgery at the University of Maryland School of Medicine, specializing in thoracic malignancies and airway surgery.

Dr. Donahue received his Medical Degree from Harvard Medical School. He completed a residency in Surgery at Massachusetts General Hospital in Boston and a fellowship in Cardiothoracic Surgery at the Mayo Clinic in Rochester, MN. He currently serves with the United States Naval Medical Reserves and was recently deployed for one year with a forward surgical team in Afghanistan.

Dr. Donahue is the recipient of multiple research grant awards including the VA Career Development Award and the Thoracic Surgery Foundation for Research and Education research grant. He is affiliated with several top-rated hospitals in the region, including the University of Maryland Medical Center, Upper Chesapeake Medical Center, Harford Memorial Hospital, St. Joseph Medical Center and the Baltimore VA Medical Center.

Research Interests:

Dr. Donahue’s research efforts are focused on esophageal cancer. The fundamental goal of his research is to develop novel therapies that will improve survival outcomes for esophageal cancer patients. To this end, he is working to gain a detailed understanding of the intracellular mechanisms that drive the development and progression of esophageal cancer.

Currently, he is focused on the study of post-transcriptional gene regulation by RNA-binding proteins and microRNAs. His lab analyzes expression of these factors in esophageal cancer cell lines and human specimens. In addition to linking their expression with patient prognosis, they utilize advanced cell biology techniques to identify their targets and determine the effects of modulating expression of individual RNA-binding proteins and microRNAs. Dr. Donahue’s ultimate goal is to combine this work with modern nanotechnology to develop of RNA-based therapeutics for the disease.