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Guofeng  Xie

Guofeng Xie M.B.B.S., Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
Location: UMMC, N3W62
Phone: (410) 328-5780
Fax: (410) 328-8315

Personal History:

Dr. Xie is a member of the Experimental Therapeutics Program within the University of Maryland Marlene and Stewart Greenebaum Cancer Center Program in Oncology. Experimental Therapeutics researchers collaborate with both basic and clinical research investigators, focusing on the rapid transfer of knowledge from the laboratory to the clinic. Dr. Xie's research centers on the identification of novel genes and proteins that are important targets in colon cancer treatment.

Research Interests:

Dr. Xie is researching the role of matrix metalloproteinases in mediating farnesoid X receptor- and muscarinic receptor-dependent intestinal epithelial cell proliferation and colon neoplasia.

Clinical Specialty:

  • Board certified in Internal Medicine and Gastroenterology
  • Esophageal motility disorders and colorectal cancer


Xie, G., Y. Jia and E. Aamodt. A C. elegans mutant screen based on antibody or histochemical staining. Genetic analysis: Biomolecular Engineering 12:95-100, 1995.

Jia, Y., Xie, G., Aamodt, E. pag 3, a C. elegans gene involved in touch neuron gene expression and coordinated movement. Genetics 142:141-147, 1996.

Jia, Y*., Xie, G*., McDermott, J., Aamodt, E. The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1. *The first two authors contributed equally. Development 124:2063-2073, 1997.

Xie, G., Habbersett, R., Jia, Y., Peterson, S., Lehnert, B., Bradbury, M., D'Anna, J. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene 16:721-736, 1998.

Sandeep, B., Kurimasa, A., Xie, G., Taya, Y., Araki, R., Abe, M, Crissman, H., Ouyang, H., Li, G., Chen, D. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J Biol Chem 274:17139-17143,1999.

Xie, G., Raufman, J-P. Association of protein kinase A with A-kinase anchoring protein150 facilitates pepsinogen secretion from gastric chief cells. Am. J. Physiol. 281:G1051-G1058, 2001.

Khurana, S., Chacon, I., Xie, G., Yamada, M., Wess, J., Raufman, J-P., Kennedy, R. Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. Eur. J. Pharmacol. 493:127-132, 2004.

Xie, G., Drachenberg, C., Yamada, M., Wess, J., Raufman, J-P. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated y M1 and M3 muscarinic receptors. Am. J. Physiol. 289:G521-G529, 2005.

Cheng, K., Xie, G., Raufman, J-P. Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem. Pharmacol. 73:1001-1012, 2007.

Hamilton J.P., Xie, G., Raufman, J-P., Hogan, S., Griffin, T.L., Packard, C.A., Chatfield, D.A., Hagey, L.R., Steinbach, J.H., Hofmann, A.F. Human cecal bile acids: concentration and spectrum. Am. J. Physiol. 293(1):G256-63. 2007.

Raufman, J-P., Samimi, R., Shah, N., Khurana, S., Shant, J., Drachenberg, C., Xie, G., Wess, J., Cheng K. Genetic ablation of M3 muscarinic receptors attenuates murine colon neoplasia. Cancer Res. 68(10), May 15, 2008.

Cheng, K., Samimi, R., Xie, G., Shant, J., Drachenberg., Wade, M., Davis, R., Nomikos, G., Raufman, J-P. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am. J. Physiol. 295(3):G591-7, 2008.

Xie, G., Cheng, K., Shant, J., Raufman, J-P. Acetylcholine-Induced Activation of M3 Muscarinic Receptors Stimulates Robust Matrix Metalloproteinase Gene Expression in Human Colon Cancer Cells. Am. J. Physiol. 2009.

Belo, A., Cheng, K., Chahdi, A., Shant, J., Xie, G., Khurana, S., and Raufman, J-P. Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. Am J Physiol, 300: G749-760, 2011.

Raufman, JP., Shant, J., Xie, G., Cheng, K., Gao, X, Shiu, B., Shah, N., Drachenberg, C., Heath, J., Wess, J and Khurana K. Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin+/- mice. Carcinogenesis, 32(9): 1396-402, 2011.

Raufman, JP., Cheng, K., Saxena, N., Chahdi, A., Belo, A., Khurana, S and Xie, G. Muscarinic receptor agonists stimulate matrix metalloproteinase-1-dependent invasion of human colon cancer cells. Biochemical and Biophysical Research Communications, 415(2): 319-324, 2011.

Xie, G., Peng, Z and Raufman, JP. Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross-talk stimulates colon cancer cell proliferation. Am J Physiol, 302:G1006-15, 2012

Peng, Z., Raufman, JP and Xie, G. Src-Mediated Cross-Talk Between Farnesoid X and Epidermal Growth Factor Receptors Inhibits Human Intestinal Cell Proliferation and Tumorigenesis.  PLoS One, 7(10): e48461, 2012.

Peng, Z., Heath, J., Drachenberg C., Raufman JP and Xie, G. Cholinergic Muscarinic Receptor Activation Augments Murine Intestinal Epithelial Cell Proliferation and Tumorigenesis. BMC Cancer, 13:204, 2013.

von Rosenvinge EC, Cheng K, Drachenberg CB, Fowler CB, Evers DL, Xie G, Raufman JP. Bedside to Bench: Role of Muscarinic Receptor Activation in Ultrarapid Growth of Colorectal Cancer in a Patient with Pheochromocytoma. Mayo Clinic Proceedings. 88:1340-6, 2013.

Cheng, K., Xie, G., Khurana, S., Heath, J., Drachenberg, C., Timmons, Shah, N and Raufman, JP. Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Molecular Cancer, 13:77 2014.