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Hervé S.G Tettelin
 

Hervé S.G Tettelin Ph.D.
Academic Title: Associate Professor
Primary Appointment: Microbiology and Immunology
Additional Title(s): Associate Professor, Institute for Genome Sciences; Adjunct Scientist, The J. Craig Venter Institute
tettelin@som.umaryland.edu
Location: Biopark II, 629
Phone: (410) 706-6764
Fax: (410) 706-1482
Lab: (410) 706-6775

Personal History

I received the degree of Industrial Engineer in Biotechnology from the Institut Supérieur Industriel de la Province de Liège, Belgium, and my B.S. and Ph.D. in Applied Natural Sciences from the Université Catholique de Louvain, Belgium. I am currently affiliated with the Institute for Genome Sciences (IGS)
 
During my Ph.D. thesis, I coordinated the work of 25 laboratories in Europe for the sequencing of yeast chromosome VII. Upon joining TIGR as a postdoctoral fellow in May 1997, I was the primary person responsible for the bioinformatics analysis of chromosome 2 of the human malarial parasite Plasmodium falciparum. Since then, I became a faculty member and led several published whole genome projects on human pathogens including Neisseria meningitidis (meningococcus), Streptococcus pneumoniae (pneumococcus), multiple strains of Streptococcus agalactiae (group B Streptococcus), Ehrlichia chaffeensis, Anaplasma phagocytophilum and Neorickettsia sennetsu. I am also the principal investigator for microarray-based functional genomics projects on these and other pathogens, conducting studies both at the DNA level - comparative genome hybridizations - and the RNA level - transcriptional profiling. My most prominent scientific contributions relate to our pioneering work on the reverse vaccinology approach, in collaboration with Novartis Vaccines and Diagnostics (formerly Chiron Vaccines). This work resulted in new vaccines currently being tested in clinical trials and also led to the new concept of the bacterial pan-genome.

Research Interests

My general interests are the use of genomics, comparative genomics and functional genomics to understand bacterial diversity and virulence, study host-pathogen interactions and identify vaccine candidates and drug targets to cure disease. 

Specific research efforts are: 


Publications

Tettelin H. (2004) Streptococcal genomes provide food for thought (News and Views). Nat. Biotechnol. 22, 1523-1524.

Ward N., Larsen Ø., Sakwa J., Bruseth L., Khouri H., Durkin A.S., Dimitrov G., Jiang L., Scanlan D., Kang K., Lewis M., Nelson K.E., Methé B., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D., Ravel J., Tettelin H., Ren Q., Read T., DeBoy R., Seshadri R., Salzberg S.L., Jensen H.B., Kåre Birkeland N., Nelson W., Dodson R.J., Grindhaug S.H., Holt I., Eidhammer I., Jonasen I., Vanaken S., Utterback T., Feldblyum T.V., Lillehaug J., Fraser C.M., and Eisen J.A. (2004) Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath). PLoS Biol. 2, 1616-1628 [2(10): e303].

Tettelin H. and Parkhill J. (2004) The use of genome annotation data and its impact on biological conclusions (correspondence letter). Nature Genetics 36, 1028-1029.

Nierman W., DeShazer D., Kim H., Tettelin H., Nelson K, Feldblyum T., Ulrich R., Ronning C., Brinkac L., Daugherty S., Davidsen T., DeBoy R., Dimitrov G., Dodson R., Durkin S., Gwinn M., Haft D., Khouri H., Kolonay J., Madupu R., Mohammoud Y., Nelson W., Radune D., Romero C., Sarria S., Selengut J., Shamblin C., Sullivan S., White O., Yu Y., Zafar N., Zhou L., and Fraser C.M. (2004) Structural Flexibility in the Burkholderia mallei Genome. Proc. Natl. Acad. Sci. USA 101, 14246-14251.

Tettelin H. and Hollingshead S.K. (2004) Comparative genomics of S. pneumoniae: intra-strain diversity and genome plasticity. In The pneumococcus, pp. 15-29, Tuomanen E., Mitchell T., Morrison D. and Spratt B. Eds. ASM Press (Washington, DC, USA).

Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Davidsen T.M., Dodson R.J., Deboy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin A.S., Daugherty S.C., Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J., Ayodeji B., Shatsman S., McLeod M.P., Majs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Weinstock G.M., Norris S.J., Fraser C.M., and Paulsen I.T. (2004) Comparison of the genome of the oral pathogen, Treponema denticola, with other spirochete genomes. Proc. Natl. Acad. Sci. USA 101, 5646-5651.

Wu M., Sun L.V., Vamathevan J., Riegler M., DeBoy R., Brownlie J.C., McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R., Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F., Nelson W.C., Mohamoud Y., Lee P., Berry K., Young M.B., Utterback T., Weidman J., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H., O'Neill S.L., and Eisen J.A. (2004) Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements. PLoS Biol. 2: 327-341.

Radune D. and Tettelin H. (2004) Optimized multiplex polymerase chain reaction, an effective method for rapid gap closure. In Methods in Molecular Biology 255: Bacterial Artificial Chromosomes, pp. 309-318, Zhao S. and Stodolsky M. Eds, Humana Press Inc. (Totowa, NJ, USA). [PubMed]

Tettelin H. and Feldblyum T. (2004) Genome sequencing and analysis. In Genomics, Proteomics and Vaccines, pp. 45-73, Grandi G. Ed., John Wiley and Sons Ltd (London, United Kingdom).

Telford J.L., Margarit y Ros I., Maione D., Masignani V., Tettelin H., Bensi G., and Grandi G. (2004) Vaccines against pathogenic streptococci. In Genomics, Proteomics and Vaccines, pp. 205-222, Grandi G. Ed., John Wiley and Sons Ltd (London, United Kingdom).

Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M., Haft D.H., Kolonay J.F., Nelson W.C., Mason T., Tallon L., Gray J., Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., and Fraser C.M. (2003) Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83. J. Bacteriology 185, 5591-5601.

Read T.D., Peterson S.N., Tourasse N., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Økstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M., DeBoy R.T., Madupu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstø A-B., and Fraser C.M. (2003) The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423, 81-86.

Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., Deboy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., and Heidelberg J.F. (2003) Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc. Natl. Acad. Sci. USA 100, 5455-5460.

Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T., Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B., Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D., Ketchum K.A., Dougherty B.A., and Fraser C.M. (2003) Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science 299, 2071-2074.

Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L., Brinkac L.M., Beanan M.J., Daugherty S.C., Deboy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., and Fraser C.M. (2002) The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proc. Natl. Acad. Sci. USA 99: 13148-13153.

Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., and Fraser C.M. (2002) Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc. Natl. Acad. Sci. USA 99: 12391-12396.

Grifantini R., Bartolini E., Muzzi A., Draghi M., Frigimelica E., Berger J., Ratti G., Petracca R., Galli G., Agnusdei M., Giuliani M.M., Santini L., Brunelli B., Tettelin H., Rappuoli R., Randazzo F., and Grandi G. (2002) Previously unrecognized vaccine candidates against Group B meningococcus identified by DNA microarrays. Nat. Biotechnol. 20: 914-921.

Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.L., Yang F., Holt I., Umayam L.A., Mason T., Brenner M., Shea T.P., Parksey D., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J., Khouri H., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., and Fraser C.M. (2002) The complete genome sequence of Cholorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium. Proc. Natl. Acad. Sci. USA 90, 9509-9514.

Read T.D., Gill S.R., Tettelin H., and Dougherty B.A. (2001) Finding drug targets in microbial genomes. Drug Discovery Today 6, 887-892.

Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S., Heidelberg J., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D., Holtzapple E., Khouri H., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., and Fraser C.M. (2001) Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science 293, 498-506. Fast Breaking Paper. Hot paper 1. Hot paper 2.

Masignani V., Giuliani M.M., Tettelin H., Commanducci M., Rappuoli R., and Scarlato V. (2001) A Mu-like prophage in serogroup B Neisseria meningitidis coding for surface-exposed antigens. Infection and Immunity 69, 2580-2588.

Peterson S., Cline R.T., Tettelin H., Sharov V., and Morrison D.A. (2000) Gene expression analysis of the Streptococcus pneumoniae competence regulons by use DNA microarrays. J. Bacteriology 182, 6192-6202.

Saunders N.J., Jeffries A.C., Peden J.F., Hood D.W., Tettelin H., Rappuoli R., and Moxon E.R. (2000) Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58. Mol. Microbiol. 37, 207-215.

Heidelberg J., Eisen J.A., Nelson W.C., Clayton R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D., Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L., Utterback T., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J., Venter J.C., and Fraser C.M. (2000) DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406, 477-484.

Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., and Venter J.C. (2000) Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287, 1809-1815. Hot Paper in The Scientist

Pizza M., Scarlato V., Masignani V., Giuliani M.M., Arica B., Comanducci M., Jennings G.T., Baldi L., Bartolini E., Capecchi B., Galeotti C.L., Luzzi E., Manetti R., Marchetti E., Mora M., Nuti S., Ratti G., Santini L., Savino S., Scarselli M., Storni E., Zuo P., Broeker M., Hundt E., Knapp B., Blair E., Mason T., Tettelin H., Hood D.W., Jeffries A.C., Saunders N.J., Granoff D.M., Venter J.C., Moxon E.R., Grandi G., and Rappuoli R. (2000) Whole genome sequencing to identify vaccine candidates against serogroup B meningococcus. Science 287, 1816-1820.


Schoen C., Tettelin H., Parkhill J., and Frosch M. (2009) Genome flexibility in Neisseria meningitidis. Vaccine 27 supplement 2, B103-B111. Epub 2009 June 24.

Ishmael N., Dunning Hotopp J.C., Ioannidis P., Biber S., Sakamoto J., Siozios S., Nene V., Werren J., Bourtzis K., Bordenstein S.R., Tettelin H. (2009) Extensive Genomic Diversity of Closely Related Wolbachia Strains. Microbiology 155, 2211-2222. Epub 2009 Apr 23.

Bordenstein S.R., Paraskevopoulos C., Dunning Hotopp J.C., Sapountzis P., Lo N., Bandi C., Tettelin H., Werren J.H., and Bourtzis K. (2009) Parasitism and mutualism in Wolbachia: what the phylogenomic trees can and can not say. Mol. Biol. Evol. 26, 231-241. Epub 2008 Oct. 28.

Tettelin H. and Feldblyum T. (2009) Bacterial genome sequencing. In Methods in Molecular Biology 551: Molecular Epidemiology of Microorganisms, pp. 231-247, Caugant D.A. Ed., Humana Press Inc. (Clifton, NJ, USA).

Tettelin H. (2009) The bacterial pan-genome and reverse vaccinology. In Genome Dynamics 6: Microbial Pathogenomics, pp. 35-47, de Reuse H. and Bereswill S. Eds, Karger (Basel, Switzerland). DOI: 10.1159/000235761.

Kilian M., Poulsen K., Blomqvist T., Håvarstein L.S., Bek-Thomsen M., Tettelin H., and Sørensen U.B.S. (2008) Evolution of Streptococcus pneumoniae and its close commensal relatives. PLoS ONE 3(7), e2683, doi:10.1371/journal.pone.0002683. 

Tettelin H., Riley D., Cattuto C., and Medini D. (2008) Comparative genomics: the bacterial pan-genome. Curr. Opin. Microbiol. 11: 472-477 (doi:10.1016/j.mib.2008.09.006).

Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., and Holmes, D.S. (2008) Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications. BMC Genomics 9, 597, doi:10.1186/1471-2164-9-597. PMCID: PMC2621215.

Bek-Thomsen M., Tettelin H., Hance I., Nelson K.E., and Kilian M. (2008) Population diversity and dynamics of Streptococcus mitis, Streptococcus oralis and Streptococcus infantis in the upper respiratory tract of adults determined by a non-culture strategy. Infect. Immun., 76, 1889-1896. Epub 2008 Mar 3.

Jiang S.-M., Ishmael N., Dunning Hotopp J., Puliti M., Tissi 3., Kumar n., Cieslewicz M.J., Tettelin H., and Wessels M.R. (2008) Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity. J. Bacteriol. 190, 1956-1965. Epub 2008 Jan. 18.

Masignani V., Tettelin H., and Rappuoli R. (2007) Vaccines against infectious diseases: a biotechnology-driven evolution. In Genomic and Personalized Medicine, Willard H.F. and Ginsburg G.S. Eds, Elsevier/Academic Press (San Diego, CA, USA), vol. 1; pp: 562-570.

Raghavan N., Tettelin H., Miller A., Hostetler J., Tallon L., and Knight M. (2007) Nimbus (BgI): An active non-LTR retrotransposon of the Schistosoma mansoni snail host Biomphalaria glabrata. Int. J. Parasitol. 37, 1307-1318. Epub 2007 Apr. 19.

Dunning Hotopp J.C., Clark M.E., Oliveira D.C.S.G., Foster J.M., Fischer P., Mun~oz Torres M.C., Giebel J.D., Kumar N., Ishmael N., Wang S., Ingram J., Nene R.V., Shepard J., Tomkins J., Richards S., Spiro D.J., Ghedin E., Slatko B.E., Tettelin H.*, and Werren J. H.* [*These authors have contributed equally to this work] (2007) "Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes." Science 317, 1753-1756. Epub 2007 Aug. 30.

Tettelin H., Rappuoli R., and Fraser-Liggett C.M. (2007) Using genomics to identify novel vaccine candidates against pathogens. In The Jordan Report, Accelerated Development of Vaccines 2007, U.S. Department of Health and Human Services, pp. 37-42.

Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., DeBoy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W., Madupu R., Mohamoud Y., Holley T., Fedorova N., Khouri H., Bottomley S.P, Whittington R.J., Adler B., Songer J.G., Rood J.I., and Paulsen I.T. (2007) Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nat. Biotechnol. 25, 569-575.

Lanie J.A., Ng W-L, Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., and Winkler M. (2006) Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. J. Bacteriol. 189, 38-51.

Tettelin H., Medini D., Donati C., and Masignani V. (2006) Towards a universal group B Streptococcus vaccine using multi-strain genome analysis. Expert Rev. Vaccines 5, 687-694. [PubMed]

Dunning Hotopp J.C., Grifantini R., Kumar N., Tzeng Y.L., Fouts D., Frigimelica E., Draghi M., Giuliani M.M., Rappuoli R., Stephens D.S., Grandi G., and Tettelin H. (2006) Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen specific genes. Microbiology 152, 3733-3749. Featured in Microbiology Today

Savard J., Tautz D., Richards S., Weinstock G.M., Gibbs R.A., Werren J.H., Tettelin H., and Lercher M.J. (2006) Phylogenomic analysis reveals bees and wasps (Hymenoptera) at the base of the radiation of holometabolous insects. Genome Res. 16, 1334-1338.

Baldo L., Dunning Hotopp J.C., Jolley K.A., Bordenstein S.R., Biber S.A., Choudhury R.R., Hayashi C., Maiden M.C.J., Tettelin H., and Werren J.H. (2006) A multilocus sequence typing system for the endosymbiont Wolbachia. Appl. Environ. Microbiol. 72, 7098-7110.

Ramaswamy S.V., Ferrieri P., Madoff L.C., Flores A.E., Kumar N., Tettelin H., and Paoletti L.C. (2006) Identification of novel cps locus polymorphisms in nontypeable group B Streptococcus. J. Med. Microbiol. 55, 775-783. [PubMed]

Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.R., Khouri H., Zhang C., Hua N., Lin Q., Ohashi N., Zhi N., Nelson W., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., and Tettelin H. (2006) Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2, e21. Featured in Nature Reviews Microbiology

Medini D., Donati C., Tettelin H., Masignani V., and Rappuoli R. (2005) The microbial pan-genome. Curr. Opin. Genet. Dev. 15, 589-594.

Tettelin H., Masignani M., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H., Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D., Dimitrov G., Watkins K., O'Connor K.J.B., Smith S., Utterback T.R., White O., Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L., Wessels M.R., Rappuoli R., and Fraser C.M. (2005) Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome." Proc. Natl. Acad. Sci. USA 102, 13950-13955. Erratum in: Proc. Natl. Acad. Sci. USA 102, 16530. Featured in Nature Reviews Microbiology. Featured in The Scientist.

Maione D., Margarit I., Rinaudo C.D., Masignani V., Mora M., Scarselli M., Tettelin H., Brettoni C., Iacobini E.T., Rosini R., D'Agostino N., Miorin L., Buccato S., Mariani M., Galli G., Nogarotto R., Nardi Dei G., Vegni F., Fraser C.M., Mancuso G., Teti G., Madoff L.C., Paoletti L.C., Rappuoli R., Kasper D.L., Telford J.L., and Grandi G. (2005) Identification of a universal Group B Streptococcus vaccine by multiple genome screen. Science 309, 148-150. Featured in The Scientist.


Tettelin H., Radune D., Kasif S., Khouri H., and Salzberg S.L. (1999) Optimized multiplex PCR: efficiently closing a whole genome shotgun sequencing project. Genomics 62, 500-507.

Salzberg S.L., Pertea M., Delcher A.L., Gardner M.J., and Tettelin H. (1999) Interpolated markov models for eukaryotic gene finding. Genomics 59, 24-31.

Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Smith H.O., Fraser C.M., Venter J.C., and Hoffman S.L. (1999) The malaria genome sequencing project: complete sequence of P. falciparum chromosome 2. Parassitologia 41, 69-75.

Jing J., Lai Z., Aston C., Lin J., Carucci D.J., Gardner M.J., Mishra B., Anantharaman T.S., Tettelin H., Cummings L.M., Hoffman S.L., Venter J.C., and Schwartz D.C. (1999) Optical mapping of Plasmodium falciparum chromosome 2. Genome Research 9, 175-181. [PubMed]

Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L., Koonin E.V., Shallom S., Mason T., Yu K., Fujii C., Pedersen J., Shen K., Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S., Zhou L., Sutton G.G., Clayton R.L., White O., Smith H.O., Fraser C.M., Adams M.D., Venter J.C., and Hoffman S.L. (1998) Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 282, 1126-1132.

Carucci D.J., Gardner M.J., Tettelin H., Cummings L.M., Smith H.O., Adams M.D., Venter J.C., and Hoffman S.L. (1998) Sequencing the genome of Plasmodium falciparum. Current Opinion in Infectious Diseases 11, 531-534.

Carucci D.J., Gardner M.J., Tettelin H., Cummings L.M., Smith H.O., Adams M.D., Hoffman S.L., and Venter J.C. (1998) The malaria genome sequencing project. Expert Rev. Mol. Med. 1998, 1-9. Online Journal

Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Adams M.D., Smith H.O., Venter J.C., and Hoffman S.L. (1998) The malaria genome sequencing project. Protist 149, 109-112.

Tettelin H., Thierry A., Goffeau A., and Dujon B. (1998) Physical mapping of chromosomes VII and XV of Saccharomyces cerevisiae at 3.5 kb average resolution to allow their complete sequencing. Yeast 14, 601-616.

Caro L.H.P., Tettelin H., Vossen J.H., Ram A.F.J., van den Ende H., and Klis F.M. (1997) In silicio identification of glycosyl-phosphatidylinositol-anchored plasma membrane and cell wall proteins of Saccharomyces cerevisiae. Yeast 13, 1477-1489.

Tettelin H., ..., and Kleine K. (115 authors) (1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature 387 supplement, 81-84.

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