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Henryk Szmacinski Ph.D.

Academic Title: Adjunct Associate Professor
Primary Appointment: Biochemistry and Molecular Biology
Location: Institute of Human Virology, N252
Phone: 410-706-7500
Phone: 410-706-2116
Fax: 410-706-8408

Research Interests:

Molecular spectroscopy, fluorescence-based sensing and imaging, plasmonic substrates, single cell assays


  1. Szmacinski H, Toshchakov V, Piao W, Lakowicz JR. Imaging of Protein Secretion from a Single Cell Using Plasmonic Substrates. BioNanoScience, 2013, 3: 30-36. NIHMSID 438573.
  2. Szmacinski H, Badugu R, Mahdavi F, Blair S, and Lakowicz JR. Large Fluorescence Enhancements of Fluorophore Ensembles with Multi-Layer Plasmonic Substrates: Comparison of Theory and Experimental Results, J. Phys. Chem. C 2012, 116: 21563-21571. NIHMSID 476812.
  3. Szmacinski H, Badugu R, Lakowicz JR. Fabrication and Characterization of Planar Plasmonic Substrates with High Fluorescent Enhancement. J. Phys. Chem. C 114: 21142-21149, 2010. NIHMSID 2621805.
  4. H. Szmacinski, Z. Murtaza, and J.R. Lakowicz, Time-Resolved Method for One-Step Immunoassays Using Plasmonic Nanostructures. J. Phys Chem. C, 2010, 114: 7236-7241. NIHMSID 132114.
  5. Szmacinski H, Ray K, and Lakowicz JR. Metal-Enhanced Fluorescence of Tryptophan Residues in Proteins. Application towards Label-Free Bioassays. Anal. Biochem. 2009, 385: 358-364. NIHMSID 120432.
  6. Szmacinski H. and Lakowicz JR. Depolarization of Surface Enhanced Fluorescence: A New Approach to Fluorescence Polarization Assays. Anal. Chem. 2008, 80:6260-6266. NIHMSID 120429.
  7. Szmacinski H, Smith, D, Hanson MA, Kostov Y, Lakowicz JR, and Rao G. A Novel Method for Monitoring Monoclonal Antibody Production during Cell Culture. Biotechnol. Bioengin. 100(3): 448-457, 2008. NIHMSID 132478.
  8. Szmacinski H, Lakowicz JR. Lifetime-based sensing and imaging. Sensors and Actuators B 29:16-24, 1995.
  9. Lakowicz JR, Szmacinski H, Nowaczyk K, Lederer WJ, Kirby MS, Johnson ML. Fluorescence lifetime imaging of intracellular calcium in COS cells. Cell Calcium 15:17-27, 1994.
  10. Szmacinski H, Lakowicz JR, Johnson ML. Fluorescence Lifetime Imaging Microscopy (FLIM). Homodyne Technique Using High-Speed Image Intensifier. In Methods in Enzymology, Vol. 240, ( M.L. Johnson and L. Brand, Eds.), Academic Press, 1994, pp. 723-748.