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Sharon M Tennant
 

Sharon M Tennant Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
stennant@medicine.umaryland.edu
Location: HSF-II, S355
Phone: (410) 706-5336 (office)
Phone: (410) 706-5328 (lab)

Research Interests:

Dr. Tennant is head of the Molecular Diagnostics Section of the Center for Vaccine Development in the Division of Geographic Medicine. She performs research on non-typhoidal Salmonella (NTS) such as Salmonella Typhimurium and Salmonella Enteritidis and is developing diagnostic assays to detect these bacteria as well as vaccines to prevent disease. She also investigates the pathogenesis of NTS strains isolated from sub-Saharan Africa.


Publications:

Levy H, Diallo S, Tennant SM, Livio S, Sow SO, Tapia M, Fields PI, Mikoleit M, Tamboura B, Kotloff KL, Lagos R, Nataro JP, Galen JE, Levine MM. 2008. PCR method to identify Salmonella enterica serovars Typhi, Paratyphi A, and Paratyphi B among Salmonella Isolates from the blood of patients with clinical enteric fever. J Clin Microbiol. 46(5):1861-6.

Galen JE, Pasetti MF, Tennant SM, Olveira-Ruiz P, Sztein MB, and Levine MM. Salmonella enterica serovar Typhi Live Vector Vaccines Finally Come of Age. Immunology and Cell Biology 87, 400-412 (5 May 2009).

Tennant SM, Diallo S, Levy H, Livio S, Sow SO, Tapia M, Fields PI, Mikoleit M, Tamboura B, Kotloff KL, Nataro JP, Galen JE, Levine MM. 2010. Identification by PCR of non-typhoidal Salmonella enterica serovars associated with invasive infections among febrile patients in Mali. PLoS Negl Trop Dis. 4(3):e621.

Tennant SM*, Zhang Y*, Galen JE, Geddes, CD, Levine MM. 2011. Ultra-fast and Sensitive Detection of Non-typhoidal Salmonella using Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF). PLoS One 6(4):e18700. (* co-first authors)

Simon R, Tennant SM, Galen JE, Levine MM. 2011. Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: Revisiting the role of host innate susceptibility and routes of challenge. Vaccine. 29(32):5094-106.

Tennant SM, Wang JY, Galen JE, Simon R, Passetti M, Gat O, Levine MM. 2011. Engineering and pre-clinical evaluation of attenuated non-typhoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infect. Immun. 79(10):4175-85.

Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM. 2011. Salmonella Enteritidis Core-O Polysaccharide (COPS) conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with Salmonella Enteritidis. Infect. Immun. 79(1):4240-9.

Gat O, Galen JE, Tennant SM, Simon R, Blackwelder WC, Silverman DJ, Pasetti M, Levine MM. 2011. Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines. PLoS Negl Trop Dis. Nov;5(11):e1373. Epub 2011 Nov 1.

Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM, Al-Mashhadani MN, Kariuki S, Msefula CL, Gordon MA, de Pinna E, Wain J, Heyderman RS, Obaro S, Alonso PL, Mandomando I, Maclennan CA, Tapia MD, Levine MM, Tennant SM, Parkhill J, Dougan G. 2012. Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nat Genet. 44(11):1215-21.