World-renowned pediatric gastroenterologist, research scientist and entreprenuer Alessio Fasano, M.D., founded the University of Maryland Center for Celiac Research in 1996. The Center for Celiac Research offers state-of-the art research, teaching and clinical expertise for the diagnosis, treatment and prevention of gluten-related disorders, including celiac disease, wheat allergy and gluten sensitivity.
A native of Salerno, Italy, Dr. Fasano completed his medical training at the University of Naples and founded the University of Maryland School of Medicine’s Division of Pediatric Gastroenterology and Nutrition in 1993. Ten years later, he published the groundbreaking study in the Annals of Medicine that established the prevalence rate of celiac disease at one in 133 people in the U.S.
A firm believer in the serendipitous discoveries that result from collaboration, Dr. Fasano leads a team of approximately 30 researchers in nine countries and enjoys research partnerships with institutions around the world. His research focuses on the mucosal biology of the gut and transcends the disciplines of microbiology, physiology, and molecular and cell biology. The “Fasano team” discovered bacterial toxins that cause diarrhea, leading to the development of new vaccines. Their work also led to the discovery in 2000 of the ancient molecule “zonulin,” which regulates the impermeability of the intestine in a condition also known as “leaky gut.”
Dr. Fasano’s research has linked an overproduction of zonulin to the pathogenesis of a series of autoimmune diseases, including type 1 diabetes, celiac disease and multiple sclerosis. Widely sought after by national and international media for his expertise on celiac disease, gluten disorders and intestinal permeability, Dr. Fasano has been featured in hundreds of interviews including media outlets such as The Wall Street Journal; NPR; New York Times Magazine; Bloomberg News; USA Today; Los Angeles Times; “Good Morning America”; The Globe and Mail; Vogue; and numerous health-related websites and magazines.
Dr. Fasano has published more than 200 peer-reviewed papers and has filed more than 160 patent applications. An elected member of the American Society for Clinical Investigation, he has received numerous awards for his translational science and other achievements. He has been named as one of America’s Top Doctors by Castle Connolly for five consecutive years (2007-2011) and was a 2005 finalist for the NIH Director’s Pioneer Award. The Daily Record in Baltimore has named Fasano as an Influential Marylander in 2011, Innovator of the Year in 2005 and a Physician Health Care Hero in 2004.
His other honors include the 2006 Best Academic/Industry Collaboration Award from the Greater Baltimore Committee, the 2006 Entepreneur of the Year Award from the University of Maryland, and the 2009 Researcher of the Year Award from the University of Maryland. His students also have selected him twice as Teacher of the Year. His research has been funded by the National Insitutes of Health without interruption since 1995.
Dr. Fasano and his team of international researchers continue to unravel complex molecular mysteries, leading to a greater understanding of the complicated nature of gluten-related disorders, including celiac disease, gluten sensitivity and wheat allergy. As director of the Center for Celiac Research, he spearheads its mission to increase awareness of celiac disease and improve the quality of life and support for people with celiac disease and their families.
* The Mucosal Biology Research Center, founded in 2005 by Dr. Fasano, is an organized research center within the University of Maryland School of Medicine that houses the University of Maryland Center for Celiac Research.
Dr. Fasano’s research focuses on mucosal biology, crossing the disciplines of microbiology, molecular and cell biology, and physiology. By focusing on the cross talk between enteric pathogens and their hosts, Dr. Fasano’s group have elucidate various intracellular signaling pathways that govern eukaryotic cell functions. Among others, Dr. Fasano discovered and characterized several new bacterial toxins involved in the pathogenesis of diarrheal diseases. This information has been used to develop new attenuated vaccines, including cholera and shigella. The characterization of one of these toxins (Zonula Occludens Toxin from Vibrio cholerae) led to the discovery of a molecule, named zonulin, involved in the regulation of the permeability of intercellular tight junctions of epithelial and endothelial barriers. This discovery shed light on the regulation of molecules trafficking between body compartments and mechanisms of innate immunity. Dr. Fasano’s research has linked zonulin to the pathogenesis of a series of autoimmune diseases, including type 1-diabetes, celiac disease, and multiple sclerosis. This information was used to create a platform research plan with ramifications in embryogenesis, drug, antigen, and gene delivery, immunomodulation, and prevention and treatment of inflammatory, autoimmune, and neoplastic diseases.
Search My Publications in PubMed
R. Lu, W. Wang, S. Uzzau, R. Vigorito, H.R. Zielke, A. Fasano. Affinity Purification and Partial Characterization of the Zonulin/Zonula Occludens Toxin (Zot) Receptor from Human Brain. J. Neurochem. 2000, 74:320-326.
I. Hill, A. Fasano, R. Schwartz, D. Counts, M. Glock, K. Horvath. The prevalence of celiac disease in at risk groups of children in United States. Ped. Res. 2000;136(1):86-90.
A. Fasano, T. Not, W. Wang, S. Uzzau, I. Berti, A. Tommasini, S.E. Goldblum. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000:358;1518-1519.
D.Sblattero, I. Berti, C. Trevisol, R. Marzari, A. Tommasini, A. Bradbury, A. Fasano, A. Ventura, T. Not. Human tissue transaminase ELISA: a powerful mass screening diagnostic assay for celiac disease. Am J. Gastroenterol. 2000:98:1253-1257..
F. Raimondi, J.P.Y. Kao, C. Fiorentini, A. Fabbri, G. Donelli, N. Gasparini, A. Rubino, A. Fasano. Enterotoxicity and Cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin in vitro systems. Infect. Immun. 2000;68:3180-3185.
S. Uzzau and A. Fasano. Cross talk between enteric pathogens and the intestine. Cell Microbiol. 2000: 2:83-89.
V. H. Shah, H. Rotterdam, D.P. Kotler, A. Fasano, P.H.R. Green. All that Scallops is not celiac disease. Gastrointest. Endosc. 2000:51:717-720.
W. Wang, R. Lu, M.R. Di Pierro, A. Fasano. Zonula Occludin Toxin, a Microtubule Binding Protein. World J. Gastroenterol 2000;6:330-334.
V. Baldas, A. Tommasini, C. Trevisiol, I. Berti, A. Fasano, D. Sblattero, A. Bradbury, R. Marzari, A. Ventura, T. Not. The development of a novel rapid non-invasive screening test for celiac disease. Gut 2000;47:628-631.
A McVeigh, A. Fasano, D A Scott, D C Robertson, S J Savarino. Molecular Characterization of an Allelic Variant of Enteroaggregative Escherichia coli Heat-Stable Enterotoxin from Enterotoxigenic Escherichia Coli. Infect. Immun. 2000:68:5710-5715.
W. Wang, S. Uzzau, S.E. Goldblum, A. Fasano. Human Zonulin, a Potential Modulator of Intestinal Tight Junctions. J. Cell Sci. 2000; 113:4435-4440.
S. Uzzau, R. Lu, W. Wang, C. Fiore, A. Fasano Purification and Preliminary Characterization of the Zonula Occludens Toxin Receptor from Human (CaCo2) and Murine (IEC6) intestinal Cell Lines. FEMS Microbiol Lett. 2001 Jan 1;194(1):1 5.
A. Fasano. Bacterial Infections: small intestine and colon. Cur. Opin. Gastroenterol 2001; 17:4-9.
A. Fasano. Regulation of intercellular tight junctions by Zonula occludens toxin (Zot) and its eukaryotic analogue zonulin. Ann. New York Acad. Sci. 2001; 915:214-222.
A. Fasano. The genome of the smartest pathogen decoded: is the cholera war over? J Pediat Gastroenterol Nutr 2001; 32:1-3.
A. Fasano, C. Catassi. Current Approaches to Diagnosis and Treatment of Celiac Disease: An Evolving Spectrum. Gastroenterology 2001;120:636 651.
A. Fasano. Celiac disease: the past, the present, the future Pediatrics 2001; 107:768-770.
T.L. Watts, A. Fasano. Modulation of Intestinal Permeability: a Novel and Innovative Approach for the Oral Delivery of Drugs, Macromolecules, and Antigens. Biothec Gen Engin Rev 2001; 16:433-453.
A. Fasano. Vibrio cholerae genome decoded: is the war over? J. Pediatr Gastroenterol Nutr 2001; 32:1-3
F. Raimondi, J. B. Kaper, E. C. Boedecker, Marcia K. Wolf, S. Guandalini, A. Fasano. Enteropathogenic E. Coli strain RDEC-1 produces a novel enterotoxic factor active in rabbit ileum in vitro. J. Pediatr Gastroenterol Nutr 2001; 32:122-126
M. Di Pierro, A. Fasano. Zonula occludens toxin: an innovative method of oral drugs delivery. Minerva Pediatr. 2001;53:15 22..
M. Di Pierro, R. Lu, S.Uzzau, W.Wang, K. Margaretten, C. Pazzani, F. Maimone, and A. Fasano. Zonula occludens toxin structure –function analysis: identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem 2001; 276:19160 19165.
A. Rabsztyn, P.H.R. Green, I. Berti, A. Fasano, J.A. Perman, K. Horvath. Macroamylasemia in patients with active celiac disease. Am J Gastroenterol 2001;96:1096-1100.
A. Fasano. Nitric oxide and intestinal water and electrolyte transport: in, out, or both? J. Pediatr Gastroenterol Nutr 2001;32:527 8.
A. Fasano. Intestinal zonulin: open Sesame! Gut 2001;49:159 62.
E. Bucci, T.L. Watts, H.E. Kwansa A. Fasano, B.A. Matheson, A. Rebel, R.C. Koehler. Cell free Hemoglobin, Oxygen Off Load and Vasoconstriction. Anasthesiol Intensivmed Notfallmed Schmerzther 2001;36:S123 4.
Fabiani E, Catassi C and the International Working Group on Eu-tTG (*includes A. Fasano). The serum IgA class anti-tissue transglutaminase antibodies in the diagnosis and follow-up of coeliac disease. Results of an international multi-centre study. Eur J Gastroenterol Hepatol 2001;13: 659-665.
M.M. Pietzak, C. Catassi, S. Drago, F. Fornaroli, and A. Fasano. Celiac Disease: Going Against the Grains. Nutr Clin prac 2001;16:335-344.
S. Drago, M Di Pierro, C. Catassi, A. Fasano. Recent developments in the pathogenesis, diagnosis and treatment of celiac disease. Expert Opin Ther Patents 2002;12:45-51.
M. Rossi, F. Maurano, D. Luongo, A. Fasano, S. Uzzau, S. Auricchio, R. Troncone. Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin. Immunol Let, 2002;1:217 221.
C Catassi, A Fasano. New developments in childhood celiac disease. Curr Gastroenterol Rep 2002;4:238 243.
A. Fasano. Toxins and the gut: role in human diseases. Gut, 50 Suppl 3:III9 III14, 2002.
A. Alaedini, PH Green, HW Sander, AP Hays, ET Gamboa, A Fasano, M Sonnenberg, LD Lewis, N Latov. Ganglioside reactive antibodies in the neuropathy associated with celiac disease. J Neuroimmunol 2002, 127: 145-148.
RM Vigneulle, S. Rao, A. Fasano, TJ MacVittie. Structural and functional alterations of the gastrointestinal tract following radiation induced injury in the rhesus monkey. Dig Dis Sci 2002;47:1480-91.
G. Davidson, G. Barnes, D. Bass, M. Cohen, A. Fasano, O. Fontaine, S. Guandalini. Infectious diarrhea in children: working group report of the first world congress of pediatric gastroenterology, hepatology, and nutrition. J Ped Gastroenterol Nutr 2002; 35 (Suppl 2):S143 50.
R. El Asmar, P. Panigrahi, P. Bamford, I. Berti,T. Not, G.V. Coppa, C. Catassi, A. Fasano. Host-Dependent Activation of the Zonulin System is Involved in the Impairment of the Gut Barrier Function Following Bacterial Colonization. Gastroenterology 2002;123:1607-1615.
C. Catassi, F. Fornaroli, A. Fasano. Celiac disease: From basic immunology to bedside practice. Clin Appl Immunol Rev 2002;.3:61-71.
E. Bucci, T.L. Watts, H.E. Kwansa, A. Fasano. Different efficacy in vitro of hemoglobin based oxygen carriers and red cells. Adv Exp Med Biol 2003;510:89-92.
M.G. Clemente, S. De Virgiliis, J. S. Kang, R. Macatagney, M.P. Musu, M.R. DiPierro, S. Drago, M. Congia, A. Fasano. Early effects of gliadin on enterocyte intracellular signalling invovled in intestinal barrier function. Gut 2003;52:218-223.
A. Fasano. European and North American populations should be screened for coeliac disease. Gut 2003;52:168-169.
N.N. Salama, A. Fasano, R. Lu, N.D. Eddington. Effect of the biologically active fragment of zonula occludens toxin, DeltaG, on the intestinal paracellular transport and oral absorption of mannitol. Int J Pharm 2003;251:113 121.
C.S. Karyekar, A. Fasano, S. Raje, R. Lu, T.C. Dowling, N.D. Eddington. Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. J
Pharm Sci 2003;92:414 423.
A. Fasano, I. Berti, T. Gerarduzzi, T. Not, R.B. Colletti, S. Drago, Y. Elitsur, P.H.R. Green, S. Guandalini, I. Hill, M. Pietzak, A. Ventura, M. Thorpe, D. Kryszak, F. Fornaroli, S.S. Wasserman, J.A. Murray, K. Horvath. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Int Med 2003;163:286-292.
M. Marinaro, A. Fasano, M.T. De Magistris. Zonula Occludens Toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infect. Immun. 2003;71:1897-1902.
A. Fasano. Bioterrorism and Biological Warfare: not only a respiratory affair. J. Ped. Gastroenterol Nutr. 2003;36:305-306.
Fornaroli F, Drago S, Di Pierro MR, Catassi C, Fasano A. Celiac disease. A world in exploration. Minerva Pediatr 2003;55:23-31.
A. Fasano. Celiac Disease – How to Handle a Clinical Chameleon. N Engl J Med 2003: 348;2568-70.
Neri E, Not T, Horvath K, Kryszak D, Drago S, Di Pierro MR, Tommasini A, Ventura A, Fasano A. Human tissue transglutaminase ELISA and an old study: a revision of the blood donor screening study for coeliac disease in the USA. Scand J Gastroenterol. 2004;2:195-7.
N. N. Salama, A. Fasano, M. Thakar, and N. D. Eddington. The Effect of ¿G On the Transport and Oral Absorption of Macromolecules. J. Pharm Sci. 2004;93:1310-9.
A. Fasano, J.P. Nataro. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Adv Drug Deliv Rev. 2004;56:795-807.
E. Salazar-Lindo, S. Allen, D.R. Brewster, E.J. Elliott, A. Fasano, A.I. Phillips, I.R. Sanderson, P.I. Tarr, Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Intestinal infections and environmental enteropathy: working group report of the second world congress of pediatric gastroenterology, hepatology, and nutrition. J Pediatr Gastroenterol Nutr. 2004:39:S662-9.
T.C. Johnson, B. Diamond, L. Memeo, H. Negulescu, Z. Hovhanissyan, V. Verkarre, H. Rotterdam, A. Fasano, S. Caillat-Zucman, E. Grosdidier, R. Winchester, C. Cellier, B. Jabri, P.H. Green. Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. Clin Gastroenterol Hepatol;2004;2:888-94.
M.G. Clemente, M.P. Musu, R. Troncone, U. Volta, M. Congia, C. Ciacci, E. Neri, T. Not, G. Maggiore, P. Strisciuglio, G.R. Corazza, G. Gasbarrini, L. Cicotto, G. Sole, A. Fasano, S. De Virgiliis. Enterocyte actin autoantibody detection: a new diagnostic tool in celiac disease diagnosis: results of a multicenter study. Am J of Gastroenterol 2004;99:1551-6.
C. Catassi and A. Fasano. Celiac disease as a cause of growth retardation in childhood. Curr Opin Peds 2004;16:445-9.
A. Fasano and J.P. Nataro. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Adv Drug Deliv Rev. 2004;56:795-807.
F. Katouzian, D. Sblattero, T. Not, A. Tommasini, E. Giusto, D. Meiacco, M. Stebel, R. Marzari, A. Fasano, A. Ventura. Dual sugar gut-permeability testing on blood drop in animal models. Clin Chim Acta. 2005;352:191-7.
I.D. Hill, M.H. Dirks, G.S. Liptak, R.B. Colletti, A. Fasano, S. Guandalini, E.J. Hoffenberg, K. Horvath, J.A. Murray, M. Pivor, E.G. Seidman. Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:1-19.
T. Watts, I. Berti, A. Sapone, T. Gerarduzzi, T. Not, R. Zielke, A. Fasano. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic prone rats. Proc Natl Acad Sci USA 2005;102:2916-21.
A. Fasano. Clinical presentation of celiac disease in the pediatric population. Gastroenterology 2005;128(4 Suppl 1):S68-73.
C.E. Semrad, A. Fasano, A. Picarelli, L. Sabbatella, K. Sullivan. Seeing the light with celiac. Clin Immunol. 2005;115:236-9.
A. Fasano and C. Catassi. Coeliac disease in children. Best Pract. Res. Clin. Gastroenterol. 2005;19:467-78.
E. Smecuol, E. Sugai, S. Niveloni, H. Vazquez, S. Pedreira, R. Mazure, M.L. Moreno, M. Label, E. Maurino, A. Fasano, J. Meddings, J.C. Bai. Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. Clin. Gastroenterol. Hepatol. 2005;3:335-41.
A. Fasano and T. Shea-Donohue. Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat. Clin. Prac. Gastro. & Hepatol. 2005;2:416-22.
C.R. Taddei, A. Fasano, A.J. Ferreira, L.R. Trabulsi M.B. Martinez. Secreted autotransporter toxin produced by a diffusely adhering Escherichia coli strain causes intestinal damage in animal model assays. FEMS Microbiol Lett. 2005;250:263-9.
S. Gadewar. A. Fasano. Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea. Curr Opin Pharmacol. 2005;5:559-65.
D. Menon, C.S. Karyekar A. Fasano, R. Lu, N.D. Eddington. Enhancement of brain distribution of anticancer agents using DeltaG, the 12kDa active fragment of ZOT. Int. J Pharm. 2005;306:122-31.
S. Gadewar, A. Fasano. Celiac disease: is the atypical really typical? Summary of the recent national institutes of health consensus conference and latest advances. Curr Gastroenterol Rep. 2005;7:455-61.
M.D. Angelis, C.G. Rizzello, A. Fasano, M.G. Clemente, C.D. De Simone, M. Silano, M.D. Vincenzi, I Losito, M Gobbetti. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue probiotics and gluten intolerance. Biochim Biophys Acta. 2006;1762:80-93.
A.E. Kalaydjian, W. Eaton, N Cascella, A. Fasano. The gluten connection: The association between schizophrenia and celiac disease. Acta Psychiatr. Scand 2006;113:82-90.
S. Drago, R. El Asmar, M. DiPierro, A. Tripathi, M. Clemente, A. Sapone, M. Thakar, G. Iacono, A. Carroccio, C. D’Agate, T. Not, L. Zampini, C. Catassi, and A. Fasano. Gliadin, Zonulin, And Gut Permeability: Effects on Celiac and Non-Celiac Intestinal Mucosa and Intestinal Cell Lines. Scan. J Gastroenterol. 2006;41:408-419.
K. E. Thomas, A. Sapone, A. Fasano, and S.N. Vogel. Gliadin Stimulation of Murine Macrophage Inflammatory Gene Expression and Intestinal Permeability Are MyD88-Dependent: Role of the Innate Immune Response in Celiac Disease. J Immunol 2006;176:2512-2521.\
Fasano A, Ghandehari H. Challenges in pediatric drug delivery: the case of vaccines. Adv Drug Deliv Rev. 2006; 58:1-3.
Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev. 2006;58:15-28.
Gelfond D, Fasano A. Celiac disease in the pediatric population. Pediatr Ann 2006;35:275-79.
Motlekar NA, Fasano A, Wachtel MS, Youan BB. Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin. J Drug Target. 2006;14:321-9.
A. Sapone, L. de Magistris, M. Pietzak, M.G. Clemente, A. Tripathi, F. Cucca, R. Lampis, D. Kryszak, M. Carteni, M. Generoso, D. Iafusco, F. Prisco, F. Laghi, G. Riegler, R. Carratu, D. Counts and A. Fasano. Zonulin up-regulation is associated to increase in gut permeability in subjects with Type 1 diabetes and their relatives. Diabetes 2006;55:1443-9.
D. Branski, A. Fasano, R. Troncone. Latest developments in the pathogenesis and treatment of celiac disease. J Pediatr. 2006;149:295-300.
Fasano A. Systemic autoimmune disorders in celiac disease. Curr Opin Gastroenterol. 2006;22:674-9.
Goldberg, D, Kryszak, D, Fasano, A, Green, PH. Screening for celiac disease in family members: is follow-up testing necessary? Dig Dis Sci. 2007;52(4):1082-6.
Catassi, C, Kryszak,D, Louis-Jacques, O, Duerksen, DR, Hill,I, Crowe, SE, Brown, AR, Procaccini, NJ, Wonderly, BA, Hartley, MDP, Moreci, J, Bennett,N, Horvath, K, Burk, M, Fasano, A. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102:1454-60.
Catassi, C, Fabiani, E, Iacono, G, D’Agate, C, Francavilla, R, Biagi, F, Volta, U, Accomando, S, Picarelli, A, DeVitis, I, Pianelli, G, Gesuita, R, Carle, F, Mandolesi, A, Bearzi, I, Fasano, A. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 2007;85: 160-6.
Antalis TM, Shea-Donohue T, Vogel SN, Sears C, Fasano, A. Mechanisms of disease: protease functions in intestinal mucosal pathobiology. Nat Clin Pract Gastroenterol Hepatol. 2007;4:393-402.
Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther. 2007;26:757-66.
Hernandez L, Johnson TC, Naiyer AJ, Kryszak D, Ciaccio EJ, Min A, Bodenheimer HC Jr, Brown RS Jr, Fasano A, Green PH. Chronic hepatitis C virus and celiac disease, is there an association? Dig Dis Sci. 2008; 53:256-261.
Song KH, Fasano A, Eddington ND. Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int J Pharm. 2008;351(1-2):8-14.
Song KH, Fasano A, Eddington ND. Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur J Pharm Biopharm. 2008; 69(1):231-237.
Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008;135:194-204.
Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M, Mearin ML, Ortigosa L, Phillips A; Celiac Disease Working Group. Federation of international societies of pediatric gastroenterology, hepatology, and nutrition consensus report on celiac disease. J Pediatr Gastroenterol Nutr. 2008;47:214-9.
Abu-Zekry M, Kryszak D, Diab M, Catassi C, Fasano A. Prevalence of celiac disease in Egyptian children disputes the east-west agriculture-dependent spread of the disease. J Pediatr Gastroenterol Nutr. 2008;47:136-40.
Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of PAR2 and TLR4 signal transduction: A novel paradigm for receptor cooperativity. J Biol Chem. 2008;283(36):24314-25.
Fasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol. 2008;173:1243-52.
Harris KM, Fasano A, Mann DL. Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J Immunol. 2008;181:4457-60.
Catassi C, Fasano A. Celiac Disease. Curr Opin Gastroenterol. 2008;24:687-91.
Catassi C, Fasano A Is this really celiac disease? Pitfalls in diagnosis. Curr Gastroenterol Rep. 2008 Oct;10(5):466-72
Lu R, Fasano S, Madayiputhiya N, Morin NP, Nataro J, Fasano A. Isolation, identification, and characterization of small bioactive peptides from lactobacillus GG conditional media that exert both anti-gram-negative and gram-positive bactericidal activity. J Pediatr Gastroenterol Nutr. 2009;49:23-30
Simpson M, Mojibian M, Barriga K, Scott FW, Fasano A, Rewers M, Norris JM. An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus. Pediatr Diabetes. 2009;10:563-72.
Visser J, Rozing J, Sapone A, Lammers K, Fasano A. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci. 2009;1165:195-205
Fasano A. Surprises from celiac disease. Sci Am. 2009;301:54-61.
Zawahir S, Safta A, Fasano A. Pediatric celiac disease. Curr Opin Pediatr. 2009;1165:655-660.
Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A. Differential Mucosal IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease. Int Arch Allergy Immunol. 2009;152:75-80.
Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A. 2009;106:16799-804. PMID: 19805376.
Fasano A. Should we screen for celiac disease? BMJ 2009;339:b3592.
Nhu QM, Shirey K, Teijaro JR, Farber DL, Netzel-Arnett S, Antalis TM, Fasano A, Vogel SN. Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol. 2010;3:29-39.
Fasano A, Counts D. Commentary on "Anti-pituitary antibodies in children with newly diagnosed celiac disease: a novel finding contributing to linear growth." Am J Gastroenterol. 2010; 105(3):697-8.PMID: 20203647
Harris KM, Fasano A, Mann DL. Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: Implications for celiac disease. Clin Immunol. 2010;135:430-9. PMID: 20153259
Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, Antalis TM. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A. 2010;107:4200-5. PMID: 20142489
Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med. 2010;123:691-3.PMID: 20670718
Visser JT, Lammers K, Hoogendijk A, Boer MW, Brugman S, Beijer-Liefers S, Zandvoort A, Harmsen H, Welling G, Stellaard F, Bos NA, Fasano A, Rozing J. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia. 2010;53(12):2621-2628.
Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42:530-8.PMID: 20868314.
Shea-Donohue T, Fasano A, Smith A, Zhao A. Enteric pathogens and gut function: Role of cytokines and STATs. Gut Microbes. 2010;1:316-324. PMID: 21327040
Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011;37:94-100.
Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. FASEB J. 2011;25(1):144-158.
Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity and cancer. Physiol Rev 2011;91(1):151-175.
Lammers KM, Khandelwal S, Chaudhry F, Kryszak D, Puppa EL, Casolaro V, Fasano A. Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology. 2011;132:432-40. PMID: 21091908.
Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, Stefanile R, Mazzarella G, Tolone C, Russo MI, Esposito P, Ferraraccio F, Cartenì M, Riegler G, de Magistris L, Fasano A. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med. 2011;9:23. PMID: 21392369
Salerno-Goncalves R, Fasano A, Sztein MB. Engineering of a Multicellular Organotypic Model of the Human Intestinal Mucosa. Gastroenterology. 2011, June 30 [Epub ahead of print]. PMID: 21723866