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Pamela J Amelung
 

Pamela J Amelung M.D.
Academic Title: Clinical Associate Professor
Primary Appointment: Medicine
pamela.amelung@philips.com
Location: Baltimore VA Medical Center, Room 3D-122
Phone: (410) 605-7000 ext 5762 (office)
Phone: (410) 706-6252 (lab)
Fax: (410) 605-7915

Research Interests

Dr. Amelung directs the Airways Research Center of the Division of Pulmonary and Critical Care Medicine. This is a state-of-the-art research facility equipped to analyze the physiology, and the cell biological, biochemical, and immune processes in patients with diseases of the airways, and response to therapeutic interventions. Dr. Amelung participates in phase I – IV investigational trials in asthma and chronic obstructive pulmonary disease, funded both by the pharmaceutical industry and the NIH. She has an interest in treatment of these diseases with steroids and the cellular aspects of steroid resistance in these disorders. Dr. Amelung’s other interests include the use of home monitoring for airways diseases and the utility of exhaled breath condensate in identifying and monitoring airways inflammation.


Publications

Refereed Journal Articles
 
1.     Amelung PJ, Panhuysen CIM, Postma DS, Levitt RC, Koeter GH, Francomano CA, Bleecker ER, Meyers DA. Atopy and bronchial hyperresponsiveness: Exclusion of linkage to candidate loci on chromosomes 11q and 6p. Clin Exp Allergy 1992; 22:1077-1084.
 
2.     Meyers DA, Postma DS, Panhuysen CIM, Amelung PJ, Levitt RC, Bleecker ER. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994; 23(2): 464-470.
 
3.     Xu J, Levitt RC, Panhuysen CIM, Postma DS, Taylor EW, Amelung PJ, Holroyd KJ, Bleecker ER, Meyers DA. Evidence for two unlinked loci regulating total serum IgE levels. Am J Human Genetics 1995; 57:425-430.
 
4.     Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Panhuysen CIM, Meyers DA, Levitt RC. Genetic susceptibility to asthma: bronchial hyperresponsiveness coinherited with a major gene for atopy. New Eng J Med 1995; 333:894-900.
 
5.     Bleecker ER, Amelung PJ, Levitt RC, Postma DS, Meyers DA. Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin & Exp Allergy 1995; 25:84-88.
 
6.     Collaborative Study of the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997; 15: 389-397.
 
7.     Amelung PJ, Postma DS, Xu J, Meyers DA, Bleecker ER. Exclusion of chromosome 11q and the FceR1-b gene as aetiological factors in allergy and asthma in a population of Dutch asthmatic families. Clin & Exp Allergy 1998; 28: 397-403.
 
8.     Hawkins GA, Amelung PJ, Smith RS, Jongepier H, Howard TJ, Koppleman GH, Meyers DA, Bleecker ER, Postma DS. Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel. DNA Seq 2004;15(3):167-73.
 
Editorials and Scientific Reviews
 
1.      Amelung PJ, Bleecker ER. The genetics of asthma. J Resp Dis Management., UK. 1996; 1(2):12-13.
 
2.      Amelung PJ, Postma DS, Panhuysen CIM, Meyers DA, Bleecker ER. Susceptibility loci regulating total serum IgE levels, bronchial hyperresponsiveness and clinical asthma map to chromosome 5q. Chest 1997; 111(6 Suppl):77S-78S.
 
Book Chapters
 
1.     Meyers DA, Postma DS, Panhuysen CIM, Amelung PJ, Levitt RC, Bleecker ER. Genetics of asthma and COPD. In: Bronchitis V, DS Postma, J Gerritsen, Eds., Van Gorcum, Assen, Netherlands, 1994; pp. 172-183.
 
2.     Amelung PJ, Scott AF, Bleecker ER. Genetics of Bronchial Hyperresponsiveness. In: Lung Biology in Health and Diseases, C Lenfant, Exec. Ed. Genetics of Asthma, S Leggett, DA Meyers, Eds, Marcel Dekker, Inc., New York 1996: pp. 525-545.
 
3.     Amelung PJ, Bleecker ER. The Genetic Basis of Allergy and Asthma. In: Immunotherapy of Asthma. Bousquet, Yssel, Eds., Marcel Dekker, Inc, New York, NY, 1998; 535-550.