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Michael L Terrin
 

Michael L Terrin M.D.C.M., M.P.H.

Academic Title: Professor
Primary Appointment: Epidemiology & Public Health
Secondary Appointments: Medicine
mterrin@epi.umaryland.edu
Location: HH, 200
Phone: (410) 706-6139
Fax: (410) 706-4400

Personal History:

Education

1970: B.A., Brown University, Biology
1974: M.D., C.M., McGill University, Medicine
1980: M.P.H., Johns Hopkins University School of Hygiene and Public Health

Faculty Appointments

1982-2004: Adjunct Assistant Professor, University of Maryland, Department of Epidemiology and Preventive Medicine

Hospital Appointments

1974-1975: Intern, Montreal General Hospital
1975-1976: Assistant Resident in Medicine, Montreal General Hospital
1976-1977: Resident in Medicine, Montreal General Hospital
1977-1978: Fellow in Pulmonary Medicine, Montreal General Hospital
1978-1979: Fellow in Pulmonary Medicine, Clinical, Johns Hopkins Medical Institutions
1978-1980: Fellow in Pulmonary Medicine, Clinical and Research, Johns Hopkins Medical Institutions
1982-1983: Attending in Internal Medicine, Howard County General Hospital
2006-present: University of Maryland Medical System

Research Interests:

Clinical Trials; Pulmonary Disease; Cardiovascular Epidemiology; Data Coordinating Centers


Current Grant Support:

R01 HL074815 (Terrin)
07/10/03-06/30/09
NHLBI
FOCUS Data Coordinating Center: Transfusion Therapy Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS)
A randomized, clinical trial testing which of two blood transfusion regimes (10g/dl trigger or symptomatic trigger) is better for recovery (ability to walk without human assistance) in the management of anemia in elderly, cardiovascular patients who have just had surgical repair for hip fracture.
Role: PI

P30 AG028747 (Goldberg/Magaziner)
07/01/06-06/30/11
NIA
Claude D. Pepper Older Americans Independence Center (OAIC) (RC1 & RC5)
The mission of this OAIC is to conduct exercise and motor learning based rehabilitation research to optimize the recovery of older adults who have suffered a stroke, hip fracture or other chronic debilitating disease, and translate these findings into effective community-rehabilitation programs.
Role: Investigator

R01 AG18668 (Magaziner/Yu-Yahiro)
09/01/01-08/31/08
NIA
Determinants of Recovery from Hip Fracture (Bone Metabolism)
The purpose of this ancillary research project is to: 1) describe changes in bone metabolism during the year after hip fracture for those who receive a home-based exercise intervention and compare these changes with those observed in hip fracture patients not receiving intervention; 2) evaluate the association between markers of bone metabolism and BMD; 3) evaluate the relationship between changes in body composition post-fracture with and with exercise and levels of leptin, and; 4) to measure three genetic markers of osteoporosis.
Role: Investigator

No number (Terrin)
07/01/05-06/30/08
NIH via UMDNJ (Carson) (U01 HL073958)
FOCUS-Detection of Myocardial Infarction (subcontract)
The purpose of this subcontract is to support the tracking of materials (ECGs, blood specimens) and data management for assessment of blood troponin levels, ECG findings, and acute coronary syndrome diagnoses reported from the core labs supported by the award to the clinical Coordinating Center under the direction of Dr. J. Carson (PI of prime).
Role: PI of Subcontract/Investigator

U01 HL74815-S1 (Terrin)
08/01/07-06/30/09
NHLBI
Life-Threatening Pulmonary Complications of Organ Transplantation: An Investigation of the Pathogenesis of Bronchiolitis Obliterans and Its Novel Treatment with Aerosolized Liposomal Cyclosporin A (Bench to Bedside)
The purpose of this proposal is to study the pathogenesis and treatment of bronchiolitis obliterans with inhaled liposomal cyclosporine in two high-risk transplant populations.

R01 HL085706-01 (Gruber-Baldini)
02/12/08-01/31/11
NHLBI
FOCUS Hip Fracture Transfusion Trial: Delirium & Other Cognitive Outcomes
The specific aims of this ancillary study is 1) to determine whether a symptomatic transfusion strategy (8 g/dL) is associated with higher delirium severity post-randomization (during hospitalization) compared to a 10 g/dL transfusion strategy; 2) to examine whether a symptomatic transfusion strategy (8 g/dL) is associated with persistent delirium symptoms from hospitalization to 30 days post-randomization compared to a 10 g/dL transfusion strategy; and 3) to examine the association of in-hospital delirium symptom severity and persistent delirium symptoms on later functional outcomes, including the primary FOCUS outcome of inability to walk at 60 days.

R34 AG028684 (Terrin)
08/01/07-07/31/08
NIA
Doxycycline Treatment of Abdominal Aortic Aneurysm: Planning
The purpose of this planning grant is to prepare protocol and selected Manual of Procedures chapters and to develop sample size calculations and analysis plans for a future investigator-initiated clinical trial testing the use of doxycycline to treat small aortic aneurysms.

R21 HD056424 (Viscardi)
09/01/07-08/31/09
NIH
Azithromycin to Prevent BPD in Ureaplasma-Infected Preterms: Single Dose PK Study
The specific aims of this proposal will address the first steps in preparing for a large, multi-center safety and efficacy trials of azithromycin in the preterm population.

T32 AG000262 (Magaziner/Baumgarten)
05/01/08-04/30/13
NIA
Research Training in the Epidemiology of Aging
The objective of this program is to train pre- and post-doctoral students to conduct independent and original research in the epidemiology of aging, with an emphasis on the prevention of late-life disability and functional decline. The program emphasizes four broad substantive areas including: musculoskeletal epidemiology, neuroepidemiology, genetic epidemiology, and the epidemiologic study of long-term care for chronic diseases.

T32 GM075767-01 (P. Dischinger/J. Hirshon)
07/01/07-06/30/12
NIH
Injury Control and Trauma Response
This training program is designed to enable trainees to 1) master a core curriculum in epidemiology and biostatistics; 2) become knowledgeable about the basic biological and psychosocial aspects of trauma and injury prevention; 3) become an expert in at least one substantive area relevant to injury prevention and control; 4) learn to contribute to a research team under the supervision of a primary mentor with expertise in an aspect of injury prevention and controls; and 5) demonstrate the capacity to conduct independent, original research.

Publications:

Recent Publications

Moore RD, Charache S, Terrin ML, Barton FB, Ballas SK, and the MSH Investigators. Cost-effectiveness of hydroxyurea in sickle cell anemia. Am J Hematol 2000;64:26-31.

Knatterud GL, Rosenberg Y, Campeau L, Geller NL, Hunninghake DB, Forman SA, Forrester JS, Gobel FL, Herd JA, Hickey A, Hoogwerf BJ, Terrin ML, White C and the Post CABG Investigators. Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the Post Coronary Artery Bypass Graft Trial. Circulation 2000;102:157-65.

Walenga JM, Hoppensteadt D, Pifarre R, Fox NL, Forman S, Hunninghake DB, Campeau L, Herd JA, Hoogwerf BJ, Hickey A, Probstfield JL, Terrin ML. The hemostatic effects of warfarin titration in Post CABG patients in comparison to placebo treatment. J Thromb Thrombolysis 2001;11:143-149.

Sadanandan S, Buller C, Menon V, Dzavik V, Terrin ML, Thompson B, Lamas G, Hochman J. The late open artery hypothesis - A decade later. Am Heart J 2001;142:411-421.

White C, Gobel FL, Campeau L, Knatterud GL, Forman SA, Forrester JS, Geller NL, Herd JA, Hickey A, Hoogwerf BJ, Hunninghake DB, Rosenberg Y, Terrin ML and the Post CABG Investigators. Effect of an aggressive lipid-lowering strategy on progression of atherosclerosis in the left main coronary artery from patients in the Post Coronary Artery Bypass Graft Trial. Circulation 2001;104:2660-2665.

Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H, Bresnitz EA, DePalo L, Hunninghake G, Iannuzzi MC, Johns CJ, McLennan G, Moller DR, Newman LS, Rabin DL, Rose C, Rybicki B, Weinberger SE, Terrin ML, Knatterud GL, Cherniak R, ACCESS Research Group. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med 2001;164:1885-1889.

Rybicki BA, Iannuzzi MC, Frederick MM, Thompson BW, Rossman MD, Bresnitz EA, Terrin ML, Moller DR, Barnard J, Baughman RP, DePalo L, Hunninghake G, Johns C, Judson MA, Knatterud GL, McLennan G, Newman LS, Rabin DL, Rose C, Teirstein AS, Weinberger SE, Yeager H, Cherniack R. Familial aggregation of sarcoidosis. A case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med 2001; 164:2085-2091.

Schulman SP, Thiemann DR, Ouyang P, Chandra NC, Schulman DS, Reis SE, Terrin ML, Forman S, de Albuquerque CP, Bahr RD, Townsend SN, Cosgriff R, Gerstenblith G. Effects of acute hormone therapy on recurrent ischemia in postmenopausal women with unstable angina. J Am Coll Cardiol 2002;39:231-237.

Kasper EK, Gerstenblith G, Hefter G, Van Anden E, Brinker JA, Thiermann DR, Terrin ML, Forman S, Gottlieb SH. A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission. J Am Coll Cardiol 2002; 39:471-480.

Aversano T, Aversano LT, Passamani E, Knatterud GL, Terrin ML, Williams DO, Forman SA for the Atlantic Cardiovascular Patient Outcomes Research Team (C-PORT). Thrombolytic therapy vs primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery. A randomized controlled trial. J Am Med Assoc 2002;287:1943-1951.

Brown ST, Brett I, Almenoff PL, Lesser M, Terrin ML, Tierstein AS for the ACCESS Research Group. Recovery of cell wall-deficient organisms from blood does not distinguish between patients with sarcoidosis and control subjects. Chest 2003; 123:413-417.

Knatterud GL, White C, Geller NL, Campeau L, Forman SA, Domanski M, Forrester JS, Gobel FL, Herd JA, Hickey A, Hoogwerf BJ, Hunninghake DB, Terrin ML, Rosenberg Y and the Post CABG Investigators. Angiographic changes in saphenous vein grafts are predictors of clinical outcomes. Am Heart J 2003;145:262-269.

Steinberg MH, Barton F, Castro O, Pegelow CH, Ballas SK, Kutlar A, Orringer E, Bellevue R, Olivieri N, Eckman J, Varma M, Ramirez G, Adler B, Smith W, Carlos T, Ataga K, DeCastro L, Bigelow C, Saunthararajah Y, Telfer M, Vichinsky E, Claster S, Shurin S, Bridges K, Waclawiw M, Bonds D, Terrin ML. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: Risks and benefits up to 9 years of treatment. J Am Med Assoc 2003;289:1645-1651.

Herd JA, Hoogwerf BJ, Barton F, Terrin ML, Czajkowski SM, Lindquist R, Dupuis G. Heart rate and blood pressure responses to mental stress and clinical cardiovascular events in men and women after coronary artery bypass grafting: The Post Coronary Artery Bypass Graft (Post-CABG) Biobehavioral Study. Am Heart J 2003;146:273-279.

Lindquist R, Dupuis G, Terrin ML, Hoogwerf B, Czajkowski S, Herd JA, Barton FB, Tracy MF, Hunninghake DB, Treat-Jacobson D, Shumaker S, Zyzanski S, Goldenberg I, Knatterud GL for the Post CABG Biobehavioral Study Investigators. Comparison of health-related quality-of-life outcomes in men and women after coronary artery bypass surgery through 1 year: findings from the Post CABG Biobehavioral Study. Am Heart J 2003;146:1038-1044.

Terrin ML. Fundamentals of Clinical Trials for Medical Rehabilitation. Am J Phys Med Rehabil 2003;82:S22-S25.

Judson MA, Baughman RP, Thompson BW, Tierstein AS, Terrin ML, Rossman MD, Yeager H, McLennan G, Bresnitz EA, DePalo L, Hunninghake G, Iannuzzi MC, Johns CJ, Moller DR, Newman LS, Rabin DL, Rose C, Rybicki BA, Weinberger SE, Knatterud GL, Cherniak R and ACCESS Research Group. Two year prognosis of sarcoidosis: the ACCESS experience. Sarcoidosis Vasc Diffuse Lung Dis 2003;20:204-211.

Weinrich M, Good DC, Reding MJ, Roth EJ, Cifu DX, Silver KH, Craik RL, Magaziner J, Terrin ML, Schwartz M, Gerber L. Timing, intensity, and duration of rehabilitation for hip fracture and stroke. Report of a Workshop at the National Center for Medical Rehabilitation Research. Neurorehabil Neural Repair 2004;18:12-28.

Fox NL, Hoogwerf BJ, Czajkowski S, Lindquist R, Dupuis G, Herd JA, Campeau L, Hickey A, Barton FB, Terrin ML, for the POST CABG Study Investigators. Quality of Life in POST CABG Patients: Results from the POST CABG Trial. Chest 2004;126:487-495.

Carson J, Terrin ML, Magaziner J. Anemia and postoperative rehabilitation. Can J Anesth 2004;5(6):S60-S64.

Terrin ML. Evaluating and Implementing Data and Safety Monitoring Plans. J Investig Med 2004;52:495-563.

Newman L, Rose C, Bresnitz E, Rossman M, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller D, McLennan G, Hunninghake G, DePalo L, Baughman R, Iannuzzi M, Judson M, Knatterud G, Thompson B, Teirstein A, Yeager H, Johns CJ, Rabin D, Rybicki B, Cherniack R. A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors. Am J Respir Crit Care Med 2004; 170:1324-1330.

Canner PL, Furberg CD, Terrin ML, McGovern ME. Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project). Am J Cardiol 2005;95:254-257.

Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith, G. L-Arginine Therapy in Acute Myocardial Infarction: The Vascular Interaction with Age in Myocardial Infarction (VINTAGE MI) Randomized Clinical Trial. J Am Med Assoc 2006;295:58-64.

Dupuis G, Kennedy E, Lindquist R, Barton FB, Terrin ML, Hoogwerf BJ, Czajkowski SM, Herd JA, for the Post CABG Biobehavioral Study Investigators. Coronary Artery Bypass Graft Surgery and Cognitive Performance. Am J Crit Care 2006;15(5):471-479.

Carson JL, Terrin ML, Magaziner J, Chaitman BR, Apple FS, Heck DA, Sanders D, for the FOCUS Investigators. Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS). Transfusion 2006;46:2192-2206.

Eisenstein EL, Collins R, Cracknell BS, Podesta O, Reid ED, Sandercock P, Shakhov Y, Terrin ML, Sellers MA, Califf RM, Granger CB, Diaz R. Sensible approaches for reducing clinical trial costs. Clinical Trials 2008;5:75-84.

Baxter BT, Terrin ML, Dalman RL. Medical Management of Small Abdominal Aortic Aneurysms. Circulation 2008;117:1883-1889 [PMID: 18391122].