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Michael L. Terrin, MDCM, MPH

Academic Title:

Professor

Primary Appointment:

Epidemiology & Public Health

Secondary Appointment(s):

Medicine

Email:

mterrin@som.umaryland.edu

Location:

Howard Hall, 140

Phone (Primary):

(410) 706-6139

Fax:

(410) 706-4400

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Education and Training

  • 1970, B.A., Brown University, Biology                                      
  • 1974, M.D.,C.M., McGill University, Medicine                                   
  • 1980, M.P.H., Johns Hopkins University School of Hygiene and Public Health, Epidemiology

Biosketch

Dr. Michael Terrin is an internist with subspecialty certification in pulmonary medicine, and an MPH in epidemiology. Dr. Terrin has directed or been deputy director of Coordinating Centers for more than 25 studies with emphases on clinical trials and cohort studies. In 1979-1982, he held a cardiovascular epidemiology training grant at the Johns Hopkins University School of Hygiene and Public Health.

 

He led the Data Coordinating Center for the NHLBI-sponsored Multicenter Study of Hydroxyurea (MSH) in Sickle Cell Anemia and for the NHLBI-sponsored FOCUS clinical trial comparing transfusion strategies. He was responsible for the data coordination of a landmark study in pulmonary embolism (PIOPED) and for the portion of the first NHLBI-initiated thrombolytic agent clinical trials, TIMI I and TIMI II, that discovered t-PA’s dose and patient characteristic-dependent risk of cerebral hemorrhage in acute myocardial infarction.

 

He is currently contact and Data Coordinating Center (DCC) Principal Investigator for the NIA-sponsored Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT), DCC Principal Investigator for the NICHD-sponsored Azithromycin to Prevent BPD in Ureaplasma-Infected Preterms (AZIP3), Principal Investigator for the NHLBI Progenitor Cell Biology Consortium (PCBC) Administrative Coordinating Center and Principal Investigator for the NHLBI Progenitor Cell Translational Consortium (PCTC) Administrative Coordinating Center.

 

Dr. Terrin is co-Principal Investigator of the Biostatistics and Bioinformatics Core (Core 1) of the University of Maryland, Baltimore, Older Americans Independence Center (Claude D. Pepper Center). Dr. Terrin has served in a mentorship capacity to associate professors and assistant professors who have established research independence.

 

Dr. Terrin is a faculty member in the Department of Epidemiology and Public Health, Division of Gerontology, and on the Department’s training grant (T32) for the Epidemiology of Aging. Dr. Terrin as dedicated his career to the design, conduct and analysis of clinical investigations with an emphasis on coordinating center data functions.

 

Research/Clinical Keywords

Clinical Trials; Pulmonary Disease; Cardiovascular Epidemiology; Data Coordinating Centers

Highlighted Publications

  1. Baxter TB, Matsumura J, Curci J, McBride R, Blackwelder WC, Liu X, Larson L, and Terrin ML. Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial(N-TA3CT): Design of a Phase IIb, Placebo-Controlled, Double-Blind, Randomized Clinical Trial of Doxycycline for the Reduction of Growth of Small Abdominal Aortic Aneurysm. Contemporary Clinical Trials 2016; 48:91-98. doi: 10.1016/j.cct.2016.03.008.
  2. Timofte I, Terrin M, Barr E, Sanchez P, Kim J, Reed R, Britt E, Ravichandran B, Rajagopal K, Griffith B, Pham S, Pierson RN 3rd, Iacono A. Belatacept for Renal Rescue in Lung Transplant Patients. Transpl Int 2016; 29:453-463. doi: 10.1111/tri.12731. [PMID:26678245]
  3. Albrecht JS, Marcantonio ER, Roffey DM, Orwig D, Magaziner J, Terrin M, Carson JL, Barr E, Brown JP, Gentry EG, Gruber-Baldini AL; Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair Cognitive Ancillary Study Investigators. Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture. J Am Geriatr Soc 2015;63:970-976. doi: 10.1111/jgs.13334. Epub 2015 May 4. [PMID: 25943948; PMCID: PMC4439362]

Additional Publication Citations

  1. Merchan LM, Hassan HE, Terrin ML, Waites KB, Kaufman DA, Ambalavanan N, Donohue P, Dulkerian SJ, Schelonka R, Magder LS, Shukla S, Eddington ND, Viscardi RM. Pharmacokinetics, Microbial Response, and Pulmonary Outcomes of Multidose Intravenous Azithromycin in Preterm Infants at Risk for Ureaplasma Respiratory Colonization. Antimicrob Agents Chemother 2015; 59(1):570-578. doi: 10.1128/AAC.03951-14. Epub 2014 Nov 10.
  2. Liu X, Post WS, McLenithan J, Terrin ML, Magder L, Zeb I, Budoff M, Mitchell BD. Determinants of intrathoracic adipose tissue and associations with cardiovascular disease risk factors in Amish. Nutrition, metabolism, and cardiovascular diseases: NMCD 2014; 24(3):286-293. doi: 10.1016/j.numecd.2013.9.015. [PMCID: PMC4109402]
  3. Quinn CC, Shardell MD, Terrin ML, Barr EA, Park D, Shaikh F, Guralnik JM, Gruber-Baldini AL. Mobile Diabetes Intervention for Glycemic Control in 45 to 64 Year Old Persons with Type 2 Diabetes. J Applied Gerontol. 2016; 35:227-243. Epub August 6, 2014. DOI: 10.1177/ 0733464814542611. [PMID 25098253]
  4. Quinn C, Sareh PL, Shardell ML, Terrin ML, Barr EA, Gruber-Baldini A. Mobile Diabetes Intervention for Glycemic Control: Impact on Physician Prescribing. J Diabetes Sci Technol. Epub February 5, 2014. DOI: 10.1177/1932296813514503.
  5. Afshar M, Smith GS, Terrin ML, Barrett M, Lissauer ME, Mansoor S, Jeudy J, Netzer G. Blood Alcohol Content, Injury Severity and Acute Respiratory Distress Syndrome. J Trauma Acute Care Surg 2014;76:1447-1455. [PMCID:PMC4034145]
  6. Qian J, Simoni-Wastila L, Rattinger GB, Lehmann S, Langenberg P, Zuckerman IH, Terrin M. Associations of depression diagnosis and antidepressant treatment with mortality among young and disabled Medicare beneficiaries with COPD. Gen Hosp Psychiatry 2013; 35:612-618. doi: 10.1016/j.genhosppsych.2013.06.005. Epub 2013 Jul 18. [PMID: 23871313]
  7. Gruber-Baldini A, Marcantonio E, Orwig D, Magaziner J, Terrin M, Barr E, Brown JP, Paris B, Zagorin A, Roffey DM, Zakriya K, Blute MR, Hebel JR, Carson JL. Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds JAGS 2013. J Am Geriatr Soc 2013; 61:1286-1295.
  8. Viscardi RM, Othman AA, Hassan HE, Eddington ND, Abebe E, Terrin ML, Kaufman DA, Waites KB. Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. Antimicrob Agents Chemother 2013; 57:2127-2133. doi: 10.1128/AAC.02183-12. Epub 2013 Feb 25. [PMID: 23439637; PMCID: PMC3632913]
  9. Qian J, Simoni-Wastilla L, Langenburg P, Rattinger GB, Zuckerman IH, Lehmann S, Terrin M. Effects of Depression Diagnosis and Antidepressant Treatment on Mortality in Medicare Beneficiaries with Chronic Obstructive Pulmonary Disease. J Am Geriatr Soc 2013; 61:754-761. doi:10.1111/jgs.12220. Epub 2013 Apr 25. [PMID: 23617752]
  10. Horenstein RB, Mitchell BD, Post WS, Leutjohann D, Bergmann K, Ryan KA, Terrin ML, Shuldiner AR, Steinle NI. The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish. Arterioscler Thromb Vasc Biol 2013;33(2):413-9. doi: 10.1161/ATVBAHA.112.245480. Epub Dec 13, 2012. [PMID: 23241408]
  11. Ruiz A, Hernandez I, Ronsende-Roca M, Gonzalez-Perez A, Rodriguez-Noriega E, Ramirez-Lorca R, Mauleon A, Moreno-Rey C, Boswell L, Tune L, Valero S, Alegret M, Gayan J, Becker JT, Real LM, Tarraga L, Ballard C, Terrin ML, Sherman S, Payami H, Lopez OL, Mintzer JE, Boada M. Exploratory analysis of 7 Alzheimer’s disease genes: Disease Progression, Neurobiol Aging 2013;34(4):1310.e1-7. doi: 10.1016/j.neurobiolaging. 2012. 08.014. Epub Oct 1, 2012. [PMID: 23036585]
  12. Verceles AC, Liu XL, Terrin ML, Scharf SM, Shanholtz C, Harris A, Ayanleye A, Parker A, Netzer G. Ambient Light Levels and Critical Care Outcomes. Journal of Critical Care. Epub Jul 2, 2012. [PMID:22762935]

View a complete list of Dr. Terrin's publications on PubMed

Awards and Affiliations

  • 1970   Phi Beta Kappa, Member

  • 1970   Sigma Xi, Associate Member

  • 1973   Scarlet Key, Member

  • 1980   Delta Omega, Member

  • 1992   American College of Chest Physicians, Fellow

Grants and Contracts

Ongoing Research Support

U24 HL134763 (Terrin/Viscardi)                                 09/20/16-05/31/23

NHLBI

Progenitor Cell Translational Consortium Coordinating Center (U24)

The Progenitor Cell Translational Consortium Administrative Coordinating Center (PCTC-ACC) will provide the administrative infrastructure needed to organize interactions and facilitate collaborations between PCTC investigators, oversee programs using set-aside funds to stimulate collaborative research and skills development, and enable the timely sharing of PCTC-generated data and reagents among PCTC investigators and with the research community. The PCTC-ACC will also facilitate access to expertise for preparation of FDA IND and IDE applications. [newly funded award].

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U01 HL099997 (Terrin)                                              09/30/09-04/30/17                

NHLBI                                                                                

Progenitor Cell Biology Consortium Administrative Coordinating Center

The Progenitor Cell Biology Consortium Administrative Coordinating Center will make available to the public accessible video reports on the research accomplishments of the Consortium, to the general scientific community reports and data from the Consortium that will advance their research on stem and progenitor cell related health problems and to the members of the Consortium data and meta-data from each other’s work to advance their collaborative research. In addition to providing all involved with newly developed, valuable information, the exchange of this information is expected to result in new therapeutic approaches that could shift paradigms and enormously improve outcomes of some of the most frequently fatal diseases in the U.S.

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R01 AG037120 (Terrin/Baxter/Matsumura)               08/15/11-02/28/17                

NIA                                                                                     

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT)

The primary aim of this multi-site clinical trial is to determine if doxycycline (100mg bid) will inhibit by at least 40% the increase in greatest transverse diameter of small abdominal aortic aneurysms over a 24-month period of observation in comparison to a placebo-treated control group.

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T32 AG000262 (Magaziner/Baumgarten)                  05/01/13-04/30/18      

NIA                                                                                     

Research Training in the Epidemiology of Aging

The objective of this program is to train pre- and post-doctoral students to conduct independent and original research in the epidemiology of aging, with an emphasis on the prevention of late-life disability and functional decline. The program emphasizes four broad substantive areas including: musculoskeletal epidemiology, neuroepidemiology, genetic epidemiology, and pharmacoepidemiology.

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R01 AG035009 (Magaziner)                                      09/01/10-05/31/17                

NIA                                                                                     

Community Ambulation Following Hip Fracture

This randomized controlled multi-center study will evaluate the effect of a 4 month, home delivered multi-component intervention on survival and the ability to ambulate independently in the community among older men and women who have sustained a hip fracture. The project also will investigate precursors to community ambulation and the cost effectiveness of delivering the program to this frail and disabled population of older persons.

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P30 AG028747 (Magaziner)                                       07/01/16-06/30/21                

NIH/NIA                                                                              

Claude D. Pepper Older American Independence Center

The aims of the UM-OAIC are to: 1) conduct research that examines the mechanisms underlying the functional impairments associated with stroke, hip fracture, and prevalent chronic diseases in older people; 2) design novel, exercise and activity-based rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them; 3) translate interventions developed in UM-OAIC clinical laboratories and in other clinical centers for implementation and rigorous evaluation in community settings; 4) support pilot and exploratory studies, development projects, and externally-funded projects that support the UM-OAIC mission; and 5) to foster the career development of junior faculty/scholars into independent, academic scientists with expertise in the study of older persons with disabling diseases through mentor-based, bench-to-bedside translational research training that includes didactic and experiential/practical-applied training in conducting independent, aging research.

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R01 HD067126 (Terrin/Viscardi)                                03/01/11-02/29/17                

NICHD                                                                                                                              

Azithromycin to prevent BPD in Ureaplasma-infected Preterms

This study will 1) evaluate the safety of and how the body processes the antibiotic azithromycin, 2) determine the effectiveness of a 3-day course of azithromycin in eliminating Ureaplasma infection from the lungs of preterm infants, and 3) compare the lung health outcomes of the infants treated with azithromycin with the outcomes of placebo-treated infants.

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R21 AG050890 (Verceles)                                                   08/01/15-05/31/17                

NIH                                                                                                                                             

Rehabilitation, NMES and High Protein to Reduce Post ICU Syndrome in the Elderly

This pilot study will determine whether or not there is evidence of beneficial treatment effects and feasibility of administering neuromuscular electrical stimulation or protein supplementation to elderly, intensive care unit patients to prevent weakness and loss of function experienced as a "Post ICU Syndrome”. Dr. Terrin will provide advice on clinical trial design, data collection and data analysis.

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