Pinaki Panigrahi M.B.B.S., Ph.D.
Academic Title: Associate Professor
Primary Appointment: Pediatrics
Secondary Appointments: Epidemiology and Preventive Medicine
ppanigrahi@peds.umaryland.edu
Location: UMMC, N5W68
Phone: (410) 706-1803

Personal History

Fellow, Infectious Diseases Society of America

Faculty Young Investigator Award; Eastern Society for Pediatric Research: 1994

Secretary, International Campylobacter and Helicobacter Society: 1994-1998

Research Interests

Dr. Panigrahi's primary research focus is centered around intestinal microflora and gut development. Investigations in his lab have included pathogenesis of Neonatal Necrotizing Enterocolitis, and host-bacteria interactions in various gastrointestinal diseases including Campylobacter, Helicobacter, and Vibrio cholerae. He uses in vitro and in vivo modeling and other molecular tools to examine changes in gene expression in the host and bacteria in the developing human intestine. Role of probiotics and prebiotics in modulation of infection and inflammation are also being actively studied in clinical and experimental model systems. His work has been supported by multiple NIH and State of Maryland grants. Dr. Panigrahi's efforts have fostered large scale public health projects in India such as population-based surveillance, study of mechanisms of acquisition of neonatal infections, and design of appropriate interventions. New teaching and training modules designed by him for village level workers in India to identify sick newborns for timely referral to the hospital has resulted in drastic reduction in neonatal and infant mortality in study areas. He teaches GCP courses for clinical trials and GLP laboratory regulations. Ongoing health projects by Dr. Panigrahi's research team in India include WHO-recommended essential newborn care in the community and neonatal resuscitation following NRP protocols, childhood malaria and other childhood and adolescent infectious diseases.

Publications

See supplemental tables for Pinaki P, Braileanu GT, Chen H, and Stine OC. 2007. Probiotic bacteria change E. coli-induced gene expression in cultured colonocytes: implications in intestinal pathophysiology. World Journal of Gastroenterology (In press).

Pinaki P, Braileanu GT, Chen H, and Stine OC. 2007. Probiotic bacteria change E. coli-induced gene expression in cultured colonocytes: implications in intestinal pathophysiology. World Journal of Gastroenterology (In press).

Tripathy R, Parida S, Das L, Mishra D, Tripathy D, Das M, Chen H, Maguire JH, and Panigrahi P. 2007. Clinical manifestations and predictors of severe malaria in Indian children. Pediatrics. Vol. 120. No. 3. e454-e460.

Chen Y, Bystricky P, Adeyeye J, Panigrahi P, Ali A, Johnson JA, Bush C, Morris JG Jr. and O C Stine 2007. The Capsule biogenesis genes are embedded in the LPS region In non-O1 Vibrio cholerae NRT36S. BMC Microbiology. 2007, 7:20.

Panigrahi P. Necrotizing Enterocolitis: a practical guide to its prevention and management. 2006. Pediatr Drugs. 8(3):151-165.

Gorthi SP, Kapoor L, Chaudhry R, Sharma N, Perez-Perez G I, Panigrahi P, Behari M. 2006. Guillain-Barré Syndrome: Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India. National Medical Journal of India. 19(3):137-139.

Agarwal R, Sharma N, Chaudhry R, Deorari A, Paul VK, Gewolb IH, and Panigrahi P. 2003. Effects of Oral Lactobacillus GG on Enteric Microflora in Low-Birth-Weight Neonates. J Pediatr Gastroenterol Nutr. Mar;36(3):397-402.

Asmar RE, Panigrahi P, Bamford P, Berti I, Not T, Coppa G.V, Catassi C, and Fasano A. 2002. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. Nov;123(5):1607-15.

Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, and Panigrahi P, 1999. Stool microflora in extremely low birthweight infants. Arch Dis Childhood. 80:167-173

CAMPYLOBACTER: Pathogenic Mechanisms. 1998. In: Albert Lastovica, Diane G. Newell, and Ethleen Lastovica (Eds). In: Campylobacter, Helicobacter and Related Organisms. The Rustica Press, Institute of Child Health, Cape Town.

Panigrahi P, Gewolb IH, Penelope Bamford and Horvath K. 1997. Role of Glutamine in bacterial transcytosis and epithelial cell injury. J. Parent. Ent. Nutr. 21(2): 75-80.

RITARD Model for Studying Vibrio cholerae and other enteric infections. 1997. In: Oto Zak and Merle Sande (Eds) Experimental Models in Antimicrobial Chemotherapy Academic Press.

Mehta D, Horvath K, Hill ID, Rolston D, and Panigrahi P. 1997. Epidermal growth factor upregulates NA+/Glucose cotransport in presence of cholera toxin: studies in an in vitro model. J. Parent. Ent. Nutr.21(4): 185-191

Panigrahi P, Bamford P, Horvath K, Morris JG Jr, and Gewolb IH. 1996. E. coli transcytosis in a Caco-2 cell model: implications in neonatal necrotizing enterocolitis. Ped. Res. 40 (3):415-421

Morris JG Jr, Sztein MB, Rice EW, Nataro JP, Losonsky GA, Panigrahi P, Tacket CO, and Johnson JA. 1996. Vibrio cholerae O1 can assume a chlorine resistant rugose survival form which is virulent for humans. J. Infect. Dis. 174:1364-1368

Hopkins RJ, Morris JG Jr. Papadimitriou JC, Drachenberg C, Smoot D, James SP, and Panigrahi P, 1996. Loss of Helicobacter pylori hemagglutination with serial laboratory passage and correlation of hemagglutination with gastric cell adherence. Pathobiol. 64:247-254

Diversity in in vitro adherence of C. jejuni. 1995. In: D. G. Newell and J. Ketley (Eds) Campylobacter VIII. Plenum Publishing Corp, New York.

Morris JG Jr, Losonsky GE, Johnson JA, Tacket CO, Nataro JP, Panigrahi P, and Levine MM. 1995. Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers. J. Infect. Dis. 171:903-908

Comstock LE, Maneval D Jr, Panigrahi P, Joseph A, Levine MM, Kaper JB, Morris JG Jr, and Johnson JA. 1995. The capsule and O antigen in V. cholerae O139 Bengal are associated with a genetic region not present in V. cholerae O1. Infect. Immun. 63 (1):317-323

Diversity in in vitro adherence of C. jejuni. In: D. G. Newell and J. Ketley (Eds) Campylobacter VIII. Plenum Publishing Corp, New York. 1995

Panigrahi P, Gupta S, Gewolb IH, and Morris JG Jr. 1994. Occurrence of Necrotizing Enterocolitis may be dependent on patterns of bacterial adherence and intestinal colonization: Studies in Caco-2 tissue culture and weanling rabbit models. Ped. Res. 36 (1):115-121

Gupta S, Morris JG Jr. Panigrahi P, Nataro J, Glass RI, and Gewolb IH. 1994. Molecular epidemiology of endemic necrotizing enterocolitis in a university hospital:lack of association of NEC with a specific infectious agent. Ped. Infect. Dis. J. 13 (8):728-734

Johnson JA, Salles CA, Panigrahi P, Albert MJ, Wright AC, Johnson RJ, and Morris JG Jr. 1994. Vibrio cholerae O139 synonym Bengal is closely related to Vibrio cholerae El Tor but has important differences. Infect. Immun. 62 (5):2108-2110

Russell RG, Kiehlbauch, Sarmiento JI, Panigrahi P, Blake, P, and Haberberger R. 1994. Ribosomal RNA patterns identify additional strains of Campylobacter jejuni and Campylobacter coli among isolates serotyped by heat stable and heat labile antigens. Lab. Animal. Sci. 44:579-583

Panigrahi P, Losonsky J, and Morris JG Jr. 1992. Human immune response Campylobacter jejuni proteins expressed in vivo. Infect. Immun.; 60: 4938-4944

Johnson JA, Panigrahi P, Morris JG Jr. 1992. Non-O1 Vibrio cholerae produces a polysachharide capsule that determines colony morphology, serum resistance and virulence in mice. Infect. Immun.; 60:864-869

Rice EW, Johnson CJ, Clark RM, Fox KR, Reasoner DJ, Dunnigan ME, Panigrahi P, Johnson JA, and Morris JG Jr. 1992. Chlorine and survival of "rugose" Vibrio cholerae. Lancet; 340:740

Panigrahi P, Tall BD, Russell RG, DeTolla LJ, and Morris JG Jr. 1990. Development of an in vitro model for study of non-O1 Vibrio cholerae virulence using Caco-2 cells. Infect.Immun.; 58: 3415-3424

Russell RG, Sarmiento JI, Fox J, and Panigrahi P. 1990. Evidence of reinfection with multiple strains of Campylobacter jejuni and Campylobacter coli in Macaca nemestrina housed under hyperendemic conditions. Infect. Immun.; 58:2149-2155




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