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Michael T Shipley
Ph.D.
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| Academic Title:
Professor |
| Primary Appointment:
Anatomy and Neurobiology |
| Administrative Title:
Chair |
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mshipley@umaryland.edu |
| Location:
HSF,
222 |
| Phone:
(410) 706-3590 |
| Fax:
(410) 706-2512 |
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Personal History
I received my PhD in Neuroscience from M.I.T. and took postdoctoral training at the University of Aarhus, Denmark; University of Oslo, Norway and University of Lausanne, Switzerland.
Research Interests
All biological systems share common mechanisms at the cellular and molecular levels, yet they exhibit tremendous diversity of organization and function. This diversity arises at the level of cell-cell communication. The most complex degree of cell-cell communication is in the nervous system. In the brain, this complexity is expressed at the level of neural networks. Neural networks are the unique, defining characteristic of the nervous system.
Our research centers on understanding the organization, function and development of neural networks.
Development and functional organization of the olfactory system:
Cellular/molecular bases of early olfactory development. Studies also include transmitter and biophysical bases of olfactory bulb neural network unctions using an in vitro slice developed in this laboratory, in vivo and computational models. This research is supported by 2 NIH R01 grants and a Program project grant of which Dr. Shipley is Program Director.
Neural transmission:
Functions of transmitters including pathogenesis in epileptic seizures; responses of astrocytes and microglia to transmitters and seizures. This research is supported by an R01 grant, a contract from DoD. Anatomical and physiological studies of locus coeruleus-NE function is supported by a collaborative NIH grant.
Functional organization of the midbrain periaqueductal gray (PAG):
Research in this laboratory has disclosed a high degree of neural network organization n the PAG, a structure, critical to the expression of behavioral responses and autonomic adjustments critical to the survival of the organism and species propagation. Current research focuses on the regulation and integration of the functions mediated by these discretely organized PAG networks. This research is supported by NIH grants.
Lab Techniques and Equipment
Electrophysiology: synaptic potentials, intracellular, patch clamping, voltage sensitive dyes, in vivo and in vitro, computational modeling. Cell and organotypic slice culture techniques.
Neuroanatomy: tract tracing, immunohistochemistry, image analysis.
Molecular biology: in situ hybridization; collaborative studies using gene cloning, transgenic techniques.
Laboratory Personnel:
Postdocs
Graduate Students
- Jason Aungst, M.S., Ph.D., completed his degree in 2006 and is now at the NIH in Bethesda, MD
Publications
Carlson, G., M.T. Shipley and A. Keller. Long lasting depolarizations (LLDs) in olfactory bulb mitral cells. J. Neuroscience (2000) 20: 2011-2021. PubMed
Leinders-Zufall, T., A. P. Lane, A. C. Puche, W. Ma, M.V. Novotny, M. T. Shipley and F. Zufall. Ultrasensitive detection of putative pheromones by mammalian vomeronasal neurons. Nature, (2000) 405:792-796. PubMed
Aroniadou-Anderjaska, V. F-M. Zhou, C.A. Priest, M. Ennis, and M. T. Shipley. Tonic and synaptically evoked presynaptic inhibition of sensory input to the rat olfactory bulb via GABA(B) heteroreceptors. J. Neurophysiology (2000) 84: 1194-1203. PubMed
Ennis, M. Zhou, F.M., L.A. Zimmer, Ciombor, K., Margolis, F., Aroniadou-Anderjaska, V., Shipley, M.T. Dopamine D2 Receptor-Mediated Presynaptic Inhibition of Olfactory Nerve Terminals. J. Neurophysiology (2001) 86: 2986-2997. PubMed
Hayar, A., P. Heyward, T. Heinbockel, M.T. Shipley, and M. Ennis. Direct excitation of mitral cell via activation of alpha1-adrenoceptors in rat olfactory bulb slices. J. Neurophysiology (2001) 86: 2173-2182. PubMed
Heyward, P.M., Ennis, M., Keller, A., and Shipley, M.T. Bistability of olfactory bulb mitral cells. J. Neuroscience (2001) 21: 5311-5320. PubMed
Aungst, J.L., P.M. Heyward, A.C. Puche, S.V. Karnup, A. Hayar, G. Szabo, M.T. Shipley. (2003) Center-Surround Inhibition Among Olfactory Bulb Glomeruli. Nature 426:623-629. PubMed
Hayar, A., S. Karnup, M. T. Shipley, and M Ennis. (2004) Olfactory Bulb Glomeruli: External Tufted Cells Intrinsically Burst at Theta Frequency and Are Entrained by Patterned Olfactory Input. J. Neurosci. 24: 1190-1199. PubMed
Hayar, A., S. Karnup, M Ennis and M. T. Shipley, External Tufted Cells: A Major Excitatory Element that Coordinates Glomerular Activity. (2004) J. Neurosci. 24: 6676-6685. PubMed
Shipley, M.T., M. Ennis and A.C. Puche Olfactory System, In The Rat nervous System, Third Edition, Ed by George Paxinos, Elsevier Academic Press, San Diego, 2004
Wachowiak M, McGann JP, Heyward PM, Shao Z, Puche AC, Shipley MT. (2005) Inhibition of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx. J. Neurophysiol. In Press. PubMed
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