Braxton Mitchell, M.P.H., Ph.D.
Professor of Medicine
Professor, Department of Epidemiology and Preventative Medicine
M.P.H.: University of Michigan
Ph.D.: University of Michigan
Clinical and Research Interests:
My research involves the use of genetic epidemiologic methods to try to
dissect the genetic and environmental determinants
of type 2 diabetes, cardiovascular disease, and obesity, with the hope of detecting and
identifying common gene variants that may have pleiotropic effects on this
constellation of traits. To pursue these goals, I utilize a variety of
methods that are derived from both genetic epidemiology and statistical
genetics. Because of the underlying complexity of these disorders, I am
particularly interested in exploiting methods which allow for consideration
of gene X environment and gene X gene interaction effects. Additionally,
I have an interest in the genetic epidemiology of osteoporosis, and I am currently
involved in several family-based studies to understand the genetic and
lifestyle factors which lead to variation in bone density. One aim of
these studies is to identify specific gene variants that are associated
with low (or high) bone density and to understand how lifestyle factors
might influence the expression of these variants.
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Academic Office:410-706-0161
Fax: 410-706-1622
E-mail: bmitchel@medicine.umaryland.edu
Address:
Department of Epidemiology and Preventative Medicine
University of Maryland, School of Medicine
660 W. Redwood Street, HH - Room 492
Baltimore, Maryland 21201
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Key Papers
- Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, Henkel RD, Sharp MR, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: The San Antonio Family Heart Study. Circulation 94:2159-2170, 1996.
- Mitchell BD, Blangero J, Comuzzie AG, Almasy LA, Shuldiner AR, Silver K, Stern MP, MacCluer JW, Hixson JE. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. J Clin Invest 101:584-587, 1998.
- Mitchell BD, Almasy LA, Schneider JL, Blangero J, Rainwater DL, Stern MP, MacCluer JW. Diabetes and hypertension in Mexican American families: relation to cardiovascular risk. Am J Epidemiol 149:1047-1056, 1999.
- Mitchell BD, Cole SA, Hsueh W-C, Comuzzie AG, Blangero J, MacCluer JW, Hixson JE. Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans. Diabetes 49:513-516, 2000.
- Hsueh WC, Mitchell BD, Aburomia R, Sakul H, Ehm MG, Michelsen B, Wagner MJ, St. Jean PL, Knowler WC, Burns DK, Bell CJ, Shuldiner AR. Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. Diab Care 23:595-601, 2000.
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