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Human Research Protocols

Exercise Bike

Many of the research protocols investigate physiological mechanisms of glucose counter-regulation in response to glucose clamps. With glucose clamps, blood glucose is maintained for periods of time at specific desired levels. Examples of clamped glucose levels are euglycemia (normal blood glucose, ~90 mg/dl) or various levels of hypoglycemia (low blood glucose, one standard hypoglycemic clamp we use is ~50mg/dl), or hyperglycemia (looking at levels of glycemia over 180 mg/dl). A physiologic level of insulin is continuously infused and a dextrose infusion is variably infused to maintain blood glucose at desired levels.

Exercise, investigational devices, medications, cardiovascular effects, and investigational drugs are also studied in conjunction with glucose clamps. This not only helps to determine their physiologic effects, but may lead to more effective ways of treating diabetes. Human Research at University of Maryland, Baltimore, is under the auspices of the Human Research Protections Office located at Biopark I, 800 W. Baltimore St., Suite 100, Baltimore, MD 21201.

Active Protocols in the Davis Lab:

  1. Metabolic Causes of Thrombosis in Type 2 Diabetes (recruiting healthy and Type 2 DM participants)
  2. Mechanisms of Hypoglycemia Associated Autonomic Dysfunction (recruiting Healthy and Type 1 DM participants)
  3. Mechanisms of Hypoglycemia Associated Autonomic Failure in Type 1 DM (recruiting Healthy and Type 1 Dm participants)
  4. Mechanisms of Ramipril Reduction on the Onset of Type 2 DM (recruiting pre-diabetic and pre-hypertensive participants)
  5. Effects of Pramlintide on Endogenous Production of VLDL-Triglyceride and Glucose in the Post Prandial State in Type 2 Diabetes Mellitus