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Publications - Shigella

Black RE, Levine MM, Clements ML, Losonsky G, Herrington D, Berman S, Formal SB. Prevention of shigellosis by a Salmonella typhi-shigella sonnei bivalent vaccine. J. Infect. Dis. 1987;155:1260-1265.

DuPont HL, Levine MM, Hornick RB, Formal SB. Inoculum size in shigellosis and implications for expected mode of transmission. J. Infect. Dis. 1989;159:1126-1128.

Herrington DA, Van De Verg L, Formal SB, Hale TL, Tall BD, Cryz SJ, Tramont ED, Levine MM. Studies in volunteers to evaluate candidate Shigella vaccines: Further experience with a bivalent Salmonella typhi-Shigella sonnei vaccine and protection conferred by previous Shigella sonnei disease. Vaccine 1990;18:353-357.

Van de Verg L, Herrington DA, Murphy JR, Wasserman SS, Formal SB, Levine MM. Specific IgA secreting cells in peripheral blood following oral immunization with bivalent Salmonella typhi/Shigella sonnei vaccine or infection with pathogenic S. sonnei in humans. Infect. Immun. 1990;58:2002-2004.

Black RE, Levine MM. Intestinal protein loss in shigellosis. Nutrition Res. 1991;11:1215-1220.

Cohen D, Green M, Block C, Slepon R, Ambar R, Wasserman SS, Levine MM. Reduction of transmission of shigellosis by control of houseflies (Musca domestica). Lancet 1991;337:993-997.

Ferreccio C, Prado V, Ojeda A, Cayazzo M, Abrego P, Guers L, Levine MM. Epidemiologic patterns of acute diarrhea and endemic Shigella infections in a poor periurban setting in Santiago, Chile. Amer. J. Epidemiol. 1991;134:614-627.

Levine O, Levine MM. Are houseflies (Musca domestica) mechanical vectors for transmitting Shigella infection? Rev. Infect. Dis. 1991;13:688-696.

Guerrant R., Araujo V., Soares E., Kotloff K., Lima A., Cooper W., Lee A. Measurement of fecal lactoferrin as a marker of fecal leukocytes and inflammatory enteritis. J Clin Micro 1992;30:1238-1242.

Kotloff K., Herrington D., Hale T., Newland J. Van De Verg L., Cogan J., Snoy P., Sadoff J., Formal S., Levine M. Safety, immunogenicity, and efficacy in monkeys and humans of invasive Escherichia coli K-12 hybrid vaccine candidates expressing Shigella flexneri 2a somatic antigen. Infect Immun 1992;60:2218-2224.

Levine MM, McEwen J, Losonsky G, Reymann M, Harari L, Brown JE, Taylor DN, Donohoue-Rolfe A, Cohen D, Bennish, Lim Y-L, Arnon R. Antibodies to Shiga holotoxin and to two synthetic peptides of the B subunit in sera of patients with Shiga dysentery. J Clin Microbiol 1992;30:1636-1641.

Tacket CO, Binion SB, Bostwick E, Losonsky G, Roy MJ, Edelman R. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Amer J Trop Med Hyg 1992;47:276-283.

Van de Verg L, Herrington D, Boslego J, Lindberg AA, Levine MM. Age-specific prevalence of serum antibodies to the invasion plasmid and lipopolysaccharide antigens of Shigella in Chilean and North American populations. J. Infect. Dis. 1992;166:158-161.

Kotloff KL, Losonsky GA, Nataro JP, Wasserman SS, Hale TL, Taylor DN, Newland JW, Sadoff JC, Formal SB, Levine MM. Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2. Vaccine, 1995, 13:495-502.

Noriega FR, Wang JY, Losonsky G, Maneval DR, Hone DM, Levine MM. Construction and characterization of attenuated )aroA )virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine. Infect Immun 62:5168-5172, 1995.

Noriega FR, Liao FM, Formal SB, Fasano A, Levine MM. Prevalence of Shigella enterotoxin among Shigella clinical isolates of diverse serotypes. J. Infect. Dis. 172: 1408-1410, 1995.

Kotloff KL, Noriega F, Losonsky GA, Sztein MB, Wasserman SS, Nataro JP, Levine MM. Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG. Infect. Immun. 1996;64:4542-4548.

Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered )guaB-A )virG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infect. Immun. 1996;64:3055-3061.

Fasano A, Noriega FR, Liao FM, Wang W, Levine MM. Effect of Shigella enterotoxin 1 (ShET1) on rabbit intestine in vitro and in vivo. Gut 1997;40:505-511.

Maurelli AT, Fernandez RE, Bloch CA, Rode CK, Fasano A. "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 1998;95:3943-8.

Henderson IR, Czeczulin J, Eslava C, Noriega F, Nataro JP. Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infect. Immun. 1999;67:5587-96.

Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. World Health Organ. 1999;77:651-66.

Levine MM, Cohen D, Green M, Levine OS, Mintz ED. Fly control and shigellosis. Lancet. 1999;353:1020.

Noriega FR, Liao FM, Maneval DR, Ren S, Formal SB, Levine MM. Strategy for cross-protection among Shigella flexneri serotypes. Infect. Immun. 1999;67:782-8.

Prado V, Lagos R, Nataro JP, San Martin O, Arellano C, Wang JY, Borczyk AA, Levine MM. Population-based study of the incidence of Shigella diarrhea and causative serotypes in Santiago, Chile. Pediatr. Infect. Dis J. 1999;18:500-5.

Al-Hasani K, Henderson IR, Sakellaris H, Rajakumar K, Grant T, Nataro JP, Robins-Browne R, Adler B. The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation. Infect Immun. 2000, 68:2457-63.

Kotoff KL, Noriega FR, Samandari T, Sztein MB, Losonsky GA, Nataro JP, Picking WD, Barry EM, Levine MM. Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans. Infect Immun. 2000,68:1034-9.

Samandari T, off KL, Losonsky GA, Picking WD, Sansonetti PJ, Levine MM, Sztein MB. Production of IFN-gamma and IL-10 to Shigella invasins by mononuclear cells from volunteers orally inoculated with a Shiga toxin-deleted Shigella dysenteriae type 1 strain. J Immunol. 2000, 164:2221-32.

Kotloff KL, Taylor DN, Sztein MB, Wasserman SS, Losonsky GA, Nataro JP, Venkatesan M, Hartman A, Picking WD, Katz DE, Campbell JD, Levine MM, Hale TL. Phase I evaluation of virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults. Infection and Immunity. 2002, 70:2016-2021.

Behrens M, Sheikh J, Nataro JP. Regulation of overlapping pic/set locus in Shigella flexneri and enteroaggregative Escherichia coli. Infection & Immunity. 2002, 70:2915-2925.