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2012 Publications

Pollard AJ, Savulescu J, Oxford J, Hill AV, Levine MM, Lewis DJ, Read RC, Graham DY, Sun W, Openshaw P, Gordon SB. Human microbial challenge: the ultimate animal model. Lancet Infect Dis. 2012 Dec;12(12):903-5. PMID: 23174372

Robins-Browne RM, Levine MM. Laboratory diagnostic challenges in case/control studies of diarrhea in developing countries. Clin Infect Dis. 2012 Dec;55 Suppl 4:S312-6. PMID: 23169943, PMCID: PMC3502310

Levine MM, Robins-Browne RM. Factors that explain excretion of enteric pathogens by persons without diarrhea. Clin Infect Dis. 2012 Dec;55 Suppl 4:S303-11. PMID: 23169942, PMCID: PMC3502317

Panchalingam S, Antonio M, Hossain A, Mandomando I, Ochieng B, Oundo J, Ramamurthy T, Tamboura B, Zaidi AK, Petri W, Houpt E, Murray P, Prado V, Vidal R, Steele D, Strockbine N, Sansonetti P, Glass RI, Robins-Browne RM, Tauschek M, Svennerholm AM, Kotloff K, et al.Diagnostic microbiologic methods in the GEMS-1 case/control study.Clin Infect Dis. 2012 Dec;55 Suppl 4:S294-302. PMID: 23169941, PMCID: PMC3502308

Muhsen K, Levine MM. A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries. Clin Infect Dis. 2012 Dec;55 Suppl 4:S271-93.  PMID: 23169940, PMCID: PMC3502312

Levine MM, Kotloff KL, Nataro JP, Muhsen K. The Global Enteric Multicenter Study (GEMS): impetus, rationale, and genesis.Clin Infect Dis. 2012 Dec;55 Suppl 4:S215-24. PMID: 23169934, PMCID: PMC3502311

Rheingans R, Kukla M, Faruque AS, Sur D, Zaidi AK, Nasrin D, Farag TH, Levine MM, Kotloff KL. Determinants of household costs associated with childhood diarrhea in 3 South Asian settings. Clin Infect Dis. 2012 Dec;55 Suppl 4:S327-35. PMID: 23169945, PMCID: PMC3502314

Rheingans R, Kukla M, Adegbola RA, Saha D, Omore R, Breiman RF, Sow SO, Onwuchekwa U, Nasrin D, Farag TH, Kotloff KL, Levine MM. Exploring household economic impacts of childhood diarrheal illnesses in 3 African settings. Clin Infect Dis. 2012 Dec;55 Suppl 4:S317-26. PMID: 23169944, PMCID: PMC3502313

Biswas K, Carty C, Horney R, Nasrin D, Farag TH, Kotloff KL, Levine MM. Data management and other logistical challenges for the GEMS: the data coordinating center perspective. Clin Infect Dis. 2012 Dec;55 Suppl 4:S254-61. PMID: 23169938, PMCID: PMC3502309

Sommerfelt H, Steinsland H, van der Merwe L, Blackwelder WC, Nasrin D, Farag TH, Kotloff KL, Levine MM, Gjessing HK. Case/control studies with follow-up: Constructing the source population to estimate effects of risk factors on development, disease, and survival. Clin Infect Dis. 2012 Dec;55 Suppl 4:S262-70. PMID: 23169939, PMCID: PMC3502318

Blackwelder WC, Biswas K, Wu Y, Kotloff KL, Farag TH, Nasrin D, Graubard BI, Sommerfelt H, Levine MM. Statistical methods in the Global Enteric Multicenter Study (GEMS). Clin Infect Dis. 2012 Dec;55 Suppl 4:S246-53. PMID: 23169937, PMCID: PMC3502316

Kotloff KL, Blackwelder WC, Nasrin D, Nataro JP, Farag TH, van Eijk A, Adegbola RA, Alonso PL, Breiman RF, Faruque AS, Saha D, Sow SO, Sur D, Zaidi AK, Biswas K, Panchalingam S, Clemens JD, Cohen D, Glass RI, Mintz ED, Sommerfelt H, Levine MM. The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study. Clin Infect Dis. 2012 Dec;55 Suppl 4:S232-45. PMID: 23169936, PMCID: PMC3502307

Farag TH, Nasrin D, Wu Y, Muhsen K, Blackwelder WC, Sommerfelt H, Panchalingam S, Nataro JP, Kotloff KL, Levine MM.Some epidemiologic, clinical, microbiologic, and organizational assumptions that influenced the design and performance of the Global Enteric Multicenter Study (GEMS). Clin Infect Dis. 2012 Dec;55 Suppl

4:S225-31. PMID: 23169935, PMCID: PMC3502315

Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM, Al-Mashhadani MN, Kariuki S, Msefula CL, Gordon MA, de Pinna E, Wain J, Heyderman RS, Obaro S, Alonso PL, Mandomando I, MacLennan CA, Tapia MD, Levine MM, Tennant SM, Parkhill J, Dougan G. Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nat Genet. 2012 Nov;44(11):1215-21.  PMID: 23023330, PMCID: PMC3491877

Pasetti MF, Levine MM. Insights from natural infection-derived immunity to cholera instruct vaccine efforts. Clin Vaccine Immunol. 2012 Nov;19(11):1707-11. PMID: 22993412, PMCID: PMC3491553

Boyd MA, Laurens MB, Fiorella PD, Mendley SR. Peritonitis and technique failure caused by Roseomonas mucosa in an adolescent infected with HIV on continuous cycling peritoneal dialysis. J Clin Microbiol. 2012 Nov;50(11):3801-4. PMID: 22933600, PMCID: PMC3486232

Shirley DA, Moonah SN, Kotloff KL. Burden of disease from cryptosporidiosis. Curr Opin Infect Dis. 2012 Oct;25(5):555-63. Review. PMID: 22907279

Adhikari RP, Ajao AO, Aman MJ, Karauzum H, Sarwar J, Lydecker AD, Johnson JK, Nguyen C, Chen WH, Roghmann MC. Lower antibody levels to Staphylococcus aureus exotoxins are associated with sepsis in hospitalized adults with invasive S. aureus infections. J Infect Dis. 2012 Sep 15;206(6):915-23. PMID: 22807524

Jackson LA, Chen WH, Stapleton JT, Dekker CL, Wald A, Brady RC, Edupuganti S, Winokur P, Mulligan MJ, Keyserling HL, Kotloff KL, Rouphael N, Noah DL, Hill H, Wolff MC. Immunogenicity and safety of varying dosages of a monovalent 2009 H1N1 influenza vaccine given with and without AS03 adjuvant system in healthy adults and older persons. J Infect Dis. 2012 Sep 15;206(6):811-20. PMID: 22782949, PMCID:


Laurens MB, Duncan CJ, Epstein JE, Hill AV, Komisar JL, Lyke KE, Ockenhouse CF, Richie TL, Roestenberg M, Sauerwein RW, Spring MD, Talley AK, Moorthy VS; Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection. A consultation on the optimization of controlled human malaria

infection by mosquito bite for evaluation of candidate malaria vaccines. Vaccine. 2012 Aug 3;30(36):5302-4. PMID: 22659449

Del Canto F, Botkin DJ, Valenzuela P, Popov V, Ruiz-Perez F, Nataro JP, Levine MM, Stine OC, Pop M, Torres AG, Vidal R. Identification of Coli Surface Antigen 23, a novel adhesin of enterotoxigenic Escherichia coli. Infect Immun. 2012 Aug;80(8):2791-801. PMID: 22645287, PMCID: PMC3434557

Ramirez K, Wahid R, Richardson C, Bargatze RF, El-Kamary SS, Sztein MB, Pasetti MF. Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers. Clin Immunol. 2012 Aug;144(2):98-108. PMID: 22710446

Fairhurst RM, Nayyar GM, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg. 2012 Aug;87(2):231-41. Review.  PMID: 22855752, PMCID: PMC3414557

Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, et al. Analysis of Plasmodium falciparum diversity in natural infections by deep

sequencing. Nature. 2012 Jul 19;487(7407):375-9. PMID: 22722859

Khatun F, Zaman F, Mosaiab T, Mostafa F, Zaman M, Rehana F, Nasrin D, Jamal F, Nahar N, Rahmatullah M. Evaluation of antinociceptive and antihyperglycemic activities in methanol extracts of whole plants of Alternanthera philoxeroides (Mart.) Griseb. (Amaranthaceae) in mice. Pak J Pharm Sci. 2012

Jul;25(3):583-7.  PMID: 22713945

Faherty CS, Redman JC, Rasko DA, Barry EM, Nataro JP. Shigella flexneri effectors OspE1 and OspE2 mediate induced adherence to the colonic epithelium following bile salts exposure. Mol Microbiol. 2012 Jul;85(1):107-21. PMID: 22571618, PMCID: PMC3399131

Marohn ME, Santiago AE, Shirey KA, Lipsky M, Vogel SN, Barry EM. Members of the Francisella tularensis phagosomal transporter subfamily of major facilitator superfamily transporters are critical for pathogenesis. Infect Immun. 2012 Jul;80(7):2390-401. PMID: 22508856, PMCID: PMC3416476

Maiga AW, Fofana B, Sagara I, Dembele D, Dara A, Traore OB, Toure S, Sanogo K, Dama S, Sidibe B, Kone A, Thera MA, Plowe CV, Doumbo OK, Djimde AA. No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. Am J Trop Med Hyg. 2012 Jul;87(1):23-8. PMID: 22764287, PMCID: PMC3391052

Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG, Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malar J. 2012 Jun 18;11:207. PMID: 22709627, PMCID: PMC3489583

Chen WH, Winokur PL, Edwards KM, Jackson LA, Wald A, Walter EB, Noah DL, Wolff M, Kotloff KL; Pandemic H1N1 Vaccine Adult Study Group. Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009. Vaccine. 2012 Jun 13;30(28):4240-8. PMID: 22537984, PMCID: PMC3490194

Wahid R, Simon R, Zafar SJ, Levine MM, Sztein MB. Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans. Clin Vaccine Immunol. 2012 Jun;19(6):825-34. PMID: 22492745, PMCID: PMC3370435

Hutter J, Pasetti MF, Sanogo D, Tapia MD, Sow SO, Levine MM. Naturally acquired and conjugate vaccine-induced antibody to Haemophilus influenzae type b (Hib) polysaccharide in Malian children: serological assessment of the Hib immunization program in Mali. Am J Trop Med Hyg. 2012 Jun;86(6):1026-31. PMID: 22665612, PMCID: PMC3366516

Chen WH. Turning down the heat: the potential role of RIP140 in inflammation. Cell Mol Immunol. 2012 May;9(3):195-6. PMID: 22504951

Gandhi K, Thera MA, Coulibaly D, Traoré K, Guindo AB, Doumbo OK, Takala-Harrison S, Plowe CV. Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein. Am J Trop Med Hyg. 2012 May;86(5):775-81. PMID: 22556073, PMCID: PMC3335679

Armah GE, Breiman RF, Tapia MD, Dallas MJ, Neuzil KM, Binka FN, Sow SO, Ojwando J, Ciarlet M, Steele AD. Immunogenicity of the pentavalent rotavirus vaccine in African infants. Vaccine. 2012 Apr 27;30 Suppl 1:A86-93.  PMID: 22520142

Tapia MD, Armah G, Breiman RF, Dallas MJ, Lewis KD, Sow SO, Rivers SB, Levine MM, Laserson KF, Feikin DR, Victor JC, Ciarlet M, Neuzil KM, Steele AD. Secondary efficacy endpoints of the pentavalent rotavirus vaccine against gastroenteritis in sub-Saharan Africa. Vaccine. 2012 Apr 27;30 Suppl 1:A79-85.  PMID: 22520141

Sow SO, Tapia M, Haidara FC, Ciarlet M, Diallo F, Kodio M, Doumbia M, Dembélé RD, Traoré O, Onwuchekwa UU, Lewis KD, Victor JC, Steele AD, Neuzil KM, Kotloff KL, Levine MM. Efficacy of the oral pentavalent rotavirus vaccine in Mali. Vaccine. 2012 Apr 27;30 Suppl 1:A71-8.  PMID: 22520140

Simon R, Levine MM.Glycoconjugate vaccine strategies for protection against invasive Salmonella infections. Hum Vaccin Immunother. 2012 Apr;8(4):494-8.  Review. PMID: 22370510, PMCID: PMC3426074

Sabui S, Dutta S, Debnath A, Ghosh A, Hamabata T, Rajendran K, Ramamurthy T, Nataro JP, Sur D, Levine MM, Chatterjee NS. Real-time PCR-based mismatch amplification mutation assay for specific detection of CS6-expressing allelic variants of enterotoxigenic Escherichia coli and its application in assessing diarrheal cases and asymptomatic controls. J Clin Microbiol. 2012 Apr;50(4):1308-12.  PMID: 22219305, PMCID: PMC3318556

Levine OS, O'Brien KL, Deloria-Knoll M, Murdoch DR, Feikin DR, DeLuca AN, Driscoll AJ, Baggett HC, Brooks WA, Howie SR, Kotloff KL, Madhi SA, Maloney SA, Sow S, Thea DM, Scott JA.The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia etiology study. Clin Infect Dis. 2012

Apr;54 Suppl 2:S93-101. PMID: 22403238, PMCID: PMC3297546

Fernandez Vina MA, Hollenbach JA, Lyke KE, Sztein MB, Maiers M, Klitz W, Cano P, Mack S, Single R, Brautbar C, Israel S, Raimondi E, Khoriaty E, Inati A, Andreani M, Testi M, Moraes ME, Thomson G, Stastny P, Cao K.Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):820-9. Review.  PMID: 22312049, PMCID: PMC3267126

Noonan K, Rudraraju L, Ferguson A, Emerling A, Pasetti MF, Huff CA, Borrello I. Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses. Clin Cancer Res. 2012 Mar 1;18(5):1426-34.  PMID: 22241792, PMCID: PMC3640365

Martinez-Becerra FJ, Kissmann JM, Diaz-McNair J, Choudhari SP, Quick AM, Mellado-Sanchez G, Clements JD, Pasetti MF, Picking WL.Broadly protective Shigella vaccine based on type III secretion apparatus proteins. Infect Immun. 2012 Mar;80(3):1222-31. PMID: 22202122, PMCID: PMC3294653

Mathanga DP, Walker ED, Wilson ML, Ali D, Taylor TE, Laufer MK.Malaria control in Malawi: current status and directions for the future. Acta Trop. 2012 Mar;121(3):212-7. Review.  PMID: 21763670

Venkatesan M, Amaratunga C, Campino S, Auburn S, Koch O, Lim P, Uk S, Socheat D, Kwiatkowski DP, Fairhurst RM, Plowe CV. Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples. Malar J. 2012 Feb 10;11:41.  PMID: 22321373, PMCID: PMC3295709

Boisen N, Scheutz F, Rasko DA, Redman JC, Persson S, Simon J, Kotloff KL, Levine MM, Sow S, Tamboura B, Toure A, Malle D, Panchalingam S, Krogfelt KA, Nataro JP. Genomic characterization of enteroaggregative Escherichia coli from children in Mali. J Infect Dis. 2012 Feb 1;205(3):431-44. PMID: 22184729, PMCID: PMC3256949

Chen WH, Toapanta FR, Shirey KA, Zhang L, Giannelou A, Page C, Frieman MB, Vogel SN, Cross AS. Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza. Immunol Lett. 2012 Jan 30;141(2):227-34. PMID: 22037624, PMCID: PMC3243824

Orenstein LA, Orenstein EW, Teguete I, Kodio M, Tapia M, Sow SO, Levine MM. Background rates of adverse pregnancy outcomes for assessing the safety of maternal vaccine trials in sub-Saharan Africa. PLoS One. 2012;7(10):e46638. PMID: 23056380, PMCID: PMC3464282

Toapanta FR, Bernal PJ, Sztein MB.Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level. Front Cell Infect Microbiol. 2012;2:128. PMID: 23087912, PMCID: PMC3473368

McArthur MA, Sztein MB. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS One. 2012;7(6):e38408. PMID: 22679502, PMCID: PMC3367967

Chen WH, El-Kamary SS. Vaccines for enteric infections. Curr Opin Gastroenterol. 2012 Jan;28(1):18-23. Review. PMID: 22080824

Faherty C, Harper JM, Shea-Donohue T, Barry EM, Kaper JB, Fasano A, Nataro JP. Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo. PLoS One. 2012;7(11):e49980. PMID: 23166804, PMCID: PMC3500342

Laufer MK, Thesing PC, Dzinjalamala FK, Nyirenda OM, Masonga R, Laurens MB, Stokes-Riner A, Taylor TE, Plowe CV. A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. PLoS One. 2012;7(8):e42284. PMID: 22912697,

PMCID: PMC3422316

Lyke KE, Wang A, Dabo A, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. PLoS One. 2012;7(6):e37868. PMID: 22693628, PMCID: PMC3367916

Lyke KE, Dabo A, Arama C, Daou M, Diarra I, Wang A, Plowe CV, Doumbo OK, Sztein MB. Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium. PLoS One. 2012;7(2):e31647. PMID: 22348117, PMCID: PMC3279404

Thera MA, Plowe CV.Vaccines for malaria: how close are we? Annu Rev Med. 2012;63:345-57. Review. PMID: 22077719, PMCID: PMC3338248