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2011 Publications

Levine MM. "IDEAL" vaccines for resource poor settings. Vaccine. 2011 Dec 30;29 Suppl 4:D116-25. Review.

PMID: 22486974

Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara T, Ndounga M, Dysoley L, Endo H, Hombhanje F, Ferreira MU, Plowe CV, Tanabe K. Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations. J Infect Dis. 2011 Dec 15;204(12):1980-8. PMID: 22021623, PMCID: PMC3209816

Atmar RL, Bernstein DI, Harro CD, Al-Ibrahim MS, Chen WH, Ferreira J, Estes MK, Graham DY, Opekun AR, Richardson C, Mendelman PM. Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med. 2011 Dec 8;365(23):2178-87. PMID: 22150036

Galen JE, Simon R, Ernst RK. Salmonella expressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens. Expert Rev Vaccines. 2011 Dec;10(12):1679-82. PMID: 22085171, PMCID: PMC3289411

 Wu T, Grassel C, Levine MM, Barry EM. Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit. Infect Immun. 2011 Dec;79(12):4912-22. PMID: 21969003, PMCID: PMC3232646

Simon JK, Carter M, Pasetti MF, Sztein MB, Kotloff KL, Weniger BG, Campbell JD, Levine MM. Safety, tolerability, and immunogenicity of inactivated trivalent seasonal influenza vaccine administered with a needle-free disposable-syringe jet injector. Vaccine. 2011 Nov 28;29(51):9544-50. PMID: 21986218

Gat O, Galen JE, Tennant S, Simon R, Blackwelder WC, Silverman DJ, Pasetti MF, Levine MM. Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines. PLoS Negl Trop Dis. 2011 Nov;5(11):e1373. PMID: 22069504, PMCID: PMC3206010

Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A,  Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, et al. Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science. 2011 Oct 28;334(6055):475-80. PMID: 21903775

Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM. Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving  as live oral vaccines and as reagent strains. Infect Immun. 2011 Oct;79(10):4175-85. PMID: 21807911, PMCID: PMC3187273

Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM. Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis. Infect Immun. 2011 Oct;79(10):4240-9. PMID: 21807909, PMCID: PMC3187246

Dondorp AM, Fairhurst RM, Slutsker L, Macarthur JR, Breman JG, Guerin PJ, Wellems TE, Ringwald P, Newman RD, Plowe CV. The threat of artemisinin-resistant malaria. N Engl J Med. 2011 Sep 22;365(12):1073-5. PMID: 21992120

Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S, Lyke KE, Wu Y, Blackwelder WC, et al. A field trial to assess a blood-stage malaria vaccine. N Engl J Med.

2011 Sep 15;365(11):1004-13. PMID: 21916638, PMCID: PMC3242358

Ruiz-Perez F, Wahid R, Faherty CS, Kolappaswamy K, Rodriguez L, Santiago A, Murphy E, Cross A, Sztein MB, Nataro JP. Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12881-6.

PMID: 21768350, PMCID: PMC3150873

Salerno-Goncalves R, Fasano A, Sztein MB. Engineering of a multicellular organotypic model of the human intestinal mucosa. Gastroenterology. 2011Aug;141(2):e18-20. PMID: 21723866, PMCID: PMC3328095

Ohtake S, Martin RA, Saxena A, Lechuga-Ballesteros D, Santiago AE, Barry EM, Truong-Le V. Formulation and stabilization of Francisella tularensis live vaccine strain. J Pharm Sci. 2011 Aug;100(8):3076-87.  PMID: 21491457, PMCID: PMC3356159

Simon R, Tennant SM, Galen JE, Levine MM. Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge. Vaccine. 2011 Jul 18;29(32):5094-106. Review.  PMID: 21616112, PMCID: PMC3152302

Mandomando I, Naniche D, Pasetti MF, Cuberos L, Sanz S, Vallès X, Sigauque B, Macete E, Nhalungo D, Kotloff KL, Levine MM, Alonso PL. Assessment of the epidemiology and burden of measles in Southern Mozambique. Am J Trop Med Hyg. 2011 Jul;85(1):146-51. PMID: 21734140, PMCID: PMC3122359

Ulmer JB, Sztein MB. Promising cutting-edge technologies and tools to accelerate the discovery and development of new vaccines. Curr Opin Immunol. 2011 Jun;23(3):374-6. PMID: 21524899

Lyke KE, Fernández-Viňa MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB. Association of HLA alleles with Plasmodium falciparum severity in Malian children. Tissue Antigens. 2011 Jun;77(6):562-71. PMID:

21447146, PMCID: PMC3152196

Gunther VJ, Putnak R, Eckels KH, Mammen MP, Scherer JM, Lyons A, Sztein MB, Sun W. A human challenge model for dengue infection reveals a possible protective role for sustained interferon gamma levels during the acute phase of illness. Vaccine. 2011 May 17;29(22):3895-904. PMID: 21443963

Frosch AE, Venkatesan M, Laufer MK. Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data. Malar J. 2011 May 9;10:116. PMID: 21554692, PMCID: PMC3112453

Lagos RE, Muñoz AE, Levine MM, Lepetic A, François N, Yarzabal JP, Schuerman L. Safety and immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Chilean children. Hum Vaccin. 2011 May;7(5):511-22. PMID: 21441782

Simon JK, Maciel M Jr, Weld ED, Wahid R, Pasetti MF, Picking WL, Kotloff KL, Levine MM, Sztein MB. Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates. Clin Immunol. 2011 May;139(2):185-92. PMID: 21388888, PMCID: PMC3078965

Tennant SM, Zhang Y, Galen JE, Geddes CD, Levine MM. Ultra-fast and sensitive detection of non-typhoidal Salmonella using microwave-accelerated metal-enhanced fluorescence ("MAMEF"). PLoS One. 2011 Apr 8;6(4):e18700. PMID: 21494634, PMCID: PMC3073000

Chen WH, Cross AS, Edelman R, Sztein MB, Blackwelder WC, Pasetti MF. Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine. Vaccine. 2011 Apr 5;29(16):2865-73. PMID: 21352939, PMCID: PMC3070775

Yang Y, Berry AA, Lee WC, Garnett JA, Marchant J, Levine JA, Simpson PJ, Fogel SA, Varney KM, Matthews SJ, Nataro JP, Inman KG. Complete 1H, 13C and 15N NMR assignments for donor-strand complemented AafA, the major pilin of aggregative adherence fimbriae (AAF/II) from enteroaggregative E. coli. Biomol NMR Assign. 2011 Apr;5(1):1-5.  PMID: 20814767

Farfán MJ, Toro CS, Barry EM, Nataro JP. Shigella enterotoxin-2 is a type III effector that participates in Shigella-induced interleukin 8 secretion by epithelial cells. FEMS Immunol Med Microbiol. 2011 Apr;61(3):332-9.  PMID: 21219446, PMCID: PMC3055916

Gladwin MT, Kato GJ, Weiner D, Onyekwere OC, Dampier C, Hsu L, Hagar RW, Howard T, Nuss R, Okam MM, Tremonti CK, Berman B, Villella A, Krishnamurti L, Lanzkron S, Castro O, Gordeuk VR, Coles WA, Peters-Lawrence M, Nichols J, Hall MK, Hildesheim M, et al. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. JAMA. 2011 Mar 2;305(9):893-902. PMID: 21364138, PMCID: PMC3403835

Simon JK, Ramirez K, Cuberos L, Campbell JD, Viret JF, Muñoz A, Lagos R, Levine MM, Pasetti MF. Mucosal IgA responses in healthy adult volunteers following intranasal spray delivery of a live attenuated measles vaccine. Clin Vaccine Immunol. 2011 Mar;18(3):355-61. PMID: 21228137, PMCID: PMC3067370

Wahid R, Pasetti MF, Maciel M Jr, Simon JK, Tacket CO, Levine MM, Sztein MB. Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD-S. Typhi-specific IgA and IgG B memory cells in humans. Clin Immunol. 2011

Feb;138(2):187-200. PMID: 21146460, PMCID: PMC3035995

Hedt BL, Laufer MK, Cohen T. Drug resistance surveillance in resource-poor settings: current methods and considerations for TB, HIV, and malaria. Am J Trop Med Hyg. 2011 Feb;84(2):192-9. Review.  PMID: 21292884, PMCID: PMC3029167

Levine MM, Farag TH. Invasive salmonella infections and HIV in Northern Tanzania. Clin Infect Dis. 2011 Feb 1;52(3):349-51.  PMID: 21217182

Breman JG, de Quadros CA, Dowdle WR, Foege WH, Henderson DA, John TJ, Levine MM. The role of research in viral disease eradication and elimination programs: lessons for malaria eradication. PLoS Med. 2011 Jan 25;8(1):e1000405.  Review.  PMID: 21311582, PMCID: PMC3026693

malERA Consultative Group on Vaccines. A research agenda for malaria eradication: vaccines. PLoS Med. 2011 Jan 25;8(1):e1000398. Review.  PMID: 21311586, PMCID: PMC3026701

malERA Consultative Group on Drugs. A research agenda for malaria eradication: drugs. PLoS Med. 2011 Jan 25;8(1):e1000402. Review. PMID: 21311580, PMCID: PMC3026688

Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, Doumbo OK, Greenwood B, Hall BF, Levine MM, Mendis K, Newman RD, Plowe CV, Rodríguez MH, Sinden R, Slutsker L, Tanner M. A research agenda to underpin malaria eradication. PLoS Med. 2011 Jan 25;8(1):e1000406. Review.  PMID: 21311579, PMCID: PMC3026687

Rapoport AP, Aqui NA, Stadtmauer EA, Vogl DT, Fang HB, Cai L, Janofsky S, Chew A, Storek J, Akpek G, Badros A, Yanovich S, Tan MT, Veloso E, Pasetti MF, Cross A, Philip S, Murphy H, Bhagat R, Zheng Z, Milliron T, Cotte J, et al. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood. 2011 Jan 20;117(3):788-97. PMID: 21030558, PMCID: PMC3035073

Vendrell A, Gravisaco MJ, Pasetti MF, Croci M, Colombo L, Rodríguez C, Mongini C, Waldner CI. A novel Salmonella Typhi-based immunotherapy promotes tumor killing via an antitumor Th1-type cellular immune response and neutrophil activation in a mouse model of breast cancer. Vaccine. 2011 Jan 17;29(4):728-36. PMID: 21095252

Pasetti MF, Simon JK, Sztein MB, Levine MM. Immunology of gut mucosal vaccines. Immunol Rev. 2011 Jan;239(1):125-48. Review. PMID: 21198669, PMCID: PMC3298192