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Publications

David J. Weber

  1. Abeygunawardana, C., Weber, D. J., Frick, D. N., Bessman, M. J., and Mildvan, A. S. (1993) Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR, Biochemistry 32, 13071-13080.
  2. Abeygunawardana, C., Weber, D. J., Gittis, A. G., Frick, D. N., Lin, J., Miller, A. F., Bessman, M. J., and Mildvan, A. S. (1995) Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase, Biochemistry 34, 14997-15005.
  3. Amburgey, J. C., Abildgaard, F., Starich, M. R., Shah, S., Hilt, D. C., and Weber, D. J. (1995) 1H, 13C and 15N NMR assignments and solution secondary structure of rat Apo-S100 beta, J Biomol NMR 6, 171-179.
  4. Andrec, M., Inman, K. G., Weber, D. J., Levy, R. M., and Montelione, G. T. (2000) A Bayesian statistical method for the detection and quantification of rotational diffusion anisotropy from NMR relaxation data, J Magn Reson 146, 66-80.
  5. Baldisseri, D. M., Margolis, J. W., Weber, D. J., Koo, J. H., and Margolis, F. L. (2002) Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction, J Mol Biol 319, 823-837.
  6. Baldisseri, D. M., Rustandi, R. R., Zhang, Z., Tang, C., Bair, C. L., Landar, A., Landar, A., Zimmer, D. B., and Weber, D. J. (1999) 1H, 13C and 15N NMR sequence-specific resonance assignments for rat apo-S100A1(alpha alpha), J Biomol NMR 14, 91-92.
  7. Charpentier, T. H., Wilder, P. T., Liriano, M. A., Varney, K. M., Pozharski, E., MacKerell, A. D., Jr., Coop, A., Toth, E. A., and Weber, D. J. (2008) Divalent metal ion complexes of S100B in the absence and presence of pentamidine, J Mol Biol 382, 56-73.
  8. Chuang, W. J., Weber, D. J., Gittis, A. G., and Mildvan, A. S. (1993) Mutational tests of the NMR-docked structure of the staphylococcal nuclease-metal-3',5'-pdTp complex, PROTEINS:Struct.,Funct.,Genet. 17, 36-48.
  9. Drohat, A. C., Amburgey, J. C., Abildgaard, F., Starich, M. R., Baldisseri, D., and Weber, D. J. (1996) Solution structure of rat apo-S100B as determined by NMR spectroscopy, Biochemistry 35, 11577-11588.
  10. Drohat, A. C., Baldisseri, D. M., Rustandi, R. R., and Weber, D. J. (1998) Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy, Biochemistry 37, 2729-2740.
  11. Drohat, A. C., Tjandra, N., Baldisseri, D. M., and Weber, D. J. (1999) The use of dipolar couplings for determining the solution structure of rat apo-S100B, Protein Science 8, 800-809.
  12. Ellis, K. C., Tenenholz, T. C., Jerng, H., Hayhurst, M., Dudlak, C. S., Gilly, W. F., Blaustein, M. P., and Weber, D. J. (2001) Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A), Biochemistry 40, 5942-5953.
  13. Frick, D. N., Weber, D. J., Abeygunawardana, C., Gittis, A. G., Bessman, M. J., and Mildvan, A. S. (1995) NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme, Biochemistry 34, 5577-5586.
  14. Frick, D. N., Weber, D. J., Gillespie, J. R., Bessman, M. J., and Mildvan, A. S. (1994) Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes, J Biol Chem 269, 1794-1803.
  15. Garbuglia, M., Verzini, M., Rustandi, R. R., Osterloh, D., Weber, D. J., Gerke, V., and Donato, R. (1999) Role of the C-terminal extension in the interaction of S100A1 with GFAP, tubulin, the S100A1- and S100B-inhibitory peptide, TRTK-12, and a peptide derived from p53, and the S100A1 inhibitory effect on GFAP polymerization, Biochem Biophys Res Commun 254, 36-41.
  16. Garrett, S. C., Varney, K. M., Weber, D. J., and Bresnick, A. R. (2006) S100A4: a mediator of metastasis, J. Biol. Chem. 281, 677-680.
  17. Gitti, R., Wright, N. T., Margolis, J. W., Varney, K. M., Weber, D. J., and Margolis, F. L. (2005) Backbone dynamics of the olfactory marker protein (OMP) as studied by 15N NMR relaxation methods, Biochemistry in press.
  18. Inman, K. G., Baldisseri, D. M., Miller, K. E., and Weber, D. J. (2001) Backbone dynamics of the calcium-signaling protein apo-S100B as determined by 15N NMR relaxation, Biochemistry 40, 3439-3448.
  19. Inman, K. G., Yang, R., Rustandi, R. R., Miller, K. E., Baldisseri, D. M., and Weber, D. J. (2002) Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12, J.Mol.Biol. 324, 1003-1014.
  20. Klenk, K. C., Tenenholz, T. C., Matteson, D. R., Rogowski, R. S., Blaustein, M. P., and Weber, D. J. (2000) Structural and functional differences of two toxins from the scorpion Pandinus imperator, PROTEINS:Struct.,Funct.,Genet. 38, 441-449.
  21. Landar, A., Rustandi, R. R., Weber, D. J., and Zimmer, D. B. (1998) S100A1 utilizes different mechanisms for interacting with calcium-dependent and calcium-independent target proteins, Biochemistry 37, 17429-17438.
  22. Markowitz, J., Carrier, F., Varney, K. M., Mackerell, A. D., Jr., and Weber, D. J. (2005) Inhibitor design and calcium dependence of the S100B-p53 tumor suppressor interaction, AACR Meeting Abstracts 2005, 1140-a-.
  23. Markowitz, J., Chen, I., Gitti, R., Baldisseri, D. M., Pan, Y., Udan, R., Carrier, F., MacKerell, A. D., Jr., and Weber, D. J. (2004) Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction, J Med Chem 47, 5085-5093.
  24. Markowitz, J., MacKerell, A. D., Jr., Carrier, F., Charpentier, T. H., and Weber, D. J. (2005) Design of inhibitors for S100B, Current Topics in Medicinal Chemistry 5, 1093-1108.
  25. Markowitz, J., MacKerell, A. D., Jr., and Weber, D. J. (2007) A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins, Mini reviews in medicinal chemistry 7, 609-616.
  26. Markowitz, J., Rustandi, R. R., Varney, K. M., Wilder, P. T., Udan, R., Wu, S. L., Horrocks, W. D., and Weber, D. J. (2005) Calcium-Binding Properties of Wild-Type and EF-Hand Mutants of S100B in the Presence and Absence of a Peptide Derived from the C-Terminal Negative Regulatory Domain of p53, Biochemistry 44, 7305-7314.
  27. Mildvan, A. S., Weber, D. J., and Abeygunawardana, C. (1999) Solution structure and mechanism of the MutT pyrophosphohydrolase, Adv Enzymol Relat Areas Mol Biol 73, 183-207.
  28. Prosser, B. L., Wright, N. T., Hernandez-Ochoa, E. O., Varney, K. M., Liu, Y., Olojo, R. O., Zimmer, D. B., Weber, D. J., and Schneider, M. F. (2008) S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling, J Biol Chem 283, 5046-5057.
  29. Rifat, D., Wright, N. T., Varney, K. M., Weber, D. J., and Black, L. W. (2008) Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target, J Mol Biol 375, 720-734.
  30. Rogowski, R. S., Collins, J. H., O'Neill, T. J., Gustafson, T. A., Werkman, T. R., Rogawski, M. A., Tenenholz, T. C., Weber, D. J., and Blaustein, M. P. (1996) Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels, Mol Pharmacol 50, 1167-1177.
  31. Rustandi, R., Vallely, K. M., Varlamova, O., Klein, M. G., Almo, S. C., Bresnick, A. R., and Weber, D. J. (2001) 1H, 13C, 15N NMR sequence-specific resonance assignments for human apo-mts1 (S100A4), J. Biomol. NMR 19, 381-382.
  32. Rustandi, R. R., Baldisseri, D. M., Drohat, A. C., and Weber, D. J. (1999) Structural changes in the C-terminus of Ca2+-bound rat S100B upon binding to a peptide derived from the C-terminal regulatory domain of p53, Protein Science 8, 1743-1751.
  33. Rustandi, R. R., Baldisseri, D. M., Inman, K. G., Nizner, P., Hamilton, S. M., Landar, A., Landar, A., Zimmer, D. B., and Weber, D. J. (2002) Three-dimensional solution structure of the calcium-signaling protein apo-S100A1 as determined by NMR, Biochemistry 41, 788-796.
  34. Rustandi, R. R., Baldisseri, D. M., and Weber, D. J. (2000) Structure of the negative regulatory domain of p53 bound to S100B, Nat Struct Biol 7, 570-574.
  35. Rustandi, R. R., Drohat, A. C., Baldisseri, D. M., Wilder, P. T., and Weber, D. J. (1998) The Ca2+-dependent interaction of S100B with a peptide derived from p53, Biochemistry 37, 1951-1960.
  36. Tenenholz, T. C., Klenk, K. C., Matteson, D. R., Blaustein, M. P., and Weber, D. J. (2000) Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides, Rev Physiol Biochem Pharmacol 140, 135-185.
  37. Tenenholz, T. C., Rogowski, R. S., Collins, J. H., Blaustein, M. P., and Weber, D. J. (1997) Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels, Biochemistry 36, 2763-2771.
  38. Velarde, J. J., Varney, K. M., Inman, K. G., Farfan, M., Dudley, E., Fletcher, J., Weber, D. J., and Nataro, J. P. (2007) Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli, Mol Microbiol 66, 1123-1135.
  39. Weber, D. J., Abeygunawardana, C., Bessman, M. J., and Mildvan, A. S. (1993) Secondary structure of the MutT enzyme as determined by NMR, Biochemistry 32, 13081-13088.
  40. Weber, D. J., Bhatnagar, S. K., Bullions, L. C., Bessman, M. J., and Mildvan, A. S. (1992) NMR and isotopic exchange studies of the site of bond cleavage in the MutT reaction, J Biol Chem 267, 16939-16942.
  41. Weber, D. J., Gittis, A. G., Mullen, G. P., Abeygunawardana, C., Lattman, E. E., and Mildvan, A. S. (1992) NMR docking of a substrate into the X-ray structure of staphylococcal nuclease, PROTEINS:Struct.,Funct.,Genet. 13, 275-287.
  42. Weber, D. J., Libson, A. M., Gittis, A. G., Lebowitz, M. S., and Mildvan, A. S. (1994) NMR docking of a substrate into the X-ray structure of the Asp-21-->Glu mutant of staphylococcal nuclease, Biochemistry 33, 8017-8028.
  43. Weber, D. J., Mullen, G. P., and Mildvan, A. S. (1991) Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR, Biochemistry 30, 7425-7437.
  44. Weber, D. J., Rustandi, R. R., Carrier, F., and Zimmer, D. B. (2000) Interaction of dimeric S100B(bb) with the tumor suppressor protein: A model for Ca-dependent S100-target protein interactions, Kluwer Academic Publishers, Dordrecht, The Netherlands.
  45. Weber, D. J., Serpersu, E. H., Gittis, A. G., Lattman, E. E., and Mildvan, A. S. (1993) NMR docking of the competitive inhibitor thymidine 3',5'-diphosphate into the X-ray structure of staphylococcal nuclease, PROTEINS:Struct.,Funct.,Genet. 17, 20-35.
  46. Wilder, P. T., Baldisseri, D. M., Udan, R., Vallely, K. M., and Weber, D. J. (2003) Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis, Biochemistry 42, 13410-13421.
  47. Wilder, P. T., Lin, J., Bair, C. L., Charpentier, T. H., Yang, D., Liriano, M., Varney, K. M., Lee, A., Oppenheim, A. B., Adhya, S., Carrier, F., and Weber, D. J. (2006) Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B, Biochim Biophys Acta 1763, 1284-1297.
  48. Wilder, P. T., Rustandi, R. R., Drohat, A. C., and Weber, D. J. (1998) S100B inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner, Protein Sci 7, 794-798.
  49. Wilder, P. T., Varney, K. M., Weiss, M. B., Gitti, R. K., and Weber, D. J. (2005) Solution Structure of Zinc- and Calcium-Bound Rat S100B as Determined by Nuclear Magnetic Resonance Spectroscopy, Biochemistry 44, 5690-5702.
  50. Wright, N. T., Cannon, B. R., Zimmer, D. B., and Weber, D. J. (2009) S100A1: Structure, function, and therapeutic potential, Curr Chem Biol in press.
  51. Wright, N. T., Inman, K. G., Levine, J. A., Cannon, B. R., Varney, K. M., and Weber, D. J. (2008) Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B, J Biomol NMR 42, 279-286.
  52. Wright, N. T., Margolis, J. W., Margolis, F. L., and Weber, D. J. (2005) Refinement of the solution structure of rat olfactory marker protein (OMP), J Biomol NMR 33, 63-68.
  53. Wright, N. T., Prosser, B. L., Varney, K. M., Zimmer, D. B., Schneider, M. F., and Weber, D. J. (2008) S100A1 and calmodulin compete for the same binding site on ryanodine receptor, J Biol Chem 283, 26676-26683.
  54. Wright, N. T., Varney, K. M., Ellis, K. C., Markowitz, J., Gitti, R. K., Zimmer, D. B., and Weber, D. J. (2005) The three-dimensional solution structure of Ca2+-bound S100A1 as determined by NMR spectroscopy, J Mol Biol 353, 410-426.
  55. Yang, R., Weber, D. J., and Carrier, F. (2006) Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18, Nucleic Acids Res 34, 1224-1236.
  56. Zimmer, D. B., Landar, A. L., Rustandi, R. R., and Weber, D. J. (1998) S100A1 Interaction with calcium-dependent and calcium-independent target proteins, Biochemistry.
  57. Zimmer, D. B., and Weber, D. J. (2000) S100-mediated signal transduction in neurological and other disease states, Kluwer, Dordrecht.
  58. Zimmer, D. B., Wright Sadosky, P., and Weber, D. J. (2003) Molecular mechanisms of S100-target protein interactions, Microsc Res Tech 60, 552-559.

Frank L. Margolis

  1. Baldisseri, D. M., Margolis, J. W., Omotosho, P. A., Volkman, B. F., and Margolis, F. L. (2000) Sequence-specific NMR resonance assignments of the backbone atoms for the olfactory marker protein, OMP, J Biomol NMR 17, 353-354.
  2. Baldisseri, D. M., Margolis, J. W., Weber, D. J., Koo, J. H., and Margolis, F. L. (2002) Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction, J Mol Biol 319, 823-837.
  3. Buiakova, O. I., Baker, H., Scott, J. W., Farbman, A., Kream, R., Grillo, M., Franzen, L., Richman, M., Davis, L. M., Abbondanzo, S., Stewart, C. L., and Margolis, F. L. (1996) Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons, Proc Natl Acad Sci U S A 93, 9858-9863.
  4. Koo, J. H., Gill, S., Pannell, L. K., Menco, B. P., Margolis, J. W., and Margolis, F. L. (2004) The interaction of Bex and OMP reveals a dimer of OMP with a short half-life, J Neurochem 90, 102-116.
  5. Koo, J. H., Saraswati, M., and Margolis, F. L. (2005) Immunolocalization of Bex protein in the mouse brain and olfactory system, J Comp Neurol 487, 1-14.
  6. Reisert, J., Yau, K. W., and Margolis, F. L. (2007) Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons, J Physiol 585, 731-740.
  7. Schulze, D. H., Pyrski, M., Ruknudin, A., Margolis, J. W., Polumuri, S. K., and Margolis, F. L. (2002) Sodium-calcium exchangers in olfactory tissue, Ann N Y Acad Sci 976, 67-72.
  8. Wright, N. T., Margolis, J. W., Margolis, F. L., and Weber, D. J. (2005) Refinement of the solution structure of rat olfactory marker protein (OMP), J Biomol NMR 33, 63-68.

Alex C. Drohat

  1. Bennett, M. T., Rodgers, M. T., Hebert, A. S., Ruslander, L. E., Eisele, L., and Drohat, A. C. (2006) Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability, J Am Chem Soc 128, 12510-12519.
  2. Cao, C., Kwon, K., Jiang, Y. L., Drohat, A. C., and Stivers, J. T. (2003) Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I, J Biol Chem 278, 48012-48020.
  3. Drohat, A. C., Amburgey, J. C., Abildgaard, F., Starich, M. R., Baldisseri, D., and Weber, D. J. (1996) Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy, Biochemistry 35, 11577-11588.
  4. Drohat, A. C., Baldisseri, D. M., Rustandi, R. R., and Weber, D. J. (1998) Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy, Biochemistry 37, 2729-2740.
  5. Drohat, A. C., Jagadeesh, J., Ferguson, E., and Stivers, J. T. (1999) Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase, Biochemistry 38, 11866-11875.
  6. Drohat, A. C., Kwon, K., Krosky, D. J., and Stivers, J. T. (2002) 3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member, Nat Struct Biol 9, 659-664.
  7. Drohat, A. C., and Stivers, J. T. (2000) Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2, Biochemistry 39, 11865-11875.
  8. Drohat, A. C., Tjandra, N., Baldisseri, D. M., and Weber, D. J. (1999) The use of dipolar couplings for determining the solution structure of rat apo-S100B(betabeta), Protein Sci 8, 800-809.
  9. Drohat, A. C., Xiao, G., Tordova, M., Jagadeesh, J., Pankiewicz, K. W., Watanabe, K. A., Gilliland, G. L., and Stivers, J. T. (1999) Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187, Biochemistry 38, 11876-11886.
  10. Fitzgerald, M. E., and Drohat, A. C. (2008) Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex, J Biol Chem 283, 32680-32690.
  11. Fitzgerald, M. E., and Drohat, A. C. (2008) Structural studies of RNA/DNA polypurine tracts, Chem Biol 15, 203-204.
  12. Guan, X., Madabushi, A., Chang, D. Y., Fitzgerald, M. E., Shi, G., Drohat, A. C., and Lu, A. L. (2007) The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase, Nucleic Acids Res 35, 6207-6218.
  13. Jiang, Y. L., Drohat, A. C., Ichikawa, Y., and Stivers, J. T. (2002) Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis, J Biol Chem 277, 15385-15392.
  14. Landar, A., Hall, T. L., Cornwall, E. H., Correia, J. J., Drohat, A. C., Weber, D. J., and Zimmer, D. B. (1997) The role of cysteine residues in S100B dimerization and regulation of target protein activity, Biochim Biophys Acta 1343, 117-129.
  15. Morgan, M. T., Bennett, M. T., and Drohat, A. C. (2007) Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG, J Biol Chem 282, 27578-27586.
  16. Rustandi, R. R., Baldisseri, D. M., Drohat, A. C., and Weber, D. J. (1999) Structural changes in the C-terminus of Ca2+-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53, Protein Sci 8, 1743-1751.
  17. Rustandi, R. R., Drohat, A. C., Baldisseri, D. M., Wilder, P. T., and Weber, D. J. (1998) The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53, Biochemistry 37, 1951-1960.
  18. Stivers, J. T., and Drohat, A. C. (2001) Uracil DNA glycosylase: insights from a master catalyst, Arch Biochem Biophys 396, 1-9.
  19. Wilder, P. T., Rustandi, R. R., Drohat, A. C., and Weber, D. J. (1998) S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner, Protein Sci 7, 794-798.

Lindsay W. Black

  1. Bair, C. L., and Black, L. W. (2007) A type IV modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified DNAs, J Mol Biol 366, 768-778.
  2. Bair, C. L., Rifat, D., and Black, L. W. (2007) Exclusion of glucosyl-hydroxymethylcytosine DNA containing bacteriophages is overcome by the injected protein inhibitor IPI*, J Mol Biol 366, 779-789.
  3. Baumann, R. G., Mullaney, J., and Black, L. W. (2006) Portal fusion protein constraints on function in DNA packaging of bacteriophage T4, Mol Microbiol 61, 16-32.
  4. Black, L. W., and Peng, G. (2006) Mechanistic coupling of bacteriophage T4 DNA packaging to components of the replication-dependent late transcription machinery, J Biol Chem 281, 25635-25643.
  5. Fokine, A., Leiman, P. G., Shneider, M. M., Ahvazi, B., Boeshans, K. M., Steven, A. C., Black, L. W., Mesyanzhinov, V. V., and Rossmann, M. G. (2005) Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry, Proc Natl Acad Sci U S A 102, 7163-7168.
  6. Rifat, D., Wright, N. T., Varney, K. M., Weber, D. J., and Black, L. W. (2008) Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target, J Mol Biol 375, 720-734.

James P. Nataro

  1. Farfan, M. J., Inman, K. G., and Nataro, J. P. (2008) The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins, Infect Immun 76, 4378-4384.
  2. de Luna, M. G., Scott-Tucker, A., Desvaux, M., Ferguson, P., Morin, N. P., Dudley, E. G., Turner, S., Nataro, J. P., Owen, P., and Henderson, I. R. (2008) The Escherichia coli biofilm-promoting protein Antigen 43 does not contribute to intestinal colonization, FEMS Microbiol Lett 284, 237-246.
  3. Boisen, N., Struve, C., Scheutz, F., Krogfelt, K. A., and Nataro, J. P. (2008) New adhesin of enteroaggregative Escherichia coli related to the Afa/Dr/AAF family, Infect Immun 76, 3281-3292. V
  4. elarde, J. J., Varney, K. M., Inman, K. G., Farfan, M., Dudley, E., Fletcher, J., Weber, D. J., and Nataro, J. P. (2007) Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli, Mol Microbiol 66, 1123-1135.

France Carrier

  1. Yang, R., Weber, D. J., and Carrier, F. (2006) Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18, Nucleic Acids Res 34, 1224-1236.
  2. Wilder, P. T., Lin, J., Bair, C. L., Charpentier, T. H., Yang, D., Liriano, M., Varney, K. M., Lee, A., Oppenheim, A. B., Adhya, S., Carrier, F., and Weber, D. J. (2006) Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B, Biochim Biophys Acta 1763, 1284-1297.
  3. Markowitz, J., Mackerell, A. D., Jr., Carrier, F., Charpentier, T. H., and Weber, D. J. (2005) Design of Inhibitors for S100B, Curr Top Med Chem 5, 1093-1108.
  4. Markowitz, J., Chen, I., Gitti, R., Baldisseri, D. M., Pan, Y., Udan, R., Carrier, F., MacKerell, A. D., Jr., and Weber, D. J. (2004) Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction, J Med Chem 47, 5085-5093.
  5. Maiguel, D. A., Jones, L., Chakravarty, D., Yang, C., and Carrier, F. (2004) Nucleophosmin sets a threshold for p53 response to UV radiation, Mol Cell Biol 24, 3703-3711.
  6. Kim, M. S., Blake, M., Baek, J. H., Kohlhagen, G., Pommier, Y., and Carrier, F. (2003) Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA, Cancer Res 63, 7291-7300.
  7. Yang, C., and Carrier, F. (2001) The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response, J Biol Chem 276, 47277-47284.

A-Lien Lu-Chang

  1. Bai, H., and Lu, A. L. (2007) Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS, J Bacteriol 189, 902-910.
  2. Bai, H., Grist, S., Gardner, J., Suthers, G., Wilson, T. M., and Lu, A. L. (2007) Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis, Cancer Lett 250, 74-81.
  3. Shi, G., Chang, D. Y., Cheng, C. C., Guan, X., Venclovas, C., and Lu, A. L. (2006) Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1, Biochem J 400, 53-62.
  4. Lu, A. L., Lee, C. Y., Li, L., and Li, X. (2006) Physical and functional interactions between Escherichia coli MutY and endonuclease VIII, Biochem J 393, 381-387.
  5. Lu, A. L., Bai, H., Shi, G., and Chang, D. Y. (2006) MutY and MutY homologs (MYH) in genome maintenance, Front Biosci 11, 3062-3080.
  6. Chang, D. Y., and Lu, A. L. (2005) Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe, J Biol Chem 280, 408-417.
  7. Bai, H., Jones, S., Guan, X., Wilson, T. M., Sampson, J. R., Cheadle, J. P., and Lu, A. L. (2005) Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis, Nucleic Acids Res 33, 597-604.
  8. Lee, C. Y., Bai, H., Houle, R., Wilson, G. M., and Lu, A. L. (2004) An Escherichia coli MutY mutant without the six-helix barrel domain is a dimer in solution and assembles cooperatively into multisubunit complexes with DNA, J Biol Chem 279, 52653-52663.
  9. Lu, A. L., and Wright, P. M. (2003) Characterization of an Escherichia coli mutant MutY with a cysteine to alanine mutation at the iron-sulfur cluster domain, Biochemistry 42, 3742-3750.
  10. Li, L., and Lu, A. L. (2003) The C-terminal domain of Escherichia coli MutY is involved in DNA binding and glycosylase activities, Nucleic Acids Res 31, 3038-3049.
  11. Gu, Y., Parker, A., Wilson, T. M., Bai, H., Chang, D. Y., and Lu, A. L. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6, J Biol Chem 277, 11135-11142.
  12. Chang, D. Y., and Lu, A. L. (2002) Functional interaction of MutY homolog with proliferating cell nuclear antigen in fission yeast, Schizosaccharomyces pombe, J Biol Chem 277, 11853-11858.
  13. Parker, A., Gu, Y., Mahoney, W., Lee, S. H., Singh, K. K., and Lu, A. L. (2001) Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair, J Biol Chem 276, 5547-5555.
  14. Li, X., and Lu, A. L. (2001) Molecular cloning and functional analysis of the MutY homolog of Deinococcus radiodurans, J Bacteriol 183, 6151-6158.
  15. Parker, A., Gu, Y., and Lu, A. L. (2000) Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria, Nucleic Acids Res 28, 3206-3215.
  16. Li, X., Wright, P. M., and Lu, A. L. (2000) The C-terminal domain of MutY glycosylase determines the 7,8-dihydro-8-oxo-guanine specificity and is crucial for mutation avoidance, J Biol Chem 275, 8448-8455.
  17. Li, X., and Lu, A. L. (2000) Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA, Nucleic Acids Res 28, 4593-4603.
  18. Wright, P. M., Yu, J., Cillo, J., and Lu, A. L. (1999) The active site of the Escherichia coli MutY DNA adenine glycosylase, J Biol Chem 274, 29011-29018.
  19. Lu, A. L., and Fawcett, W. P. (1998) Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombe, J Biol Chem 273, 25098-25105.
  20. Lu, A. L., Yuen, D. S., and Cillo, J. (1996) Catalytic mechanism and DNA substrate recognition of Escherichia coli MutY protein, J Biol Chem 271, 24138-24143.

Wuyuan Lu

  1. Pazgier, M., Liu, M., Zou, G., Yuan, W., Li, C., Li, J., Monbo, J., Zella, D., Tarasov, S. G., and Lu, W. (2009) Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX, Proc Natl Acad Sci U S A.
  2. Hu, Y., Ye, F., Lu, W., Hong, D., Wan, X., and Xie, X. (2009) HPV16 E6-Induced and E6AP-Dependent Inhibition of the Transcriptional Coactivator hADA3 in Human Cervical Carcinoma Cells, Cancer Invest, 1.
  3. Zou, G., de Leeuw, E., Lubkowski, J., and Lu, W. (2008) Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide, J Mol Biol 381, 1281-1291.
  4. Zhang, B., Luo, Y., Weng, Q., He, Q., Lu, W., and Yang, B. (2008) CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901, Invest New Drugs 26, 517-524.
  5. Rajabi, M., de Leeuw, E., Pazgier, M., Li, J., Lubkowski, J., and Lu, W. (2008) The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability, J Biol Chem 283, 21509-21518.
  6. Li, C., Liu, M., Monbo, J., Zou, G., Yuan, W., Zella, D., Lu, W. Y., and Lu, W. (2008) Turning a scorpion toxin into an antitumor miniprotein, J Am Chem Soc 130, 13546-13548.
  7. Klotman, M. E., Rapista, A., Teleshova, N., Micsenyi, A., Jarvis, G. A., Lu, W., Porter, E., and Chang, T. L. (2008) Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission, J Immunol 180, 6176-6185.
  8. Zou, G., de Leeuw, E., Li, C., Pazgier, M., Zeng, P., Lu, W. Y., Lubkowski, J., and Lu, W. (2007) Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs, J Biol Chem 282, 19653-19665.
  9. Wu, Z., Li, X., Ericksen, B., de Leeuw, E., Zou, G., Zeng, P., Xie, C., Li, C., Lubkowski, J., Lu, W. Y., and Lu, W. (2007) Impact of pro segments on the folding and function of human neutrophil alpha-defensins, J Mol Biol 368, 537-549.
  10. Pazgier, M., Li, X., Lu, W., and Lubkowski, J. (2007) Human defensins: synthesis and structural properties, Curr Pharm Des 13, 3096-3118.
  11. Lu, W., Cui, Z., Wang, D., Lee, K. S., Park, N. S., Kim, D. H., and Jin, B. R. (2007) Molecular cloning and characterization of a cDNA encoding a novel antibacterial peptide, defensin, from the mulberry longicorn beetle, Apriona germari, DNA Seq 18, 160-164.
  12. de Leeuw, E., and Lu, W. (2007) Human defensins: turning defense into offense?, Infect Disord Drug Targets 7, 67-70.
  13. de Leeuw, E., Burks, S. R., Li, X., Kao, J. P., and Lu, W. (2007) Structure-dependent functional properties of human defensin 5, FEBS Lett 581, 515-520.
  14. Szyk, A., Wu, Z., Tucker, K., Yang, D., Lu, W., and Lubkowski, J. (2006) Crystal structures of human alpha-defensins HNP4, HD5, and HD6, Protein Sci 15, 2749-2760.
  15. Pazgier, M., Hoover, D. M., Yang, D., Lu, W., and Lubkowski, J. (2006) Human beta-defensins, Cell Mol Life Sci 63, 1294-1313.
  16. Lu, W. J., and Abrams, J. M. (2006) Lessons from p53 in non-mammalian models, Cell Death Differ 13, 909-912.
  17. Buck, C. B., Day, P. M., Thompson, C. D., Lubkowski, J., Lu, W., Lowy, D. R., and Schiller, J. T. (2006) Human alpha-defensins block papillomavirus infection, Proc Natl Acad Sci U S A 103, 1516-1521.
  18. Aono, S., Li, C., Zhang, G., Kemppainen, R. J., Gard, J., Lu, W., Hu, X., Schwartz, D. D., Morrison, E. E., Dykstra, C., and Shi, J. (2006) Molecular and functional characterization of bovine beta-defensin-1, Vet Immunol Immunopathol 113, 181-190.
  19. Xie, C., Zeng, P., Ericksen, B., Wu, Z., Lu, W. Y., and Lu, W. (2005) Effects of the terminal charges in human neutrophil alpha-defensin 2 on its bactericidal and membrane activity, Peptides 26, 2377-2383.
  20. Xie, C., Prahl, A., Ericksen, B., Wu, Z., Zeng, P., Li, X., Lu, W. Y., Lubkowski, J., and Lu, W. (2005) Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids, J Biol Chem 280, 32921-32929.
  21. Wu, Z., Li, X., de Leeuw, E., Ericksen, B., and Lu, W. (2005) Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?, J Biol Chem 280, 43039-43047.
  22. Wu, Z., Cocchi, F., Gentles, D., Ericksen, B., Lubkowski, J., Devico, A., Lehrer, R. I., and Lu, W. (2005) Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro, FEBS Lett 579, 162-166.
  23. Sun, L., Finnegan, C. M., Kish-Catalone, T., Blumenthal, R., Garzino-Demo, P., La Terra Maggiore, G. M., Berrone, S., Kleinman, C., Wu, Z., Abdelwahab, S., Lu, W., and Garzino-Demo, A. (2005) Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection, J Virol 79, 14318-14329.
  24. Ericksen, B., Wu, Z., Lu, W., and Lehrer, R. I. (2005) Antibacterial activity and specificity of the six human {alpha}-defensins, Antimicrob Agents Chemother 49, 269-275.
  25. Wu, Z., Ericksen, B., Tucker, K., Lubkowski, J., and Lu, W. (2004) Synthesis and characterization of human alpha-defensins 4-6, J Pept Res 64, 118-125.
  26. Wu, Z., Prahl, A., Powell, R., Ericksen, B., Lubkowski, J., and Lu, W. (2003) From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain, J Pept Res 62, 53-62.
  27. Wu, Z., Powell, R., and Lu, W. (2003) Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide, J Am Chem Soc 125, 2402-2403.
  28. Wu, Z., Hoover, D. M., Yang, D., Boulegue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J., and Lu, W. (2003) Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3, Proc Natl Acad Sci U S A 100, 8880-8885.

John M. Hamlyn

  1. Manunta, P., Ferrandi, M., Bianchi, G., and Hamlyn, J. M. (2009) Endogenous ouabain in cardiovascular function and disease, J Hypertens 27, 9-18.
  2. Blaustein, M. P., Zhang, J., Chen, L., Song, H., Raina, H., Kinsey, S. P., Izuka, M., Iwamoto, T., Kotlikoff, M. I., Lingrel, J. B., Philipson, K. D., Wier, W. G., and Hamlyn, J. M. (2009) The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension, Hypertension 53, 291-298.
  3. Blaustein, M. P., Hamlyn, J. M., and Pallone, T. L. (2007) Sodium pumps: ouabain, ion transport, and signaling in hypertension, Am J Physiol Renal Physiol 293, F438; author reply F439.
  4. Hamlyn, J. M. (2004) Biosynthesis of endogenous cardiac glycosides by mammalian adrenocortical cells: three steps forward, Clin Chem 50, 469-470.
  5. Hamlyn, J. M., Laredo, J., Shah, J. R., Lu, Z. R., and Hamilton, B. P. (2003) 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications, Ann N Y Acad Sci 986, 685-693.

Kristen M. Varney (formally Kristen Vallely)

  1. Ruminski, R. R., Underwood, S., Vallely, K., and Smith, S. J. (1998) Synthesis and Characterization of [Ru(dpop')(2)](PF(6))(2). A Ruthenium(II) Complex with the Novel Mixed-Denticity Bridging Ligand Dipyrido(2,3-a:3',2'-j)phenazine (dpop'), Inorg Chem 37, 6528-6531.
  2. Rustandi, R., Vallely, K. M., Varlamova, O., Klein, M. G., Almo, S. C., Bresnick, A. R., and Weber, D. J. (2001) 1H, 13C, 15N NMR sequence-specific resonance assignments for human apo-Mts1 (S100A4), J Biomol NMR 19, 381-382.
  3. Vallely, K. M., Rustandi, R. R., Ellis, K. C., Varlamova, O., Bresnick, A. R., and Weber, D. J. (2002) Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy, Biochemistry 41, 12670-12680.
  4. Wilder, P. T., Baldisseri, D. M., Udan, R., Vallely, K. M., and Weber, D. J. (2003) Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis, Biochemistry 42, 13410-13421.
  5. Gitti, R. K., Wright, N. T., Margolis, J. W., Varney, K. M., Weber, D. J., and Margolis, F. L. (2005) Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements, Biochemistry 44, 9673-9679.
  6. Markowitz, J., Rustandi, R. R., Varney, K. M., Wilder, P. T., Udan, R., Wu, S. L., Horrocks, W. D., and Weber, D. J. (2005) Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53, Biochemistry 44, 7305-7314.
  7. Wilder, P. T., Varney, K. M., Weiss, M. B., Gitti, R. K., and Weber, D. J. (2005) Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy, Biochemistry 44, 5690-5702.
  8. Wright, N. T., Varney, K. M., Ellis, K. C., Markowitz, J., Gitti, R. K., Zimmer, D. B., and Weber, D. J. (2005) The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy, J Mol Biol 353, 410-426.
  9. Garrett, S. C., Varney, K. M., Weber, D. J., and Bresnick, A. R. (2006) S100A4, a mediator of metastasis, J Biol Chem 281, 677-680.
  10. Wilder, P. T., Lin, J., Bair, C. L., Charpentier, T. H., Yang, D., Liriano, M., Varney, K. M., Lee, A., Oppenheim, A. B., Adhya, S., Carrier, F., and Weber, D. J. (2006) Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B, Biochim Biophys Acta 1763, 1284-1297.
  11. Velarde, J. J., Varney, K. M., Inman, K. G., Farfan, M., Dudley, E., Fletcher, J., Weber, D. J., and Nataro, J. P. (2007) Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli, Mol Microbiol 66, 1123-1135.
  12. Charpentier, T. H., Wilder, P. T., Liriano, M. A., Varney, K. M., Pozharski, E., MacKerell, A. D., Jr., Coop, A., Toth, E. A., and Weber, D. J. (2008) Divalent metal ion complexes of S100B in the absence and presence of pentamidine, J Mol Biol 382, 56-73.
  13. Malashkevich, V. N., Varney, K. M., Garrett, S. C., Wilder, P. T., Knight, D., Charpentier, T. H., Ramagopal, U. A., Almo, S. C., Weber, D. J., and Bresnick, A. R. (2008) Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA, Biochemistry 47, 5111-5126.
  14. Prosser, B. L., Wright, N. T., Hernandez-Ochoa, E. O., Varney, K. M., Liu, Y., Olojo, R. O., Zimmer, D. B., Weber, D. J., and Schneider, M. F. (2008) S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling, J Biol Chem 283, 5046-5057.
  15. Rifat, D., Wright, N. T., Varney, K. M., Weber, D. J., and Black, L. W. (2008) Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target, J Mol Biol 375, 720-734.
  16. Wright, N. T., Inman, K. G., Levine, J. A., Cannon, B. R., Varney, K. M., and Weber, D. J. (2008) Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B, J Biomol NMR 42, 279-286.
  17. Wright, N. T., Prosser, B. L., Varney, K. M., Zimmer, D. B., Schneider, M. F., and Weber, D. J. (2008) S100A1 and calmodulin compete for the same binding site on ryanodine receptor, J Biol Chem 283, 26676-26683.