Alan R. Shuldiner, M.D.
Associate Dean for Personalized & Genomic Medicine
John Whitehurst Professor of Medicine
Head, Division of Endocrinology, Diabetes & Nutrition
Director, Program in Personalized Medicine, University of Maryland School of Medicine
K12 Principal Investigator & Program Director
Dr. Shuldiner studies the genetics of complex disorders including type 2 diabetes, insulin resistance obesity, osteoporosis, and cardiovascular disease. He works as part of a large multidisciplinary team with expertise in clinical research, molecular genetics, cell biology, genetic epidemiology and statistical genetics. Utilizing candidate gene and genome-wide approaches, his team searches for susceptibility genes for these complex diseases and traits. Recent studies focus on gene-environment interactions and pharmacogenomics. Identification of susceptibility genes for these disorders and determining how they interact with the environment and lifestyle factors will provide novel avenues for therapy and prevention. At his Amish Research Clinic in Strasburg, PA, Dr. Shuldiner has recruited and studied over 4,000 Old Order Amish subjects for these studies. Recent accomplishments include the discovery of gene variants that influence fasting glucose and diabetes, height, lipids, blood pressure, uric acid, and response to aspirin and clopidogrel (Plavix). Translational studies are underway to begin to apply this new genetic knowledge to improve clinical care, a step toward personalized medicine.
Mary-Claire Roghmann, M.D., M.S.
Professor, Department of Epidemiology & Public Health
Dr. Roghmann is the principal investigator of the University of Maryland’s Clinical Research Curriculum Award (K30). She is responsible for advising K12 Scholars on their didactic training.
Dr. Roghmann is an infection disease physician whose research interests are focused on understanding the determinants and the outcomes of infections caused by antibiotic resistant bacteria particularly methicillin-resistant S. aureus. She has specific methodologic expertise in epidemiology and outcomes research, which she gained through a Masters degree. However, like many clinical investigators, she works with a multidisciplinary research team of biostatisticians, microbiologists, geneticist and others
Multidisciplinary Advisory Committee (MAC)
Per the NIH guidelines, the MAC is responsible for recruiting and selecting CR Scholars to the Program; establishing and reviewing the core curriculum; approving the education and career development plans (e.g., curriculum, mentors, research experience) and customizing an individual career development program for each CR Scholar; providing interim monitoring and evaluation of each CR Scholar’s progress with recommendations for modifications in the plan, if necessary, or termination of a CR Scholar who is not making adequate progress; and monitoring and evaluating the overall effectiveness of the Program.
The current membership of the University of Maryland Baltimore Multidisciplinary Advisory Committee (MAC) is as follows:
- Derek Haseltine, M.Ed., Director for Research Career Development, School of Medicine
- Charles D. Howell, M.D., Gastroenterology & Hepatitis, School of Medicine
- Bruce E. Jarrell, M.D., Executive Vice Dean, School of Medicine
- Deanna L. Kelly, Pharm.D., Psychiatry, School of Medicine
- Steven J. Kittner, M.D., Neurology, School of Medicine
- Karen L. Kotloff, , M.D., Pediatrics and Medicine, School of Medicine
- Timothy F. Meiller, D.D.S., Ph.D., Diagnostic Sciences, Dental School
- Mary-Claire Roghmann, M.D., M.S., Epidemiology & Preventive Medicine, School of Medicine
- Wendy Sanders, M.A., Assistant Dean for Research Career Development, School of Medicine
- Alan R. Shuldiner, M.D., Endocrinology & Genomics, School of Medicine
- Barbara A. Smith, Ph.D., RN, Associate Dean for Research, School of Nursing
- Soren Snitker, M.D., Ph.D., Endocrinology, School of Medicine