Leadership

Alan R. Shuldiner, M.D.
John Whitehurst Professor of Medicine
Head, Division of Endocrinology, Diabetes & Nutrition
Director, Program in Genetics and Genomic Medicine, University of Maryland School of Medicine
K12 Principal Investigator & Program Director

Dr. Shuldiner studies the genetics of complex disorders including type 2 diabetes, insulin resistance obesity, osteoporosis, and cardiovascular disease. He works as part of a large multidisciplinary team with expertise in clinical research, molecular genetics, cell biology, genetic epidemiology and statistical genetics. Utilizing candidate gene and genome-wide approaches, his team searches for susceptibility genes for these complex diseases and traits. Recent studies focus on gene-environment interactions and pharmacogenomics. Identification of susceptibility genes for these disorders and determining how they interact with the environment and lifestyle factors will provide novel avenues for therapy and prevention. At his Amish Research Clinic in Strasburg, PA, Dr. Shuldiner has recruited and studied over 4,000 Old Order Amish subjects for these studies. Recent accomplishments include the discovery of gene variants that influence fasting glucose and diabetes, height, lipids, blood pressure, uric acid, and response to aspirin and clopidogrel (Plavix). Translational studies are underway to begin to apply this new genetic knowledge to improve clinical care, a step toward personalized medicine.

Carol O. Tacket, M.D.
Professor of Medicine
Chief, Adult Clinical Studies Section, Center for Vaccine Development
Program Director, University of Maryland General Clinical Research Center
K12 Co-Program Director

 Dr. Tacket conducts Phase 1 and 2 clinical trials of experimental vaccines, primarily those directed against enteric infections such as cholera, typhoid and E. coli, and of other biologics, such as mucosal adjuvants, transgenic plant-based vaccines and milk immunoglobulin concentrates.  Dr. Tacket is interested in novel approaches to mucosal vaccination, including live viral and bacterial vectors, attenuated strains, plant-based vaccines, and mucosal adjuvants.  She develops Phase 1 and 2 clinical protocols in which volunteers from the community enroll, and supervises clinical nursing staffs involved in inpatient and outpatient vaccination studies and oversees regulatory affairs.  She is involved with inpatient challenge studies, when appropriate, to test efficacy of candidate vaccines.  Dr. Tacket is the Program Director of the School of Medicine's General Clinical Research Center (GCRC).  


Mary-Claire Roghmann, M.D., M.S.
Associate Professor
Division of Healthcare Outcomes Research,  Department of Epidemiology & Preventive Medicine

Dr. Roghmann is the principal investigator of the University of Maryland’s Clinical Research Curriculum Award (K30). She is responsible for advising K12 Scholars on their didactic training. 

Dr. Roghmann is an infection disease physician whose research interests are focused on understanding the determinants and the outcomes of infections caused by antibiotic resistant bacteria particularly methicillin-resistant S. aureus. She has specific methodologic expertise in epidemiology and outcomes research, which she gained through a Masters degree. However, like many clinical investigators, she works with a multidisciplinary research team of biostatisticians, microbiologists, geneticist and others

Multidisciplinary Advisory Committee (MAC)

Per the NIH guidelines, the MAC is responsible for recruiting and selecting CR Scholars to the Program; establishing and reviewing the core curriculum; approving the education and career development plans (e.g., curriculum, mentors, research experience) and customizing an individual career development program for each CR Scholar; providing interim monitoring and evaluation of each CR Scholar’s progress with recommendations for modifications in the plan, if necessary, or termination of a CR Scholar who is not making adequate progress; and monitoring and evaluating the overall effectiveness of the Program.

The current membership of the University of Maryland Baltimore Multidisciplinary Advisory Committee (MAC) is as follows:

• William T. Carpenter, Jr., M.D., Psychiatry, School of Medicine
• Michael Donnenberg, M.D., Infectious Diseases, School of Medicine
• Charles D. Howell, M.D., Gastroenterology & Hepatitis, School of Medicine
• Bruce E. Jarrell, M.D., Vice Dean for Academic Affairs, School of Medicine
• Steven J. Kittner, M.D., Neurology, School of Medicine
• Stephen B. Liggett, M.D., Medicine and Physiology, School of Medicine
• Karen L. Kotloff, , M.D., Pediatrics and Medicine, School of Medicine
• Timothy F. Meiller, D.D.S., Ph.D., Diagnostic Sciences, Dental School
• Ligia Peralta, M.D., Adolescent and Young Adult Medicine, School of Medicine
• Robert R. Redfield, M.D., Infectious Diseases, Institute for Human Virology
• Mary-Claire Roghmann, M.D., M.S., Epidemiology & Preventive Medicine, School of Medicine
• Alan R. Shuldiner, M.D., Endocrinology & Genomics, School of Medicine
• J. Marc Simard, M.D., Ph.D., Neurosurgery, School of Medicine
• Barbara A. Smith, Ph.D., RN, Associate Dean for Research, School of Nursing
• Soren Snitker, M.D., Ph.D., Endocrinology, School of Medicine
• Carol O. Tacket, M.D., Center for Vaccine Development & General Clinical Research Center, School of Medicine
• Angela Wilks, PhD., Associate Professor, Pharmaceutical Sciences, School of Pharmacy

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