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December 2009
 
Publications
Dear Colleagues:
What's on My Mind Podcast
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Dean Reece

What’s on my mind this month is the need to advocate for medical research funding. In October, I joined other academic medicine leaders at the National Press Club in Washington, DC, to thank the Obama Administration, Congress and the American taxpayers for the much-needed $10.4 billion in medical research funding included in the American Recovery and Reinvestment Act (ARRA), and to urge them to support significant annual budget increases for the National Institutes of Health (NIH) in order to sustain the momentum created by these funds.

The Obama administration has declared its willingness to invest in future breakthroughs in science and medicine. The ARRA grants will support the full spectrum of medical research, with emphasis on such areas as H1N1 flu, heart disease, HIV/AIDS, autism, and cancer. The president hopes the investment will also lead to new jobs conducting research, manufacturing and supplying medical equipment, and building and modernizing laboratories and research facilities.

School of Medicine researchers have already received $40 million in stimulus funding, although most of the ARRA funding has not been awarded. These grants support our work in cutting-edge fields such as personalized medicine, organ transplantation, stem cell research, health disparities and gene therapy.

As you know, biomedical research is about investment, with the associated short- and long-term return on that investment. The long-term benefit includes bringing hope to patients with new cures and preventive tools to improve human health, and also serving as a major economic engine. In the short term, our research can rejuvenate the struggling economy by the creation of well-paying jobs. The ARRA funds enable us to grow our economic footprint by recruiting new research scientists to explore exciting, growing fields such as stem cell research, and also funds the networks of staff to support them.

These innovative new projects explore cutting-edge ideas about the future of medicine and bring much-needed jobs to Maryland. We hope both the science and the jobs will last long after the stimulus dollars are spent. In order for this to happen, we must redouble our efforts to deepen and broaden our research programs. We must think big and think programmatically. We must identify collaborators and seek funding to support new program project or center grant ideas.

For the momentum that we’ve gained from the ARRA funds to blossom into cures that will save lives years down the road, we are dependent on robust and sustained NIH support. We’re very excited about this ‘shot in the arm,’ but we need continued and consistent funding of biomedical research to achieve the greatest possible benefit for human health and the economy.

The Association of Academic Medical Centers has established a coalition of concerned patients and physicians and researchers from across America to spearhead a national campaign called Research Means Hope to advocate for sustained, real growth in federal support for medical research funded by the National Institutes of Health. I urge you to send a message to President Obama to thank him for his support of the NIH and to express your support for significant annual increases in funding for medical research. It is critical the president receives as many mes-sages as possible while key decisions are being made about funding for next year.

Please visit the Research Means Hope Website for more information on how to get involved: www.researchmeanshope.org.

In the relentless pursuit of excellence, I am

Sincerely yours,

signature

E. Albert Reece, MD, PhD, MBA
Vice President for Medical Affairs, University of Maryland
John Z. and Akiko K. Bowers Distinguished Professor &
Dean, University of Maryland School of Medicine

 
Publications

Nicholas Carbonetti, PhD

Nicholas Carbonetti

Nicholas Carbonetti, PhD, associate professor, Department of Microbiology & Immunology, along with Charlotte Andreasen, PhD, and Daniel Powell, graduate student, both from the Molecular Microbiology & Immunology Program, co-authored “Pertussis Toxin Stimulates IL-17 Production in Response to Bordetella pertussis Infection in Mice” in PLoS ONE, Volume 4, September 17, 2009.

Marcus C. Chibucos, PhD

Marcus C. Chibucos, PhD, bioinformatics analyst, Institute for Genome Sciences, was first author on “Describing Commonalities in Microbial Effector Delivery Using the Gene Ontology” in Trends in Microbiology, July 2009, Vol. 17, Number 7, 312–319.

Gregory Melikian, PhD

Gregory Melikian
Gregory Melikian, PhD, professor, Department of Microbiology & Immunology and Institute of Human Virology, along with Yuri Kim, PhD, research associate, and Olga Latinovic, PhD, research associate, both from the Department of Microbiology & Immunology and Institute of Human Virology, co-published “HIV Enters Cells via Endocy-tosis and Dynamin-Dependent Fusion with Endosomes” in Cell, 2009, 137:433-444, and “Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-helix Bundle Formation” in PLoS Pathogens, 2009 5(9):e1000585.

Rita Verma, MBBS

Rita Verma, MBBS, associate professor, Department of Pediatrics, published an abstract entitled “Clinical Determinants and Utility of Early Postnatal Maximum Weight Loss in Fluid Management of Extremely Low Birth Weight Infants” in Early Human Development, 2009, 85, 59-64. Dr. Verma’s abstract is available at www. sciencedirect.com.

W. Florian Fricke, PhD
and Jacques Ravel, PhD

Florian Fricke

W. Florian Fricke, PhD (pictured), research associate, Department of Microbiology & Immunology and Institute for Genome Sciences, and Jacques Ravel, PhD, associate professor, Department of Microbiology & Immunology and Institute for Genome Sciences, were first and last authors, respectively, of an article entitled “Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family” in Bacteriology, 2009 August; 191(15):4750-7. In addition, Drs. Fricke and Ravel, along with David Rasko, PhD, assistant professor, Department of Microbiology & Immunology and Institute for Genome Sciences, co-authored an article entitled “Antimicrobial Resistance-encoding APEC Plasmids in Salmonella Enteric Serovar Kentucky from Poultry” in Applied and Environmental Microbiology, 2009 September; 75(18).

Geoffrey Crawford, MD

Geoffrey Crawford, MD, preventive medicine resident/PGY-2, Department of Epidemiology & Preventive Medicine, published an article on controversial author-physician Louis-Ferdinand Celine. Dr. Crawford’s article, “Monstrosity, Medicine and Misunderstanding. The Infamy and Polemics of the Twentieth-century Literary Giant Louis-Ferdinand Celine,” was published by Pharos, the magazine of the Alpha Omega Alpha Honor Medical Society, 2009 Summer;72(3):14-22. For more information, please see PubMed ID: 19722299.

David A. Jerrard, MD

David Jerrard
David A. Jerrard, MD, associate professor, Department of Emergency Medicine, published an article entitled “Male Patient Visits to the Emergency Department Decline During the Play of Major Sporting Events” in the May 2009 issue of the Western Journal of Emergency Medicine.

Mary McKenna, PhD

Mary McKenna

Mary McKenna, PhD, associate professor, Department of Pediatrics, published “Neurodegeneration and Regeneration” in a May 2009 special issue of the Journal of Neurochemistry, volume 109, issue s1, pages 1-313.

Michelle G. Giglio, PhD

Michelle G. Giglio, PhD, assistant professor, Department of Medicine and Institute for Genome Sciences, was first author on “Applying the Gene Ontology in Microbial Annotation” in a special edition of Trends in Microbiology, July 2009, Vol. 17, Number 7, 262–268.

Ribal Darwish, MD, and
Nana Amiridze, MD, PhD


Nana Amiridze
Ribal Darwish, MD, assistant professor, Department of Anesthesiology, and Nana Amiridze, MD, PhD (pictured), assistant professor, Department of Diagnostic Radiology & Nuclear Medicine, co-authored “Hemodynamic Instability during Treatment of Intracranial Dural Arteriovenous Fistula and Carotid Cavernous Fistula with Onyx: Preliminary Results and Anesthesia Considerations” in the September 2009 issue of the Journal of NeuroInterventional Surgery, doi:10.1136/jnis.2009.000042.

Linda Lewin, MD

Linda Lewin, MD, clinical associate professor, Department of Pediatrics, published the manuscript “Improving Education in Primary Care: Development of an Online Curriculum Using the Blended Learning Model.” To read Dr. Lewin’s abstract, click here.

Events

Kenneth H. Butler, DO

Kenneth Butler

Kenneth H. Butler, DO, associate professor, Department of Emergency Medicine, was an invited speaker at the Third International Congress of the Polish Society for Emergency Medicine, held in Wroclaw, Poland, in June 2009. He served as course director for the pre-conference advanced airway management course and presented a lecture on rapid-sequence intubation.

Joana Carneiro da Silva, PhD

Joana Carneiro da Silva
Joana Carneiro da Silva, PhD, assistant professor, Department of Microbiology & Immunology and Institute for Genome Sciences, presented a lecture entitled, “Apicom-plexan Parasites: A Model System for Disease and for Evolutionary Genomics” at the Gordon Research Conference on Evolutionary & Ecological Functional Genomics, in Tilton, New Hampshire, in July 2009.

Steven J. Czinn, MD

Steve Czinn

Steven J. Czinn, MD, professor and chair, Department of Pediatrics, was the invited plenary session speaker at the 15th International Workshop on Campylobactyer, Helcobacter and Related Organisms (CHRO) held in Toki Messe, Japan, September 2009, presenting “Vaccine Development to Prevent or Eradicate H.pylori Infection: An Update.”

Laundette Jones, PhD

Laundette Jones
Laundette Jones, PhD, assistant professor, Department of Pharmacology & Experimental Therapeutics, was one of four panelists who spoke before the 300+ audience at the American Cancer Society’s South Atlantic Division’s “Making Strides against Breast Cancer Kick-Off Breakfast” on August 19, 2009, at M&T Bank Stadium in Baltimore. This event marked the beginning of the 2009 National Breast Cancer Awareness Month. Dr. Jones spoke on “Increasing the Impact of Breast Cancer Research through Multidisciplinary Partnership.” Other speakers spoke on the clinical efforts regarding the treatment of cancer.

Amal Mattu, MD, and
Michael E. Winters, MD

Amal Mattu

Amal Mattu, MD (pictured), associate professor, and Michael E. Winters, MD, assistant professor, both from the Department of Emergency Medicine, were featured speakers at the 1st Annual Symposium on Critical Care in the Emergency Department sponsored by Florida Emergency Physicians in Orlando, Florida, in June 2009. They presented six and four lectures, respectively, during the two-day event. The symposium was organized at the suggestion of Dr. Mattu, who remained a resource for the sponsoring association during planning.

Larry D. Weiss, MD, JD, FAAEM

Larry Weiss

Larry D. Weiss, MD, JD, FAAEM, professor, Department of Emergency Medicine, gave a series of grand rounds lectures at the Harvard Medical School-affiliated pro-grams in emergency medicine at both the Brigham & Women’s Hospital and the Beth Israel Deaconess Medical Center in Boston, Massachusetts, in July 2009. His topics were “Risk Reduction in Emergency Medicine,” “The Anatomy of a Medical Malpractice Lawsuit” and “Emergency Physician Advocacy.”

New Staff

Andrew B. Dunsmore, PhD

Andrew Dunsmore

Andrew B. Dunsmore, PhD, joined the Office of Development as assistant dean for Development in October 2009. Dr. Dunsmore comes to the School of Medicine from the Johns Hopkins University, where he held the position of director of Development in the Department of Neurosurgery. In 2007 he obtained a Doctor of Philosophy from the University of Tennessee, where he had previously earned bachelors and masters degrees. Dr. Dunsmore has previous experience in higher education and medical devel-opment, including director of Development and Alumni Affairs for both the University of Tennessee College of Social Work and Hiwassee College and associate director of Medical Development for Washington University School of Medicine. The assistant dean for Development provides executive level leadership and counsel in the strategic and operational work of the development office. This position assists the associate dean for Development and the School of Medicine dean in expanding effective fundraising throughout the institution by engaging department chairs and directors of programs, centers and institutes as well as division heads and other medical faculty.

New Faculty

Erik von Rosenvinge, MD

Erik von Rosenvinge

Erik von Rosenvinge, MD, joined the Department of Medicine, in the Division of Gastroenterology & Hepatology, in July 2009 as an assistant professor. Dr. von Rosenvinge graduated, with Alpha Omega Alpha honors, from the New York University School of Medicine and completed his residency in internal medicine at David Grant United States Air Force Medical Center at Travis Air Force Base in northern California and UC Davis Medical Center in Sacramento, California. He served in the United States Air Force as an internist for four years before completing his gastroenterology fellowship in the combined University of Maryland/National Institutes of Health Scholars Program in 2009. Dr. von Rosenvinge’s research interests include Clostridium difficile infection, GI peptides and improving the techniques and patient comfort of endoscopy.

James Campagna, MD, and Amber Marshall,MD

James Campagna, MD, and Amber Marshall, MD, joined the Department of Emergency Medicine in July 2009 as clinical instructors, after completing the University of Maryland’s emergency medicine residency. Dr. Campagna received his medical degree from SUNY Upstate Medical University; Dr. Marshall received her medical degree from Tufts University School of Medicine. Their clinical responsibilities are in the emergency department at Mercy Medical Center in Baltimore. Dr. Campagna has an academic interest in critical care emergency medicine and faculty development. Dr. Marshall’s academic interest is in the use of ultrasound in emergency medicine.

Howard Kader, MD

Howard Kader, MD, joined the Department of Pediatrics, in the Division of Pediatric Gastroenterology, in July 2009 as an assistant professor. He received his medical degree from the University of Nebraska College of Medicine and then went on to complete an internship in general surgery at Washington Hospital Center in Washington, DC. His internship in pediatrics was completed at Creighton-Nebraska Universities Health Foundation’s Joint Pediatric Residency Program, at the University of Nebraska Medical Center (UNMC), and was followed by a two year pediatric residency at UNMC. Dr. Kader also completed a clinical and research fellowship in pediatric gastroenterology and nutrition at Children’s Hospital of Philadelphia.

Jennifer Reifel Saltzberg, MD

Jennifer Reifel Saltzberg, MD, joined the Department of Emergency Medicine in July 2009 as a clinical instructor. She is a graduate of the David Geffen School of Medicine at UCLA and of the emergency medicine residency at Henry Ford Hospital in Detroit, Michigan. Her academic interest is international emergency medicine.

Geoffrey L. Rosenthal, MD, PhD

Geoffrey Rosenthal

Geoffrey L. Rosenthal, MD, PhD, joined the Department of Pediatrics in July 2009 as a professor. He also is director of the University of Maryland Hospital for Children’s Heart Program and executive director of Critical Care Services. Prior to his recruitment to Maryland, Dr. Rosenthal worked for seven years at the Cleveland Clinic where he was a pediatric cardiologist, director of Pediatric Cardiovascular Research, director of Inpatient Medicine and director of Training for the Pediatric and Congenital Heart Center.

Dr. Rosenthal earned his BA in psychology from Boston University’s College of Liberal Arts, his MS in biostatistics from Georgetown University, his MD from the University of Maryland School of Medicine, and his PhD in epidemiology from the University of Maryland’s Graduate School. His pediatric internship and residency were completed at Baylor College of Medicine in Houston, Texas. Dr. Rosenthal then completed a two-year pediatric cardiology fellowship and advanced training in pediatric cardiac intensive care at the Lillie Frank Abercrombie Section of Cardiology at Texas Children’s Hospital in Houston. This was followed by a one-year teaching scholars program at the University of Washington School of Medicine. During this same time, Dr. Rosenthal worked as a pediatric cardiac intensivist and director of cardiovascular intense care services.

He is as a member of the Pediatric Advisory Committee to the FDA, co-chair of the Quality Metrics Working Group of the AC/PC Section of the American College of Cardiology and an executive committee member of the Section of Cardiology and Cardiac Surgery of the American Academy of Pediatrics. Dr. Rosenthal’s clinical interests are in pediatric cardiology, adult congenital cardiology and pediatric cardiac intensive care. His research interests focus on epidemiology and public health as they pertain to congenital heart disease and the primary prevention in the pediatric population of modifiable risk factors for adult coronary artery disease.

Under Dr. Rosenthal’s leadership, the heart program at the University of Maryland Hospital for Children will expand comprehensive cardiovascular care to meet the needs of the children of Maryland.

Suzie Noronha, MD

Suzie Noronha, MD, joined the Department of Pediatrics, in the Division of Pediatric Hematology/Oncology, in July 2009 as a clinical assistant professor. Dr. Noronha received her medical degree, cum laude, from the University at Buffalo School of Medicine & Biomedical Sciences. She completed her residency at the University of North Carolina-Chapel Hill, followed by a fellowship in pediatric hematology/oncology at Johns Hopkins Hospital and the National Cancer Institute.

Honors & Awards

Misbah Khan, MD, MPH

Misbah Khan

Misbah Khan, MD, MPH, clinical professor, Department of Pediatrics, was presented with a Lifetime Achievement Award from the Maryland Chapter of the American Academy of Pediatrics at their annual awards dinner in Baltimore in September 2009. She was honored with this well-deserved award because of her tireless dedication and devotion to the children of Maryland.

 

 

Grants & Contracts

Mordecai P. Blaustein, MD

Mordecai Blaustein

Mordecai P. Blaustein, MD, professor, Department of Physiology, received a $15,600 summer student supplement grant from the National Institute of Neurological Disorders and Stroke. This supplement is issued under NIH Notice NOT-OD-09-060 American Recovery and Reinvestment Act of 2009 and supports his current grant entitled “Sodium Ions and Calcium Signaling in Neurons and Glia.”

A-Lien Lu-Chang, PhD

A-Lien Lu-Chang

A-Lien Lu-Chang, PhD, professor, Department of Biochemistry & Molecular Biology, received a five-year $1,377,045 research grant from the National Cancer Institute for her work entitled “Repair of Oxidatively Damaged Guanines.”

 

Ricardo Feldman, PhD

Ricardo Feldman

Ricardo Feldman, PhD, associate professor, Department of Microbiology & Immunology, received a five-year $1,750,000 Maryland Stem Cell Research Foundation grant for his work entitled “Generation of Patient-Specific iPS Cells for Modeling and Treating Gaucher Disease.”

 

Martin Flajnik, PhD

Martin Flajnik

Martin Flajnik, PhD, professor, Department of Microbiology & Immunology, received a one-year $77,273 ARRA administrative supplement to his R01 National Institute of Health (NIH) grant entitled “Ontogeny and Phylogeny of the MHC.” In addition, Dr. Flajnik received a one-year $70,711 ARRA Research Resources supplement and a $37,680 ARRA summer student supplement to his R01 NIH grant entitled “Evolution of Adaptive Immunity.”

W. Florian Fricke, PhD and Owen White, PhD

Florian Fricke

W. Florian Fricke, PhD (pictured), research associate, Department of Microbiology & Immunology and Institute for Genome Sciences, and Owen White, PhD, professor, Department of Epidemiology & Preventive Medicine, and director of Bioinformatics, Institute for Genome Sciences, received a two-year $439,600 National Science Foundation grant to generate a bioinformatic resource for their work entitled “Automated and Portable Sequence Analysis Using Virtual Machines and Cloud Computing.”

James Kaper, PhD

James Kaper

James Kaper, PhD, professor and chair, Department of Microbiology & Immunology, received a one-year $132,803 T32 grant from the National Institute of Allergy and Infectious Diseases for “Immunity and Infection.”

 

Ferenc Livak, MD

Ferenc Livak

Ferenc Livak, MD, assistant professor, Department of Microbiology & Immunology, received a one-year $10,787 American Recovery and Reinvestment Act supplement to his R21 grant for his work entitled “Antibody Affinity Maturation in the Aging Bone Marrow.”

Myron Levine, MD

Mike Levine

Myron Levine, MD, professor, Department of Medicine, and director, Center for Vaccine Development, received a four-year $10,499,702 Gates Foundation Global Health Grant for his work entitled “Efficacy of Maternal Immunization with Influenza Vaccine in Preventing Influenza in Infants and Mothers in Mali, West Africa.” This award funds a project that proposes to provide quantitative information on the burden of influenza among pregnant women and young infants in Mali, West Africa (one of the world’s least developed countries in a region from which few data currently exist) and on the potential benefits to mothers and their young infants that can be derived from immunizing women with influenza vaccines late in their pregnancy.

Margaret M. McCarthy, PhD

Peg McCarthy

Margaret M. McCarthy, PhD, professor, Department of Physiology, received a $21,144 summer student supplement grant from the National Institute of Neurological Disorders and Stroke. This supplement is issued under NIH Notice NOT-OD-09-060 American Recovery and Reinvestment Act of 2009 and supports her current grant “Estradiol and Hippocampal Development.” In addition, Dr. McCarthy received a second administrative supplement grant from the National Institute of Neurological Disorders and Stroke in the amount of $128,270. This supplement is issued under NIH Notice NOT-OD-09-056 American Recovery and Reinvestment Act of 2009 and supports her current grant entitled “Estradiol and Hippocampal Development.”

Kamal Moudgil, MD, PhD

Kamal Moudgil

Kamal Moudgil, MD, PhD, associate professor, Department of Microbiology & Immunology, received a four-year $1,500,000 R01 grant from the National Center for Complementary and Alternative Medicine for his work entitled “Immune Modulation of Autoimmunity by Herbal Products.”

 

John Sacci, PhD

John Sacci

John Sacci, PhD, associate professor, Department of Microbiology & Immunology, received a two-year $75,000 R03 National Institutes of Health grant for “Plasmodium Induced New Permeation Pathways during Hepatocyte Infection.”

 

Eric Toth, PhD

Eric Toth

Eric Toth, PhD, assistant professor, Department of Biochemistry & Molecular Biology, received a four-year $720,000 research grant from the American Cancer Society for his work entitled “Structural and Biochemical Studies of the Human MutY Homologue hMYH.”

 

Paul A. Welling, MD

Paul Welling

Paul A. Welling, MD, professor, Department of Physiology, received a two-year $999,876 Challenge Grant from the National Institute of Diabetes and Digestive and Kidney Diseases for his work entitled “Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension.”

 

Gerald Wilson, PhD

Gerald Wilson

Gerald Wilson, PhD, associate professor, Department of Biochemistry & Molecular Biology, received a five-year $1,384,404 research grant from the National Cancer Institute for his work entitled “Mechanisms Directing Oncoprotein and Cytokine mRNA Decay.”

 
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