Publications - Autism/Rett Syndrome

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15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hogart, A., Nagarajan, R.P., Yasui, D.H., Patzel, K.A. and LaSalle, J.M. Human Mol. Genetics 16:691-703, 2007. [paper] 

Defects in MECP2 expression and epigenetic regulation are common in autism brain. Nagarajan, R., Patzel, K., Hogart, A., Martin, M. and LaSalle, J. KeystoneSymposia on Epigenetics, Breckenridge, CO 2007. [abstract] 

Dynamic changes in histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2. Thatcher, K.N. and LaSalle, J.M. Epigenetics 1(1): 24-31, 2006. [paper] 

Early growth response gene 2 (Egr2) is dysregulated in autism and Rett syndrome brain. Swanberg, S.E., Nagarajan, R.P. and LaSalle, J.M. SFN, 2007: 54.6/Q1. [abstract] 

Gain of imprinted expression of 15q11-13 GABAA receptor subunit genes in Rett syndrome and autism cerebral cortex. Hogart, A., Nagarajan, R., Yasui, D., Patzel, K. and LaSalle, J. 7th Annual Rett Syndome Symposium, Chicago, IL, 2006. [abstract] 

Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Thatcher, K., Brauschweig, D., Samaco, R. and LaSalle, J. ASHG, 2003. [abstract] 

Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Thatcher, K., Peddada, S., Yasui, D. and LaSalle, J. Human Molecular Genetics 14(6): 785-797, 2005. [paper] 

Loss of biallelic expression of 15q11-13 GABAA receptor subunit genes in Rett syndrome and autism cerebral cortex. Hogart, A., Nagarajan, R. Yasui, D., Patzel, K. and LaSalle, J. ASHG, 2006. [abstract] 

Multiple pathways regulate MeCP2 in normal brain delveopment and exhibit defects in non-MECP2 mutant Rett and autism samples. Samaco, R., Nagarajan, R., Braunschweig, D. and LaSalle, J. ASHG, 2003. [abstract] 

Reciprocal co-regulation if EGR2 and MECP2 is disrupted in Rett syndrome and autism. Swanberg, S., Nagarajan, R., Peddada, s., Yasuiand, D and LaSalle, J Human Mol. Genetics 18(3): 525-534, 2009. [paper] 

Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett Syndrome and autism. Swanberg, S., Nagariajan, R., Yasui, D., Peddada, S. and LaSalle, J. ASHG, 2008. [abstract] 

Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with abberrant MECP2 promoter methylation. Nagarajan, R., Hogart, A., Martin, M. and LaSalle, J. ASHG, 2006. [abstract] 

Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promotor methylation. Nagarajan, R.P., Hogart, A.R., Gwye, Y., Martin, M.R. and LaSalle, J.M. Epigenetics 1(4): 172-182, 2006. [paper]