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Core C

Imagining, Computation & Electrophysiology

Core Leader

Dr. Wier
Withrow G. Wier, PhD 

This core provides support for the PPG in the areas of imaging, database development and management, data storage, backup and archiving, and electrophysiology.

Major Purposes of the PPG Server

  • Organization of Data: Help people find and manage all the files they need. These files include original data files, analysis files and manuscripts that need to be prepared.
  • Animal Colony Management software  
  • Relationable Database of Results: This database would contain specific results from each project as described in the application.

These functions are implemented with a Dell PowerEdge 2850 Server, with 2 TeraBytes of storage capacity.

how the server works 

The experiments described in this Program are usually performed on tissue from rats and mice. Each piece of experimental data in the database is thus related to a particular experimental animal, and each animal used in the Program is assigned a unique number.

As an example of the data that are associated with each animal, consider one of the ouabain-hypertensive (OH) rats produced by Core B. Hemodynamic data (blood pressure and heart rate) are obtained before and at weekly intervals after implanting ouabain pellets. The data recorded in the database include the source (supplier of the animal), gender, housing conditions (e.g. temperature, diet, light/dark cycle), veterinary comments, date of implantation (one could later investigate the effect of seasonality), the person performing the implantation, the longitudinal hemodynamic data, the weight of the animal, etc. With the hemodynamic data, we record the date and the person taking the measurements. Eventually, tissue from these animals are harvested for experimental purposes.

Several projects share tissue from one animal. Therefore, we are collecting all the data in one place, so that we can know what results were obtained in each animal. Furthermore, the combined use of OH rats and transgenic animals by the different projects requires that the availability of these animals be carefully coordinated throughout this program. Core A is responsible for coordinating the availability of animals (via close interaction with Core B) with the schedules of key personnel in each of the projects. This guarantees the most efficient use of tissue from all animal models.