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The aim of this program is to elucidate fundamental mechanisms involved in the long-term elevation of blood pressure. The program is based on evidence that endogenous ouabain, a novel adrenocortical hormone, is elevated in many patients with essential hypertension and in many animal models of salt-dependent hypertension. We focus on the key roles of endogenous ouabain, ouabain-sensitive Na+ pumps (Na+, K+ -ATPase) and the Na+/Ca2+ exchanger (NCX)  in the pathogenesis of essential hypertension, as illustrated in Figure 1 and described in the overview below. The program fosters research interactions among a team of University of Maryland scientists and collaborators at other institutions around the world.

Figure 1

sequence of research
caption for figure 1
PPG Organization

PPG Organization

Project Leaders and Core Directors