Department of Biochemistry and Molecular Biology
Fluorescence Spectroscopy
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The department has a very active scientific and educational thrust in the area of fluorescence technology and biological applications, as parallel technical development and bio-application benefit each other. In some respect, the size and recognition of this endeavor is unique to our department. Much of this work is undertaken in collaboration with other departments of University of Maryland, or national and foreign institutions or corporations. A description of these activities can be found under the heading of Center for Fluorescence Spectroscopy. The leader of research in Fluorescence Spectroscopy is Dr. Joseph Lakowicz, who is currently demonstrating the potential of two-photon fluorescence excitation, light quenching (simulated emission), fluorescence lifetime-based imaging, and fluorescence anisotropy using transition metal complexes, to address biochemical and biophysical questions. Simultaneously, novel chemical sensors and probes are being developed for application in medicine and biotechnology. In related efforts, Dr. Richard Thompson is developing fluorescence-based fiber optic biosensors for metal ions and other analytes of clinical, research, and practical interest. In addition, drug interaction with topoisomerases are being studied using differential polarized phase fluorometry and related techniques.
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