UM SOM: Artificial Organs Lab
Strain Controlled LVAD Unloading and Cardiac Remodeling in Heart Failure
Overview
In spite of new medical therapies and intervention treatments, long-term sequelae of infarction remain a major clinical problem. In the United States, more than a million patients sustain LV injury from infarct annually, and more than five million suffer with heart failure (HF). Acute cardiac remodeling after infarction appears to be an adaptive process of hypertrophy in response to increased LV loading conditions and stretch with loss of contractility. As the scar expands, LV geometry becomes spherical, and normally perfused zones progressively become hypocontractile.
The objectives of this study are to:
-
Predict remodeling after MI using sonomicrometry array localization (SAL) strain maps
-
Show how reduction of LV strain by mechanical unloading using a left ventricular assist device (LVAD) reduces infarct size and remodeling
-
Show how post MI hypertophy and impaired EC coupling and apoptosis is regionally related to strain and reduced with unloading.
Printer friendly
Email this page