Publications

2008

• Casey PA, McKenna MC, Fiskum G, Saraswati M, Robertson CL.  Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.  J Neurotrauma. 2008 Jun;25(6):603-14

• Danilov CA, Fiskum G.  Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation.  Glia. 2008 Mar 13;56(7):801-808 [Epub ahead of print]

• Ahn E.S., Robertson C.L., Vereczki V., Hoffman G.E., Fiskum G.  Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.  J. Neurosurg. 2008 Jan;108(1):124-31.

• Bambrick L.L., Fiskum G.  Mitochondrial dysfunction in mouse trisomy 16 brain.  Brain Res. 2008 Jan 10;1188:9-16. Epub 2007 Oct 26.

2007

• Carlson D.E., Nguyen P.X., Soane L., Fiedler S.M., Fiskum G., Chiu W.C., Scalea T.M.  Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria.  Shock. 2007 Feb;27(2):192-8.
• Robertson, C., Saraswati, M., Fiskum, G. (2007)  Mitochondrial dysfunction early after traumatic brain injury in immature rats.  J. Neurochem. 101 (5), 1248–1257.
• Richards E.M., Fiskum G., Rosenthal R.E., Hopkins I., McKenna M.C.  Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism.  Stroke. 2007 May;38(5):1578-84. Epub 2007 Apr 5.
• Kahraman S., Fiskum G.  Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes.  Neurochem Res. 2007 Apr-May;32(4-5):799-806. Epub 2006 Dec 27.
• Kristian, T., Pivovarova, N.B., Fiskum, G., Andrews, S.B. (2007)  Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention J. Neurochem. 102 (4), 1346–1356.
• Soane L., Siegel Z.T., Schuh R.A., Fiskum G.  Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria.  J. Neurosci. Res. 2007 Dec 3 [Epub ahead of print]
• Soane L., Kahraman S., Kristian T., Fiskum G.  Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.  J Neurosci Res. 2007 Nov 15;85(15):3407-15.
• Kingsbury, T.J., Bambrick, L., Roby, C.D., Krueger, B.K. (2007)  Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons. J. Neurochem. 103 (2), 761–770.
• Mehrabyan, Z., Chandrasekaran, K., Kalakonda, S., Kristian, T., Fiskum, G., Kalvakolanu, D.V.  The IFN-β and Retinoic Acid-Induced Cell Death Regulator GRIM-19 is Upregulated During Focal Cerebral Ischemia.  Journal of Interferon & Cytokine Research. 2007, 27(5): 383-392. 

2006

• Chandrasekaran, K., Hazelton, J.L., Wang, Y., Fiskum, G., Kristian, T. (2006) Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J. Neurosci.26:13123-13127
• Robertson, C.L., Soane, L., Siegel, Z.T., Fiskum, G (2006) The potential role of mitochondria in pediatric traumatic brain injury. Dev. Neurosci.28:432-446
• Kim, G.J., Fiskum, G., Morgan, W.F. (2006) A role for mitochondrial dysfunction in perpetuating radiation-induced geonomic instability. Cancer Res. 66:10377-10383
• Bambrick, L.L., Chandrasekaran, K., Mehrabyan, Z., , Wright, C., Krueger, B. K., Fiskum, G. (2006) Cyclosporin A increases mitochondrial calcium uptake capacity in cortical astrocytes but not cerebellar granule neurons. J. Bioenerg, Biomemb.38:43-47
• Vereczki, V., Koves, K., Csaki, A., Grosz, K., Hoffman, G.E., Fiskum, G., (2006) Distribution of hypothalamic, hippocampal and other limbic peptidergic neuronal cell bodies giving rise to retinopetal fibers: anterograde and retrograde tracing and neuropeptide immunohistochemical studies. Neuroscience.140:1089-1100
• Hilton, G.D., Bambrick, L.L., Thompson, S.M., McCarthy, M.M. (2006) Estradiol modulation of kainic acid-induced calcium elevation in neonatal hippocampal neurons. Endocrinology.147:1246-1255
• Dorsey, S.G., Renn, C.L., Carim-Todd, L., Barrick, C.A., Bambrick, L., Krueger, B.K., Ward, C.W., Tessarollo, L. (2006) In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron.51:21-28
• Kristian, T., Hopkins, I.B., McKenna, M.C., Fiskum, G. (2006) Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation. J. Neurosci. Methods 152:136-143
• Vereczki, V., Martin, E., Rosenthal, R.E., Hof, P.R., Hoffman, G.E., Fiskum, G. (2006) Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab.26:821-835
• Balan, I.S., Fiskum, G., Hazelton, J., Cotto-Cumba, C., Rosenthal, R.E. (2006) Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. Stroke.37:3008-3013
• Robertson, C.L., Puskar, A., Hoffman, G.E., Murphy, A.Z., Saraswati, M., Fiskum, G. (2006) Physiologic progesterone reduces mitochondrial dysfuntion and hippocampal cell loss after traumatic brain injury in female rats. Exp. Neurol.197:235-243
• Richards, E.M., Rosenthal, R.E., Kristian, T., Fiskum, G. (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Rad. Biol. Med.40:1960-1970

2005

• Schuh, R., Kristian, T., Fiskum, G. (2005) Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J. of Neurochem.92:388-394
• Rosenthal, R.E., Bogaert, Y.E., Fiskum, G. (2005) Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs. Neurosci. Letts.378:82-87
• Chinopoulos, C., Starkov, A.A., Grigoriev, S., Dejean, L.M., Kinnally, K.W., Liu, X., Ambudkar, I.S., Fiskum, G. (2005) Diacylglycerols activate mitochondrial cationic channel(s) and release sequestered Ca^2+. J. of Bioenerg. Biomemb. 37:237-247
• Hainsworth, A.H., Bermpohl, D., Webb, T.E., Darwish, R., Fiskum, G., Qiu, J., McCarthy, D., Moskowitz, M.A., Whalen, M.J. (2005) Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J.Cereb. Blood Flow Metab.25:1030-1040
• Soane, L., Fiskum, G. (2005) Inhibition of Mitochondrial Neural Cell Death Pathways by Protein Transduction of Bcl-2 Family Proteins. J. Bioeneg. Biomemb.37:179-190
• Zanelli, S.A., Solenski, N.J., Rosenthal, R.E., Fiskum,G (2005) Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann.N.Y. Acad. Sci.1053:153-161
• Schuh, R.A., Kristian, T., Gupta, R.K., Flaws, J.A., Fiskum, G. (2005) Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol. Sci.88:495-504
• Vereczki, V., Martin, E., Rosenthal. R., Hof, P., Hoffman, G., Fiskum, G. (2005)Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, methabolic dysfunction and neuronal death. J. Cereb. Blood Flow Metab.26:821-835
• Rosenthal. R.E., Fiskum, G. (2005) Oxygen: You can get too much of a good thing. Hosp. Med. 66:76-77
• Nunez, J.L., Bambrick, L.L., Krueger, B.K., McCarthy, M.M. (2005) Prolongation and enhancement of gamma-aminobutyric acid receptor mediated excitation by chronic treatment with estradiol in developing rat hippocampal neurons. Eur. J. Neurosci. 21:3251-3261
• Martin, E., Rosenthal, R., Fiskum, G. (2005) Pyruvate Dehydrogenase Complex: Metabolic Link to Ischemic Brain Injury and Target of Oxidative Stress. J. of Neurosci.Res.79:240-247
• Kowaltowski, A., Fiskum, G. (2005) Redox Mechanisms of Cytoprotection by Bcl-2. Antioxidants & Redox Signaling.7:508-514
• Mehrabian, Z., Liu, L., Fiskum, G., Rapoport, S., Chandrasekaran, K. (2005) Regulation of mitochondrial gene expression by energy demand in neural cell. J. of Neurochem. 93:850-860
• Ahn, E.S., Robertson, C.L., Vereczki, V., Hoffman, G.E., Fiskum, G. (2005) Synthes Award for Resident Research on Brain and Craniofacial Injury: Normoxic ventilatory resuscitation after controlled cortical impact reduces peroxynitrite-mediated protein nitration in teh hippocampus. Clin Neurosurg. 52:348-356
• Soane, L., Fiskum, G. (2005) TAT-mediated intracellular delivery of the loop deletion BCL-2 protein protects neurons against cell death. J. Neurochem.95:230-243

2004

• Bambrick, L., Kristian, T., Fiskum, G. (2004) Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochemistry Res. 29:601-609
• Kowaltowski, A., Fenton, R., Fiskum, G. (2004) Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radical Biology & Medicine. 37:1845-1853
• Krajewska, M., Rosenthal, R.E., Mikolajczyk, J., Stennicke, H.R., Wiesenthal, T., Ma, J., Naito, M., Salvesen, G.S., Reed, J.C., Fiskum, G., Krajewski, S. (2004) Early processing of Bid and caspase-6,-8,-10,-14 in the canine brain during cardiac arrest and resuscitation. Exp. Neuro. 189:261-279
• Kowaltowski, A., Fenton, R.G., Fiskum, G. (2004) Family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radical Biology & Medicine. 37:1-9
• Kristian, T., Fiskum, G. (2004) A flourescence based technique for screening compounds that protect against damage to brain mitochondria. Brain Res.Protocol. 13:176-182
• Chinopoulos, C., Gerencser, A.A., Doczi, J., Fiskum, G., Adam-Vizi, V. (2004) Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La^3+ in cultured cortical neurons. J. Neurochem. 91:471-483
• Fiskum, G. (2004) Mechanisms of neuronal death and neuroprotection. J. Neurosurg. Anesthesiol. 16:108-110
• Kristian, T. (2004) Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calicum. 36:221-233
• Fiskum, G. (2004) Mitochondria and Neuroprotection - In memory of Albert L. Lehninger. J. Bioenerg and Biomemb. 36:275-276
• Starkov, A.A., Fiskum, G., Chinopoulos, C., Lorenzo, B.J., Browne, S.E., Patel, M.S., Beal, M.F. (2004) Mitochondrial alpha-keotglutarate dehydrogenase complex generates reactive oxygen species. J. Neurosci. 24:7779-7788
• Robertson, C.L. (2004) Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J. Bioenerg. and Biomemb. 36:363-368
• Starkov, A.A., Chinopoulos, C., Fiskum, G. (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calicum. 36:257-264
• Polster, B.M., Fiskum, G. (2004) Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90:1281-1289
• Robertson, C.L., Bucci, C.J., Fiskum, G. (2004) Mitochondrial response to calcium in the developing brain. Developmental Brain Res. 151:141-148
• Fiskum, G., Rosenthal, R., Vereczki, V., Martin, E., Hoffman, G., Chinopoulos, C., Kowaltowski, A. (2004) Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J. Bioenerg. and Biomemb. 36:347-351

2003

• Bambrick, L.L., Yarowsky, P.J., Krueger, B.K. (2003) Abnormal calcium regulation in astrocytes rom the Ts65Dn mouse, a partial trisomy of chromosome 16. J. Neurosci. 73: 89-94
• Bambrick, L.L., Yarowsky, P.J., Krueger, B.K. (2003) Altered astrocyte calcium homeostatsis and proliferation in the Tz65Dn mouse, a model of down syndrome. J. Neurosci. Res. 73:89-94
• Kingsbury, T.J., Murray, P.D., Bambrick, L.L., Krueger, B.K. (2003) Ca^2+ -dependent regulation of TrkB expression in neurons. J. Biological Chemistry. 278:40744-40748
• Madhavarao, C.N., Chinopoulos, C., Chandrasekaran, K., Namboodiri, M.A. (2003) Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J. Neurochem. 86:824-835
• Chinopoulos, C., Starkov, A.A., Fiskum, G. (2003) Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J. Biological Chemistry. 278:27382-27389
• Niculescu, T., Weerth, S., Soane, L., Niculescu, F., Rus, V., Raine, C.S., Shin, M.L., Rus, H. (2003) Effects of membrane attack complex of complement on apoptosis in experiemental autoimmune encephalomyelitis. Annual New York Academy of Science. 1010:530-533
• Rosenthal, R.E., Silbergleit, R., Hof, P.R., Haywood, Y., Fiskum, G. (2003) Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke. 34:1311-1316
• Lolic, M.M., Silbergleit, R., Fiskum, G., Rosenthal, R.E. (2003) Hyperbaric oxygen reduces stroke infarct volume and myeloperoxidase activity and improves neurological outcome. Brain Res. 971:90-94
• Polster, B.M., Basanez, G., Young, M., Suzuki, M., Fiskum, G. (2003) Inhibition of Bax-Induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J. Neurosci. 23:2735-2743
• Fiskum, G., Starkov, A., Polster, B.M., Chinopoulos, C. (2003) Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's Disease. Annual New York Academy of Science. 991:111-119
• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fikum, G. (2003) Neuroprotective effects of bilobalide, a component of Ginkgo Biloba Extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry. 1:S89-94
• Hoffman, G.E., Moore, N., Fiskum, G., Murphy, A.Z. (2003) Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Experimental Neurology. 182:124-134
• Polster, B., Robertson, C., Bucci, C., Suzuki, M., Fiskum, G. (2003) Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release. Cell Death Differential. 10:365-370
• Starkov, A.A., Fiskum, G. (2003) Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86:1101-1107
• Badea, T.D., Park, J.H., Soane, L., Niculescu, T., Niculescu, F., Rus, H., Shin, M.L. (2003) Sublytic terminal complement attack induces c-fos transcriptional activation in myotubes. J. Neuroimmunology. 142:58-66

2002

• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fiskum, G. (2002) Bilobalide, a component of the Ginkgo Biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. Cell Molecular Biology. 48:663-669
• Uchino, H., Minamikawa-Tachino, R., Kristian, T., Perkins, G., Narazaki, M., Siesjo, B.K., Shibasaki, F. (2002) Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhabit calcineurin and the mitochondrial permeability transition. Neurobiological Disorders. 10:219-233
• Kowaltowski, A.J., Cosso, R.G., Campos, C.B., Fiskum, G. (2002) Effect of Bcl-2 overexpression on mitochondrial structure and function. J. Biological Chem. 277:42802-42807.
• Yoshimoto, T., Kristian, T., Hu, B.R., Ouyang, Y., Siesjo, B.K. (2002) Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A. Brain Res. 932:99-109
• Perkins, D., Yu, Y., Bambrick, L.L., Yarowsky, P.J., Aurelian, L. (2002) Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects. Exp. Neurology. 174:118-122
• Dorsey, S.G., Bambrick, L.L., Balice-Gordon, R.J., Krueger, B.K. (2002) Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16. J. Neurosci. 17:401-411
• Liu, Y., Fiskum, G., Schubert, D. (2002) Generation of reactive oxygen species by the mitochrondrial electron transport chain. J. Neurochem. 80:780-787
• Kristian, T., Weatherby, T.M., Bates, T.E., Fiskum, G. (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. J. Neurochem. 83:1297-1308.
• Lolic, M.M., Silberglet, R., Fiskum , G., Rosenthal, R.E., (2002) Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity. Brain Res. 971:90-94
• Starkov, A.A., Polster, B.M., Fiskum, G. (2002) Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83:220-228
• Starkov, A.A., Polster, B.M., and Fiskum, G. (2002) Regulation of mitochrondrial reactive oxygen species generation by calcium and bax. J. Neurochem. 83:220-228
• Badea, T., Niculescu, F., Soane, L., Fosbrink, M., Hila, S., Rus, V., Shin, M.L., Rus, H. (2002) RGC-32 increases p34^CDC2 kinase activity and entry of aortic smooth muscle cells into S-Phase. J. Biological Chem. 277:502-508
• Rosen, G.M., Tsai, P., Weaver, J.M., Porasuphatana, S., Roman, L.J., Starkov, A.A., Fiskum, G., Pou, S. (2002) The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J. Biol. Chem. 277:40275-40280
• Barna, G., Sebestyen, A., Chinopoulos, C., Nagy, K., Mihalik, R., Paku, S., Kopper, L. (2002) TGF beta 1 kills lymphoma cells using mitochrondrial apoptotic pathway with the help of caspase-8. Anticancer Res. 22:3867-3872
• Qiu, J., Whalen, M.J., Lowenstein, P., Fiskum, G., Fahy, B., Darwish, R., Aarabi B., Yuan, J., Moskowitz, M.A. (2002) Upregulation of the Fas receptor death inducing signaling omplex after traumatic brain injury in mice and humans. J. Neurosci. 22:3504-3511

2001

• Kristian, T., Bernardi, P., Siesjo, B.K. (2001) Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury. J Neurotrauma 18:1059 -1074
• Kochanek, P.M., Hendrich, K.S., Robertson, C.L., Williams, D.S., Melick, J.A., Ho, C., Marion, D.W., Jackson, E.K. (2001) Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion. Magn Reson Med 45:924-929
• DasGupta, S.F., Rapoport, S.I., Gerschenson, M., Murphy, E., Fiskum, G., Russell, S.J., Chandrasekaran, K. (2001) ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10
• Polster, B.M., Kinnally, K.W., Fiskum, G. (2001) BH3 domain peptide induces cell type-selective mitochondriral outer membrane permeability. J. Biological Chem. 276:37887-37894
• Soane, L., Cho, H.J., Niculescu, F., Rus, H., Shin, M.L. (2001) C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167:2305-2311
• Chandrasekaran, K., Mehrabian, Z., Murray, P., and Fiskum, G. (2001) Chronic exposure of neural cells to elevated intracellular sodium decreases mitochondrial mRNA expression. Mitochondrion 1:141-150
• Robertson, C.L., Bell, M.J., Kochanek, P.M., Adelson, P.D., Ruppel, R.A., Carcillo, J.A., Wisniewski, S.R., Mi, Z., Janesko, K.L., Clark, R.S., Marion, D.W., Graham, S.H., Jackson, E.K. (2001) Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 29:2287-2293
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Wisniewski, S.R., Tsuji, T., Janesko, K.L., Ohta, H., Adelson, P.D., Marion, D.W., Kochanek, P.M. (2001) Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18:861-868
• Chinopoulos, C., Adam-Vizi, V. (2001) Mitochondria deficient in comlex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J Neurochem 76:302-306
• Kushnareva, Y.E., Polster, B.M., Sokolove, P.M., Kinnally, K.W., Fiskum, G. (2001) Mitochondrial precursor signal pepide induces a unique permeability transition and release of cyochrome c from liver and brain mitochondria. Biochemical Biophysical 386:144-145
• Starkov, A.Y., Fiskum, G. (2001) Myxothiazol induces H2O2 production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun 281:645-650
• Chandrasekaran, K., Mehrabian, Z., Spinnewyne, B., Drieu, K., Fiskum, G. (2001) Neuroprotective effects of bilobalide, a component of the Ginko biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 922:282-292
• Hila, S., Soane, L., Koski, C.L. (2001) Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD. Glia 36:58-67

2000

• Katsura, K., Rodriquez de Turco, E.B., Kristian, T., Folbergrova, J., Bazan, N.G., Siesjo, B.K. (2000) Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain. J. Neurochem 6:2521-2527
• Fiskum, G., Kowaltowksi, A.J., Andreyev, A.Y., Kushnareva, Y.E., Starkov, A.A. (2000) Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol 322:222-234
• Robertson, C., Hendrich, K., Kochanek, P., Jackson, E., Melick, J., Graham, S., Marion, D., Williams, D., Ho, C. (2000) Assesment of 2-chloroadenosine after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report. Acta Neurochir Suppl 76:187-189
• Kowaltowski, A.J., Vercesi, A.E., Fiskum, G. (2000) Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine. Cell Death Differential 207-214
• Kochanek, P.M., Clark, R.S., Ruppel, R.A., Adelson, P.D., Bell, M.J., Whalen, M.J., Robertson, C.L., Satchell, M.A., Seidberg, N.A., Marion, D.W., Jenkins, L.W. (2000) Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med 2000 1:4-19.
• Kristián, T., Gertsch, J., Bates, T., Siesjö, B.K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone 0. J. Neurochem 74:1999-2009
• Li, P-A., Kristián, T., He, Q-P., Siesjö, B.K. (2000) Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol 165:153-163
• Kowaltowski, A.J., Smaili, S.S., Russell, J.T., Fiskum, G. (2000) Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2 overexpression. American Journal of Physiology 48:852-859
• Chinopoulos, C., Tretter, L., Rozsa, A., Adam-Vizi, V. (2000) Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: The role of ATP depletion and rise of [Ca(2+)](i). J Neurosci 20:2094-2103
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Adelson, P.D., Tsuji, T., Wisniewski, S.R., Ohta, H., Janesko, K.L., Kochanek, P.M. (2000) Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: a preliminary report. Acta Neurochir Suppl 76:419-421
• MacKenzie, A., LaCasse, E. (2000) Inhabition of IAP's protection by Diablo/Smac: new therapeutic opportunities? Cell Death and Differentiation 7:866-867
• Mitochondria as targets of neuroprotection by Bcl-2 family proteins
• No long term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats
• Bogaert, Y.E., Rex-Sheu, K.F., Hof, P.R., Brown, A.M., Blass, J.P., Rosenthal, R.E., Fiskum, G. (2000) Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resusciation. Experimental Neurology 161:115-125
• Buee, L., Mailliot, C., Podevin-Dimster, V., Rosenthal, R.E., Delacourte, A., Fiskum, G. (2000) Rapid tau protein dephosphorylation and differential rephosphorylation during cardiac arrest-induced cerebral ischemia and reperfusion. J. Cereb. Blood Flow Metab 20:543-549
• Chinopoulos, C., Tretter, L., Adam-Vizi, V.(2000) Reversible deolarization of in situ mitochondria by oxidative stress parallels a decrease n NAD(P)H level in nerve terminals. Neurochem Int 36:483-488.

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