Neuroprotection Publications

Back to Brain Injury & Neuroprotection Research 

2013

• Zhang F, Guo A, Liu C, Comb M, Hu B.  Phosphorylation and assembly of glutamate receptors after brain ischemia.  Stroke. 2013 Jan;44(1):170-6. [Epub 2012 Dec 4.]
• Balan I, Saladino A, Aarabi B, Castellani R, Wade C, Stein DM, Eisenberg H, Chen HH, Fiskum G.  Cellular Alterations in Human Traumatic Brain Injury: Changes in Mitochondrial Morphology Reflect Regional Levels of Injury Severity.  J Neurotrauma. March 30:367-381 (2013) 

2012

• Polster BM.  AIF, reactive oxygen species, and neurodegeneration: A "complex" problem. Neurochem Int. 2012 Dec (12). [Epub ahead of print]  
• Clerc P, Carey GB, Mehrabian Z, Wei M, Hwang H, Girnum GD, Chen H, Martin SS, Polster BM.  Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-based Respirometry.  PLoS One. Aug; 7(8):e42487. Epub 2012..
• Perez-Pinzon MA, Stetler RA, Fiskum G.  Novel mitochondrial targets for neuroprotection.  Journal of Cerebral Blood Flow & Metabolism. Jul; 32 (7): 1362-76.  (2012).
• McCranor BJ, Bozym RA, Vitolo MI, Fierke CA, Bambrick L, Polster BM, Fiskum G, Thompson RB.  Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion.  J. Bioenerg Biomembr.  Apr; 44(2):253-63.  (2012).
•  Onken M, Berger S, Kristian T.Simple model of forebrain ischemia in mouse.  Journal of Neuroscience Methods 204: 254-261. (2012).
• Zhuo, J., Xu, S., Porter, J., Mullins,R.J., Simon, J.Z., Fiskum, G., and Gullapalli, R.P.,  Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. NeuroImage 59: 467-477 (2012).
• Regenold, W.T., Pratt, M., Nekkalapu, S., Shapiro, P.S., Kristian, T., and Fiskum, G., Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling. Journal of Psychiatric Research 46: 95-104 (2012).

2011

• Zhang Z, Wakabayasahi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H,  The dynamin-related to GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells.  Mol Biol Cell.  22 (13):2235-45. (2011)
•  Wang, Hong, Sreenevasan, Urmilla, Hu Hong, Saladino, Andrew, Polster, B.M., Lund, L.M., Gong, Da-wei, Stanley W.C., Sztalryd, Carole.  Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria.  Journal of Lipid Research 52: 2159-2168. (2011).
• Su Xu, Jiachen Zhuo, Jennifer Racz, Da Shi, Steven Roys, Gary Fiskum, Rao Gullapalli; Early Microstructural and Metabolic Changes Following Controlled Cortical Impact Injury in rat: A Magnetic Resonance Imaging and Spectroscopy Study. Journal of Neurotrauma 28:2091-2102 (2011).
•    Greco T, Shafer J, Fiskum G,Sulforaphane inhibits mitochondrial permeability transition and oxidative stress, Free Radical Biology & Medicine 51: 2164–2171 (2011). 
•  Kahraman S, Bambrick LL, Fiskum G.  Effects of FK506 and cyclosporin a on calcium ionophore-induced mitochondrial depolarization and cytosolic calcium in astrocytes and neurons J Neurosci Res. 89 (12): 1973-8 (2011). 
• Toman J and Fiskum G.   Influence of aging on membrane permeability transition in brain mitochondria J Bioenerg Biomembr. Feb;  43(1):3-10. (2011).
• Kristian T, Balan I, Schuh R, Onken M.  Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection. Journal of Neuroscience Research 89:1946–1955 (2011).
• Schuh RA, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H, Polster BM.  Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity. Journal of Neuroscience Research 89:1979–1988 (2011). 

2010

• Scafidi S, Racz J, Hazelton J, McKenna MC, Fiskum G.  Neuroprotection by Acetyl-L-Carnitine after Traumatic Injury to the Immature Rat Brain. Dev Neurosci. 32(5-6): 480-7 (2010).
• Greco T. and Fiskum G., Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition. J Bioenerg Biomembr 42: 491-497 (2010).
• Scafidi, S., Fiskum, G., Lindauer, S., Bamford, P., Shi, D., Hopkins, I., and McKenna, M., Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. Journal of Neurochem. 114 (3): 820-831 (2010).
• Hazelton, J.L., Balan, I.S., Elmer, G.I., Kristian, T., Rosenthal, R.E., Krause, G., Sanderson, T.H., and Fiskum, G., Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death. Journal of  Neurotrauma. 27 (4):753-762 (2010).
• Greco, T and Fiskum, G.,  Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression. J of Alzheimer's Disease, 20 Suppl 2:S427-37 (2010).
• Soane, L., Polster, B.M., and Fiskum, G., Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia, in “Apoptosis: Physiology and Pathology of Cell Death”, John C. Reed and Douglas Green, Eds., Cambridge University Press pp. 153-163 (2010).
• Soane, L.,  Dai, W.L., Fiskum, G., and Bambrick, L.L. Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. J. Neurosci. Res. 88 (6):1355-63 (2010).
• Khairallah, Ramzi,  Sparagna, Genevieve, Khanna, Nishanth O'Shea, Karen, Hecker, Peter Kristian, Tibor Fiskum, Gary, Des Rosiers, Christine, Polster, Brian, Stanley, William    Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition Biochim Biophys Acta 1797 (8): 1555–1562 (2010).
   

2009

• Balan I, Fiskum G, Kristian T., Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymaticnitrotetrazolium blue staining technique. Brain Res. 1316:112-119 (2010).
• Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. Real-time visualization of cytoplasmic calpain activation and calcium ceregulation in acute clutamte excitotoxicity. J Neurochem. 110 (3): 990-1004 (2009).
• Schuh RA, Richardson JR, Gupta RK, Flaws JA, Fiskum G., Effects on the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. Neurotoxicology, 30 (2):274-80 (2009).
• Siebert A, Desai V, Chandrasekaran K, Fiskum G, Jafri, MS. Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures. J Neurosci Res. 87(7):1659-69 (2009).
• Scafidi S, O'Brien J, Hopkins I, Robertson C, Fiskum G, McKenna M., Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats. J Neurochem. 109 Suppl 1:189-97 (2009).
• Robertson CL, Scafidi S, McKenna MC, Fiskum G. Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Experimental Neurology 218 (2): 371-380 (2009). 
• Danilov CA, Chandrasekaran K, Racz J, Soane L, Zielke C, Fiskum G., Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia. 57(6):645-56 (2009).
• Hazelton JL, Petrasheuskaya M, Fiskum G, Kristián T. Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons. J Neurosci Res. 87(5):1250-9 (2009).
• Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria Free Radic Biol Med. 46(7):939-47 (2009).
• O’Shea, K.M., Khairallah, R.J., Sparagna, G.C., Xu, W., Hecker, P., Frayne-Robillard, I., Des Rosiers, C., Kristian, T., Murphy, R.C., Fiskum, G., and Stanley, W.C.  Dietary ω-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca²+-induced permeability transition.  J Mol Cell Cardiol. 47 (6): 819-827 (2009). 

2008

• Fiskum G, Danilov CA, Mehrabian Z, Bambrick LL, Kristian T, McKenna MC, Hopkins I, Richards EM, Rosenthal RE. Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytes. Ann N Y Acad Sci. 1147:129-38. (2008).
• Kahraman, S., Zup, S.L., McCarthy, M. and Fiskum, G. GABAergic Mechanism of Propofol Toxicity in Immature Neurons J. Neurosurg Anesthesiol  20:233-40 (2008). 
• Casey PA, McKenna MC, Fiskum G, Saraswati M, Robertson CL.  Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.  J Neurotrauma. 25(6):603-14 (2008). 
• Danilov CA, Fiskum G.  Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation.  Glia. 13;56(7):801-808 (2008). 
• Ahn E.S., Robertson C.L., Vereczki V., Hoffman G.E., Fiskum G.   Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.  J. Neurosurg. 108(1):124-131 (2008).
• Bambrick L.L., Fiskum G.,  Mitochondrial dysfunction in mouse trisomy 16 brain.  Brain Res. 10;1188:9-16 (2008). 
• Soane L., Siegel Z.T., Schuh R.A., Fiskum G.  Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res.  1;86(6):1267-76 (2008).

2007

• Carlson D.E., Nguyen P.X., Soane L., Fiedler S.M., Fiskum G., Chiu W.C., Scalea T.M., Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria.  Shock. 27(2):192-8 (2007).
• Robertson, C., Saraswati, M., Fiskum, G., (2007)  Mitochondrial dysfunction early after traumatic brain injury in immature rats.  J. Neurochem. 101 (5), 1248–1257 (2007).
• Richards E.M., Fiskum G., Rosenthal R.E., Hopkins I., McKenna M.C.  Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism.  Stroke. 38(5):1578-84 (2007). 
• Johnson-Cadwell LI, Jekabsons MB, Wang A, Polster BM, Nicholls DG. 'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress. J Neurochem. 101(6):1619-31 (2007).
• Kahraman S., Fiskum G.  Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes.  Neurochem Res. 32(4-5):799-806 (2007).
• Kristian, T., Pivovarova, N.B., Fiskum, G., Andrews, S.B. Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention J. Neurochem. 102 (4), 1346–1356 (2007).
• Soane L., Kahraman S., Kristian T., Fiskum G.  Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.  J Neurosci Res. 15;85(15):3407-15 (2007).
• Kingsbury, T.J., Bambrick, L., Roby, C.D., Krueger, B.K.  Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons. J. Neurochem. 103 (2), 761–770 (2007).
• Mehrabyan, Z., Chandrasekaran, K., Kalakonda, S., Kristian, T., Fiskum, G., Kalvakolanu, D.V.  The IFN-β and Retinoic Acid-Induced Cell Death Regulator GRIM-19 is Upregulated During Focal Cerebral Ischemia.  J. Interferon Cytokine Res. 27(5): 383-392 (2007). 

2006

• Chandrasekaran, K., Hazelton, J.L., Wang, Y., Fiskum, G., Kristian, T., Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J. Neurosci.26:13123-13127 (2006). 
• Robertson, C.L., Soane, L., Siegel, Z.T., Fiskum, G., The potential role of mitochondria in pediatric traumatic brain injury. Dev. Neurosci.28:432-446 (2006). 
• Kim, G.J., Fiskum, G., Morgan, W.F., A role for mitochondrial dysfunction in perpetuating radiation-induced geonomic instability. Cancer Res. 66:10377-10383 (2006). 
• Bambrick, L.L., Chandrasekaran, K., Mehrabyan, Z., , Wright, C., Krueger, B. K., Fiskum, G., Cyclosporin A increases mitochondrial calcium uptake capacity in cortical astrocytes but not cerebellar granule neurons. J. Bioenerg, Biomembr.38:43-47 (2006). 
• Vereczki, V., Koves, K., Csaki, A., Grosz, K., Hoffman, G.E., Fiskum, G., Distribution of hypothalamic, hippocampal and other limbic peptidergic neuronal cell bodies giving rise to retinopetal fibers: anterograde and retrograde tracing and neuropeptide immunohistochemical studies. Neuroscience.140:1089-1100 (2006).
• Hilton, G.D., Bambrick, L.L., Thompson, S.M., McCarthy, M.M., Estradiol modulation of kainic acid-induced calcium elevation in neonatal hippocampal neurons. Endocrinology.147:1246-1255 (2006). 
• Dorsey, S.G., Renn, C.L., Carim-Todd, L., Barrick, C.A., Bambrick, L., Krueger, B.K., Ward, C.W., Tessarollo, L. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron.51:21-28 (2006). 
• Kristian, T., Hopkins, I.B., McKenna, M.C., Fiskum, G. Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation. J. Neurosci Methods 152:136-143 (2006). 
• Vereczki, V., Martin, E., Rosenthal, R.E., Hof, P.R., Hoffman, G.E., Fiskum, G.  Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab.26:821-835 (2006). 
• Balan, I.S., Fiskum, G., Hazelton, J., Cotto-Cumba, C., Rosenthal, R.E.  Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. Stroke.37:3008-3013 (2006). 
• Robertson, C.L., Puskar, A., Hoffman, G.E., Murphy, A.Z., Saraswati, M., Fiskum, G., Physiologic progesterone reduces mitochondrial dysfuntion and hippocampal cell loss after traumatic brain injury in female rats. Exp. Neurol.197:235-243 (2006). 
• Richards, E.M., Rosenthal, R.E., Kristian, T., Fiskum, G., Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Rad. Biol. Med.40:1960-1970 (2006). 

2005

• Schuh, R., Kristian, T., Fiskum, G., Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J. of Neurochem.92:388-394 (2005) 
• Rosenthal, R.E., Bogaert, Y.E., Fiskum, G. Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs. Neurosci. Letts.378:82-87 (2005)
• Chinopoulos, C., Starkov, A.A., Grigoriev, S., Dejean, L.M., Kinnally, K.W., Liu, X., Ambudkar, I.S., Fiskum, G., Diacylglycerols activate mitochondrial cationic channel(s) and release sequestered Ca^2+. J. of Bioenerg. Biomemb. 37:237-247 (2005) 
• Hainsworth, A.H., Bermpohl, D., Webb, T.E., Darwish, R., Fiskum, G., Qiu, J., McCarthy, D., Moskowitz, M.A., Whalen, M.J., Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J.Cereb. Blood Flow Metab.25:1030-1040 (2005) 
• Soane, L., Fiskum, G.  Inhibition of Mitochondrial Neural Cell Death Pathways by Protein Transduction of Bcl-2 Family Proteins. J. Bioeneg Biomembr 37:179-190 (2005) 
• Zanelli, S.A., Solenski, N.J., Rosenthal, R.E., Fiskum,G Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann.N.Y. Acad. Sci.1053:153-161 (2005) 
• Schuh, R.A., Kristian, T., Gupta, R.K., Flaws, J.A., Fiskum, G. Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol. Sci.88:495-504 (2005) 
• Vereczki, V., Martin, E., Rosenthal. R., Hof, P., Hoffman, G., Fiskum, G. Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, methabolic dysfunction and neuronal death. J. Cereb. Blood Flow Metab.26:821-835 (2005) 
• Rosenthal. R.E., Fiskum, G.,  Oxygen: You can get too much of a good thing. Hosp. Med. 66:76-77 (2005) 
• Nunez, J.L., Bambrick, L.L., Krueger, B.K., McCarthy, M.M.  Prolongation and enhancement of gamma-aminobutyric acid receptor mediated excitation by chronic treatment with estradiol in developing rat hippocampal neurons. Eur. J. Neurosci. 21:3251-3261 (2005) 
• Martin, E., Rosenthal, R., Fiskum, G.  Pyruvate Dehydrogenase Complex: metabolic link to ischemic brain injury and target of oxidative stress. J. of Neurosci.Res.79:240-247 (2005)
• Kowaltowski, A., Fiskum, G.,  Redox Mechanisms of Cytoprotection by Bcl-2. Antioxidants & Redox Signaling.7:508-514 (2005)
• Mehrabian, Z., Liu, L., Fiskum, G., Rapoport, S., Chandrasekaran, K. Regulation of mitochondrial gene expression by energy demand in neural cell. J. of Neurochem. 93:850-860 (2005)
• Ahn, E.S., Robertson, C.L., Vereczki, V., Hoffman, G.E., Fiskum, G.,  Synthes Award for Resident Research on Brain and Craniofacial Injury: Normoxic ventilatory resuscitation after controlled cortical impact reduces peroxynitrite-mediated protein nitration in teh hippocampus. Clin Neurosurg. 52:348-356 (2005)
• Soane, L., Fiskum, G.  TAT-mediated intracellular delivery of the loop deletion BCL-2 protein protects neurons against cell death. J. Neurochem.95:230-243 (2005)

2004

• Bambrick, L., Kristian, T., Fiskum, G.,  Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochemistry Res. 29:601-609 (2004)
• Kowaltowski, A., Fenton, R., Fiskum, G.,  Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radical Biology & Medicine. 37:1845-1853 (2004)
• Krajewska, M., Rosenthal, R.E., Mikolajczyk, J., Stennicke, H.R., Wiesenthal, T., Ma, J., Naito, M., Salvesen, G.S., Reed, J.C., Fiskum, G., Krajewski, S.,  Early processing of Bid and caspase-6,-8,-10,-14 in the canine brain during cardiac arrest and resuscitation. Exp. Neuro. 189:261-279 (2004)
• Kristian, T., Fiskum, G.,  A fluorescence based technique for screening compounds that protect against damage to brain mitochondria. Brain Res.Protocol. 13:176-182 (2004)
• Chinopoulos, C., Gerencser, A.A., Doczi, J., Fiskum, G., Adam-Vizi, V.  Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La^3+ in cultured cortical neurons. J. Neurochem. 91:471-483 (2004)
• Fiskum, G.  Mechanisms of neuronal death and neuroprotection. J. Neurosurg. Anesthesiol. 16:108-110 (2004)
• Kristian, T.  Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calcium. 36:221-233 (2004)
• Fiskum, G.  Mitochondria and Neuroprotection - In memory of Albert L. Lehninger. J. Bioenerg Biomembr. 36:275-276 (2004)
• Starkov, A.A., Fiskum, G., Chinopoulos, C., Lorenzo, B.J., Browne, S.E., Patel, M.S., Beal, M.F. (2004) Mitochondrial alpha-keotglutarate dehydrogenase complex generates reactive oxygen species. J. Neurosci. 24:7779-7788 (2004)
• Robertson, C.L. Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J. Bioenerg Biomembr. 36:363-368 (2004)
• Starkov, A.A., Chinopoulos, C., Fiskum, G.  Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium. 36:257-264 (2004)
• Polster, B.M., Fiskum, G.  Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90:1281-1289 (2004)
• Robertson, C.L., Bucci, C.J., Fiskum, G.  Mitochondrial response to calcium in the developing brain. Developmental Brain Res. 151:141-148 (2004)
• Fiskum, G., Rosenthal, R., Vereczki, V., Martin, E., Hoffman, G., Chinopoulos, C., Kowaltowski, A.  Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J. Bioenerg Biomembr. 36:347-351 (2004)

2003

• Bambrick, L.L., Yarowsky, P.J., Krueger, B.K.  Altered astrocyte calcium homeostatsis and proliferation in the Tz65Dn mouse, a model of Down syndrome. J. Neurosci. Res. 73:89-94 (2003)
• Kingsbury, T.J., Murray, P.D., Bambrick, L.L., Krueger, B.K.  Ca^2+ -dependent regulation of TrkB expression in neurons. J. Biological Chemistry. 278:40744-40748 (2003)
• Madhavarao, C.N., Chinopoulos, C., Chandrasekaran, K., Namboodiri, M.A.  Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J. Neurochem. 86:824-835 (2003)
• Chinopoulos, C., Starkov, A.A., Fiskum, G.  Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J. Biological Chemistry. 278:27382-27389 (2003)
• Niculescu, T., Weerth, S., Soane, L., Niculescu, F., Rus, V., Raine, C.S., Shin, M.L., Rus, H.  Effects of membrane attack complex of complement on apoptosis in experimental autoimmune encephalomyelitis. Annual New York Academy of Science. 1010:530-533 (2003)
• Rosenthal, R.E., Silbergleit, R., Hof, P.R., Haywood, Y., Fiskum, G.  Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke. 34:1311-1316 (2003)
• Lolic, M.M., Silbergleit, R., Fiskum, G., Rosenthal, R.E.  Hyperbaric oxygen reduces stroke infarct volume and myeloperoxidase activity and improves neurological outcome. Brain Res. 971:90-94 (2003)
• Polster, B.M., Basanez, G., Young, M., Suzuki, M., Fiskum, G.  Inhibition of Bax-Induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J. Neurosci. 23:2735-2743 (2003)
• Fiskum, G., Starkov, A., Polster, B.M., Chinopoulos, C.  Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's Disease. Annual New York Academy of Science. 991:111-119 (2003)
• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fikum, G.  Neuroprotective effects of bilobalide, a component of Ginkgo Biloba Extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry. 1:S89-94 (2003)
• Hoffman, G.E., Moore, N., Fiskum, G., Murphy, A.Z.  Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Experimental Neurology. 182:124-134 (2003)
• Polster, B., Robertson, C., Bucci, C., Suzuki, M., Fiskum, G.  Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release. Cell Death Differential. 10:365-370 (2003)
• Starkov, A.A., Fiskum, G.  Regulation of brain mitochondrial h1O2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86:1101-1107 (2003)
• Badea, T.D., Park, J.H., Soane, L., Niculescu, T., Niculescu, F., Rus, H., Shin, M.L.  Sublytic terminal complement attack induces c-fos transcriptional activation in myotubes. J. Neuroimmunology. 142:58-66 (2003)

2002

• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fiskum, G. Bilobalide, a component of the Ginkgo Biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. Cell Molecular Biology. 48:663-669 (2002) 
• Uchino, H., Minamikawa-Tachino, R., Kristian, T., Perkins, G., Narazaki, M., Siesjo, B.K., Shibasaki, F.  Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhabit calcineurin and the mitochondrial permeability transition. Neurobiological Disorders. 10:219-233  (2002)
• Kowaltowski, A.J., Cosso, R.G., Campos, C.B., Fiskum, G.  Effect of Bcl-2 overexpression on mitochondrial structure and function. J. Biological Chem. 277:42802-42807. (2002)
• Yoshimoto, T., Kristian, T., Hu, B.R., Ouyang, Y., Siesjo, B.K.  Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A. Brain Res. 932:99-109 (2002)
• Perkins, D., Yu, Y., Bambrick, L.L., Yarowsky, P.J., Aurelian, L.  Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects. Exp. Neurology. 174:118-122 (2002)
• Dorsey, S.G., Bambrick, L.L., Balice-Gordon, R.J., Krueger, B.K.  Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16. J. Neurosci. 17:401-411 (2002)
• Liu, Y., Fiskum, G., Schubert, D.  Generation of reactive oxygen species by the mitochrondrial electron transport chain. J. Neurochem. 80:780-787 (2002)
• Kristian, T., Weatherby, T.M., Bates, T.E., Fiskum, G.  Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. J. Neurochem. 83:1297-1308 (2002)
• Lolic, M.M., Silberglet, R., Fiskum , G., Rosenthal, R.E.,  Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity. Brain Res. 971:90-94 (2002)
• Starkov, A.A., Polster, B.M., Fiskum, G.  Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83:220-228 (2002)
• Badea, T., Niculescu, F., Soane, L., Fosbrink, M., Hila, S., Rus, V., Shin, M.L., Rus, H. RGC-32 increases p34^CDC2 kinase activity and entry of aortic smooth muscle cells into S-Phase. J. Biological Chem. 277:502-508 (2002)
• Rosen, G.M., Tsai, P., Weaver, J.M., Porasuphatana, S., Roman, L.J., Starkov, A.A., Fiskum, G., Pou, S.  The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J. Biol. Chem. 277:40275-40280 (2002)
• Barna, G., Sebestyen, A., Chinopoulos, C., Nagy, K., Mihalik, R., Paku, S., Kopper, L.  TGF beta 1 kills lymphoma cells using mitochrondrial apoptotic pathway with the help of caspase-8. Anticancer Res. 22:3867-3872 (2002)
• Qiu, J., Whalen, M.J., Lowenstein, P., Fiskum, G., Fahy, B., Darwish, R., Aarabi B., Yuan, J., Moskowitz, M.A.  Upregulation of the Fas receptor death inducing signaling complex after traumatic brain injury in mice and humans. J. Neurosci. 22:3504-3511 (2002)

2001

• Kristian, T., Bernardi, P., Siesjo, B.K.  Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury. J Neurotrauma 18:1059 -1074 (2001)
• Kochanek, P.M., Hendrich, K.S., Robertson, C.L., Williams, D.S., Melick, J.A., Ho, C., Marion, D.W., Jackson, E.K.  Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion. Magn Reson Med 45:924-929 (2001)
• DasGupta, S.F., Rapoport, S.I., Gerschenson, M., Murphy, E., Fiskum, G., Russell, S.J., Chandrasekaran, K.  ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10 (2001)
• Polster, B.M., Kinnally, K.W., Fiskum, G.  BH3 domain peptide induces cell type-selective mitochondrial outer membrane permeability. J. Biological Chem. 276:37887-37894 (2001)
• Soane, L., Cho, H.J., Niculescu, F., Rus, H., Shin, M.L.  C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167:2305-2311 (2001)
• Chandrasekaran, K., Mehrabian, Z., Murray, P., and Fiskum, G.  Chronic exposure of neural cells to elevated intracellular sodium decreases mitochondrial mRNA expression. Mitochondrion 1:141-150 (2001)
• Robertson, C.L., Bell, M.J., Kochanek, P.M., Adelson, P.D., Ruppel, R.A., Carcillo, J.A., Wisniewski, S.R., Mi, Z., Janesko, K.L., Clark, R.S., Marion, D.W., Graham, S.H., Jackson, E.K.  Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 29:2287-2293 (2001)
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Wisniewski, S.R., Tsuji, T., Janesko, K.L., Ohta, H., Adelson, P.D., Marion, D.W., Kochanek, P.M.  Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18:861-868 (2001)
• Chinopoulos, C., Adam-Vizi, V.  Mitochondria deficient in comlpex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J Neurochem 76:302-306 (2001)
• Kushnareva, Y.E., Polster, B.M., Sokolove, P.M., Kinnally, K.W., Fiskum, G.  Mitochondrial precursor signal peptide induces a unique permeability transition and release of cytochrome c from liver and brain mitochondria. Arch Biochemical Biophysical 386:144-145 (2001)
• Starkov, A.Y., Fiskum, G.  Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun 281:645-650 (2001)
• Chandrasekaran, K., Mehrabian, Z., Spinnewyne, B., Drieu, K., Fiskum, G.  Neuroprotective effects of bilobalide, a component of the Ginko biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 922:282-292 (2001)
• Hila, S., Soane, L., Koski, C.L.  Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD. Glia 36:58-67 (2001)

2000

• Katsura, K., Rodriquez de Turco, E.B., Kristian, T., Folbergrova, J., Bazan, N.G., Siesjo, B.K.  Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain. J. Neurochem 6:2521-2527 (2000)
• Fiskum, G., Kowaltowksi, A.J., Andreyev, A.Y., Kushnareva, Y.E., Starkov, A.A.  Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol 322:222-234 (2000)
• Robertson, C., Hendrich, K., Kochanek, P., Jackson, E., Melick, J., Graham, S., Marion, D., Williams, D., Ho, C.  Assesment of 2-chloroadenosine after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report. Acta Neurochir Suppl 76:187-189 (2000)
• Kowaltowski, A.J., Vercesi, A.E., Fiskum, G.  Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine. Cell Death Differential 207-214 (2000)
• Kochanek, P.M., Clark, R.S., Ruppel, R.A., Adelson, P.D., Bell, M.J., Whalen, M.J., Robertson, C.L., Satchell, M.A., Seidberg, N.A., Marion, D.W., Jenkins, L.W.  Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med 2000 1:4-19 (2000)
• Kristián, T., Gertsch, J., Bates, T., Siesjö, B.K.  Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. J. Neurochem 74:1999-2009 (2000)
• Li, P-A., Kristián, T., He, Q-P., Siesjö, B.K.  Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol 165:153-163 (2000)
• Kowaltowski, A.J., Smaili, S.S., Russell, J.T., Fiskum, G.  Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2 overexpression. American Journal of Physiology 48:852-859 (2000)
• Chinopoulos, C., Tretter, L., Rozsa, A., Adam-Vizi, V.  Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: The role of ATP depletion and rise of [Ca(2+)](i). J Neurosci 20:2094-2103 (2000)
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Adelson, P.D., Tsuji, T., Wisniewski, S.R., Ohta, H., Janesko, K.L., Kochanek, P.M. Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: a preliminary report. Acta Neurochir Suppl 76:419-421 (2000)
• Fiskum, G., Polster, B.M., Kowaltowski, A.J.,  Mitochondria as targets of neuroprotection by Bcl-2 family protein. Pharmacology of Cerebral Ischemia 177-188 (2000)
• Bogaert, Y.E., Rex-Sheu, K.F., Hof, P.R., Brown, A.M., Blass, J.P., Rosenthal, R.E., Fiskum, G.  Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resusciation. Experimental Neurology 161:115-125 (2000)
• Buee, L., Mailliot, C., Podevin-Dimster, V., Rosenthal, R.E., Delacourte, A., Fiskum, G.  Rapid tau protein dephosphorylation and differential rephosphorylation during cardiac arrest-induced cerebral ischemia and reperfusion. J. Cereb. Blood Flow Metab 20:543-549 (2000)
• Chinopoulos, C., Tretter, L., Adam-Vizi, V. Reversible depolarization of in situ mitochondria by oxidative stress parallels a decrease n NAD(P)H level in nerve terminals. Neurochem Int 36:483-488. (2000)