Publications

2009

• Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. Real-time Visualization of Cytoplasmic Calpain Activation and Calcium Deregulation in Acute Glutamte Excitotoxicity. J Neurochem. 2009 May (110) 990-1004
• Schuh RA, Richardson JR, Gupta RK, Flaws JA, Fiskum G. Effects on the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. Neurotoxicology, 2009 Mar;30(2):274-80
• Siebert A, Desai V, Chandrasekaran K, Fiskum G, Jafri MS. Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures.
  J Neurosci Res. 2009 May 15;87(7):1659-69.
• Scafidi S, O'Brien J, Hopkins I, Robertson C, Fiskum G, McKenna M. Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats. J Neurochem. 2009 May;109 Suppl 1:189-97.
• Robertson CL, Scafidi S, McKenna MC, Fiskum G. Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Exp Neurol. 2009 May 7. [Epub ahead of print]
• Danilov CA, Chandrasekaran K, Racz J, Soane L, Zielke C, Fiskum G. Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia. 2009 Apr 15;57(6):645-56.
• Hazelton JL, Petrasheuskaya M, Fiskum G, Kristián T. Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons. J Neurosci Res. 2009 Apr;87(5):1250-9.
• Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.Free Radic Biol Med. 2009 Apr 1;46(7):939-47.
• O’Shea, K.M., Khairallah, R.J., Sparagna, G.C., Xu, W., Hecker, P., Frayne-Robillard, I., Des Rosiers, C., Kristian, T., Murphy, R.C., Fiskum, G., and Stanley, W.C. (2009) Dietary ω-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca²+-induced permeability transition.  J Mol Cell Cardiol. 47 2009 Aug. 819-827
• Soane, L.,  Dai, W.L., Fiskum, G., and Bambrick, L.L. (2009) Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. J. Neurosci. Res. (In press)

2008

• Fiskum G, Danilov CA, Mehrabian Z, Bambrick LL, Kristian T, McKenna MC, Hopkins I, Richards EM, Rosenthal RE. Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytes. Ann N Y Acad Sci. 2008 Dec;1147:129-38. Review.
• Kahraman, S., Zup, S.L., McCarthy, M. and Fiskum, G. GABAergic Mechanism of Propofol Toxicity in Immature Neurons 2008 Neurosurg Anesthesiol Oct. 20:233-40
• Casey PA, McKenna MC, Fiskum G, Saraswati M, Robertson CL.  Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.  J Neurotrauma. 2008 Jun;25(6):603-14
• Danilov CA, Fiskum G.  Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation.  Glia. 2008 Mar 13;56(7):801-808
• Ahn E.S., Robertson C.L., Vereczki V., Hoffman G.E., Fiskum G.   Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.  J. Neurosurg. 2008 Jan;108(1):124-31.
• Bambrick L.L., Fiskum G.   Mitochondrial dysfunction in mouse trisomy 16 brain.  Brain Res. 2008 Jan 10;1188:9-16. Epub 2007 Oct 26.

2007

• Carlson D.E., Nguyen P.X., Soane L., Fiedler S.M., Fiskum G., Chiu W.C., Scalea T.M.  Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria.  Shock. 2007 Feb;27(2):192-8.
• Robertson, C., Saraswati, M., Fiskum, G. (2007)  Mitochondrial dysfunction early after traumatic brain injury in immature rats.  J. Neurochem. 101 (5), 1248–1257.
• Richards E.M., Fiskum G., Rosenthal R.E., Hopkins I., McKenna M.C.  Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism.  Stroke. 2007 May;38(5):1578-84. Epub 2007 Apr 5.
• Johnson-Cadwell LI, Jekabsons MB, Wang A, Polster BM, Nicholls DG. (2007) 'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress. J Neurochem. 2007 Jun;101(6):1619-31. Epub 2007 Apr 16.
• Kahraman S., Fiskum G.  Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes.  Neurochem Res. 2007 Apr-May;32(4-5):799-806. Epub 2006 Dec 27.
• Kristian, T., Pivovarova, N.B., Fiskum, G., Andrews, S.B. (2007)  Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention J. Neurochem. 102 (4), 1346–1356.
• Soane L., Siegel Z.T., Schuh R.A., Fiskum G.  Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria.  J. Neurosci. Res. 2007 Dec 3
• Soane L., Kahraman S., Kristian T., Fiskum G.  Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.  J Neurosci Res. 2007 Nov 15;85(15):3407-15.
• Kingsbury, T.J., Bambrick, L., Roby, C.D., Krueger, B.K. (2007)  Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons. J. Neurochem. 103 (2), 761–770.
• Mehrabyan, Z., Chandrasekaran, K., Kalakonda, S., Kristian, T., Fiskum, G., Kalvakolanu, D.V.  The IFN-β and Retinoic Acid-Induced Cell Death Regulator GRIM-19 is Upregulated During Focal Cerebral Ischemia.  Journal of Interferon & Cytokine Research. 2007, 27(5): 383-392. 

2006

• Chandrasekaran, K., Hazelton, J.L., Wang, Y., Fiskum, G., Kristian, T. (2006) Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J. Neurosci.26:13123-13127
• Robertson, C.L., Soane, L., Siegel, Z.T., Fiskum, G (2006) The potential role of mitochondria in pediatric traumatic brain injury. Dev. Neurosci.28:432-446
• Kim, G.J., Fiskum, G., Morgan, W.F. (2006) A role for mitochondrial dysfunction in perpetuating radiation-induced geonomic instability. Cancer Res. 66:10377-10383
• Bambrick, L.L., Chandrasekaran, K., Mehrabyan, Z., , Wright, C., Krueger, B. K., Fiskum, G. (2006) Cyclosporin A increases mitochondrial calcium uptake capacity in cortical astrocytes but not cerebellar granule neurons. J. Bioenerg, Biomemb.38:43-47
• Vereczki, V., Koves, K., Csaki, A., Grosz, K., Hoffman, G.E., Fiskum, G., (2006) Distribution of hypothalamic, hippocampal and other limbic peptidergic neuronal cell bodies giving rise to retinopetal fibers: anterograde and retrograde tracing and neuropeptide immunohistochemical studies. Neuroscience.140:1089-1100
• Hilton, G.D., Bambrick, L.L., Thompson, S.M., McCarthy, M.M. (2006) Estradiol modulation of kainic acid-induced calcium elevation in neonatal hippocampal neurons. Endocrinology.147:1246-1255
• Dorsey, S.G., Renn, C.L., Carim-Todd, L., Barrick, C.A., Bambrick, L., Krueger, B.K., Ward, C.W., Tessarollo, L. (2006) In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron.51:21-28
• Kristian, T., Hopkins, I.B., McKenna, M.C., Fiskum, G. (2006) Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation. J. Neurosci. Methods 152:136-143
• Vereczki, V., Martin, E., Rosenthal, R.E., Hof, P.R., Hoffman, G.E., Fiskum, G. (2006) Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab.26:821-835
• Balan, I.S., Fiskum, G., Hazelton, J., Cotto-Cumba, C., Rosenthal, R.E. (2006) Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. Stroke.37:3008-3013
• Robertson, C.L., Puskar, A., Hoffman, G.E., Murphy, A.Z., Saraswati, M., Fiskum, G. (2006) Physiologic progesterone reduces mitochondrial dysfuntion and hippocampal cell loss after traumatic brain injury in female rats. Exp. Neurol.197:235-243
• Richards, E.M., Rosenthal, R.E., Kristian, T., Fiskum, G. (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Rad. Biol. Med.40:1960-1970

2005

• Schuh, R., Kristian, T., Fiskum, G. (2005) Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J. of Neurochem.92:388-394
• Rosenthal, R.E., Bogaert, Y.E., Fiskum, G. (2005) Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs. Neurosci. Letts.378:82-87
• Chinopoulos, C., Starkov, A.A., Grigoriev, S., Dejean, L.M., Kinnally, K.W., Liu, X., Ambudkar, I.S., Fiskum, G. (2005) Diacylglycerols activate mitochondrial cationic channel(s) and release sequestered Ca^2+. J. of Bioenerg. Biomemb. 37:237-247
• Hainsworth, A.H., Bermpohl, D., Webb, T.E., Darwish, R., Fiskum, G., Qiu, J., McCarthy, D., Moskowitz, M.A., Whalen, M.J. (2005) Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J.Cereb. Blood Flow Metab.25:1030-1040
• Soane, L., Fiskum, G. (2005) Inhibition of Mitochondrial Neural Cell Death Pathways by Protein Transduction of Bcl-2 Family Proteins. J. Bioeneg. Biomemb.37:179-190
• Zanelli, S.A., Solenski, N.J., Rosenthal, R.E., Fiskum,G (2005) Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann.N.Y. Acad. Sci.1053:153-161
• Schuh, R.A., Kristian, T., Gupta, R.K., Flaws, J.A., Fiskum, G. (2005) Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol. Sci.88:495-504
• Vereczki, V., Martin, E., Rosenthal. R., Hof, P., Hoffman, G., Fiskum, G. (2005)Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, methabolic dysfunction and neuronal death. J. Cereb. Blood Flow Metab.26:821-835
• Rosenthal. R.E., Fiskum, G. (2005) Oxygen: You can get too much of a good thing. Hosp. Med. 66:76-77
• Nunez, J.L., Bambrick, L.L., Krueger, B.K., McCarthy, M.M. (2005) Prolongation and enhancement of gamma-aminobutyric acid receptor mediated excitation by chronic treatment with estradiol in developing rat hippocampal neurons. Eur. J. Neurosci. 21:3251-3261
• Martin, E., Rosenthal, R., Fiskum, G. (2005) Pyruvate Dehydrogenase Complex: Metabolic Link to Ischemic Brain Injury and Target of Oxidative Stress. J. of Neurosci.Res.79:240-247
• Kowaltowski, A., Fiskum, G. (2005) Redox Mechanisms of Cytoprotection by Bcl-2. Antioxidants & Redox Signaling.7:508-514
• Mehrabian, Z., Liu, L., Fiskum, G., Rapoport, S., Chandrasekaran, K. (2005) Regulation of mitochondrial gene expression by energy demand in neural cell. J. of Neurochem. 93:850-860
• Ahn, E.S., Robertson, C.L., Vereczki, V., Hoffman, G.E., Fiskum, G. (2005) Synthes Award for Resident Research on Brain and Craniofacial Injury: Normoxic ventilatory resuscitation after controlled cortical impact reduces peroxynitrite-mediated protein nitration in teh hippocampus. Clin Neurosurg. 52:348-356
• Soane, L., Fiskum, G. (2005) TAT-mediated intracellular delivery of the loop deletion BCL-2 protein protects neurons against cell death. J. Neurochem.95:230-243

2004

• Bambrick, L., Kristian, T., Fiskum, G. (2004) Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochemistry Res. 29:601-609
• Kowaltowski, A., Fenton, R., Fiskum, G. (2004) Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radical Biology & Medicine. 37:1845-1853
• Krajewska, M., Rosenthal, R.E., Mikolajczyk, J., Stennicke, H.R., Wiesenthal, T., Ma, J., Naito, M., Salvesen, G.S., Reed, J.C., Fiskum, G., Krajewski, S. (2004) Early processing of Bid and caspase-6,-8,-10,-14 in the canine brain during cardiac arrest and resuscitation. Exp. Neuro. 189:261-279
• Kowaltowski, A., Fenton, R.G., Fiskum, G. (2004) Family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radical Biology & Medicine. 37:1-9
• Kristian, T., Fiskum, G. (2004) A flourescence based technique for screening compounds that protect against damage to brain mitochondria. Brain Res.Protocol. 13:176-182
• Chinopoulos, C., Gerencser, A.A., Doczi, J., Fiskum, G., Adam-Vizi, V. (2004) Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La^3+ in cultured cortical neurons. J. Neurochem. 91:471-483
• Fiskum, G. (2004) Mechanisms of neuronal death and neuroprotection. J. Neurosurg. Anesthesiol. 16:108-110
• Kristian, T. (2004) Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calicum. 36:221-233
• Fiskum, G. (2004) Mitochondria and Neuroprotection - In memory of Albert L. Lehninger. J. Bioenerg and Biomemb. 36:275-276
• Starkov, A.A., Fiskum, G., Chinopoulos, C., Lorenzo, B.J., Browne, S.E., Patel, M.S., Beal, M.F. (2004) Mitochondrial alpha-keotglutarate dehydrogenase complex generates reactive oxygen species. J. Neurosci. 24:7779-7788
• Robertson, C.L. (2004) Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J. Bioenerg. and Biomemb. 36:363-368
• Starkov, A.A., Chinopoulos, C., Fiskum, G. (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calicum. 36:257-264
• Polster, B.M., Fiskum, G. (2004) Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90:1281-1289
• Robertson, C.L., Bucci, C.J., Fiskum, G. (2004) Mitochondrial response to calcium in the developing brain. Developmental Brain Res. 151:141-148
• Fiskum, G., Rosenthal, R., Vereczki, V., Martin, E., Hoffman, G., Chinopoulos, C., Kowaltowski, A. (2004) Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J. Bioenerg. and Biomemb. 36:347-351

2003

• Bambrick, L.L., Yarowsky, P.J., Krueger, B.K. (2003) Altered astrocyte calcium homeostatsis and proliferation in the Tz65Dn mouse, a model of down syndrome. J. Neurosci. Res. 73:89-94
• Kingsbury, T.J., Murray, P.D., Bambrick, L.L., Krueger, B.K. (2003) Ca^2+ -dependent regulation of TrkB expression in neurons. J. Biological Chemistry. 278:40744-40748
• Madhavarao, C.N., Chinopoulos, C., Chandrasekaran, K., Namboodiri, M.A. (2003) Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J. Neurochem. 86:824-835
• Chinopoulos, C., Starkov, A.A., Fiskum, G. (2003) Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J. Biological Chemistry. 278:27382-27389
• Niculescu, T., Weerth, S., Soane, L., Niculescu, F., Rus, V., Raine, C.S., Shin, M.L., Rus, H. (2003) Effects of membrane attack complex of complement on apoptosis in experiemental autoimmune encephalomyelitis. Annual New York Academy of Science. 1010:530-533
• Rosenthal, R.E., Silbergleit, R., Hof, P.R., Haywood, Y., Fiskum, G. (2003) Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke. 34:1311-1316
• Lolic, M.M., Silbergleit, R., Fiskum, G., Rosenthal, R.E. (2003) Hyperbaric oxygen reduces stroke infarct volume and myeloperoxidase activity and improves neurological outcome. Brain Res. 971:90-94
• Polster, B.M., Basanez, G., Young, M., Suzuki, M., Fiskum, G. (2003) Inhibition of Bax-Induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J. Neurosci. 23:2735-2743
• Fiskum, G., Starkov, A., Polster, B.M., Chinopoulos, C. (2003) Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's Disease. Annual New York Academy of Science. 991:111-119
• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fikum, G. (2003) Neuroprotective effects of bilobalide, a component of Ginkgo Biloba Extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry. 1:S89-94
• Hoffman, G.E., Moore, N., Fiskum, G., Murphy, A.Z. (2003) Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Experimental Neurology. 182:124-134
• Polster, B., Robertson, C., Bucci, C., Suzuki, M., Fiskum, G. (2003) Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release. Cell Death Differential. 10:365-370
• Starkov, A.A., Fiskum, G. (2003) Regulation of brain mitochondrial h1O2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86:1101-1107
• Badea, T.D., Park, J.H., Soane, L., Niculescu, T., Niculescu, F., Rus, H., Shin, M.L. (2003) Sublytic terminal complement attack induces c-fos transcriptional activation in myotubes. J. Neuroimmunology. 142:58-66

2002

• Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K., Fiskum, G. (2002) Bilobalide, a component of the Ginkgo Biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. Cell Molecular Biology. 48:663-669
• Uchino, H., Minamikawa-Tachino, R., Kristian, T., Perkins, G., Narazaki, M., Siesjo, B.K., Shibasaki, F. (2002) Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhabit calcineurin and the mitochondrial permeability transition. Neurobiological Disorders. 10:219-233
• Kowaltowski, A.J., Cosso, R.G., Campos, C.B., Fiskum, G. (2002) Effect of Bcl-2 overexpression on mitochondrial structure and function. J. Biological Chem. 277:42802-42807.
• Yoshimoto, T., Kristian, T., Hu, B.R., Ouyang, Y., Siesjo, B.K. (2002) Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A. Brain Res. 932:99-109
• Perkins, D., Yu, Y., Bambrick, L.L., Yarowsky, P.J., Aurelian, L. (2002) Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects. Exp. Neurology. 174:118-122
• Dorsey, S.G., Bambrick, L.L., Balice-Gordon, R.J., Krueger, B.K. (2002) Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16. J. Neurosci. 17:401-411
• Liu, Y., Fiskum, G., Schubert, D. (2002) Generation of reactive oxygen species by the mitochrondrial electron transport chain. J. Neurochem. 80:780-787
• Kristian, T., Weatherby, T.M., Bates, T.E., Fiskum, G. (2002) Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria. J. Neurochem. 83:1297-1308.
• Lolic, M.M., Silberglet, R., Fiskum , G., Rosenthal, R.E., (2002) Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity. Brain Res. 971:90-94
• Starkov, A.A., Polster, B.M., Fiskum, G. (2002) Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83:220-228
• Badea, T., Niculescu, F., Soane, L., Fosbrink, M., Hila, S., Rus, V., Shin, M.L., Rus, H. (2002) RGC-32 increases p34^CDC2 kinase activity and entry of aortic smooth muscle cells into S-Phase. J. Biological Chem. 277:502-508
• Rosen, G.M., Tsai, P., Weaver, J.M., Porasuphatana, S., Roman, L.J., Starkov, A.A., Fiskum, G., Pou, S. (2002) The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J. Biol. Chem. 277:40275-40280
• Barna, G., Sebestyen, A., Chinopoulos, C., Nagy, K., Mihalik, R., Paku, S., Kopper, L. (2002) TGF beta 1 kills lymphoma cells using mitochrondrial apoptotic pathway with the help of caspase-8. Anticancer Res. 22:3867-3872
• Qiu, J., Whalen, M.J., Lowenstein, P., Fiskum, G., Fahy, B., Darwish, R., Aarabi B., Yuan, J., Moskowitz, M.A. (2002) Upregulation of the Fas receptor death inducing signaling omplex after traumatic brain injury in mice and humans. J. Neurosci. 22:3504-3511

2001

• Kristian, T., Bernardi, P., Siesjo, B.K. (2001) Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury. J Neurotrauma 18:1059 -1074
• Kochanek, P.M., Hendrich, K.S., Robertson, C.L., Williams, D.S., Melick, J.A., Ho, C., Marion, D.W., Jackson, E.K. (2001) Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion. Magn Reson Med 45:924-929
• DasGupta, S.F., Rapoport, S.I., Gerschenson, M., Murphy, E., Fiskum, G., Russell, S.J., Chandrasekaran, K. (2001) ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10
• Polster, B.M., Kinnally, K.W., Fiskum, G. (2001) BH3 domain peptide induces cell type-selective mitochondriral outer membrane permeability. J. Biological Chem. 276:37887-37894
• Soane, L., Cho, H.J., Niculescu, F., Rus, H., Shin, M.L. (2001) C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167:2305-2311
• Chandrasekaran, K., Mehrabian, Z., Murray, P., and Fiskum, G. (2001) Chronic exposure of neural cells to elevated intracellular sodium decreases mitochondrial mRNA expression. Mitochondrion 1:141-150
• Robertson, C.L., Bell, M.J., Kochanek, P.M., Adelson, P.D., Ruppel, R.A., Carcillo, J.A., Wisniewski, S.R., Mi, Z., Janesko, K.L., Clark, R.S., Marion, D.W., Graham, S.H., Jackson, E.K. (2001) Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 29:2287-2293
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Wisniewski, S.R., Tsuji, T., Janesko, K.L., Ohta, H., Adelson, P.D., Marion, D.W., Kochanek, P.M. (2001) Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18:861-868
• Chinopoulos, C., Adam-Vizi, V. (2001) Mitochondria deficient in comlex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J Neurochem 76:302-306
• Kushnareva, Y.E., Polster, B.M., Sokolove, P.M., Kinnally, K.W., Fiskum, G. (2001) Mitochondrial precursor signal pepide induces a unique permeability transition and release of cyochrome c from liver and brain mitochondria. Biochemical Biophysical 386:144-145
• Starkov, A.Y., Fiskum, G. (2001) Myxothiazol induces h1O2 production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun 281:645-650
• Chandrasekaran, K., Mehrabian, Z., Spinnewyne, B., Drieu, K., Fiskum, G. (2001) Neuroprotective effects of bilobalide, a component of the Ginko biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 922:282-292
• Hila, S., Soane, L., Koski, C.L. (2001) Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD. Glia 36:58-67

2000

• Katsura, K., Rodriquez de Turco, E.B., Kristian, T., Folbergrova, J., Bazan, N.G., Siesjo, B.K. (2000) Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain. J. Neurochem 6:2521-2527
• Fiskum, G., Kowaltowksi, A.J., Andreyev, A.Y., Kushnareva, Y.E., Starkov, A.A. (2000) Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol 322:222-234
• Robertson, C., Hendrich, K., Kochanek, P., Jackson, E., Melick, J., Graham, S., Marion, D., Williams, D., Ho, C. (2000) Assesment of 2-chloroadenosine after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report. Acta Neurochir Suppl 76:187-189
• Kowaltowski, A.J., Vercesi, A.E., Fiskum, G. (2000) Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine. Cell Death Differential 207-214
• Kochanek, P.M., Clark, R.S., Ruppel, R.A., Adelson, P.D., Bell, M.J., Whalen, M.J., Robertson, C.L., Satchell, M.A., Seidberg, N.A., Marion, D.W., Jenkins, L.W. (2000) Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med 2000 1:4-19.
• Kristián, T., Gertsch, J., Bates, T., Siesjö, B.K. (2000) Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone 0. J. Neurochem 74:1999-2009
• Li, P-A., Kristián, T., He, Q-P., Siesjö, B.K. (2000) Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol 165:153-163
• Kowaltowski, A.J., Smaili, S.S., Russell, J.T., Fiskum, G. (2000) Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2 overexpression. American Journal of Physiology 48:852-859
• Chinopoulos, C., Tretter, L., Rozsa, A., Adam-Vizi, V. (2000) Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: The role of ATP depletion and rise of [Ca(2+)](i). J Neurosci 20:2094-2103
• Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Adelson, P.D., Tsuji, T., Wisniewski, S.R., Ohta, H., Janesko, K.L., Kochanek, P.M. (2000) Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: a preliminary report. Acta Neurochir Suppl 76:419-421
• MacKenzie, A., LaCasse, E. (2000) Inhabition of IAP's protection by Diablo/Smac: new therapeutic opportunities? Cell Death and Differentiation 7:866-867
• Mitochondria as targets of neuroprotection by Bcl-2 family proteins
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