Neuroprotection Publications

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  •  Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.,   Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. (2013) 111(2):143-151.
  •  Zhang F, Guo A, Liu C, Comb M, Hu B.  Phosphorylation and assembly of glutamate receptors after brain ischemia.  Stroke. (2013) 44(1):170-6.
  • Balan I, Saladino A, Aarabi B, Castellani R, Wade C, Stein DM, Eisenberg H, Chen HH, Fiskum G.  Cellular Alterations in Human Traumatic Brain Injury: Changes in Mitochondrial Morphology Reflect Regional Levels of Injury Severity.  J Neurotrauma. (2013) 30:367-381. 
  • Laird M, Clerc P, Polster BM, Fiskum G Augmentation of Normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels.  Translational Stroke Research (2013) 4:643-651
  • Clerc P, Young CA, Bordt EA, Grigore AM, Fiskum G, Polster BM   Magnesium sulfate protects against the bioenergetics consequences of chronic glutamate receptor stimulation.  PLoS One (2013) 13;8(11):e79982
  • Clerc P, Ge SX, Hwang H, Waddell J, Roelof BA, Karbowski M, Sesaki H, and Polster, BM   Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.  Br J Pharmacol. (2013) Nov 11. [Epub ahead of print]
  •  Kalakonda S, Nallar SC, Jaber S, Keay SK, Rorke E, Munivenkatappa R, Lindner DJ, Fiskum GM, Kalvakolanu DV. Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice. 
  • Proc Natl Acad Sci U S A. (2013) 110(45):E4213-22.
  • Robertson CL, Saraswati M, Scafidi S, Fiskum G, Casey P, McKenna MC. Cerebral glucose metabolism in an immature rat model of pediatric traumatic brain injury. J Neurotrauma. (2013) 30(24):2066-72.
  • Owens K, Park JH, Schuh R, Kristian T. Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury. Transl Stroke Res. (2013) 4(6):618-34.
  • Kristian T, Hu B. Guidelines for using mouse global cerebral ischemia models. Transl Stroke Res. (2013) 4(3):343-50.
  • Owens K, Park JH, Kristian T. Utilizing commercial microwave for rapid and effective immunostaining. J Neurosci Methods. (2013) 219(1):20-6.
  • Polster BM. AIF, reactive oxygen species, and neurodegeneration: a "complex" problem. Neurochem Int. (2013) 62(5):695-702.
  • Clerc P, Ge SX, Hwang H, Waddell J, Roelof BA, Karbowski M, Sesaki H, and Polster, BM   Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.  Br J Pharmacol. (2013) Nov 11. [Epub ahead of print]
  • Luo T, Park Y, Sun X, Liu C, Hu B. Protein misfolding, aggregation, and autophagy after brain ischemia. Transl Stroke Res. 2013 Dec;4(6):581-8. Nov 9. [Epub 2013]
  • Degracia D, Hu B. Protein misfolding and organelle stress after brain ischemia. Transl Stroke Res. 2013 Dec;4(6):579-80. Nov 8. [Epub 2013]
  • Park Y, Luo T, Zhang F, Liu C, Bramlett HM, Dalton Dietrich W, Hu B. Downregulation of Src-kinase and glutamate-receptor phosphorylation after traumatic brain injury. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1642-9. Jul 10. [Epub 2013]
  • Sabirzhanova I, Liu C, Zhao J, Bramlett H, Dietrich WD, Hu B. Changes in the GEF-H1 pathways after traumatic brain injury. J Neurotrauma. 2013 Aug 15; 30(16):1449-56. Jul 30. [Epub 2013]













  • Kristian, T., Bernardi, P., Siesjo, B.K.  Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury. J Neurotrauma 18:1059 -1074 (2001)
  • Kochanek, P.M., Hendrich, K.S., Robertson, C.L., Williams, D.S., Melick, J.A., Ho, C., Marion, D.W., Jackson, E.K.  Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion. Magn Reson Med 45:924-929 (2001)
  • DasGupta, S.F., Rapoport, S.I., Gerschenson, M., Murphy, E., Fiskum, G., Russell, S.J., Chandrasekaran, K.  ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10 (2001)
  • Polster, B.M., Kinnally, K.W., Fiskum, G.  BH3 domain peptide induces cell type-selective mitochondrial outer membrane permeability. J. Biological Chem. 276:37887-37894 (2001)
  • Soane, L., Cho, H.J., Niculescu, F., Rus, H., Shin, M.L.  C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167:2305-2311 (2001)
  • Chandrasekaran, K., Mehrabian, Z., Murray, P., and Fiskum, G.  Chronic exposure of neural cells to elevated intracellular sodium decreases mitochondrial mRNA expression. Mitochondrion 1:141-150 (2001)
  • Robertson, C.L., Bell, M.J., Kochanek, P.M., Adelson, P.D., Ruppel, R.A., Carcillo, J.A., Wisniewski, S.R., Mi, Z., Janesko, K.L., Clark, R.S., Marion, D.W., Graham, S.H., Jackson, E.K.  Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 29:2287-2293 (2001)
  • Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Wisniewski, S.R., Tsuji, T., Janesko, K.L., Ohta, H., Adelson, P.D., Marion, D.W., Kochanek, P.M.  Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18:861-868 (2001)
  • Chinopoulos, C., Adam-Vizi, V.  Mitochondria deficient in comlpex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J Neurochem 76:302-306 (2001)
  • Kushnareva, Y.E., Polster, B.M., Sokolove, P.M., Kinnally, K.W., Fiskum, G.  Mitochondrial precursor signal peptide induces a unique permeability transition and release of cytochrome c from liver and brain mitochondria. Arch Biochemical Biophysical 386:144-145 (2001)
  • Starkov, A.Y., Fiskum, G.  Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun 281:645-650 (2001)
  • Chandrasekaran, K., Mehrabian, Z., Spinnewyne, B., Drieu, K., Fiskum, G.  Neuroprotective effects of bilobalide, a component of the Ginko biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 922:282-292 (2001)
  • Hila, S., Soane, L., Koski, C.L.  Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD. Glia 36:58-67 (2001)


  • Katsura, K., Rodriquez de Turco, E.B., Kristian, T., Folbergrova, J., Bazan, N.G., Siesjo, B.K.  Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain. J. Neurochem 6:2521-2527 (2000)
  • Fiskum, G., Kowaltowksi, A.J., Andreyev, A.Y., Kushnareva, Y.E., Starkov, A.A.  Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol 322:222-234 (2000)
  • Robertson, C., Hendrich, K., Kochanek, P., Jackson, E., Melick, J., Graham, S., Marion, D., Williams, D., Ho, C.  Assesment of 2-chloroadenosine after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report. Acta Neurochir Suppl 76:187-189 (2000)
  • Kowaltowski, A.J., Vercesi, A.E., Fiskum, G.  Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine. Cell Death Differential 207-214 (2000)
  • Kochanek, P.M., Clark, R.S., Ruppel, R.A., Adelson, P.D., Bell, M.J., Whalen, M.J., Robertson, C.L., Satchell, M.A., Seidberg, N.A., Marion, D.W., Jenkins, L.W.  Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med 2000 1:4-19 (2000)
  • Kristián, T., Gertsch, J., Bates, T., Siesjö, B.K.  Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O. J. Neurochem 74:1999-2009 (2000)
  • Li, P-A., Kristián, T., He, Q-P., Siesjö, B.K.  Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol 165:153-163 (2000)
  • Kowaltowski, A.J., Smaili, S.S., Russell, J.T., Fiskum, G.  Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2 overexpression. American Journal of Physiology 48:852-859 (2000)
  • Chinopoulos, C., Tretter, L., Rozsa, A., Adam-Vizi, V.  Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: The role of ATP depletion and rise of [Ca(2+)](i). J Neurosci 20:2094-2103 (2000)
  • Robertson, C.L., Minamino, N., Ruppel, R.A., Kangawa, K., Adelson, P.D., Tsuji, T., Wisniewski, S.R., Ohta, H., Janesko, K.L., Kochanek, P.M. Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: a preliminary report. Acta Neurochir Suppl 76:419-421 (2000)
  • Fiskum, G., Polster, B.M., Kowaltowski, A.J.,  Mitochondria as targets of neuroprotection by Bcl-2 family protein. Pharmacology of Cerebral Ischemia 177-188 (2000)
  • Bogaert, Y.E., Rex-Sheu, K.F., Hof, P.R., Brown, A.M., Blass, J.P., Rosenthal, R.E., Fiskum, G.  Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resusciation. Experimental Neurology 161:115-125 (2000)
  • Buee, L., Mailliot, C., Podevin-Dimster, V., Rosenthal, R.E., Delacourte, A., Fiskum, G.  Rapid tau protein dephosphorylation and differential rephosphorylation during cardiac arrest-induced cerebral ischemia and reperfusion. J. Cereb. Blood Flow Metab 20:543-549 (2000)
  • Chinopoulos, C., Tretter, L., Adam-Vizi, V. Reversible depolarization of in situ mitochondria by oxidative stress parallels a decrease n NAD(P)H level in nerve terminals. Neurochem Int 36:483-488. (2000)