Clinical Research Activities

The University of Maryland offers unique opportunities for clinical research into hemorrhagic shock, traumatic brain injury, orthopedic technology, anesthesia techniques, human factors, and health care systems. Clinical research is currently supported by funding from the NIH, the Department of Defense, private industry, and philanthropy. We have a large and comprehensive trauma registry (including more than 120,000 acute trauma admissions over the past three decades), 24 hour/365 day coverage by clinical research personnel, and statistical and administrative support for grants and contracts. There are more than 100 open protocols, of which at least half are prospective clinical trials of medications, monitoring devices, or new treatments.

Faculty currently serve as principal or co-investigators on a number of projects, including:

  • Prospective, randomized assessment of Factor VIIa in acute hemorrhage shock.
  • Brain acoustic monitoring in mild, moderate, and severe traumatic brain injury.
  • The role of simulation in teaching emergency airway management.
  • The effect of acupuncture therapy on pain and inflammatory mediators after orthopedic trauma.
  • High vs. low oxygen therapy and the rate of infectious complications in orthopedics.
  • Assessment of intraoperative fluid management in large abdominal surgeries.
  • Diagnosis and monitoring of shock with the Acoustic Resuscitation Monitor.
  • Rotational thromboelastography as a technique for assessing acute traumatic coagulopathy.
  • Microscopic and biochemical pathophysiology of acutely injured brain tissue.
  • The impact of daily discharge rounding on trauma patient flow and outcomes.
  • Outcomes of work-related injuries, and potential interventions.
  • Continuous video display as a tool for trauma OR management.
  • Pre-hospital airway and ventilator management in severe traumatic brain injury.
  • The use of wound infiltration anesthesia in large abdominal surgeries.
  • Regional anesthesia in orthopedic trauma, and the impact on diagnosing compartment syndrome.
  • Factor VIIa for acute traumatic brain injury in surgical and non-surgical patients.
  • Timing of surgical interventions in poly-trauma patients.
  • Techniques and outcomes in emergency airway management.
  • Genomics and proteonomics in acute injury: prognostication of outcomes.