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Translational Genomics Laboratory

Contact Information

Hours:     Monday through Friday
8am – 5pm
Main Entrance:     Bressler 7-047
(Sample Accessioning)
Address:    655 West Baltimore St.,
BRB 7-037,
Baltimore MD, 21201
Phone:     (410) 706-3339
Fax:     (410) 706-0287


Linda JengLinda Jeng, MD, PhD, FACMG,
Laboratory Director
Clinical Molecular Geneticist and Clinical Geneticist

Nicholas Ambulos, Jr., PhDNicholas Ambulos, PhD,
Technical Supervisor


Danielle Sewell,
Compliance Manager  

The Translational Genomics Laboratory (TGL) is a CAP (College of American Pathologists) accredited and CLIA (Clinical Laboratory Improvement Amendments) compliant laboratory, capable of providing support to clinical and translational genetic/genomic studies (CAP# 8017554) (CLIA# 21D2027356). TGL is part of the University of Maryland School of Medicine’s Program for Personalized and Genomic Medicine (PPGM) and the Center for Innovative Biomedical Resources (CIBR).  The TGL was developed as a critical bridge to help accelerate translation from discovery into precision health care, providing DNA sequencing, genotyping and array-based technologies.  The services offered by the TGL are similar to those offered in traditional academic genomic core labs, except that these assays are validated under CLIA which allows them to be used in the clinical decision-making process in research protocols and for routine patient care.


APOB Genotyping  5 mL Blood (EDTA) 7-10 days
CYP2C19 Genotyping (Study Protocol)  5 mL Blood (EDTA) 24 hours
CYP2C19 Sequencing  5 mL Blood (EDTA) 7-10 days
Cytogenomic Microarray  5 mL Blood (EDTA) 14-21 days
Extract and Hold  5 mL Blood (EDTA) 7-10 days    
IDH1 R132_IDH2 R140 and R172  5 mL Blood/BMA (EDTA) 7-10 days


TGL has a variety of instrumentation available for future development of clinical assays or current research testing: 

  • Applied Biosystems 3730XL (Sanger sequencing)
  • Affymetrix GeneChip system 3000 7G (chip-based arrays, e.g. CytoScan HD, DMET)
  • Applied Biosystems 7900 RT-PCR system (genotyping by Taqman©-based methods)
  • Applied Biosystems 9700 thermocycler (PCR amplification)
  • Ion Torrent Personal Genome Machine (next generation sequencing panels, e.g. Hot Spot Cancer Panel, Comprehensive Cancer Panel, and Custom AmpliSeq panels)

Please contact TGL to discuss potential development of new assays.