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Michael S. Donnenberg, MD
Professor of Microbiology & Immunology
MD:Columbia University College of Physicians and Surgeons, 1983.
Phone: (410) 706-7560
Fax: (410) 706-8700
E-mail: mdonnenb@umaryland.edu
Address:
Division of Infectious Diseases
University of Maryland School of Medicine
20 Penn St., HSF2 S403D
Baltimore, MD 21201
RESEARCH INTERESTS
Molecular and cellular pathogenesis of Escherichia coli infections.
Our laboratory is concerned with the study of bacterial pathogenesis. The primary interest is in interactions between pathogenic Escherichia coli and host cells. We use a combined molecular biology and cell biology approach to gain insight into the processes by which pathogenic E. coli cause disease. The goal is to identify and characterize bacterial genes that are involved in interactions with host cells and to identify cellular mechanisms triggered by interactions with bacteria. Our initial approach, to identify, clone and mutate bacterial genes involved in pathogenesis has led to the characterization of large gene clusters and pathogenicity islands required for adherence, host cell damage, and avoidance of host immune responses. We are currently involved in delineating the functions and cellular targets of the protein products of these genes. It is anticipated that these studies will impact not only our understanding and approach to infectious diseases, but also our appreciation for normal and abnormal cellular physiology. Further information is available on our laboratory website.
RECENT PUBLICATIONS
Donnenberg MS. Pathogenic Strategies of Enteric Bacteria. Nature, 2000; 406:768-74. UI: 20417596
Bahrani-Mougeot FK, Buckles EL, Lockatell CV, Hebel JR, Johnson DE, Tang CM, Donnenberg MS. Type-1 fimbriae and Extracellular Polysaccharides are Preeminent Uropathogenic Escherichia coli Virulence Determinants in the Murine Urinary Tract. Mol Microbiol, 2002; 45:1079-1093. UI: 12180926
Blank TE, Zhong H, Bell AL, Whittam TS, Donnenberg MS. Molecular Variation Among Type IV Pilin (bfpA) Genes From Diverse Enteropathogenic Escherichia coli Strains. Infect Immun, 2000; 68:7028-7038. UI: 11083828
Crowther LJ, Anantha RP, Donnenberg MS. The Inner Membrane Subassembly of the Enteropathogenic Escherichia coli Bundle-Forming Pilus Machine. Mol Microbiol, 2004;51:67-79. UI:15049811
Nougayrède JP, Donnenberg MS. Enteropathogenic Escherichia coli EspF is Targeted to Mitochondria and is Required to Initiate the Mitochondrial Death Pathway. Cell Microbiol, 2004; 6: 1097-1111. UI: 15469437
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To contact us:
Phone: 410-706-7560
Fax: 410-706-4619
E-mail: kvardjan@ihv.umaryland.edu
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