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Participating Sites

Study Sites Large

Center for Vaccine Development (CVD), Bamako, Mali

The "Centre pour le Développement des Vaccins du Mali" (CVD-Mali) functions under a cooperative agreement between the Ministry of Health of Mali and the CVD of the University of Maryland School of Medicine to foster research and training in vaccinology and tropical diseases in Mali. CVD-Mali, which has its headquarters in the Centre National d'Appui à la Lutte Contre la Maladie (CNAM, formerly Institut Marchoux) in Bamako (under the direction of the Ministry of Health), carries out studies in the Bamako metropolitan area and in villages up to four hours away by vehicle.

Virtually all children suffering from acute infectious diseases in Bamako who require admission to hospital are admitted to l'Hôpital Gabriel Touré (HGT), a large government hospital. CVD-Mali assigns GCP-trained physicians and nurses to work in the pediatric Emergency Room of HGT to maintain surveillance for infectious diseases of interest (including invasive Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis infections, typhoid fever, pneumonia and diarrheal diseases) treated in the ER or admitted to hospital. A fully equipped Clinical Microbiology Laboratory in HGT (with automated BACTEC machines) established by CVD-Mali in February 2002 processes ~ 2500 blood, CSF and other clinical specimen cultures from children annually.

The contact information for this site is:

CVD-Mali/CNAM/Ex Institut Marchoux
BP 125
Bamako, Mali
Telephone: 223-2-23-6031
Fax: 223-2-22-2883

Medical Research Council (MRC) Basse, the Gambia Field Site

Since 1983, the MRC has maintained a field site at Basse, located in the Upper River Division (URD), the least-developed part of The Gambia. The URD has an estimated population of 183,000, with about 44% below the age of fifteen and 27,815 children 0-59 months of age. The health care facilities that provide treatment services to the Basse population include the Basse Health Centre, the Gambisara Dispensary and Basse Trekking Clinics

The Basse site is well placed to provide excellent facilities for research in a rural setting with a high disease and mortality burden. The site has a long history of collaboration with the Ministry of Heath, Divisional health team and local government authorities and has implemented research interventions through primary health care facilities. The strengths of the Field Site include proven ability to undertake large clinical trials according to ICH Good Clinical Practice guidelines, excellent infrastructure in a rural setting, good laboratory facilities, quality data handling capacity and experienced staff.

The contact information for this site is:

Medical Research Council Laboratories, Fajara
Bacterial Diseases Research Program
PO Box 273, Banjul
The Gambia, West Africa
Telephone: 220-449-491
Fax: 220-449-5919/7924

Manhiça Health Research Center (CISM), Manhica, Mozambique

The Manhiça Health Research Center (CISM) was established in 1996 as a joint collaborative programme among the Mozambican Ministry of Health, the Eduardo Mondlane Faculty of Medicine and the Hospital Clinic of Barcelona, with core funding from the Spanish Agency for International Cooperation (AECI). Semi-rural Manhiça is situated in Southern Mozambique, about 80 Km north of the capital, Maputo. CISM is closely linked to the Manhiça District Hospital. The centre supports all areas of medical care.

Research at CISM aims to describe the epidemiology and clinical presentation of relevant diseases in the target population (and to gain insights into the pathophysiology of these infections) and to develop and test new control strategies against these diseases. CISM has fully described the epidemiology of malaria in the area in children, pregnant women and adults and has carried out descriptive studies on the prevalence and morbidity of respiratory syncytial virus, measles, diarrheal diseases, TB and sexually transmitted diseases, including HIV. Two antimalarial drug efficacy studies have been carried out. Ongoing intervention trials include a phase IIa/b malaria vaccine trial, a trial on intermittent preventive treatment (IPTi) in infants and a trial on combination of malaria strategies in pregnant women. There is also an ongoing study on the causes and risk factors of maternal mortality as well as research on HPV genotypes implicated on cervical cancer.

The contact information for this site is:

Centro de Investigation enaude da Manhica
Manhica Village Street 12
CP 1929, Maputo
Manhica, Mozambique
Telephone: 258-21-810-002
Fax: 258-22-810-181  

Center for Diseases Control Kenya Medical Research Institute (KEMRI), Kenya, India

CDC-KEMRI in Kisian will be the base of operations for this project. This unit receives administrative, logistical and scientific support from the CDC in Atlanta and KEMRI in Nairobi.

Active research programs at CDC/KEMRI are ongoing in the areas of malaria, HIV/AIDS, emerging infectious diseases, diarrheal diseases, respiratory diseases, chistosomiasis/other helminths. There are currently 29 funded research projects with funding and collaboration from CDC and a variety of other agencies and donors.

The contact information for this site is:

Unit 64112
APO AE 09831
Kisumu, Kenya
Telephone: 254-20-271-3008
Fax: 254-20-271-4745  

National Institute of Cholera and Enteric Diseases (NICED), Kolkata, India

NICED is an integral component of the Indian Council of Medical Research network and receives core support from the Ministry of Health and Family Welfare, Government of India. In addition, there are many extramural funds from the Department of Science & Technology, Department of Biotechnology, Council of Scientific and Industrial Research, etc. International Collaborative projects are also under operation supported by the Japan International Collaborative Agency, US-Vaccine Action Program, and CDC.

NICED has nine Divisions with Epidemiology, Clinical Medicine, Microbiology, Immunology and Vaccine Development, Biochemistry, Microbial Genetics, Pathophysiology, Virology and Electron Microscopy. In addition, a Vibrio Phage Reference Laboratory helps in the phage typing of Vibrio cholerae. The Media Section and Animal House Section cater to the needs of all laboratories. There is a central Library in the Institute with several PCs with Internet facilities. The Administrative section governs the general function of the Institute.

The contact information for this site is:

National Institute of Cholera & Enteric Diseases (NICED)
P-33 CIT Road, Scheme X-M
Beliaghata, Kolkata
West Bengal, India 700 010
Telephone: 91-33-2370-1176
Fax: 91-33-2370-5066

International Center for Diarrheal Disease Research - Bangladesh (ICDDR-B)

ICDDR-B Centre for Health and Population Research is a large, non-profit, international health research organization with headquarters in Dhaka, Bangladesh. It conducts research and provides service and training in a variety of important health problems that the developing countries face. ICDDR-B is a world leader in studies of and solutions for common conditions prevalent in the developing nations and associated with poverty, including infectious diseases, malnutrition, high fertility, microbial and chemical contamination of the environment and the need for better health services.

The contact information for this site is:

ICDDR-B Centre for Health and Population Research
68 Shahid Tajuddin Ahmed Sharani
Mohakhali (GPO Box 128, Dhaka 1000)
Dhaka 1212
Telephone: 88-02-886-0523
Fax: 88-02-988-5657  

Aga Khan University, Karachi, Pakistan

The Department of Pediatrics and Child Health of the Aga Khan University, Karachi, Pakistan is actively engaged in child health research relevant to developing regions of the world. The Department conducts research in several urban and rural areas throughout Pakistan.

The Gates Enteric Multi-Center Study in Pakistan is being carried out in two peri-urban coastal fishing communities located about 45 minutes from Karachi. The population under surveillance is 130,000, with a child mortality rate of about 100/1000 live births.

The contact information for this site is:

Aga Khan University
Department of Pediatrics
PO Box 3500
Staduim Road
Karachi 74800
Telephone: 92-21-486-4955
Fax: 92-21-493-4294