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Goals & Objectives

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The major goal of this project was to conduct a multi-center study to quantify the burden and identify the microbiologic etiology of severe diarrheal disease among children 0-59 months of age living in developing countries in two global regions (Africa and Asia). The study was conducted at seven experienced and well-characterized sites using a common research protocol of rigorous epidemiologic and microbiologic design, to address limitations of previous studies and to satisfy contemporary needs for information.

The ultimate goal is to provide data needed to guide development and implementation of enteric vaccines and other public health interventions that can diminish morbidity and mortality from diarrheal diseases. The following specific tasks are designed to achieve this overriding goal:

  • To quantify the burden and adverse clinical consequences of severe diarrheal disease and to identify the microbiologic etiology according to age stratum (0-11 months, 12-23 months, 24-59 months) and clinical syndrome at each individual site, in each region, and across all sites.
  • To characterize the phenotype and/or genotype distribution of major enteric pathogens.
  • To prepare an evidence-based assessment (based on disease burden, economic analysis, and public perception) of the financial costs, both public and private, of diarrheal disease caused by major indicated pathogens, by country and by region, among children 0-59 months of age, and the public demand for an intervention.
  • To archive and store the well-characterized clinical specimens and isolated etiologic agents so that they can be accessed in the future for research and technology development.