Our Research

The General Clinical Research Center is engaged in a full range of patient-oriented research. Each month new protocols are reviewed and approved for resource use. The following is a list of research currently approved by the GCRC Advisory Committee. Links to ClinicalTrials.gov for recruitment information are included when available.

Principal Investigator

IRB Protocol Number

Title

Bever, Christopher H-28737 Double-Blind, Placebo-Controlled, Phase I, Dose-Escalation Study of the Safety of a Single Dose of RTL1000 in Subjects with Relapsing Remitting or Secondary Progressive Multiple Sclerosis (RRMS or SPM)
(http://clinicaltrials.gov/ct/show/NCT00411723?order=37)
Buchanan, Robert H-21270 Adjunctive Risperidone in Clozapine Treated Patients
Cole, John H-26073 Stroke and the Genetics of Thrombomodulin
Counts, Debra H-26444 TrialNet
(http://clinicaltrials.gov/ct/show/NCT00097292?order=1)
Counts, Debra H-28102 New Onset of Type 1 Diabetes Anti-CD20 Clinical Trial
(http://clinicaltrials.gov/ct/show/NCT00279305?order=4)
Counts, Debra H-8553 Oral Insulin for Prevention of Diabetes in Patients at Risk for Type 1 Diabetes Mellitus (http://clinicaltrials.gov/ct/show/NCT00419562?order=1)
Cross, Raymond H-27882 Home Telemanagement Trial in Patients with Ulcerative Colitis (http://clinicaltrials.gov/ct2/show/NCT00620126?term=NCT00620126&rank=1)
Dowling, Thomas H-26065 Pharmacogenomic Study In Hispanic Americans With Diabetes
Dowling, Thomas H-26129 Evaluation of Renal Drug Transport in Healthy Volunteers
Dutton, Richard H-28116 Noninvasive Monitoring of Patients with Traumatic Brain Injury
Fasano, Alessio H-27529 Proton Pump Inhibitors Reduce Airway Inflammation in Asthmatics by Improving Intestinal Permeability
Fasano, Alessio H-27433 Safety Of VSL#3 for Adult Asthmatics
Fink, Jeffrey H-21249 The Prospective Cohort Study of Chronic Renal Insufficiency (CRIC)
(http://clinicaltrials.gov/ct/show/NCT00304148?order=1)
Fink, Jeffrey H-23374 Evaluating an Oral Urea Tolerance Test to Measure Overall Renal Function
Forrest, Graeme H-27719 Clinical Outcomes of Staphylococcus Aureus Bacteremia in HIV-Infected Patients
Gojo, Ivana H-27229 0507 GCC: A Phase 1 Study Of UCN-01 In Combination With Perifosine In Patients With Relapsed And Refractory Acute Leukemias
(http://clinicaltrials.gov/ct/show/NCT00301938?order=12)
Gold, James H-26601 Attention And Working Memory In Schizophrenia
Gold, James H-21890 Event-Related Potential in Schizophrenia During Visual Search
Gottlieb, Stephen H-26618 HF-Action: Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training
Greenspan, Joel H-28224 Gonadal Steroid Hormone Modulation of Pain-Related Cortical Activity
Harris, Anthony H-21329 Methodological Approaches to Risk Analysis for Emerging Pathogens: Epidemiology of Imipenem-Resistant P. Aeruginosa
Harris, Anthony  H-29244 Healthcare Worker Attitudes Towards Antimicrobial Resistance
Hebdon, Matthew H-20958 Epidemiology of Diabetes Intervention and Complications (EDIC)
Hise, Michael H-29660 Recommendations for Influenza Vaccine Use by Nephrologists
Hochberg, Marc H-22349 Clinical Center for the Osteoarthritis (OA) Initiative
Hong, Elliot H-27281 Neuroimaging Studies of Neurophysiological Phenotypes in Schizophrenia
Howell, Charles H-26317 Predicting Outcome Of Hepatitis C Treatment
Howell, Charles H-28740 Ribavirin Pharmacokinetics, Race and Outcome of Hepatitis C Treatment
Johnson, Jennifer H-29002 Understanding Resistance Mechanisms in Fecal Microorganisms
Joseph, Lyndon H-21491 Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
Kittner, Steven H-21025 Behavior, Infection & Genetics in Early-Onset Stroke (YSS)
(http://clinicaltrials.gov/ct/show/NCT00108940?order=1)
Lyke, Kiersten H-26914 Use of Preserved Specimens From Completed International Malaria Trials
Magaziner, Jay H-24580 Learning About Hip Fracture Recovery in Men and Women
McDiarmid, Melissa H-20924 Follow-up & Monitoring of Gulf War Veterans with Fragments of Depleted Uranium & Other Sources of Depleted Uranium Exposure
Mehra, Mandeep H-28083 Real Time Angiotensin Monitor for Salt Sensitivity
Mendley, Susan H-26675 Chronic Kidney Disease in Children Study (CKID)
(http://clinicaltrials.gov/ct/show/NCT00327860?order=462)
Mendley, Susan H-28893 Impact of a Multidisciplinary Weight Reduction Intervention on Blood Pressure and Non-Classical Cardiovascular Risk Factors in Obese Children and Adolescents
Mohiuddin, Majid H-26679 RTOG 0413 (NSAPB Protocol B-39): A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, Or II Breast Cancer.
(http://clinicaltrials.gov/ct/show/NCT00103181?order=131)
Nemoy, Lucia H-26512 Antibiotic Resistance Gene Reservoirs: Impact on Emergence of Resistance
Oursler, Kris Ann H-28973 Fitness and Longevity in Exercise (FLEX)
Pierson, Richard H-27115 Mechanisms Of Galtko Lung Xenograft Injury
Postolache, Teodor H-26191 Seasonality of Depression and Airborne Allergens
Postolache, Teodor H-28845 Light Treatment for Winter SAD: Metabolic Effects and Prediction of Antidepressant Response by Immediate Improvement
Roghmann, Mary-Claire H-26979 Epidemiology Of Colonization With Methicillin-Resistant Staphylococcus Aureus
Roghmann, Mary-Claire H-29678 Outcomes of and Risk Factors for Infections Due to USA300 MRSA
Rus. Violeta H-26979 A Multi-Center, Open-Label, Continuation Trial of Lymphostat-B Antibody (Monoclonal Anti-BLys Antibody) in Subjects With Systemic Lupus Erythematosus (SLE) who Completed the Phase 2 Protocol LBSl02
Ryan, Alice H-22326 Menopause, Genes and Metabolism after Weight Loss and Exercise
Saunders, Elijah H-24874 Baltimore Partnership Program to Reduce Cardiovascular Disparities
Sausville, Edward H-26463 0458GCC: A Phase I Dose Escalation Study Of Intravenous 17-Allylaminogeldanamycin (17-AAG){NSC 330507, IND 57,966] And Oral Bay 43-9006 [NSC 724772, IND 69,896] Administered In Patients With Pretreated Advanced Solid Tumors
(http://clinicaltrials.gov/ct/show/NCT00121264?order=182)
Sausville, Edward H-27439 0548GCC: A Phase 1 Study of AFP464 (Aminoflavone Prodrug) in Patients with Advanced Solid Tumors
(http://clinicaltrials.gov/ct/show/NCT00369200?order=1)
Sausville, Edward H-28248 0629GCC: A Phase I, Open-Label, Multi-Center, Dose-Escalation Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD7762 Administered as a Single Intravenous Agent and in Combination With Weekly Standard Dose Gemcitabine in Patients with Advanced Solid Malignancies
(http://clinicaltrials.gov/ct/show/NCT00413686?order=2)
Sausville, Edward  H-29693 0782GCC: A Phase I Dose-Escalation Study of Oral ABT-888 (NSC #737664) Plus Intravenous Irinotecan (CPT-11, NSC#616348) Administered in Patients With Advanced Solid Tumors
Scharf, Steven H-26178 Collection of Blood for Future Genetic Testing
Scharf, Steven H-26837 The Effect of Chronic Macrolide Administration on the Frequency and Severity of COPD Exacerbations
(http://clinicaltrials.gov/ct/show/NCT00325897?order=27)
Scharf, Steven H-28579 Anti-Leukotriene Therapy for COPD Exacerbations
(http://clinicaltrials.gov/ct/show/NCT00493974?order=79)
Scharf, Steven H-28586 Pneumococcal Vaccine Response in Chronic Obstructive Pulmonary Disease
(http://clinicaltrials.gov/ct/show/NCT00457977?order=87)
Seliger, Stephen H-27051 An Observational Study of Subclinical Ischemic Brain Disease and Cognitive Dysfunction in Chronic Kidney Disease
Shuldiner, Alan H-22773 Genome Wide Research for CVD Gene-Environment Interactions
Shuldiner, Alan H-27230 Pharmacogenomics of Anti-Platelet Interventions (PAPI) Study
Shuldiner, Alan H-20915 Genetics of Longevity in the Amish
Shuldiner, Alan H-20963 Amish Family Diabetes Study
Shuldiner, Alan H-20926 Genetics of Osteoporosis
Shuldiner, Alan H-20927 Genetics of Type 2 Diabetes and Obesity
Shulman, Lisa H-24812 Study of Antidepressants in Parkinson's Disease (SAD-PD)
(http://clinicaltrials.gov/ct/show/NCT00086190?order=49)
Silver, Kristi H-20717 Genetics of Pancreatic Function in the Development of Diabetes Mellitus
Silver, Kristi H-28064 Association of Chronic Stress with BMI in African American Females
Silver, Kristi H-26081 Linkage Of Insulin Secretion To Chromosome 15q In The Old Order Amish
Silver, Kristi H-27587 Effects of a Steroid Challenge on Glucose Tolerance
Smith, Barbara H-26583 The Effects of Resistive or Aerobic Exercise and a Nutrition (RAN) Program on Body Composition, Blood Pressure, Functional Status and Mood in University Employees
Steinle, Nannette H-23047 Cloning A Blood Pressure Gene On Chromosome 2
Streeten, Elizabeth H-28679 Clinical and Molecular Characterization of Suspected Partial 25-Hydroxyvitamin D-1-Alpha Hydroxylase Deficiency
Strome, Scott H-27065 0524GCC Mage-A3/HPV16 Peptide Based Immunotherapeutic Vaccines For Squamous Cell Carcinoma of the Head and Neck
(http://clinicaltrials.gov/ct/show/NCT00257738?order=41)
Tacket, Carol H-27424 Phase I Randomized, Double-Blind, Heterologous Prime-Boost Study Of The Safety And Immunogenicity Of Vi Polysaccharide Typhoid Vaccine After Priming By Live Attenuated Oral Vi+ Salmonella Typhi Strain CVD 909 (Typhoid CVD 36000, DMID 05-009)
(http://clinicaltrials.gov/ct/show/NCT00326443?order=23)
Tacket, Carol H-28840 Norwalk VLP 4000: Phase I Dose Escalation, Afety and Immunogenicity Study of Intranasal Norwalk VLP Vaccine with Adjuvant (MPL) and Excipients (Chitosan, Mannitol and Sucrose)
Tagamets, Malle H-21595 Functional Magnetic Resonance Imaging (fMRI) Correlates Reading, Language and Memory
Thaker, Gunvant H-23545 Familial Schizophrenia And Spectrum Personality Disorder
Thaker, Gunvant H-22053 Motion Processing In Schizophrenia
Watson, Douglas H-23089 Phase I/II, Open-Label, Pharmacokinetic and Safety Study of a Novel Protease Inhibitor (BMS-232632, Atazanavir, ATV, Reyataz) in Combination Regimens in Antiretroviral Therapy (ART)-Naïve and Experienced HIV-Infected Infants, Children, and Adolescents
Watson, Douglas H-27545 PACTG 1058: Intensive Pharmacokinetic Studies of Antiretroviral Drug Combinations in Children
Weir, Matthew H-27005 ALTOLD - Assessing Long Term Outcomes of Living Donation
Wolf, Jeffrey H-27834 GCC 0608: Phase I Study of Intra-Tumoral Injection of Dendritic Cells for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (http://clinicaltrials.gov/ct/show/NCT00492947?order=6)

 

 

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