Our Research
The General Clinical Research Center is engaged in a full range of patient-oriented research. Each month new protocols are reviewed and approved for resource use. The following is a list of research currently approved by the GCRC Advisory Committee. Links to ClinicalTrials.gov for recruitment information are included when available.
Principal Investigator |
IRB Protocol Number |
Title |
|---|---|---|
Beitelshees, Amber |
HP-40291 |
Uncoupling Protein Polymorphisms and Cardiometabolic Responses to Beta-Blockers |
Chen, Wilbur |
HP-41209 |
Influenza CVD 25000: A Randomized, Double-Blinded, Phase I/II Study of the Safety, Reactogenicity, and Immunogenicity of a Single Intramuscular Booster Dose of Inactivated Influenza Vaccine Derived from A/H5N1/Indonesia/05/05 (Clade2) in Healthy Adults 19 Years or Older Who Received Inactivated Influenza Vaccine Derived from A/H5N1/Vietnam/1203/2004 (Clade1) (http://clinicaltrials.gov/ct/show/NCT00680069) |
Chen, Wilbur |
HP-43474 |
Influenza CVD 38000: A Phase II Study in Healthy Adult and Elderly Populations to Assess the Safety and Immunogenicity of a Sanofi Pasteur H1N1 Influenza Vaccine Administered at Different Dose Levels Given With and Without GlaxoSmithKline AS03 Adjuvant |
Cole, John |
HP-43342 |
Stroke and the Genetics of Thrombomodulin |
Counts, Debra |
HP-40490 |
|
Counts, Debra |
HP-43352 |
New Onset of Type 1 Diabetes Anti-CD20 Clinical Trial |
Counts, Debra |
HP-41277 |
Oral Insulin for Prevention of Diabetes in Patients at Risk for Type 1 Diabetes Mellitus (http://clinicaltrials.gov/ct/show/NCT00419562) |
Counts, Debra |
HP-41399 |
Epidemiology of Diabetes Intervention and Complications (EDIC) (http://clinicaltrials.gov/ct/show/NCT00360893) |
Donner, Thomas |
HP-40249 |
Durable-Response Therapy Evaluation for Early or New-Onset Type 1 Diabetes (DEFEND) |
Dowling, Thomas |
HP-44028 |
Pharmacogenomic Study In Hispanic Americans With Diabetes |
Edelman, Martin |
HP-41372 |
0804 GCC: A Phase 1 Open Label, Dose Escalation Study to Evaluate the Effect of Four Doses of MAGE-A3/HPV 16 Trojan Peptides 0001 and 0002 Administered Subcutaneously in Combination with Montanide and GM CSF on Immunological Response, Safety, Tolerability, and Preliminary Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck(http://clinicaltrials.gov/ct2/show/NCT00704041) |
Feigenberg, Steven |
HP-40817 |
RTOG 0413 (NSAPB Protocol B-39): A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, Or II Breast Cancer. |
Fink, Jeffrey |
H-21249 |
The Prospective Cohort Study of Chronic Renal Insufficiency (CRIC) |
Gojo, Ivana |
HP-42937 |
0507 GCC: A Phase 1 Study Of UCN-01 In Combination With Perifosine In Patients With Relapsed And Refractory Acute Leukemias |
Hararian, Abdolreza |
HP-42869 |
B-Cell Depletion by Anti-CD20 in Renal Allograft Recipients Who Develop De Novo Anti-HLA Alloantibodies |
Harris, Anthony |
HP-42183 |
Methodological Approaches to Risk Analysis for Emerging Pathogens: Epidemiology of Imipenem-Resistant P. Aeruginosa |
Hochberg, Marc |
HP-42306 |
Clinical Center for the Osteoarthritis (OA) Initiative (http://clinicaltrials.gov/ct/show/NCT00080171) |
Hong, Elliot |
HP-43506 |
Neuroimaging Studies of Neurophysiological Phenotypes in Schizophrenia |
Horenstein, Richard |
HP-40836 |
A Randomized Controlled Clinical Trial of Clarification of Optimal Anticoagulation Through Genetics |
Howell, Charles |
HP-42624 |
Ribavirin Pharmacokinetics, Race and Outcome of Hepatitis C Treatment |
Howell, Charles |
HP-42926 |
A Phase 2, Randomized, Multicenter, Placebo-Controlled, Double-Blind, Parallel-Group Study to Evaluate the Efficacy, Safety, and Population Pharmacokinetics of Once-Daily Oral E5501 Tablets Used Up to 7 Days in Subjects with Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures |
Jain, Ajay |
HP-43996 |
Fc Receptor Polymorphisms in Colon Cancer Patients and in-vitro Antibody Dependent Cellular Cytotoxicity (ADCC) against KRAS mutant and nonmutant tumors |
Johnson, Jennifer |
HP-41043 |
Understanding Resistance Mechanisms in Fecal Microorganisms |
Johnson, Jennifer |
HP-41044 |
Antimicrobial Resistant Mechanisms from Clinical Cultures |
Katzel, Leslie |
HP-41271 |
Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS) Scan |
Kotloff, Karen |
HP-43021 |
Influenza 35000: A Phase II Study in Healthy Adult and Elderly Populations to Assess the Safety and Immunogenicity of an Unadjuvanted Sanofi Pasteur H1N1 Influenza Vaccine Administered at Two Dose Levels |
Kwok, Young |
HP-40841 |
RTOG 0534 - A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy (http://clinicaltrials.gov/ct/show/NCT00567580) |
Kwok, Young |
HP-42116 |
RTOG 0614: A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy |
Kwok, Young |
HP-42390 |
RTOG 0825 - Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma |
Kwok, Young |
HP-43116 |
RTOG 0539 Phase II Trial Of Observation For Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas |
Kwok, Young |
HP-43489 |
RTOG 0621: Adjuvant 3DCRT/IMRT in Combination With Androgen Suppression and Docetaxel for High Risk Prostate Cancer Patients Post-Prostatectomy: A Phase II Trial |
Lyke, Kiersten |
HP-43946 |
Malaria CVD 17000: Interventional Plasmodium Falciparum Malaria Challenge Model Utilizing the NF54 Strain of Parasite Transmitted by Aseptic A. Stephensi Mosquitoes to Healthy Malaria-Naïve Adult Volunteers |
Lyke, Kiersten |
HP-41298 |
Use of Preserved Specimens From Completed International Malaria Trials |
McDiarmid, Melissa |
HP-40728 |
Follow-up & Monitoring of Gulf War Veterans with Fragments of Depleted Uranium & Other Sources of Depleted Uranium Exposure |
Mendley, Susan |
HP-42179 |
Chronic Kidney Disease in Children Study (CKID) |
Mendley, Susan |
HP-42408 |
Impact of a Multidisciplinary Weight Reduction Intervention on Blood Pressure and Non-Classical Cardiovascular Risk Factors in Obese Children and Adolescents |
Noguiera, Joseph |
HP-43529 |
Study of Heart and Renal Protection (SHARP) A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Effects of Lipid-Lowering Therapy With Simvastatin and Ezetimibe Compared With Placebo on the Time to a First Cardiovascular Event (Myocardial Infarction, Stroke, Angioplasty, Bypass Surgery, or Cardiac Death) in Patients With Chronic Kidney Disease (CKD) |
Oswald, Lynn |
H-30104 |
Dopamine and Risks for Drug Abuse |
Panigrahi, Pinaki |
H-29171 |
Prevention of Neonatal Infection in The Indian Community Setting Using Probiotics |
Pierson, Richard |
H-27115 |
Mechanisms Of Galtko Lung Xenograft Injury |
Polli, James |
HP-30734 |
Evaluation of Biopharmaceutics Classification System Class 3 Drugs for Possible Biowaivers |
Polli, James |
HP-43432 |
Impact of Formulation on Ciprofloxacin Oral Absorption |
Postolache, Teodor |
HP-43574 |
Light Treatment for Winter SAD: Metabolic Effects and Prediction of Antidepressant Response by Immediate Improvement (http://clinicaltrials.gov/ct2/show/NCT00742365) |
Reeves, Gloria |
HP-43695 |
Investigating Metabolic Side Effects of Antipsychotic Medications in Children |
Reeves, Gloria |
HP-43939 |
IMPACT: Improving Metabolic Parameters of Antipsychotic Child Treatment |
Regine, William |
HP-41455 |
RTOG 0822: A Phase II\I Evaluation of Preoperative Chemoradiotherapy Utilizing Intensity Modulated Radiation Therapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer (http://clinicaltrials.gov/ct2/show/NCT00613080) |
Roghmann, Mary-Claire |
HP-40957 |
Longitudinal Study of the Human Anterior Nares Microbiome |
Royak-Schaler, Renee |
HP-40396 |
A Lowfat Eating Plan to Manage Weight Gain Among African American Breast Cancer Survivors |
Rus, Violeta |
HP-43673 |
A Multi-Center, Open-Label, Continuation Trial of Lymphostat-B Antibody (Monoclonal Anti-BLys Antibody) in Subjects With Systemic Lupus Erythematosus (SLE) who Completed the Phase 2 Protocol LBSL02 (http://clinicaltrials.gov/ct/show/NCT00583362) |
Russell, James |
HP-42940 |
Improving Neuropathy and Mobility in Subjects with Early Diabetes |
Sausville, Edward |
HP-42617 |
A Phase 1 Study of AFP464 (Aminoflavone Prodrug) in Patients with Advanced Solid Tumors(http://clinicaltrials.gov/ct/show/NCT00369200) |
Sausville, Edward |
HP-42962 |
A Phase I, Open-Label, Multi-Center, Dose-Escalation Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD7762 Administered as a Single Intravenous Agent and in Combination With Weekly Standard Dose Gemcitabine in Patients with Advanced Solid Malignancies |
Sausville, Edward |
HP-40559 |
Treatment of Melanoma With Wild-Type P53 and Detectable A 100b Using Pentamidine: A Phase II Trial with Correlative Biomarker Endpoints (http://clinicaltrials.gov/ct/show/NCT00729807) |
Sausville, Edward |
HP-40036 |
A Phase I Dose-Escalation Study of Oral ABT-888 (NSC #737664) Plus Intravenous Irinotecan (CPT-11, NSC#616348) Administered in Patients With Advanced Solid Tumors |
Scharf, Steven |
HP-40820 |
Collection of Blood for Future Genetic Testing |
Scharf, Steven |
HP-42560 |
The Effect of Chronic Macrolide Administration on the Frequency and Severity of COPD Exacerbations |
Scharf, Steven |
HP-40166 |
Pneumococcal Vaccine Response in Chronic Obstructive Pulmonary Disease |
Seliger, Stephen |
HP-42780 |
An Observational Study of Subclinical Ischemic Brain Disease and Cognitive Dysfunction in Chronic Kidney Disease |
Shuldiner, Alan |
HP-43419 |
Pharmacogenomics of Anti-Platelet Interventions (PAPI) Study |
Shuldiner, Alan |
HP-40355 |
Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes |
Silver, Kristi |
HP-40159 |
Effects of a Steroid Challenge on Glucose Tolerance |
Smith, Barbara |
HP-43898 |
The Effects of Resistive or Aerobic Exercise and a Nutrition (RAN) Program on Body Composition, Blood Pressure, Functional Status and Mood in University Employees |
Snitker, Soren |
HP-43497 |
Pharmacogenomics of Thiazolidinediones |
Suntha, Mohan |
HP-40359 |
RTOG 0617 - A Randomized Phase III Comparison of Standard- Dose (60 GY) Versus High-Dose (74 GY) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer (http://clinicaltrials.gov/ct/show/NCT00533949) |
Suntha, Mohan |
HP-41290 |
RTOG 0436 - A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer Who Are Treated Without Surgery (http://clinicaltrials.gov/ct2/show/NCT00655876) |
Suntha, Mohan |
HP-43264 |
RTOG 0619: A Randomized Phase II Trial of Chemoradiotherapy Versus Chemoradiotherapy and Vandetanib for High-Risk Postoperative Advanced Squamous Cell Carcinoma of the Head and Neck |
Tacket, Carol |
HP-42991 |
Norwalk CVD 5000 - Randomized Double-Blind Placebo-Controlled Phase 1, Safety And Immunogenicity Study Of Two Dosages Of Intranasal Norwalk Virus-Like Particle Vaccine (Norwalk VLP Antigen, MPL, Chitosan, Mannitol, Sucrose) Compared To Adjuvant/Excipients (MPL, Chitosan, Mannitol, And Sucrose) And To Placebo (Empty Device) (LV01-102) |
Tacket, Carol |
HP-40023 |
Longitudinal Study of the Human Intestinal Microbiome Before and After Antibiotic Administration |
Tracy, Kate |
HP-42266 |
Epidemiology of HPV Infection in Malian Women |
von Rosenvinge, Erik |
HP-40446 |
The Role of Biofilm in Clostridium Difficile-Associated Disease |
Watson, Douglas |
HP-41077 |
IMPAACT P 1066: A Multicenter, Open-Label, Noncomparative Study of the International Maternal, Pediatric, Adolescent Aids Clinical Trials Group (IMPAACT) to Evaluate the Safety, Pharmacokinetics, and Antiretroviral Activity of Raltegravir (Isentress, MK-0518) iN HIV-1 Infected Children and Adolescents |
Watson, Douglas |
HP-41328 |
PHACS Adolescent Master Protocol (AMP) |
Watson, Douglas |
HP-42309 |
IMPAACT 1026S: Pharmacokinetic Properties of Antiretroviral Drugs During Pregnancy |
Weir, Matthew |
HP-43605 |
ALTOLD - Assessing Long Term Outcomes of Living Donation |
Wolf, Jeffrey |
HP-40999 |
GCC 0608: Phase I Study of Intra-Tumoral Injection of Dendritic Cells for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (http://clinicaltrials.gov/ct/show/NCT00492947) |
Wozniak, Marcella |
HP-40110 |
A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Ischemic Stroke |