Our Research

The General Clinical Research Center is engaged in a full range of patient-oriented research. Each month new protocols are reviewed and approved for resource use. The following is a list of research currently approved by the GCRC Advisory Committee. Links to ClinicalTrials.gov for recruitment information are included when available.

Principal Investigator

IRB Protocol Number

Title
Amin, Pradip H-21616

RTOG 0126: A Phase III Randomized Study of High-Dose 3D-CRT/IMRT versus Standard Dose 3D-CRT / IMRT in Patients Treated for Localized Prostate Cancer (http://clinicaltrials.gov/ct2/show/NCT00033631)

Bever, Christopher

 H-28737 Double-Blind, Placebo-Controlled, Phase I, Dose-Escalation Study of the Safety of a Single Dose of RTL1000 in Subjects with Relapsing Remitting or Secondary Progressive Multiple Sclerosis (RRMS or SPM)
(http://clinicaltrials.gov/ct/show/NCT00411723)
Buchanan, Robert H-21270 Adjunctive Risperidone in Clozapine Treated Patients (http://clinicaltrials.gov/ct/show/NCT00056498 )
Chen, Wilbur H-29910

Influenza CVD 25000: A Randomized, Double-Blinded, Phase I/II Study of the Safety, Reactogenicity, and Immunogenicity of a Single Intramuscular Booster Dose of Inactivated Influenza Vaccine Derived from A/H5N1/Indonesia/05/05 (Clade2) in Healthy Adults 19 Years or Older Who Received Inactivated Influenza Vaccine Derived from A/H5N1/Vietnam/1203/2004 (Clade1) (http://clinicaltrials.gov/ct/show/NCT00680069)
Cole, John H-26073 Stroke and the Genetics of Thrombomodulin
Counts, Debra H-26444 TrialNet
(http://clinicaltrials.gov/ct/show/NCT00097292)
Counts, Debra H-28102 New Onset of Type 1 Diabetes Anti-CD20 Clinical Trial
(http://clinicaltrials.gov/ct/show/NCT00279305)
Counts, Debra H-8553 Oral Insulin for Prevention of Diabetes in Patients at Risk for Type 1 Diabetes Mellitus (http://clinicaltrials.gov/ct/show/NCT00419562)
Counts, Debra H-20958 Epidemiology of Diabetes Intervention and Complications (EDIC) (http://clinicaltrials.gov/ct/show/NCT00360893)
Cross, Raymond H-27882 Home Telemanagement Trial in Patients with Ulcerative Colitis (http://clinicaltrials.gov/ct2/show/NCT00620126)
Dowling, Thomas H-26065 Pharmacogenomic Study In Hispanic Americans With Diabetes
Dutton, Richard H-28116 Noninvasive Monitoring of Patients with Traumatic Brain Injury
Edelman, Martin H-29776 0804 GCC: A Phase 1 Open Label, Dose Escalation Study to Evaluate the Effect of Four Doses of MAGE-A3/HPV 16 Trojan Peptides 0001 and 0002 Administered Subcutaneously in Combination with Montanide and GM CSF on Immunological Response, Safety, Tolerability, and Preliminary Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck(http://clinicaltrials.gov/ct2/show/NCT00704041)
Fasano, Alessio H-27529 Proton Pump Inhibitors Reduce Airway Inflammation in Asthmatics by Improving Intestinal Permeability
Fasano, Alessio H-27433 Safety Of VSL#3 for Adult Asthmatics
Fink, Jeffrey H-21249 The Prospective Cohort Study of Chronic Renal Insufficiency (CRIC)
(http://clinicaltrials.gov/ct/show/NCT00304148)
Fink, Jeffrey H-23374 Evaluating an Oral Urea Tolerance Test to Measure Overall Renal Function
Forrest, Graeme H-27719 Clinical Outcomes of Staphylococcus Aureus Bacteremia in HIV-Infected Patients
Garofalo, Michael H-30260 RTOG 0822: A Phase II\I Evaluation of Preoperative Chemoradiotherapy Utilizing Intensity Modulated Radiation Therapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer (http://clinicaltrials.gov/ct2/show/NCT00613080)
Gojo, Ivana H-27229 0507 GCC: A Phase 1 Study Of UCN-01 In Combination With Perifosine In Patients With Relapsed And Refractory Acute Leukemias
(http://clinicaltrials.gov/ct/show/NCT00301938)
Gold, James H-26601 Attention And Working Memory In Schizophrenia
Gold, James H-21890 Event-Related Potential in Schizophrenia During Visual Search
Harris, Anthony H-21329 Methodological Approaches to Risk Analysis for Emerging Pathogens: Epidemiology of Imipenem-Resistant P. Aeruginosa
Harris, Anthony H-29244 Healthcare Worker Attitudes Towards Antimicrobial Resistance
Hise, Michael H-29660 Recommendations for Influenza Vaccine Use by Nephrologists
Hochberg, Marc H-22349 Clinical Center for the Osteoarthritis (OA) Initiative (http://clinicaltrials.gov/ct/show/NCT00080171)
Hong, Elliot H-27281 Neuroimaging Studies of Neurophysiological Phenotypes in Schizophrenia
Howell, Charles H-26317 Predicting Outcome Of Hepatitis C Treatment
Howell, Charles H-28740 Ribavirin Pharmacokinetics, Race and Outcome of Hepatitis C Treatment
Johnson, Jennifer H-29002 Understanding Resistance Mechanisms in Fecal Microorganisms
Johnson, Jennifer H-30086 Antimicrobial Resistant Mechanisms from Clinical Cultures
Kittner, Steven H-21025 Behavior, Infection & Genetics in Early-Onset Stroke (YSS)
(http://clinicaltrials.gov/ct/show/NCT00108940)
Kwok, Young H-29949 RTOG 0534 - A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy (http://clinicaltrials.gov/ct/show/NCT00567580)
Lyke, Kiersten H-26914 Use of Preserved Specimens From Completed International Malaria Trials
McDiarmid, Melissa H-20924 Follow-up & Monitoring of Gulf War Veterans with Fragments of Depleted Uranium & Other Sources of Depleted Uranium Exposure
Mehra, Mandeep H-28083 Real Time Angiotensin Monitor for Salt Sensitivity
Mendley, Susan H-26675 Chronic Kidney Disease in Children Study (CKID)
(http://clinicaltrials.gov/ct/show/NCT00327860)
Mendley, Susan H-28893 Impact of a Multidisciplinary Weight Reduction Intervention on Blood Pressure and Non-Classical Cardiovascular Risk Factors in Obese Children and Adolescents
Mohiuddin, Majid H-26679 RTOG 0413 (NSAPB Protocol B-39): A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, Or II Breast Cancer.
(http://clinicaltrials.gov/ct/show/NCT00103181)
Nemoy, Lucia H-26512 Antibiotic Resistance Gene Reservoirs: Impact on Emergence of Resistance
Onukwugha, Eberechukwu   Exploring Providers and Patients Attitudes About Discharges Against Medical Advice
Oswald, Lynn H-30104 Dopamine and Risks for Drug Abuse
Oursler, Kris Ann H-28973 Fitness and Longevity in Exercise (FLEX)
Panigrahi, Pinaki H-29171 Prevention of Neonatal Infection in The Indian Community Setting Using Probiotics
Pierson, Richard H-27115 Mechanisms Of Galtko Lung Xenograft Injury
Postolache, Teodor H-26191 Seasonality of Depression and Airborne Allergens
Postolache, Teodor H-28845 Light Treatment for Winter SAD: Metabolic Effects and Prediction of Antidepressant Response by Immediate Improvement (http://clinicaltrials.gov/ct2/show/NCT00742365)
Reeves, Gloria H-28645 Investigating Metabolic Side Effects of Antipsychotic Medications in Children
Roghmann, Mary-Claire H-26979 Epidemiology Of Colonization With Methicillin-Resistant Staphylococcus Aureus
Roghmann, Mary-Claire H-29678 Outcomes of and Risk Factors for Infections Due to USA300 MRSA
Royak-Schaler, Renee H-29431

A Lowfat Eating Plan to Manage Weight Gain Among African American Breast Cancer Survivors
Rus, Violeta H-26979 A Multi-Center, Open-Label, Continuation Trial of Lymphostat-B Antibody (Monoclonal Anti-BLys Antibody) in Subjects With Systemic Lupus Erythematosus (SLE) who Completed the Phase 2 Protocol LBSL02 (http://clinicaltrials.gov/ct/show/NCT00583362)
Ryan, Alice H-22326 Menopause, Genes and Metabolism after Weight Loss and Exercise
Saunders, Elijah H-24874 Baltimore Partnership Program to Reduce Cardiovascular Disparities (http://clinicaltrials.gov/ct/show/NCT00101478)
Sausville, Edward H-27439 0548GCC: A Phase 1 Study of AFP464 (Aminoflavone Prodrug) in Patients with Advanced Solid Tumors
(http://clinicaltrials.gov/ct/show/NCT00369200)
Sausville, Edward H-28248 0629GCC: A Phase I, Open-Label, Multi-Center, Dose-Escalation Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD7762 Administered as a Single Intravenous Agent and in Combination With Weekly Standard Dose Gemcitabine in Patients with Advanced Solid Malignancies
(http://clinicaltrials.gov/ct/show/NCT00413686)

Sausville, Edward

 H-29873 0794GCC: Treatment of Melanoma With Wild-Type P53 and Detectable A 100b Using Pentamidine: A Phase II Trial with Correlative Biomarker Endpoints (http://clinicaltrials.gov/ct/show/NCT00729807)
Sausville, Edward H-29693 0782GCC: A Phase I Dose-Escalation Study of Oral ABT-888 (NSC #737664) Plus Intravenous Irinotecan (CPT-11, NSC#616348) Administered in Patients With Advanced Solid Tumors
Sausville, Edward H-29930 0802GCC: A Multi-Center, Open-Label, Phase I Study of Single-Agent GMX1777 Administered Every 3 Weeks to Patients with Refractory Solid Tumors, Lymphomas, Chronic Lymphocytic Leukemia, or Multiple Myeloma
Scharf, Steven H-26178 Collection of Blood for Future Genetic Testing
Scharf, Steven H-26837 The Effect of Chronic Macrolide Administration on the Frequency and Severity of COPD Exacerbations
(http://clinicaltrials.gov/ct/show/NCT00325897)
Scharf, Steven H-28579 Anti-Leukotriene Therapy for COPD Exacerbations
(http://clinicaltrials.gov/ct/show/NCT00493974)
Scharf, Steven H-28586 Pneumococcal Vaccine Response in Chronic Obstructive Pulmonary Disease
(http://clinicaltrials.gov/ct/show/NCT00457977)
Seliger, Stephen H-27051 An Observational Study of Subclinical Ischemic Brain Disease and Cognitive Dysfunction in Chronic Kidney Disease
Shuldiner, Alan H-22773 Genome Wide Research for CVD Gene-Environment Interactions
Shuldiner, Alan H-27230 Pharmacogenomics of Anti-Platelet Interventions (PAPI) Study
Shuldiner, Alan H-20915 Genetics of Longevity in the Amish
Shuldiner, Alan H-20963 Amish Family Diabetes Study
Shuldiner, Alan H-20926 Genetics of Osteoporosis
Shuldiner, Alan H-20927 Genetics of Type 2 Diabetes and Obesity
Shuldiner, Alan H-27602 SMSI Continuous Glucose Sensor Study
Shulman, Lisa H-24812 Study of Antidepressants in Parkinson's Disease (SAD-PD)
(http://clinicaltrials.gov/ct/show/NCT00086190)
Silver, Kristi H-20717 Genetics of Pancreatic Function in the Development of Diabetes Mellitus
Silver, Kristi H-28064 Association of Chronic Stress with BMI in African American Females
Silver, Kristi H-26081 Linkage Of Insulin Secretion To Chromosome 15q In The Old Order Amish
Silver, Kristi H-27587 Effects of a Steroid Challenge on Glucose Tolerance
Smith, Barbara H-26583 The Effects of Resistive or Aerobic Exercise and a Nutrition (RAN) Program on Body Composition, Blood Pressure, Functional Status and Mood in University Employees
Steinle, Nannette H-23047 Cloning A Blood Pressure Gene On Chromosome 2
Streeten, Elizabeth H-28679 Clinical and Molecular Characterization of Suspected Partial 25-Hydroxyvitamin D-1-Alpha Hydroxylase Deficiency
Suntha, Mohan H-29555 RTOG 0617 - A Randomized Phase III Comparison of Standard- Dose (60 GY) Versus High-Dose (74 GY) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer (http://clinicaltrials.gov/ct/show/NCT00533949)
Suntha, Mohan H-30259 A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer Who Are Treated Without Surgery (http://clinicaltrials.gov/ct2/show/NCT00655876)
Tacket, Carol H-30477 Norwalk CVD 5000 - Randomized Double-Blind Placebo-Controlled Phase 1, Safety And Immunogenicity Study Of Two Dosages Of Intranasal Norwalk Virus-Like Particle Vaccine (Norwalk VLP Antigen, MPL, Chitosan, Mannitol, Sucrose) Compared To Adjuvant/Excipients (MPL, Chitosan, Mannitol, And Sucrose) And To Placebo (Empty Device) (LV01-102)
Tacket, Carol H-28840 Norwalk VLP 4000: Phase I Dose Escalation, Afety and Immunogenicity Study of Intranasal Norwalk VLP Vaccine with Adjuvant (MPL) and Excipients (Chitosan, Mannitol and Sucrose)
Thaker, Gunvant H-23545

Familial Schizophrenia And Spectrum Personality Disorder (http://clinicaltrials.gov/ct/show/NCT00666146)
Thaker, Gunvant H-22053 Motion Processing In Schizophrenia
Watson, Douglas H-27545 PACTG 1058: Intensive Pharmacokinetic Studies of Antiretroviral Drug Combinations in Children
Watson, Douglas H-28770 PHACS Adolescent Master Protocol (AMP)
Weir, Matthew H-27005 ALTOLD - Assessing Long Term Outcomes of Living Donation
Wolf, Jeffrey H-27834 GCC 0608: Phase I Study of Intra-Tumoral Injection of Dendritic Cells for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (http://clinicaltrials.gov/ct/show/NCT00492947)

 

 

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