Publications

Journal Articles

The following publications associated with GCRC-supported research were reported for the grant year 3/1/06 to 2/28/07.

• Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, Bergman A, Barzilai N. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol. 2006. 4:e113.
• Avila MT, Robles O, Hong LE, Blaxton TA, Myers CS, Wonodi I, Gold J, Thaker GK Deficits on the Continuous Performance Test within the schizophrenia spectrum and the mediating effects of family history of schizophrenia. J Abnorm Psychol 115 771-8 2006.
• Barrows BR, Azimzadeh AM, McCulle SL, Vives-Rodriguez G, Stark WN, Ambulos N, Yin J, Chen H, Balke CW, Moravec CS, Pierson RN, Gottlieb SS, Bond M, Johnson FL. Robust gene expression with amplified RNA from biopsy-sized human heart tissue. J Mol Cell Cardiol. 2007. 42:260-4.
• Baumgarten M, Hawkes W, Langenberg P, Magaziner J, Margolis D, Orwig D, Palmer M, Shardell M, Sterling R. Pressure ulcers in elderly hip fracture patients across the continuum of care: preliminary results. Gerontologist. 2006. 46:545.
• Bielak LF, Yu P, Ryan KA, Rumberger JA, Sheedy PF, Turner ST, Post W, Shuldiner AR, Mitchell BD, Peyser PA. Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles. Atherosclerosis. 2007.
• Brown DW, Dueker N, Jamieson DJ, Cole JW, Wozniak MA, Stern BJ, Giles WH, Kittner SJ. Preeclampsia and the risk of ischemic stroke among young women: results from the Stroke Prevention in Young Women Study. Stroke. 2006. 37:1055-9.
• Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes. 2007. 56:856-62.
• Conjeevaram HS, Fried MW, Jeffers LJ, Terrault NA, Wiley-Lucas TE, Afdhal N, Brown RS, Belle SH, Hoofnagle JH, Kleiner DE, Howell CD, Virahep-C Study Group Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology 131 470-7 2006.
• Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH, Wahed AS, Virahep-C Study Group Race, insulin resistance and hepatic steatosis in chronic hepatitis C. Hepatology 45 80-7 2007.
• Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes. 2006. 55:2654-9.
• Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes. 2006. 55:2631-9.
• de Boer IH, Sibley SD, Kestenbaum B, Sampson JN, Young B, Cleary PA, Steffes MW, Weiss NS, and Brunzell JD for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Waist circumference predicts incident microalbuminuria but not decreased creatinine clearance in type 1 diabetes mellitus. Journal of American Society of Nephrology. Accepted 12/31/2006.
• de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC. Omentin plasma levels and gene expression are decreased in obesity. Diabetes. 2007. 56:1655-61.
• Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, Diabetes Prevention Program Research Group. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med. 2006. 355:241-50.
• Fontana RJ, Kleiner DE, Bilonick R, Terrault N, Afdhal N, Belle SH, Jeffers LJ, Ramcharran D, Ghany MG, Hoofnagle JH, Virahep-C Study Group Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection. Hepatology 44 925-35 2006.
• Fu M, Sabra MM, Damcott C, Pollin TI, Ma L, Ott S, Shelton JC, Shi X, Reinhart L, O'Connell J, Mitchell BD, Baier LJ, Shuldiner AR. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. Diabetes. 2007. 56:1363-8.
• Fuller R, Luck S, Braun E, Robinson B, McMahon R, Gold J. Impaired control of Visual Attention in Schizophrenia. J of Abnormal Psychology. 2006. 115(2):266-275.
• Furuno JP, Maguire JH, Green HP, Johnson JA, Heimer R, Johnston SP, Braden CR. Edberg SC, Bell S, Hirshon JM. Clinical utility of multiple stool ova and parasite examinations in low prevalence patient populations. Clin Infect Dis. 2006. 15;43(6):795-6.
• Gold J, Fuller R, Robinson B, McMahon R, Braun E, Luck S. Intact control of working memory encoding in schizophrenia. J of Abnormal Psychology. 2006. 115(4):658-673.
• Hong LE, Summerfelt A, Wonodi I, Adami H, Buchanan RW, Thaker GK Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval. Am J Psychiatry 164 61-5 2007.
• Johnson JK, Khoie T, Shurland S, Kreisel K, Stine OS, and Roghmann, M. Increase in Skin and Soft Tissue Infections from Methicillin-Resistant Staphylococcus aureus (MRSA) due to the USA300 Clone. Emerg Infect Dis. Accepted 2/20/2007.
• Lopes-Virella MF, McHenry MB, Lipsitz S , Yim E, PF Wilson, DT Lackland, T Lyons, AJ Jenkins, G Virella, The DCCT/EDIC Research Group. Immune Complexes Containing Modified Lipoproteins Are Related to the Progression of Internal Carotid Intima-Media Thickness in Type 1 Diabetes. Atherosclerosis. Accepted 12/31/2006.
• Lyons TJ, Jenkins AJ, Zheng D, Klein RL, Otvos JD, Yu Y, Lackland DT, McGee D, McHenry MB, Lopes-Virella M, Garvey WT, and the DCCT/EDIC Research Group. Nuclear Magnetic Resonance-Determined Lipoprotein Subclass Profile in the DCCT/EDIC Cohort: Associations with Carotid Intima-Medial Thickness. Diabetic Medicine. Accepted 12/31/2006.
• MacClellan LR, Mitchell BD, Cole JW, Wozniak MA, Stern BJ, Giles WH, Brown DW, Sparks MJ, Kittner SJ. Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study. Genet Epidemiol. 2006. 30:602-8.
• Mai V, Braden CR, Heckendorf J, Pironis B, Hirshon JM. Monitoring of stool microbiota in subjects with diarrhea indicates distortions in composition. J Clin Microbiol. 2006. 44:4550-2.
• Mai V, Greenwald B, Morris JG Jr, Raufman JP, Stine OC. Effect of bowel preparation and colonoscopy on post-procedure intestinal microbiota composition. Gut. 2006. 55(12):1822-3.
• Martin CL, Albers J, Herman WH, Cleary PA,Waberski B, Greene DA, Stevens MJ, Feldman EL. Neuropathy among the Diabetes Control and Complications Trial Cohort Eight Years after Trial Completion. Diabetes Care. 2006. 29:340-344.
• McArdle PF, Pollin TI, O'Connell JR, Sorkin JD, Agarwala R, Schäffer AA, Streeten EA, King TM, Shuldiner AR, Mitchell BD. Does having children extend life span? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci. 2006. 61:190-5.
• Murdoch SJ, Boright AP, Paterson AD, Zinman B, Steffes M, Cleary P, Edwards K, Marcovina S, Purnell JQ, Brunzell JD. LDL Composition in E2/2 Subjects and LDL Distribution by apo E Genotype in Type 1 Diabetes. Atherosclerosis. Accepted 12/31/2006.
• Nataro JP, Mai V, Johnson J, Blackwelder WC, Heimer R, Tirrell S, Edberg SC, Braden CR, Morris, Jr JG, Hirshon JM. Diarrheagenic E. coli in Baltimore and New Haven. Clin Infect Dis. 2006. 15;43(4):402-7.
• Nguyen BN, Azimzadeh AM, Zhang T, Wu G, Shuurman H-J, Sachs DH, Ayares D, Allan JS, Pierson RN III. Life-Supporting Function of Genetically Modified Swine Lungs in Baboons. J Thorac CV Surg. Accepted 2/8/2007.
• Oursler KK, Sorkin JD, Smith BA, Katzel LI. Reduced aerobic capacity and physical functioning in older HIV-infected men. AIDS Res Hum Retroviruses 22 1113-21 2006.
• Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes. 2007. 56:879-83.
• Post W, Bielak LF, Ryan KA, Cheng YC, Shen H, Rumberger JA, Sheedy PF, Shuldiner AR, Peyser PA, Mitchell BD. Determinants of coronary artery and aortic calcification in the Old Order Amish. Circulation. 2007. 115:717-24.
• Roberts CG, Shen H, Mitchell BD, Damcott CM, Shuldiner AR, Rodriguez A. Variants in Scavenger Receptor Class B Type I Gene Are Associated with HDL Cholesterol Levels in Younger Women. Hum Hered. 2007. 64:107-13.
• Roghmann M, Gorman PH, Wallin MT, Kreisel K, Shurland S, Johnson JA. S. aureus colonization in community-dwelling people with spinal cord dysfunction. Arch Phys Med Rehabil. Accepted 2/20/2007.
• Roghmann M, Wallin MT, Gorman PH, and Johnson JA. Prevalence and natural history of colonization with fluoroquinolone-resistant gram-negative bacilli in community-dwelling people with spinal cord dysfunction. Arch Phys Med Rehabil. 2006. 87(10):1305-1309.
• Scott WB, Oursler KK, Katzel LI, Ryan AS, Russ DW Central activation, muscle performance and physical function in men infected with human immunodeficiency virus. Muscle and Nerve, (in press).
• Shen H, Bielak LF, Streeten EA, Ryan KA, Rumberger JA, Sheedy PF, Shuldiner AR, Peyser PA, Mitchell BD. Relationship between Vascular Calcification and Bone Mineral Density in the Old-Order Amish. Calcif Tissue Int. 2007. 80:244-50.
• Sibley SD, Thomas W, de Boer I, Brunzell JD, Steffes MW. Gender and elevated albumin excretion in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (CDDT/EDIC) Cohort: Role of central obesity. Am J Kidney Dis. 2006. 47:223-232.
• Snitker S, Le KY, Hager E, Caballero B, Black MM. Influence of Physical Activity and Body Composition on Glucose Homeostasis in a Community Sample of Adolescents. Archives of Pediatric and Adolescent Medicine. Accepted 1/31/2007.
• Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Hum Mol Genet. 2006. 15:2468-78.
• Streeten EA, McBride DJ, Pollin TI, Ryan K, Shapiro J, Ott S, Mitchell BD, Shuldiner AR, O'Connell JR. Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study. J Bone Miner Res. 2006. 21:1433-42.
• Winder R, Cortes CR, Reggia JA, Tagamets MA. Functional connectivity in fMRI: A modeling approach for estimation and for relating to local circuits. Neuroimage. 2007. 34:1093-107.
• Wonodi I, Mitchell BD, Stine OC, Hong LE, Elliott A, Kirkpatrick B, Carpenter WT, Thaker GK, Buchanan RW. Lack of association between COMT gene and deficit/nondeficit schizophrenia. Behav Brain Funct 2 42 2006.
• Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006. 290:E1253-61.
• Yu Y, Thorpe SR, Jenkins AJ, Shaw JN, Sochaski MA, McGee D, Aston CE, Orchard TJ, Silvers N, Peng YG, McKnight JA, Baynes JW, Lyons TJ, the DCCT/EDIC Research Group. Advanced Glycation End-Products and Methionine Sulfoxide of Skin Collagen in Type 1 Diabetes. Diabetologia. 2006. 49:2488 - 2498.
• Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Kunsun X, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI, International Type 2 Diabetes 1q Consortium. Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes. 2006. 55:2541-8.

Abstracts and Posters

• Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin resistance and insulin secretion. Annual Meeting of the American Diabetes Association. 2006.
• Griego JA, Cortes CR, Nune S, Tagamets MA. Network Organization During Word String Processing in Schizophrenia. Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping, June 11-15, 2006 Florence, Italy.
• Horiba MN, Burger AM, Rutter C, Gutierrez PL, Vaishampayan U, Lorusso P, Sausville EA. Detection of Hsp90α, a Circulating Isoform of Hsp90, in Plasma from Tumor-Bearing Mice and Patients. Abstract for the American Association for Cancer Research Annual Meeting. Proceedings April 14-18,2007.
• Nogueira N, Jacobs D, Klassen D, Cooper M, Al-Qudah H, Weir MR. A Cross-Sectional Study of Obese Live Kidney Donors to Asses the Risk for Hypertension and Adverse Renal Outcomes. Presented as a poster at the National Meeting of the American Society of Nephrology. 2006.
• Nogueira N, Jacobs D, Klassen D, Cooper M, Al-Qudah H, Weir MR. A Cross-Sectional Study of African American Live Kidney Donors to Asses the Risk for Hypertension and Adverse Renal Outcomes. Presented as a poster at the National Meeting of the American Society of Nephrology. 2006.
• Saunders E, Shaya FT, Gu A, Mullins CD, Johnson W. The Impact of Patient Education on Blood Pressure Control. Abstract for the 2006 International Society of Hypertension in Blacks Annual Conference.
• Saunders E, Shaya FT, Gu A, Mullins CD, Johnson W. Predictors of Isolated Systolic Hypertension in a Group of Inner City Minority Patients. Abstract for the 2006 American Society of Hypertension Annual Meeting.
• Tagamets MA, Griego JA, Cortes CR, Nune S. fMRI Correlates of Executive and Semantic Interactions in Schizophrenia. Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping, June 11-15, 2006 Florence, Italy.
• Vaishampayan UN, Sausville E, Horiba M, Heilbrun L, Burger A, Ivy P, Li J, Lorusso P. Phase I trial of intravenous 17-allylaminogeldanamycin (A) and oral BAY 43-9006 (B) in pretreated advanced malignancy: Pharmacodynamics (PD) correlated with clinical benefit. Proceedings ASCO 2007.

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