Publications
Peer-reviewed Journal Articles
Tang, T.K., Hong, T.M., Lin, C.-Y., Lai, M.L., Liu, C.H., Lo, H.J., Wang, M.E., Chen, L.B., Chen, W.T., and Ip, W., (1993). Nuclear proteins of the bovine esophageal epithelium. i. monoclonal antibody w2 specifically reacts with condensed nuclei of differentiated superficial cells. J. Cell Sci. 104, 237-247.
Monsky, W.L., Kelly, T., Lin, C.-Y., Yeh, Y., Stetler-Stevenson, W.G., Mueller, S.C., and Chen, W.T. (1993). Binding and localization of m(r) 72,000 matrix metalloproteinase at cell surface invadopodia. Cancer Res. 53, 3159-3164.
Monsky, W.L., Lin, C.-Y., Aoyama, A., Kelly, T., Akiyama, S.K., Mueller, S.C., and Chen, W.T. (1994). A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells. Cancer Res. 54, 5702-5710.
Chen, W.T., Lee, C.C., Goldstein, L., Bernier, S., Liu, C.H., Lin, C.-Y., Yeh, Y., Monsky, W.L., Kelly, T., and Dai, M. (1994). Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy. Breast Cancer Res. Treat. 31, 217-226.
Lin, C.-Y., Wang, J.-K., Torri, J., Dou, L. Sang, Q.-X. A. and Dickson R. B. (1997) Characterization of a novel, membrane-bound 80-kDa matrix-degrading protease from human breast cancer cells: monoclonal antibody production, isolation, and localization. J. Biol. Chem. 272: 9147-9152.
Lin, C.-Y., Anders, J., Johnson, M., Sang, Q. A., and Dickson, R.B. (1999) Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. J. Biol. Chem. 274: 18231-18236.
Lin, C.-Y., Anders, J., Johson, M., and Dickson, R.B. (1999) Purification and Characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. J. Biol. Chem. 274: 18237-18242.
Lee, S.-L., Dickson, R.B., and Lin, C.-Y., (2000) Activation of urokinase and hepatocyte growth factor by matriptase, an epithelial membrane-bound serine protease. J. Biol. Chem. 275: 36720-36725.
Benaud C., Dickson R.B., and Lin, C.-Y., (2001) Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor. Eur. J. Biochem. 268: 1439-1447.
Oberst, M., Anders, J., Xie, B., Singh, B., Ossandson, M., Johnson, M., Dickson R.B., and Lin, C.-Y., (2001) Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. American J. Path. 158: 1031-1311.
Enyedy, I.J., Lee, S.-L., Kuo, A.H., Dickson, R.B., Lin, C.-Y., and Wang, S., (2001) Structure-based Approach for the discovery of bis-benzamidines as novel inhibitors of matriptase. J. Med. Chem. 44: 1349-1355.
Long, Y.-Q, Lee, S.-L., Lin, C.-Y., Enyedy, I.J., Wang, S., Dickson, R.B., and Roller, P.P., (2001) Synthesis and Evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. Bioorg. & Medicinal Chem. Lett. 17:2515-2519.
Benaund, C., Oberst, M., Hobson, J.P., Spiegel, S., Dickson R.B., and Lin, C.-Y., (2002) Sphingosine 1-phosphate, present in serum lipoproteins, activates matriptase. J. Biol. Chem. 277: 10539-10546.
Oberst, M.D., Johnson, M.D., Dickson, R.B., Lin, C.-Y., Singh, B., Stewart, M., williams, A., al-Nafussi, A., Smyth, J.F., Gabra, H., and Sellar, G.C., (2002) Expression of the Serine Protease Matriptase and its Inhibitor HAI-1 in Epithelial Ovarian Cancer: Correlation with Clinical Outcome and Tumor Clinicopathological Parameters. Clinical Cancer Research, 8:1101-1107.
Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.-Y., and Taniguchi, N., (2002) Pro-metastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc-branching. J. Biol. Chem. 277:16960-16967.
Benaud, C., Oberst, M., Dickson, R.B., and Lin, C.-Y., (2002) Deregulated activation of matriptase in breast cancer cells. Clinical & Experimental Metastasis, 19:639-649.
Kang, J.Y., Dolled-Filhart, M., Ocal, T., Singh, B., Lin, C.-Y., Dickson, R.B., Rimm, D.L., and Camp, R.L., (2003) Tissue microarray analysis of HGF/Met pathway components reveals a role for met, matriptase, and HAI-1 in the progression of node-negative breast cancer. Cancer Research, 63:1101-1105.
Oberst, M.D., Singh, B., Ozdemirli, M., Dickson, R.B., Johnson, M.D., and Lin, C.-Y. (2003) Characterization of Matriptase Expression in Normal Human Tissues. J. Histochem. and Cytochem. 51:1017-1025
Oberst, M.D., Williams, C., Johnson, M.D., Dickson, R.B., and Lin, C.-Y. (2003) The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. J. Biol. Chem. 278:26773-26779.
Ihara S, Miyoshi E, Nakahara S, Sakiyama H, Ihara H, Akinaga A, Honke K, Dickson RB, Lin C.-Y., Taniguchi N. (2004) Addition of ¿1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin. Glycobiology 14:139-146.
Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin C.-Y., Dickson RB, Terao T. (2004) Inhibition of tumor invasion by genomic downregulation of matriptase through suppression of activation of receptor-bound pro-urokinase. J. Biol. Chem. 279:14899-908.
Hung RJ, Hsu I. W., Dreiling J. L., Lee M. J., Williams C. A., berst M. D., Dickson R. B., and Lin C.-Y. (2004) Assembly of Adherens Junctions Is Required for Sphingosine 1-phosphate-induced Matriptase Accumulation And Activation at Mammary Epithelial Cell-cell Contacts. Am J Physiol Cell Physiol. 286:C1159-69.
Lee M.-S., Kiyomiya K., Benaud C., Dickson R.B., and Lin C.-Y. (2005) Simultaneous activation and HAI-1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. Am J Physiol Cell Physiol. 288:C932-C941.
Lee, J.-W., Choi, J.-J., Song, S.Y., Lee, S.-J., Kim, B.-G., Park, C.-S., Lee, J.-H., Lin, C.-Y., Dickson, R.B., and Bae, D.-S. (2005) Increased Expression of Matriptase during Progression of Cervical Neoplasia. Human Pathology 36:626-33.
Oberst MD, Chen LY, Kiyomiya KI, Williams CA, Lee MS, Johnson MD, Dickson RB, Lin C.-Y. (2005) HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. Am J Physiol Cell Physiol. 289:C462-470.
Jin, X., Hirosaki, T., Lin, C.-Y., Dickson, R. B., Higashi, S., Kitamura, H., and Miyazaki, K. (2005) Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin. J Cell Biochem. 95, 632-647
Siddiqui S.F., Pawelek J., Handerson T., Lin C.-Y., Dickson R.B., Rimm D.L. and Camp R.L. (2005) Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome. Cancer Epidemiol Biomarkers Prev 14: 2517-2523.
Ahmed S., Jin X., Yagi M., Yasuda C., Sato Y., Higashi S., Lin C.-Y., Dickson R.B., and Miyazaki K. (2006) Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25). FEBS J 273: 615-627.
Ito Y., Akinaga A., Yamanaka K., Nakagawa T., Kondo A., Dickson R.B., Lin C.-Y., Miyauchi A., Taniguchi N., and Miyoshi E. (2006) Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues; its possible role in prolonged stability in vivo by aberrant glycosylation. Glycobiology 16:368-374
Saleem M., Adhami V.M., Zhong W., Longley B.J., Lin C.-Y., Dickson R.B., Reagan-Shaw S., Jarrard D.F., Mukhtar H. (2006) A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1. Cancer Epidemiol Biomarkers Prev 15:217-227
Kiyomyia, K., Lee, M., Tseng I.C., Zuo H., Barndt R.J., Johnson M.D., Dickson R.B., and Lin, C.-Y. (2006) Matriptase activation and subsequent shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells. Am J Physiol Cell Physiol 291:C40-C49.
Netzel-Arnett, S., Currie, B. M., Szabo, R., Lin, C.-Y., Chen, L. M., Chai, K. X. Antalis, T. M., Bugge, T. H., and List, K. (2006) Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J. Biol. Chem. 281(44):32941-5.
Jin, X., Yagi M., Akiyama, A., Hirosaki, T., Higashi, S., Lin, C.-Y., Dickson, R.B., Kitamura, H., and Miyazaki, K. (2006) Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis. Cancer Sci. 97(12):1327-34.
Jiang, S., Li, P., Lee,S.-L., Lin, C.-Y., Long, Y.-Q., Johnson, M.D., Dickson, R.D., and Roller,P.P., (2007) Design and Synthesis of Redox Stable Analogues of Sunflower Trypsin Inhibitors (SFTI-1) on Solid Support, Potent Inhibitors of Matriptase. Org. Lett. 9(1) pp 9 - 12; (letter)
Oo, ML., Thangada, S., Wu, M.T., Liu, C.H., Macdonald, T.L., Lynch, K.R., Lin, C.-Y., and Hla, T. (2007) Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 (S1P1) agonists induce ubiquitinylation and proteosomal degradation of the receptor. J. Biol. Chem. 282:9082-9089.
Lee M-S, Tseng I-C., Wang Y., Kiyomiya K, Dickson RB, and Lin C.-Y. (2007) Activation of matriptase in vitro: requirement for biomembrane and LDL receptor domain. Am J Physiol Cell Physiol (in press).
Chen, M., Fu, Y.-Y., Lin, C.-Y., Chen, L.-M., and Chai, K. X. (2007) Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. Biochim Biophys Acta (EPub)
Book Chapters and Reviews
Oberst, M., Johnson, M., Dickson and Lin, C.-Y. (2002). The Transmembrane Serine Protease Matriptase And Its Inhibitor HAI-1: Implications for Cellular Biology And Human Cancer, pp. 169-190. In Recent Research Developments in Biochemistry, Research Signpost.
Johnson, M.D., Oberst, M.D., Lin, C.-Y., and Dickson, R.D., (2003) Possible role of matriptase in the diagnosis of ovarian cancer. Expert Rev. Mil. Diagn. 3:331-338.
Lin, C.-Y., Oberst, M., Johnson, M., and Dickson, R.B. (2004). Matriptase. In Handbook of Proteolytic Enzymes, 2nd Edition, pp. 1559-1561, Academic Press.
Gene Sequences Published by NCBI/NIH Genebank
Lin, C.-Y., Anders, J., Johson, M., Sang, Q. A., and Dickson, R.B. (1999) Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. ACCESSION # AF118224
