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Mark F Smith

Mark F Smith Ph.D.

Academic Title: Associate Professor
Primary Appointment: Diagnostic Radiology and Nuclear Medicine
Location: Gudelsky Building, G2J04
Phone: 410-328-1320

Personal History:

Dr. Smith attended Washington University (St. Louis) and received an A.B. in Physics and Mathematics in 1979. He worked as an exploration geophysicist for Gulf Oil Corporation (Houston, TX) from 1980-1985. Dr. Smith received his Ph.D. in 1989 from the University of California, San Diego in Earth Sciences, where he studied seismological imaging of the earth. From 1989-1992 he was a Postdoctoral Fellow in nuclear medicine physics at Duke University in Durham, NC, followed by Assistant Research Professor positions in the Department of Biomedical Engineering at Duke University (1992-1997) and in the Department of Radiology at Duke University Medical Center (1995-1997). Dr. Smith was a Physicist (1998-2000) and Staff Scientist (2000-1001) in the Nuclear Medicine Department of the Clinical Center, National Institutes of Health, Bethesda, MD. He then joined the Detector and Imaging Group in the Physics Division, Thomas Jefferson National Accelerator Facility in Newport News, VA as a Biomedical Imaging Physicist (2001-2007). Dr. Smith moved to the University of Maryland School of Medicine in 2007, where he is an Associate Professor in the Department of Diagnostic Radiology and Nuclear Medicine. He serves as the nuclear medicine physicist and provides clinical support, teaches radiology and nuclear medicine residents about nuclear medicine physics, and conducts research with a focus in quantitative cardiovascular imaging.

Research Interests:

Dr. Smith's research interests are in the fields of nuclear medicine and PET instrumentation, imaging and data analysis. These include Monte Carlo modeling, image reconstruction, and pre-clinical and clinical applications. A particular interest is quantitative cardiovascular nuclear medicine imaging (PET and SPECT), and at the University of Maryland he has been involved in various projects investigating the use of PET and SPECT flow, viability and innervation images to aid electrophysiological ablation procedures to treat left ventricular tachycardia. Dr. Smith has led image reconstruction efforts for awake animal SPECT imaging and is involved in research for motion-corrected human brain PET imaging. He is the author or co-author of over 60 peer-reviewed publications and holds four U.S. patents.

Clinical Speciality:

Board certified by the American Board of Science in Nuclear Medicine (ABSNM), specialty area Nuclear Medicine Physics and Instrumentation.


Smith MF, Floyd CE Jr, Jaszczak RJ, Coleman RE. Reconstruction of SPECT images using generalized matrix inverses. IEEE Trans Med Imaging. 11: 165-175; 1992.

Smith MF, Floyd CE Jr, Jaszczak RJ. A vectorized Monte Carlo code for modeling photon transport in SPECT. Med Phys. 20: 1121-1127; 1993.

Smith MF. Modelling photon transport in non-uniform media for SPECT with a vectorized Monte Carlo code. Phys Med Biol. 38: 1459-1474; 1993.

Smith MF. Generalized matrix inverse reconstruction for SPECT using a weighted singular value spectrum. IEEE Trans Nucl Sci. 43: 2008-2017; 1996.

Smith MF, Jaszczak RJ, Wang H. Pinhole aperture design for 131I tumor imaging. IEEE Trans Nucl Sci. 44: 1154-1160; 1997.

Smith MF, Jaszczak RJ. The effect of gamma ray penetration on angle-dependent sensitivity for pinhole collimation in nuclear medicine. Med Phys. 24: 1701-1709; 1997.

Smith MF, Gilland DR, Coleman RE, Jaszczak RJ. Quantitative imaging of I-131 distributions in brain tumors with pinhole SPECT: a phantom study. J Nucl Med. 39: 856-864; 1998.

Smith MF, Jaszczak RJ. A rotating parallel hole collimator for high resolution imaging of medium energy radionuclides. IEEE Trans Nucl Sci. 45: 2102-2112; 1998.

Smith MF. The effect of contraction and twist on myocardial PET and SPECT image resolution: a mathematical phantom study. IEEE Trans Nucl Sci. 46: 1646-1654; 2000.

Smith MF, Daube-Witherspoon ME, Plascjak PS, Szajek LP, Carson RE, Everett JR, Green SL, Territo PR, Balaban RS, Bacharach SL, Eckelman WC. Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies. Med Phys. 28: 36-45; 2001.

Dilsizian V, Bacharach SL, Khin MM, Smith MF. Fluorine-18-deoxyglucose SPECT and coincidence imaging for myocardial viability: clinical and technologic issues. J Nucl Cardiol. 8: 75-88; 2001.

Metzler SD, Bowsher JE, Smith MF, Jaszczak RJ. Analytic determination of pinhole collimator sensitivity with penetration. IEEE Trans Med Imaging. 20: 730-741; 2001.

Bennett SK, Smith MF, Gottlieb SS, Fisher ML, Bacharach SL, Dilsizian V. Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy. Am J Cardiol. 89: 1431-1434; 2002.

Smith MF, Majewski S, Weisenberger AG, Kieper DA, Raylman RR, Turkington TG. Analysis of factors affecting positron emission mammography (PEM) image formation. IEEE Trans Nucl Sci. 50: 53-59; 2003.

Weisenberger AG, Wojcik R, Bradley EL, Brewer P, Majewski S, Qian J, Ranck A, Saha MS, Smith K, Smith MF, Welsh RE. SPECT-CT system for small animal imaging. IEEE Trans Nucl Sci. 50: 74-79; 2003.

Raylman RR, Majewski S, Lemieux S, Velan SS, Kross B, Popov V, Smith MF, Weisenberger AG, Wojcik R. Initial tests of a prototype MRI-compatible PET imager. Nucl Instrum Meth A. 569: 306-309; 2006.

Raylman RR, Majewski S, Lemieux SK, Velan SS, Kross B, Popov V, Smith MF, Weisenberger AG, Zorn C, Marano GD. Simultaneous MRI and PET imaging of a mouse brain. Phys Med Biol. 51: 6371-6379; 2006.

Raylman RR, Majewski S, Velan SS, Lemieux S, Kross B, Popov V, Smith MF, Weisenberger AG. Simultaneous acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a prototype MR-compatible, small animal PET imager. J Magn Reson. 186:305-310; 2007.

Smith MF. Advances in rubidium PET and integrated imaging with CT angiography. Current Cardiology Reports. 10: 135-141; 2008.

Raylman RR, Smith MF, Kinahan PE, Majewski S. Quantification of radiotracer uptake with a dedicated breast imaging system. Med Phys. 35: 4989-4997; 2008.

Fink JC, Lodge MA, Smith MF, Hinduja A, Brown J, Dinits-Pensy MY, Dilsizian V. Pre-clinical myocardial metabolic alterations in chronic kidney disease. Cardiology. 116: 160-167; 2010.

Tian J, Smith MF, Dickfeld T. Clinical application of FDG-PET imaging for three-dimensional myocardial scar and left ventricular anatomy during ventricular tachycardia ablation. PET Clin. 6: 393-402; 2011.

Weisenberger AG, Lee S, Smith MF. Motion-tracking technique in unrestrained small-animal single-photon emission computed tomography. Rev Neurosci. 22:657-663; 2011.

Tian J, Smith MF, Ahmad G, Dilsizian V, Jimenez A, Dickfeld T. Integration of 3-dimensional scar models from SPECT to guide ventricular tachycardia ablation. J Nucl Med. 53: 894-901; 2012.

Weisenberger AG, Kross B, Lee S, McKisson J, McKisson JE, Xi W, Zorn C, Reid C, Howell CR, Crowell AS, Cumberbatch L, Fallin B, Stolin A, Smith MF. PhytoBeta imager: a positron imager for plant biology. Phys Med Biol. 57: 4195-4210; 2012.

Baba JS, Endres CJ, Foss CA, Nimmagadda S, Jung H, Goddard JS, Lee S, McKisson J, Smith MF, Stolin AV, Weisenberger AG, Pomper MG. Molecular imaging of conscious, unrestrained mice with AwakeSPECT. J Nucl Med. 54: 969-976; 2013.

Weisenberger AG, Kross B, Lee SJ, McKisson J, McKisson JE, Xi W, Zorn C, Howell CR, Crowell AS, Reid CD, Smith M. Nuclear physics detector technology applied to plant biology research. Nucl Instrum Meth A. 718: 157-159; 2013.

Smith MF. Recent advances in cardiac SPECT instrumentation and system design. Curr Cardiol Rep. 15(8): 387; 2013.