Dr. Shanholtz has been involved in numerous multicenter clinical trials in critically ill medical patients with acute lung injury and the acute respiratory distress syndrome, sepsis, and critically ill oncology patients.

He has collaborated with colleagues at the Johns Hopkins School of Medicine on ventilatory strategies in acute lung injury (ARDSnet) and is collaborating with Surgical Critical Care in creating a multidisciplinary critical care research, education, and clinical service. Another interest has been in medical informatics and the development of computerized physician documentation for the School of Medicine.

Current Research Interests:
•  Acute Lung Injury
•  Sepsis
•  Medical Informatics in the Critical Care Setting