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Wei Guang M.D., Ph.D.

Academic Title: Research Associate
Primary Appointment: Pediatrics
wguang@peds.umaryland.edu
Location: BRB, 13-037
Phone: (410) 706-3872
Fax: (410) 706-0020

Personal History:

I have over 20 years of experience in general molecular biology, immunology, and protein chemistry techniques. After immigrating to the United States in 2000, as a post-doctoral fellow in the Department of Pharmaceutical Sciences at University of Maryland Baltimore, I carried out cutting-edge research on a challenging five-year project funded by NIH that was designed to study the molecular and cellular regulation of the opioid receptor with a focus on signal transduction pathways that mediate receptor function. I played a leading role in this project, become a key member of the research team, and published my findings in peer-reviewed biomedical journals. In 2006, I was recruited by the Department of Pediatrics at the University of Maryland, Baltimore as a post-doctoral fellow in the laboratory of Dr. Erik Lillehoj to investigate the role of mucins in the host response to bacterial infections at mucosal surfaces. I have gained experience with using human cell culture systems to investigate Helicobacter pylori stomach infection and inflammation, human gastric epithelial cell biology, and H. pylori microbiology. In 2007, I was promoted to the faculty position of Research Associate and I continue to pursue collaborative studies with Dr. Lillehoj.

Publications:

Guang W, Wang J, Du C, et al. Mutations of RB gene in Wilms' tumor. Zhonghua Xiao Er Wai Ke Za Zhi (Chinese Journal of Pediatric Surgery) 19:11-14, 1998.

Guang W, Guo Y, Lin Q, Du C. Polymorphism analysis of the D4S111 locus in a Chinese Han population. Zhongshan Yi Ke Da Xue Xue Bao (Academic Journal of Sun Yat-sen University of Medical Sciences) 19:255-257, 1998.

Zhou L, Mei H, Liu T, Guang W. Identification of mutations of SRD5A2 gene and SRY gene in patients with hypospadias. Zhonghua Yi Xue Yi Chuan Xue Za Zhi.(Chinese Journal of Medical Genetics) 16:311-314, 1999.

Guang W, Zhou L, Zeng R, Du C. Detection of R277Q mutation of SRD5alpha2 gene by amplification refractory mutation system. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Chinese Journal of Medical Genetics) 16:390-391, 1999.

Deng HB, Guang W, Wang JB. Selected cysteine residues in transmembrane domains of mu-opioid receptor are critical for effects of sulfhydryl reagents. J. Pharmacol. Exp. Ther. 293:113-120, 2000.

Deng HB, Yu Y, Wang H, Guang W, Wang JB. Agonist-induced mu opioid receptor phosphorylation and functional desensitization in rat thalamus. Brain Res. 898:204-214, 2001.

Guang W, Wang H, Su T, Weinstein IB, Wang JB. Role of mPKCI, a novel mu-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphine-induced analgesia. Mol. Pharmacol. 66:1285-1292, 2004.

Wang H, Guang W, Barbier E, Shapiro P, Wang JB. Mu opioid receptor mutant, T394A, abolishes opioid-mediated adenylyl cyclase superactivation. Neuroreport 18:1969-1973, 2007.

Li D, Guang W, Abuzeid WM, Roy S, Gao GP, Sauk JJ, O'Malley BW Jr. Novel adenoviral gene delivery system targeted against head and neck cancer. Laryngoscope 118:650-658, 2008.

Guang W, Kim KC, Lillehoj EP. MUC1 mucin interacts with calcium-modulating cyclophilin ligand. Int. J. Biochem. Cell Biol. 41:1354-1360, 2009.

Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP. Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen. J Biol Chem 285:20547-20557, 2010.

Guang W, Twaddell WS, Lillehoj EP. Molecular interactions between MUC1 epithelial mucin, β-catenin, and CagA proteins. In: Factors that Promote T Helper and Regulatory T Cell Responses to Helicobacter pylori Infection of the Gastric Mucosa, (Blanchard TG, ed), Frontiers in Mucosal Immunity, Lausanne, Switzerland, in press, 2012.

Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Luzina IG, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE. NEU1 sialidase expressed in human airway epithelia regulates epidermal growth reactor receptor (EGFR) and MUC1 signaling. J Biol Chem, in press, 2012.

Park Y, Guang W, Blanchard TG, Kim KC, Lillehoj EP. 2012. Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor γ. Gastroenterology, in preparation.