Bookmark and Share

Jan  Cerny
 

Jan Cerny M.D., Ph.D.

Academic Title: Adjunct Professor
Primary Appointment: Microbiology and Immunology
Secondary Appointments: Pathology
jcerny@som.umaryland.edu
Location: Bressler Research Building, 13-015
Phone: (410) 706-7114
Fax: (410) 706-6970

Research Interests:

Our laboratory has been studying the mechanisms that regulate the magnitude and the molecular repertoire of the antibody response and the differentiation of B cells towards immunological memory. Current focus is on the role of bone marrow which is a major homing site for effector B cells and for a functionally specialized subset of memory/effector T helper cells. We also examine the effects of aging on antibody repertoire. Our studies have shown that the antibody molecules produced by aged animals are encoded by different V genes, that lack somatic mutations and fail to protect the host against infection. This is, in part, due to functional changes in aging helper T cells. Moreover, the aging B cells respond differently to co-stimulatory signals that may proceed through alternative biochemical pathways.


Publications:

Zhu, H., K. Liu, J. Cerny, T. Imoto and K. Moudgil. 2005. Insertion of the Dibasic Motif in the Flanking Region of a Cyrptic Self-Determinant Leads to Activation of the Epitope-Specific T Cells. The Journal of Immunology, 175: 2252-2260.

Song, H., and J. Cerny 2003. Functional Heterogeneity of Marginal Zone B Cells Revealed by Their Ability to Generate Both Early Antibody-forming Cells and Germinal Centers with Hypermutation and Memory in Response to a T-dependent Antigen. J. Exp. Med., Vol. 198, No. 12:1923-1935.

Lu, Y-F and J. Cerny. Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice. J. Immunol. 169:4920-4927, 2002.

Lu, Y.-.F., M. Singh and J. Cerny. Canonical germinal center B cells may not dominate the memory response to antigenic challenge. Int. Immunology 13(5), 643-655, 2001.