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Steven J Czinn
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Steven J Czinn M.D.

Academic Title: Professor
Primary Appointment: Pediatrics
Administrative Title: Chair
sczinn@peds.umaryland.edu
Location: UMMC, N5E17
Phone: (410) 328-6777

Personal History:

EDUCATION
1979: M.D., Case Western Reserve University School of Medicine, Cleveland, Ohio

1975: B.S. (Magna Cum Laude) Case Western Reserve University, Cleveland, Ohio

POST GRADUATE EDUCATION & TRAINING

1982-1985: Fellowship, Pediatric Gastroenterology, Rainbow Babies & Children’s Hospital, Case Western Reserve University School of Medicine, Department of Pediatrics, Cleveland, Ohio

1980-1982: Residency, Rainbow Babies & Children’s Hospital, Case Western Reserve University School of Medicine, Department of Pediatrics, Cleveland, Ohio

1979-1980: Internship, Rainbow Babies & Children’s Hospital, Case Western Reserve University School of Medicine, Department of Pediatrics, Cleveland, Ohio

BOARD CERTIFICATIONS
1980: Diplomate, National Board of Medical Examiners

1985: Diplomate. American Board of Pediatrics

1990; 1997, 2004: Pediatric Gastroenterology

Research Interests:

Pediatric Gastroenterology

 


Publications:

Selected Recent Publications
Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Maccarthur C, Snyder J, Sherman PM, Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutri 31(5):490-7, 2000.
 
Blanchard TG, Czinn SJ. Immunology of Helicobacter pylori and prospects for vaccine. Gastroenterol Clin North Am 29(3):671-85, 2000.
 
Chelimsky G, Czinn SJ. Helicobacter pylori infection in children: Update. Curr Opinion Pediatri 12(5):460-2, 2000.
 
Kersulyte D, Mukhopadhyay AK, Velapatino B, Su WW, Pan ZJ, Garcia C, Hernandez V, Valdez Y, Mistry RS, Gilman RH, Yuan Y, Gao H, Alarcon T, Lopez-Brea M, Nair GB, Chowdhury A, Datta S, Shirai M, Nakazawa T, Ally R, Segal I, Wong BCY, Lam SK, Olfat FO, Boren T, Engstrand L, Torres O, Schneider R, Thomas JE, Czinn S, Berg DE: Differences in genotypes of Helicobacter pylori from different human populations. Journal of Bacteriology 182 (11): 3210-3218, 2000.
 
Gold BD, Van Doorn LJ, Guarner J, Owens M, Pierce-Smith D, Song Q, Hutwagner L, Sherman PM, De Mola, OL, Czinn SJ. Genotypic, Clinical and demographic characteristics of children infected with Helicobacter pylor. J. Clin Microbiol 39(4):1348-52, 2001.
 
Gottwein J, Blanchard TG, Targoni OA, Eisenberg JGC, Trezza R, Redline RV, Nedrud JG, Lehmann PV, Czinn SJ: Type 2 Protective Anti-Helicobacter Immunity is Induced with Aluminum Hydroxide or Complete Freund’s Adjuvant by Systemic Immunization. J. Infect Dis 184:308-14, 2001.
 
McGovern KJ, Blanchard TG, Gutierrez JA, Czinn SJ, Krakowka S, Youngman P. Gamma Glutamytransferase is a Helicobacter pylori virulence factor but is not essential for colonization. Infect Immun 69:4168-73, 2001.
 
Blanchard TG, Czinn SJ. Helicobacter pylori acquisition and transmission: Where does it all begin? Gastroenterology 121:483-5, 2001.
 
Chelimsky G, Czinn SJ. Peptic Ulcer Disease in Children. Pediatr Rev 22:349-55, 2001.
 
Chelimsky G, Czinn SJ. Techniques for the Evaluation of Dyspepsia in Children. J Clin Gastroenterol 33:11-3, 2001.
 
Garhart, A., Redline, R., Nedrud, J., Czinn, S. Clearance of Helicobacter pylori Infection and Resolution of Postimmunization Gastritis in a Kinetic Study of Prophylactically Immunized Mice. Infect. & Immunity 70:3529-3538, 2002.
 
Nedrud, J., Blanchard S., Czinn, S., Helicobacter pylori inflammation and immunity. Helicobacter 7:24-29, 2002.
 
Czinn S, Gold B, Dickinson C, Ramakrishna J, Orenstein S. Research agenda for pediatric gastroenterology, hepatology and nutrition: acid-peptic diseases. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children’s Digestive Health and Nutrition Foundation. J. Pediatr Gastroenterol Nutri 35 Suppl 3:S250-3, 2002.
 
Sherman P, Czinn S, Drumm B, Gottrand F, Kawakami E, Madrazo A, Oderda G, Seo J, Sullivan P, Toyoda S, Weaver L, WU T, Helicobacter pylori infection in children and adolescents: working group report of the first world congress of pediatric gastroenterology, hepatology, and nutrition. J. Pediatr Gastroenterol Nutr 35 Suppl 2:S128-133, 2002.
 
Chelimsky G, Blanchard, S, Sivit C, Davis I, Czinn S. Pneumatosis Intestinalis and Diarrhea in a child following renal transplantation. Pediatr Transplant 7(3):236-9, 2003.
 
Guarner J, Bartlett J, Whistler T, Pierce-Smith D, Owens M, Kreh R, Czinn S, Gold B.  Can pre-neoplastic lesions be detected in gastric biopsies of children with Helicobacter pylori Infection? J Pediatr Gastroenterol Nutr 37(3):309-14, 2003.
 
Orenstein S, Shalaby T, Devandry S, Liacouras C, Czinn S, Dice J, Simon T, Ahrens S, Stauffer L.   Famotidine for infant gastro-esophageal reflux: a mutli-centre, randomized, placebo-controlled, withdrawal trail. Aliment Pharmacol Ther 17(9):1097-107, 2003.
 
Aronow S, Aronow H, Blanchard T, Czinn S.J., Chelimsky G, Hair relaxers a benign caustic ingestion? J Pediatr Gastroenterol Nutri 36(1):120-5, 2003.
 
Garhart C.A,. Heinzel F.P., Czinn S.J., Nedrud J.G.. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun. 71:910-21, 2003.
 
Garhart C.A., Nedrud J.G., Heinzel F.P., Sigmund N.E., Czinn S.J.. Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun. 71:3628-33, 2003.
 
Eisenberg J.C., Czinn S.J., Garhart C.A., Redline R.W., Bartholomae W.C., Gottwein J.M., Nedrud J.G., Emancipator S.E., Boehm B.B., Lehmann P.V., Blanchard T.G. Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infect Immun. 71:1820-7, 2003.
 
Duck WM, Sobel J, Pruckler JM, Song OS, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoekstra M, Griffin P, Smoot D, Peek R, Metz DC, Bloom PB, Goldschmid S, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Vakil N, Ernst P, Czinn S, Dunne D, Gold BD: Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons. Emerging Infectious Diseases 10 (6): 1088-1094, 2004.
 
Basu M, Czinn SJ, Blanchard TG: Absence of catalase reduces long-term survival of Helicobacter pylori in macrophage phagosomes. Helicobacter 9 (3): 211-216, 2004.
 
Drakes M, Blanchard T, Czinn S: Bacterial probiotic modulation of dendritic cells. Infection and Immunity 72 (6): 3299-3309, 2004.
 
Czinn SJ: Helicobacter pylori infection: Detection, investigation, and management. Journal of Pediatrics 146 (3): S21-S26 Suppl., 2005.
 
Fiocchi C, Cucchiara T, Czinn SJ, Grand RJ, Levine AD, Seidman JG.: First International Symposium on: Pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, USA. Journal of Pediatric Gastroenterology And Nutrition 40: S1-S52 Suppl. 1 2005.
 
Arora S, Czinn SJ: Vaccination as a method of preventing Helicobacter pylori-associated gastric cancer. Cancer Epidemiology Biomarkers & Prevention 14 (8):1890-1891, 2005.
 
Matsumoto Y, Blanchard TG, Drakes ML, Basu M, Redline RW, Levine AD, Czinn SJ: Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice. Helicobacter 10 (5):407-415, 2005.
 
Drakes ML, Blanchard TG, Czinn SJ: Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis. J Leukoc Biol 78:1291-1300, 2005

Invited Reviews/Chapters/Proceedings
Czinn SJ, Robinson J, Lamm ME: Chemotaxis as a mechanism for recruitment of mucosal plasma cell precursors. In: Mestecky J, McGhee JR, Bienenstock J, Ogra PL, eds., Recent Advances in Mucosal Immunology 216A:305-311, 1987.

Czinn SJ, Lamm ME: Speculations on the homing mechanism of precursors of mucosal plasma cells. In: Mucosal Immunity and Infections at Mucosal Surfaces. Ed., W. Strober, M.E. Lamm, J.R. McGhee, and S.P. James, pp. 195-202. New York, Oxford University Press, 1988.
 
Vanderhoof JA, Drumm B, Czinn SJ: Peptic ulcer, gastritis and Campylobacter pylori. AAP Pediatric Update 10:5, 1989.
 
Czinn SJ, Speck WT: Campylobacter pylori: a new pathogen. Adv Pediatr Infect Dis 5:221-237, 1990.
 
Czinn SJ: Pediatric Gastroenterology. Nelson Textbook of Pediatrics Update 7. Ed., R. Behrman, V. Vaughan, pp. 85-94, 1990.
 
Czinn SJ: Helicobacter pylori-induced gastritis in childhood. In: Malfertheiner, P. Proceedings of the Workshop on Gastroduodenal Pathology and Campylobacter pylori. Springer-Verlag, Berlin (181-187), Ulm, 1990.
 
Czinn SJ, Halpin T: Acute Hepatic Failure. In: Practical Guide to Pediatric Intensive Care, Editor, Jeffrey Blumer, Mosby, 1991.
 
Czinn SJ: Helicobacter pylori. In: Rudolph's Pediatrics 19th Edition, Editor, Abraham M. Rudolph, M.D., Appleton & Lange, 1991.
 
Czinn SJ: Pancreatitis. In: Manual of Emergency Pediatrics, Editor, Robert Reece, W.B. Saunders, 1992.
 
Czinn SJ: Helicobacter pylori Gastroduodenal disease in children. In: Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis and Management, Eds., Robert Wyllie, M.D., Jeffrey S. Hyams, M.D., W.B. Saunders Company, 1992.
 
Westblom TU, Phadnis S, Normark S, Czinn SJ: Diagnosis of Helicobacter pylori in gastric juice aspirates using polymerase chain reaction (PCR). Proceedings of the Workshop on Helicobacter pylori, Bologna, Italy 1993.
 
Sellman S, Blanchard TG, Nedrud JG, Czinn SJ. Vaccine Strategies for prevention of Helicobacter pylori infections. Eur J Gastroenterol Hepatol 7 (suppl 1):S1-S6, 1995.
 
Kugathasan S, Czinn SJ. Management of gastrointestinal disorders in children. Curr Opin Gastroenterol 11;504-507, 1995.
 
Czinn S: Toward a vaccine. Proceedings of “Helicobacter pylori-Progress and prospects". Los Angeles, CA, Page 37-42, 1995.
 
Czinn SJ, Glassman MS. "Helicobacter pylori in infants and children". Adv Ped Infec Dis 11:389-401, 1996.
 
Czinn SJ, Lee A, Nedrud JG. The role of vaccination in preventing infection with Helicobacter pylori. Mucosal Immunology Update 2:6-8, 1996.
 
Nedrud JG, Czinn SJ: Helicobacter pylori: An update. Current Opin in Gastro 12:62-67, 1996.
 
Kugathasan S, Czinn SJ. Gastroduodenal inflammation and related disorders in children. Curr Opin Gastroenterol 12:537-543, 1996.
 
Czinn SJ, Nedrud JG. Helicobacter pylori: Infection, inflammation and the host immune response. In: Kagnoff M, Kiyono H, eds. Essentials of Mucosal Immunology San Diego: Academic Press, pp. 391-403, 1996.
 
Ernst PB, Reyes VE, Nedrud JG, Czinn SJ. In: Mucosal immunity to H. pylori: Implications for vaccine development.   Kiyono H, Ogra PL, McGhee JR, eds. Mucosal Vaccines San Diego: Academic Press, pp. 255-267, 1996.
 
Nedrud JG, Czinn SJ. Helicobacter pylori. Curr Opin Gastroenterol 13:71-78, 1997.
 
Kugathasan S, Czinn SJ. Upper gastrointestinal motility disorders in children. Curr Opin Gastroenterol 13:486-489, 1997.
 
Nedrud JG, Czinn SJ. Oral immunization for the prevention and treatment of infection with Helicobacter. In: The Immunobiology of H. pylori: from Pathogenesis to Prevention. Ernst PB, Michetti P, Smith P, eds. New York: Lippincott-Raven, pp. 273-286, 1997.
 
Czinn SJ, Nedrud JG. In: Immunopathology of Helicobacter pylori infection and disease. Strober W, Kelsall B, eds. Springer Seminars in Immunopathology Berlin: Springer, 18:495-513, 1997.
 
Kugathasan S, Czinn SJ. Helicobacter pylori and gastrointestinal disorders in children. In: Recent advances in pediatrics. David TJ ed. Edinburgh; Churchill Livinstone, 16; 91-104, 1997.
 
Czinn SJ. What is the role for vaccination in Helicobacter pylori? Gastroenterology 113:s149-s153, 1997.
 
Nudrud JG, Czinn SJ, Blanchard TG. H. pylori vaccines. In: Lee A, Kolesnikow T, Eds. Helicobacter pylori-A global pathogen: Bailliere, 1998
 
Czinn SJ, Lamm, ME: New insights in the role of IgA in gut protection. Cur Opin Gastroenterol 14:488-491, 1998.
 
Guimber D, Chelimsky G, Gottrand F, Czinn SJ: Paediatrics. Current Opinion in Gastroenterology 15: S49-S52 Suppl. 1, 1999.
 
Chelimsky G, Czinn SJ. Methodologic Considerations in the Management of Pediatric Recurrent Abdominal Pain. Evidence Based Gastroenterology: A Framework for Clinical practice. Ervine, EJ and Hunt, Eds., BC Decker, Inc., 19-27; 2001.
 
Chelimksy G, Dahms B, Czinn SJ. Peptic Ulcer Disease and Gastritis. Pediatric Gastroenterology and Nutr in Clinical Practice. Lifschitz C, Ed., 2001.
 
Blanchard TG, Drakes ML, Czinn SJ: Helicobacter infection: pathogenesis. Current Opinion in Gastroenterology 20 (1): 10-15, 2004.