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Research Interests
Dr. Khurana research is focused on signaling mechanisms of hemodynamic changes associated with cirrhosis. The hemodynamic changes observed in liver cirrhosis and animal models of experimental cirrhosis include reduced systemic vascular resistance and decreased arterial pressure. These changes are associated with vasodilation in the systemic and splanchnic circulation, and significantly contribute to the morbidity and mortality of patients with cirrhosis. Dr. Khurana is specifically interested in elucidating the role of bile acids in mediating these vascular changes.Clinical Speciality
Portal HypertensionChronic Hepatitis
Liver transplantation
Publications
Sandeep Khurana, Kunrong Chen, Jean-Pierre Raufman. Steroid Ring Hydroxylation and Conjugation Modulate Bile Acids-Mediated Cellular Signaling: Molecular Basis of Hormone-Like Behavior (In press, Medical Hypotheses and Research).
Sandeep Khurana, Guofeng Xie, Masahisa Yamada, Jurgen Wess, Richard H Kennedy, Jean-Pierre Raufman. Deoxycholyltaurine causes endothelium-dependent muscarinic receptor mediated NO-induced smooth muscle dilation in murine thoracic aorta. European Journal of Pharmacology 517:103-110,2005)
Sandeep Khurana, Guofeng Xie, J-P Raufman, Masahisa Yamada, Jurgen Wess, Richard H Kennedy. Vasodilatory effects of acetylcholine are diminished in aorta from muscarinic-3 receptor knock out mice. European Journal of Pharmacology 493:127-132, 2004.
Cheng K., Khurana Sandeep, Chen Y., Kennedy RH, Zimniak P., Raufman JP. Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. Journal of Pharmacology & Experimental Therapeutics 303(1): 29-35, 2002 Oct.