Bookmark and Share

Feng  Jiang
 

Feng Jiang M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Pathology
Additional Title(s): The Program in Genetics & Genomic Medicine and The Program in Oncology
fjiang@som.umaryland.edu
Location: MSTF 734-C
Phone: (410) 706-4854
Phone: (410) 706-7056
Fax: (410) 706-8414

Personal History:

  • MD, Southeast University, China
  • MS, Southeast University, China
  • PhD, University of Basel, Switzerland
  • University of Texas M.D. Anderson Cancer Center, Post-doctoral


Research Interests:

To understand genomic and genetic aberrations lead to tumor formation, identify cancer genes, and translate the resultant new technologies and information into clinic for diagnosis and therapeutic interventions of cancer.


Laboratory Personnel:

Post-doc Research Fellows 
Jun Shen PhD., Post-doc Research Fellow. University of Maryland School of Medicine

YuPing Mei PhD., Post-doc Research Fellow. University of Maryland School of Medicine

JiPei Liao PhD., Post-doc Research Fellow. University of Maryland School of Medicine 

Clinical Fellow
He Zhang, MD, PhD, Clinical Fellow of Pulmonary and Critical Care Medicine

Research Project Coordinator
Maria Guarnera


Publications:

Qiu, Q., Todd, N.W., Liu Z, Stass, S.A., & Jiang, F. ALDH1 Is a stem cell marker in lung cancer and predictor of poor clinical outcome. Mol. Cancer Res., in press, 2008.

Liu Z, Jiang, F. Gene Identification and survival prediction with supervised and unsupervised learning. Int. J. Data Mining and Bioinformatics, in press, 2008.

Liu Z, Gartenhaus R, Tan M, Jiang F, Jiao X. Gene and Pathway Identification with Lp Penalized. Bayesian Logistic Regression. BMC Bioinformatics, 2008. 9:412.

Yendamuri S, Vaporciyan AA, Hofstetter W, Jiang F, Spitz MR, Swisher SG, Roth JA, and Katz RL. 3p22.1 and 10q22.3 Deletions Detected by Fluorescence In Situ Hybridization (FISH) A Potential New Tool for Early Detection of Non-small Cell Lung Cancer (NSCLC). J. Thorac. Oncol., 28. 2008.

Qiu Q, Todd NW, Li R, Peng H, Liu Z, Yfantis HG, Katz RL, Stass SA, Jiang, F. Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosis. Cancer. 2008. 6: 22-29.

Katz RL, Zaidi TM, Fernandez RL, Zhang J, He W, Acosta C, Daniely M, Madi L, Vargas MA, Dong Q, Jiang XG (Jiang F), Caraway NP, Vaporciyan AA, Roth JA, Spitz MR. Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancer. Mod. Pathol. 2008.

Zhao F, Zhao M, Auerbach A, D'Costa A, Rapoport A, Burger A, Sausville B, Stass S, Jiang F, Sands A, Aguilera N Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy. Clin. Cancer Res, in press 2008.

Liu, Jiang F, Tian, G, Wang, A, Sato, F, Meltzer SJ, and Tan M.Sparse Logistic Regression with Lp Penalty for Biomarker Identification. Statistical Appl. in Genetics and Molecular Biology. 2007. 6: 2-12.

Li R, Todd NW, Qiu Q, Fan T, Zhao RY, Rodgers WH, Fang HB, Katz RL, Stass SA, Jiang F. Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. Clin Cancer Res. 2007 15;13(2):482-7.AACR Breaking News and NBC News.

Fan, T., Qiu, Q., Li, R., Todd, N.W., Katz, R.L., Stass, S.A., & Jiang, F. Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res, 2007, 67 (16).

Li R, Todd N, Stass S, and Jiang, F. Detecting genetic aberrations by in situ hybridization with quantum dots-labeled probes. Journal of Nanoscience and Nanotechnology. 2007. 10, 1-6.

Liu, Jiang F, Tian, G, Wang, A, Sato, F, Meltzer SJ, and Tan M.Sparse Logistic Regression with Lp Penalty for Biomarker Identification. Statistical Appl. in Genetics and Molecular Biology. 2007 6. 2.

Li, R., Wang, H., Bekele, B.N., Yin, Z., Caraway, N.P., Katz, R.L., Stass, S.A., & Jiang, F. Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene; 25(18):2628-35, 2006.

Li, R., Liu, Z., Fan, T., & Jiang, F. A novel in situ multiple genomic array for the detection of genetic aberrations in cancer. Lab Invest 86(6): 619-27, 2006.

Schmandt, RE., Bennett, M., Clifford, S., Thornton, A, Jiang, F., Broaddus, R.R., Sun, C.C., Lu, KH., Sood, A.K., &Gershenson, D.M. The BRK Tyrosine Kinase is Expressed in High-Grade Serous Carcinoma of the Ovary. Cancer Biol Ther. Sep; 5(9). 2006.

Jiang, F., Caraway, N.P., Li, R. & Katz, R.L. RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells. Oncogene, May, 24(21):3409-18, 2005.

Wang, H.J., Caraway, N.P., Katz, R.L., & Jiang, F.  Overexpression of potential oncogene S100A2 protein as a prognostic marker for patients with stage I non-small cell lung cancer. Int J Cancer, 116(2):666-669, 2005.

Jiang, F., Caraway, N.P., & Katz, R.L. Genomic copy number aberration of surfactant protein a (SFTPA) gene in patients with stage I non-small cell lung cancer. With figure as cover. Clinic Cancer Res. Aug; 11(14): 2005, with the image as the cover of the issue.

Gu, J., Huh, Y.O., Jiang, F., Caraway, N.C., Zaidi, T.M., & Katz, R.L. Detection of peripheral blood involvement of mantle cell lymphoma using interphase fluorescence in situ hybridization. Mod. Pathol., 17:553-560, 2004.

Barkan, G.A., Caraway, N.P., Jiang, F., Zaidi, T.M., Gernandez, R., Vaporcyin, A., Morice, R., Zhou, X., Bekele, B.N., & Katz, R.L. Comparison of molecular abnormalities in bronchial brushings and tumor touch preparations. Cancer, 16, 2004.

Jiang, F., Caraway, N.P., & Katz, R.L. Genomic signatures in primary non small cell carcinomas of lung by using CGH analysis of cDNA microarrays. Neoplasia, 6:623-635, 2004.

Jiang, F., Caraway, N.P., Sabichi, A.L., Zhang, H.Z., Ruitrok, A., Grossman, H.B., Gu, J., Lerner, S.P., Lippman, S., & Katz, R.L. Centrosomal abnormality is common in and a potential biomarker of bladder cancer. Int J Cancer, 106(5):661-665, 2003.

Sen, S., Zhou, H., Zhang, R., Yoon, D., Vakar-Lopez, F., Ito, S., Jiang, F., Johnston, D., Grossman, B., Ruifrok, A., Katz, R.L., Brinkey, W., & Czerniak, B. Amplification/overexpression of a mitotic kinase gene is associated with aneuploidy and aggressive phenotype of human bladder cancer. J Natl Cancer Inst, 94:1320-1329, 2002.

Jiang, F and Katz RL. Use of interphase fluorescence in situ hybridization as a powerful diagnostic tool in cytology. Diagn Mol Pathol. 2002 Mar;11(1):47-57.

Jiang, F., Lin, F., Caraway, N.P., & Katz, R.L. Rapid detection of IgH/BCL2 rearrangement in follicular lymphoma by interphase fluorescence in situ hybridization with bacterial artificial chromosome. A.J. Path Diagnosis, 4:66-72, 2002.

Katz, R.L., Gu, J., Caraway, N., Jiang, F., Pascoe-Miller, L., Hayes, K., & Medeiros, J. Detection of cyclin D1 translocation by fluorescence in situ hybridization is highly specific and sensitive in the diagnosis of mantle call lymphoma (MCL). Am Cli Pathology, 2:248-257, 2000.

Desper, R., Jiang, F., Kallioniemi, O.P., Moch, H., & Schaffer, A.A. Distance-based reconstruction of tree models for oncogenesis. J. Comput Biol. 6: 789-803, 2000.

Jiang, F, Desper, R., Kallioniemi, O.P., Moch, H., & Schaffer, A.A. Construction of evolutionary tree models for renal cell carcinoma oncogenesis from comparative genomic hybridization data. Cancer Res., 22:6503-6509, 2000.

Desper, R., Jiang, F., Kallioniemi, O.P., Moch, H., Papadimitriou, C.H., & Schaffer, A. Inferring tree models for oncogenesis from comparative genomehybridization data. A J Com Biol, 6:37-51, 1999.

Dellas, A., Torhorst, J., Jiang, F., Sauter, G., Mihatsch, M.J., & Moch, H. Prognostic value of genomic alterations in invasive cervical squamous cell carcinoma of clinical state IB detected by comparative genomic hybridization. Cancer Res, 15:3475-3479, 1999.

Jiang, F. , Richter, J., Schraml, P., Bubendorf, L., Gasser, T., Sauter, G., Mihatsch, M.J., & Moch, H. Chromosomal imbalances in papillary renal cell carcinoma:  genetic differences between histological subtypes. Am J Pathol, 5: 1467-1473, 1998.

Jiang, F., Moch H, Richter J, Egenter C, Gasser T, Bubendorf L, Gschwind R, Sauter G, Mihatsch MJ. Comparative genomic hybridization reveals frequent chromosome 13q and 4q losses in renal carcinomas with sarcomatoid transformation. J Pathol. 1998. 185(4):382-8.

Richter J, Jiang F, Gorog JP, Sartorius G, Egenter C, Gasser TC, Moch H, Mihatsch MJ, Sauter G. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res. 1997 Jul 15;57(14):2860-4.

Sauter G, Gasser TC, Moch H, Richter J, Jiang F, Albrecht R, Novotny H, Wagner U, Bubendorf L, Mihatsch MJ. DNA aberrations in urinary bladder cancer detected by flow cytometry and FISH. Urol Res. 1997;25 Suppl 1:S37-43.

Moch H, Sauter G, Gasser TC, Buchholz N, Bubendorf L, Richter J, Jiang F, Dellas A, Mihatsch MJ. p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma. Urol Res. 1997;25 Suppl 1:S25-30.

Li R, Todd NW, Qiu Q, Fan T, Zhao RY, Rodgers WH, Fang HB, Katz RL, Stass SA, Jiang F. Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. Clin Cancer Res. 2007 15;13(2):482-7.AACR Breaking News and NBC News.

Fan, T., Qiu, Q., Li, R., Todd, N.W., Katz, R.L., Stass, S.A., & Jiang, F. Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res, 2007, 67 (16).

Li R, Todd N, Stass S, and Jiang, F. Detecting genetic aberrations by in situ hybridization with quantum dots-labeled probes. Journal of Nanoscience and Nanotechnology. 2007. 10, 1-6.

Liu, Jiang F, Tian, G, Wang, A, Sato, F, Meltzer SJ, and Tan M.Sparse Logistic Regression with Lp Penalty for Biomarker Identification. Statistical Appl. in Genetics and Molecular Biology. 2007 6. 2.

Li, R., Wang, H., Bekele, B.N., Yin, Z., Caraway, N.P., Katz, R.L., Stass, S.A., & Jiang, F. Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene; 25(18):2628-35, 2006.

Li, R., Liu, Z., Fan, T., & Jiang, F. A novel in situ multiple genomic array for the detection of genetic aberrations in cancer. Lab Invest 86(6): 619-27, 2006.

Schmandt, RE., Bennett, M., Clifford, S., Thornton, A, Jiang, F., Broaddus, R.R., Sun, C.C., Lu, KH., Sood, A.K., &Gershenson, D.M. The BRK Tyrosine Kinase is Expressed in High-Grade Serous Carcinoma of the Ovary. Cancer Biol Ther. Sep; 5(9). 2006.

Jiang, F., Caraway, N.P., Li, R. & Katz, R.L. RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells. Oncogene, May, 24(21):3409-18, 2005.

Wang, H.J., Caraway, N.P., Katz, R.L., & Jiang, F.  Overexpression of potential oncogene S100A2 protein as a prognostic marker for patients with stage I non-small cell lung cancer. Int J Cancer, 116(2):666-669, 2005.

Jiang, F., Caraway, N.P., & Katz, R.L. Genomic copy number aberration of surfactant protein a (SFTPA) gene in patients with stage I non-small cell lung cancer. With figure as cover. Clinic Cancer Res. Aug; 11(14): 2005, with the image as the cover of the issue.

Gu, J., Huh, Y.O., Jiang, F., Caraway, N.C., Zaidi, T.M., & Katz, R.L. Detection of peripheral blood involvement of mantle cell lymphoma using interphase fluorescence in situ hybridization. Mod. Pathol., 17:553-560, 2004.

Barkan, G.A., Caraway, N.P., Jiang, F., Zaidi, T.M., Gernandez, R., Vaporcyin, A., Morice, R., Zhou, X., Bekele, B.N., & Katz, R.L. Comparison of molecular abnormalities in bronchial brushings and tumor touch preparations. Cancer, 16, 2004.

Jiang, F., Caraway, N.P., & Katz, R.L. Genomic signatures in primary non small cell carcinomas of lung by using CGH analysis of cDNA microarrays. Neoplasia, 6:623-635, 2004.

Jiang, F., Caraway, N.P., Sabichi, A.L., Zhang, H.Z., Ruitrok, A., Grossman, H.B., Gu, J., Lerner, S.P., Lippman, S., & Katz, R.L. Centrosomal abnormality is common in and a potential biomarker of bladder cancer. Int J Cancer, 106(5):661-665, 2003.

Sen, S., Zhou, H., Zhang, R., Yoon, D., Vakar-Lopez, F., Ito, S., Jiang, F., Johnston, D., Grossman, B., Ruifrok, A., Katz, R.L., Brinkey, W., & Czerniak, B. Amplification/overexpression of a mitotic kinase gene is associated with aneuploidy and aggressive phenotype of human bladder cancer. J Natl Cancer Inst, 94:1320-1329, 2002.

Jiang, F and Katz RL. Use of interphase fluorescence in situ hybridization as a powerful diagnostic tool in cytology. Diagn Mol Pathol. 2002 Mar;11(1):47-57.

Jiang, F., Lin, F., Caraway, N.P., & Katz, R.L. Rapid detection of IgH/BCL2 rearrangement in follicular lymphoma by interphase fluorescence in situ hybridization with bacterial artificial chromosome. A.J. Path Diagnosis, 4:66-72, 2002.

Katz, R.L., Gu, J., Caraway, N., Jiang, F., Pascoe-Miller, L., Hayes, K., & Medeiros, J. Detection of cyclin D1 translocation by fluorescence in situ hybridization is highly specific and sensitive in the diagnosis of mantle call lymphoma (MCL). Am Cli Pathology, 2:248-257, 2000.

Desper, R., Jiang, F., Kallioniemi, O.P., Moch, H., & Schaffer, A.A. Distance-based reconstruction of tree models for oncogenesis. J. Comput Biol. 6: 789-803, 2000.

Jiang, F, Desper, R., Kallioniemi, O.P., Moch, H., & Schaffer, A.A. Construction of evolutionary tree models for renal cell carcinoma oncogenesis from comparative genomic hybridization data. Cancer Res., 22:6503-6509, 2000.

Desper, R., Jiang, F., Kallioniemi, O.P., Moch, H., Papadimitriou, C.H., & Schaffer, A. Inferring tree models for oncogenesis from comparative genomehybridization data. A J Com Biol, 6:37-51, 1999.

Dellas, A., Torhorst, J., Jiang, F., Sauter, G., Mihatsch, M.J., & Moch, H. Prognostic value of genomic alterations in invasive cervical squamous cell carcinoma of clinical state IB detected by comparative genomic hybridization. Cancer Res, 15:3475-3479, 1999.

Jiang, F. , Richter, J., Schraml, P., Bubendorf, L., Gasser, T., Sauter, G., Mihatsch, M.J., & Moch, H. Chromosomal imbalances in papillary renal cell carcinoma:  genetic differences between histological subtypes. Am J Pathol, 5: 1467-1473, 1998.

Jiang, F., Moch H, Richter J, Egenter C, Gasser T, Bubendorf L, Gschwind R, Sauter G, Mihatsch MJ. Comparative genomic hybridization reveals frequent chromosome 13q and 4q losses in renal carcinomas with sarcomatoid transformation. J Pathol. 1998. 185(4):382-8.

Richter J, Jiang F, Gorog JP, Sartorius G, Egenter C, Gasser TC, Moch H, Mihatsch MJ, Sauter G. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res. 1997 Jul 15;57(14):2860-4.

Sauter G, Gasser TC, Moch H, Richter J, Jiang F, Albrecht R, Novotny H, Wagner U, Bubendorf L, Mihatsch MJ. DNA aberrations in urinary bladder cancer detected by flow cytometry and FISH. Urol Res. 1997;25 Suppl 1:S37-43.

Moch H, Sauter G, Gasser TC, Buchholz N, Bubendorf L, Richter J, Jiang F, Dellas A, Mihatsch MJ. p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma. Urol Res. 1997;25 Suppl 1:S25-30.