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Zhenqiu Liu
Ph.D.
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| Academic Title:
Assistant Professor |
| Primary Appointment:
Epidemiology and Preventive Medicine |
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zliu@umm.edu |
| Location:
MSTF,
261C |
| Phone:
(410) 706-8523 |
| Fax:
(410) 706-8548 |
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Personal History
University of Tennessee Knoxville (UTK): MS (Computer Science), PhD (Operations Research with Concentration in Data Mining). 1997-2002
Bioinformatics Cell, USAMRMC: Frederick, MD, Postdoctoral (Bioinformatics), 2003-20004
The Ohio State University: Columbus, OH, Postdoctoral (Statistic Genetics, Bioinformatics), 2004-2005
Research Interests
Statistic Genetics, Bioinformatics, and Data Mining: Currently I am working on projects in (1) ROC based methods for gene selection, pathway identification, and biomarker discovery, (2) GWAs, gene-gene interaction and genetic networks, and rare allele identification, (3) integrated analysis for multi-source genomic data, and (4) causal inference and biomarker identification and evaluation in clinical and translational cancer research. I am interested in both methodology and collaborative research and constantly looking for investigators who are willing to use cutting-edge machine learning and statistical computing techniques in their study.
Publications
Selected Publications
Liu, Z., and Bozdogan, H., Radial Basis Function Networks for Classification Using New Kernel Functions, International Journal of Neural Parallel and Scientific Computations, Volume 11, pp 43-54, 2003.
Liu, Z., Chen, D., Bensmail, H., and Xu, Y (2004), Clustering gene expression with kernel principal component analysis, Journal of Bioinformatics and Computational Biology. 2005 Apr;3(2);303-16.
Liu, Z., Chen, D., Xu, Y., and Liu, J. (2004) Logistic Support Vector machine with applications to Microarray Data. International Journal of Bioinformatics Research and Applications Vol. 1, No 2, pp 169-180.
Liu, Z, Chen, D., Bensmail, H. (2004), Gene expression data classification with kernel principal component analysis, Journal of Biomedicine and Biotechnology, vol. 2, pp 155-159.
Chen, D., Liu, Z., Ma, X., and Hua, D. (2004), Selecting Genes by Test Statistics, Journal of Biomedicine and Biotechnology, vol. 2, 132-138.
Shili Lin, Jie Ding, Crystal Dong, Zhenqiu Liu, Zhenxu J Ma, Shuyan Wan, and Yan Xu, Linkage and haplotype analysis of Kofendrerd personality disorder in NYC population. BMC Genetics, 2005, 6(Suppl 1):S76.
Liu, Z., Lin, S. (2005), Multiplies LD measure and tagging SNP selection with generalized mutual information. Genetic Epidemiology, vol.19, 4, (353-364).
Tian, J. Liu, Z. (2007). Coalescent random walks on the graphs. Journal of Computational and Applied Math 202 144-154.
Yu, C. Liu, Z., Reisner, A., McKenna, T., Reifman, J. (2006), A method for automatic identification of reliable heart rates calculated from ECG and PPG waveform. Journal of American Medical Informatics Association (JAMIA),13(3):309-20.
Liu Z., Lin S. (2005), Classification of proteomic data with kernel related algorithms, Journal of Engineering Letters, special issue in Bioinformatics 13:3, EL_13_3_18.
Liu, Z, Chen, D. Tian, J. (2008), Cancer classification with partial least square algorithm and proteomic data. Journal of Bioinformatics Research and Applications vol 4 (1), pp 1-10.
Li, R. Liu, Z., Fan, T., and Jang, F., (2006), A Novel Multiple FISH Array for Detection of Genetic Aberrations in Cancer, Laboratory Investigation 2006 Jun; 86(6):619-27.
Liu, Z., Guo, Z., Tan, M. (2007) Constructing Tumor Progression Pathways and Biomarker Discovery with DNA Methylation. Cancer Informatics, 2008:4 1-8.
Liu, Z., Lin, S. Tan, M. (2006) Genome-wide Tagging SNPs with Entropy Based Monte Carlo Method. Journal of Computational Biology Nov;13(9):1606-14.
Liu Z, Jiang F, Tian G, Tan M (2007) Sparse logistic regression with Lp penalty for biomarker identification. Statistical Applications in Genetics and Molecular Biology, Vol. 6. Issue 1, article 6.
Liu Z, Lin S, Tan M (2008). Sparse support vector machine with Lp penalty for biomarker discovery. IEEE/ACM Journal of Computational Biology and Bioinformatics (TCBB). 28 Jan 2008. IEEE computer Society Digital Library. [Epub ahead of print].
Wang, L, Lin, S, Rammoham, K, Liu, Z, Liu, J, Guinther, N, Liu, R, Zhou, Q. Wang, T, Lynn, J, Zheng, P, Liu, Y, (2007). A Destabilizing Di-nucleotide Deletion in 3'-Untranslated Region of CD24 mRNA Confers Protection against Multiple Sclerosis. PLoS Genetics 3(4): e49.
Chen X, Chen D, Liu Z. (2007), Structural risk minimization based gene expression profiling analysis. International Journal of Bioinformatics Research and Applications (IJBRA), vol. 3(2), 153-169.
Liu Z, Tan M, Jiang, F (2008), Regularized F-measure Maximization for Classification and feature selection, Journal of Biomedicine and Biotechnology (JBB), in press.
Liu Z, Tan M (2008), ROC Based Utility function Maximization for Feature Selection and Classification with Application to High Dimensional protease. Data, Biometrics. 2008 Mar 24. [Epub ahead of print], PMID: 18363775.
Liu Z, Jiang, F (2008), Gene Identification and survival prediction with supervised and unsupervised learning. International Journal of Data Mining and Bioinformatics. In process.
Qiu Q., Todd NW, Li R. Liu Z, Yfantis HG, Katz RL, Stass SA, Jiang F (2008), Magnetic Enrichment of Bronchial Epithelial Cells from Sputum for Lung Cancer Diagnosis, Cancer 114(4):275-83.
Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW. (2008), EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Mol Cancer Ther. 7(10):3176-86.
Mazan-Mamczarz K, Hagner P, Corl S, Liu Z., Gartenhaus RB (2008). Targeted Therapy of MCT-1 Reverses a Malignant Phenotype through translational repression. Leukemia Research, 2008 Sep 26. [Epub ahead of print] PMID: 18824261.
Krystyna Mazan-Mamczarz, Patrick R. Hagner, Bojie Dai, William H. Wood, Yongqing Zhang, Kevin G. Becker, Zhenqiu Liu and Ronald B. Gartenhaus (2008), Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach. Cancer Research (priority), 68(19):7730-5.
Liu Z, Gartenhaus RB, Tan M, Jang F, and Jia X (2008), Gene and Pathway Identification with Lp Penalized Bayesian Logistic Regression, BMC Bioinformatics, 9(1):412.
Tian G-L, Tang ML, T, Liu, Z, Tan M, Tang NS (2008), Sample Size Determination for the Non-randomized Triangular Model for Sensitive Questions in Survey. Statistical Methods in Medical Research. [Epub ahead of print] PMID: 19221169.
Yuexing Zhang Yan Lu, Hua Zhou, Myoung Hee Lee, Zhenqiu Liu, Bret Hassel and Anne W. Hamburge (2008), Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice, BMC Cell Biology, 2008, 9:69.
Feng Jiang, Nevins W. Todd, Qi Qiu, Zhenqiu Liu, Rixin Zhou, Ruth L. Katz, and Sanford A. Stass (2008), Combined Genetic Analysis of Sputum and Computed Tomography for Noninvasive Diagnosis of Non-Small-Cell Lung Cancer, Lung Cancer, [Epub ahead of print] PMID: 19181417
Feng Jiang, Qi Qiu, Abha Khanna, Nevins W. Todd, Janaki Deepak, lingxiao Xing, Huijun Wang, Zhenqiu Liu, Yun Su, Sanford A. Stass, and Ruth L. Katz, (2009)¸ Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer, Mol Cancer Res Mol Cancer Res. 7(3):330-8
Liu, Z, Gartenhaus RB, Chen X, Howell C, Tan M (2008), Survival Prediction and Gene Identification with Penalized Global AUC Maximization, Journal of Computational Biology, (In press).
Ying Xie, Nevins W. Todd, Zhenqiu Liu, Min Zhan, HongBin Fang, Hong Peng, Mohammed Alattar, Janaki Deepak, and Sanford A. Stass , and Feng Jiang (2009), Altered miRNA Expression in Sputum for Diagnosis of Non-small Cell Lung Cancer, Lung Cancer, (In press).
Book Chapters (refereed):
Liu, Z. and Xu, Y. (2002), Adaptive Support Vector Classification. Book chapter of Soft Computing Systems: Design, Management and Applications. IOS Press, ISBN: 1 58603 297 6. 9 pages.
Liu, Z. and Bozdogan, H. (2003), Kernel PCA for Feature Extraction with Information Complexity. Book Chapter of Statistical Data Mining and Knowledge Discovery, Chapman & Hall/CRC PP 309-322.
Liu, Z. and Bozdogan, H. (2003) Improving the performance of radial basis function classification using information criteria. Statistical Data Mining and Knowledge Discovery, Chapman & Hall/CRC. PP 193-212.
Liu, Z., and Chen, D., Chen, X. (2007). CpG island identification with higher order and variable order Markov Models. Data Mining in Biomedicine, Springer, ISBN: 978-0-387-69318-7, PP 47- 58
Chen, Z., Zhang, Z., Liu, Z., and Cheng, X. (2007), An ensemble method of discovering sample classes using gene expression profiling. Data Mining in Biomedicine, Springer, ISBN: 978-0-387-69318-7, PP 39-46
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